Pretreatment of male BALB/c mice with β-ionone potentiates thioacetamide-induced hepatotoxicity

Toxicology Letters

Volumn 105, Issue 1, 1999, Pages 39-46

  Jeong, Tae Cheon ^a   Gu, Hee Kyoung ^a   Park, Jong Il ^a   Yun, Hyo In ^b   Kim, Hyoung Chin ^a   Ha, Chang Su ^a   Roh, Jung Koo ^a  

^a Korea Research Institute of Chemical Technology   (South Korea)

^b Chungnam National University   (South Korea)

Author keywords

Ionone; Hepatotoxicity; P450 induction; Potentiation; Pretreatment; Thioacetamide

Indexed keywords

BETA IONONE; CYTOCHROME P450; THIOACETAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; LIVER MICROSOME METABOLISM; LIVER NECROSIS; LIVER TOXICITY; MALE; METABOLIC ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; XENOBIOTIC METABOLISM;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; CARCINOGENS; CYTOCHROME P-450 ENZYME SYSTEM; DRUG SYNERGISM; ENZYME INDUCTION; HEPATITIS, TOXIC; ISOENZYMES; LIVER; LIVER FUNCTION TESTS; MALE; MICE; MICE, INBRED BALB C; MICROSOMES, LIVER; NORISOPRENOIDS; TERPENES; THIOACETAMIDE;

EID: 0032995479     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(98)00386-5     Document Type: Article

References (23)

1. Blank J.A., Tucker A.N., Sweatlock J., Gasiewicz T.A., Luster M.I. Alpha-naphthoflavone antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin induced murine ethoxyresorufin O-deethylase activity and immunosuppression. Mol. Pharmacol. 32:1987;168-172.
2. Bradford M.M. A rapid and sensitive method for quantitation of microgram quantities of protein using the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
3. Camus-Randon A.M., Raffall F., Béréziat J.C., McGregor D., Konstandi M., Lang M.A. Liver injury and expression of cytochromes P450: evidence that regulation of CYP2A5 is different from that of other major xenobiotic metabolizing CYP enzymes. Toxicol. Appl. Pharmacol. 138:1996;140-148.
4. Chieli E., Malvaldi G. Role of the microsomal FAD-containing monooxygenase in the liver toxicity of thioacetamide S-oxide. Toxicology. 31:1984;41-52.
5. Dyroff M.C., Neal R.A. Identification of the major protein adduct formed in rat liver after thioacetamide administration. Cancer Res. 41:1981;3430-3435.
6. Dyroff M.C., Neal R.A. Studies of the mechanism of metabolism of thioacetamide S-oxide by rat liver microsomes. Mol. Pharmacol. 23:1983;219-227.
7. Hunter A.L., Holscher M.A., Neal R.A. Thioacetamide-induced hepatic necrosis. I. Involvement of the mixed-function oxidase enzyme system. J. Pharmacol. Exp. Ther. 200:1977;439-448.
8. Itoh K., Nakamura K., Kimura T., Itoh S., Kamataki T. Molecular cloning of mouse liver flavin containing monooxygenase (FMO1) cDNA and characterization of the expression product: metabolism of the neurotoxin, 1,2,3,4-tetrahydroisoquinoline (TIQ). J. Toxicol. Sci. 22:1997;45-56.
9. Jeong T.C., Jordan S.D., Matulka R.A., Stanulis E.D., Kaminski E.J., Holsapple M.P. Role of metabolism by esterase and cytochrome P450 in cocaine-induced suppression of the antibody response. J. Pharmacol. Exp. Ther. 272:1995;407-416.
10. Jeong T.C., Kim H.J., Yun C.-H., Lee S.S., Yang K.-H., Han S.S., Roh J.K. Induction of liver cytochrome P450 2B1 by β-ionone in Sprague Dawley rats. Biochem. Biophys. Res. Commun. 216:1995;198-202.
11. Jeong T.C., Jordan S.D., Matulka R.A., Stanulis E.D., Park S.S., Holsapple M.P. Immunosuppression induced by acute exposure to cocaine is dependent on metabolism by cytochrome P450. J. Pharmacol. Exp. Ther. 276:1996;1257-1265.
12. Jeong T.C., Gu H.K., Chun Y.J., Yun C.-H., Han S.S., Roh J.K. Effects of β-ionone on the expression of cytochrome P450s and NADPH-cytochrome P450 reductase in Sprague Dawley rats. Chem. -Biol. Interact. 114:1998;97-107.
13. Johnson K.W., Kim D.H., Munson A.E., Holsapple M.P. Dependence on intact cells for the in vitro activation of dimethylnitrosamine to an immunosuppressive form. Mutat. Res. 182:1987;211-221.
14. Koop D.R. Hydroxylation of p-nitrophenol by rabbit ethanol-inducible cytochrome P450 isozyme 3a. Mol. Pharmacol. 29:1986;399-404.
15. Liu J., Liu Y., Bullock P., Klaassen C.D. Suppression of liver cytochrome P450 by alpha-hederin: relevance to hepatoprotection. Toxicol. Appl. Pharmacol. 134:1995;124-131.
16. Lubet R.A., Meyer R.T., Cameron J.W., Nims R.W., Burke M.D., Wolff J., Guengerich F.P. Dealkylation of pentoxyresorufin: a rapid and sensitive assay for measuring induction of cytochrome(s) P-450 by phenobarbital and other xenobiotics in the rat. Arch. Biochem. Biophys. 238:1985;43-48.
17. Mangipudy R.S., Chanda S., Mehendale H.M. Tissue repair response as a function of dose in thioacetamide hepatotoxicity. Environ. Health Perspect. 103:1995;260-267.
18. Nash T. The colorimetrical estimation of formaldehyde by means of the Hantzsch reaction. Biochem. J. 55:1953;416-421.
19. Naves Y.R. Some developments in the chemistry of ionones and their derivatives-a subject review. J. Soc. Cosmet. Chem. 22:1971;439-456.
20. Parke D.V., Rahman H. The effects of some terpenoids and other dietary nutrients on hepatic drug-metabolizing enzymes. Biochem. J. 113:1969;12.
21. Porter W.R., Neal R.A. Metabolism of thioacetamide and thioacetamide S-oxide by rat liver microsomes. Drug Metab. Dispos. 6:1978;379-388.
22. Roth L., Harbison R.D., James R.C., Tobin T., Roberts S.M. Cocaine hepatotoxicity: influence of hepatic enzyme inducing and inhibiting agents on the site of necrosis. Hepatology. 15:1992;934-940.
23. Thompson M.L., Shuster L., Casey E., Kanel G.C. Sex and strain differences in response to cocaine. Biochem. Pharmacol. 33:1984;1299-1307.