Early bacterial dependent induction of inducible nitric oxide synthase (iNOS) in epithelial cells upon transfer of CD45RBhigh CD4 + T cells in a model for experimental colitis

Inflammatory Bowel Diseases

Volumn 13, Issue 12, 2007, Pages 1467-1474

  Dijkstra, Gerard ^a   Yuvaraj, Saravanan ^a,c   Jiang, Han Qing ^b   Bun, Judy C A M ^a   Moshage, Han ^a   Kushnir, Natasha ^b   Peppelenbosch, Maikel P ^a   Cebra, John J ^b   Bos, Nicolaas A ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

CD45RBhigh CD4+ T cells; IBD; iNOS; Microflora; SCID

Indexed keywords

CD45RB ANTIGEN; CYTOKINE; INDUCIBLE NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CELL TRANSFER; COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; ENTERITIS; ENZYME ACTIVITY; ENZYME INDUCTION; EPITHELIUM CELL; HELICOBACTER; HELICOBACTER MURIDUM; IMMUNOHISTOCHEMISTRY; INTESTINE FLORA; LISTERIA MONOCYTOGENES; LYMPHOCYTIC INFILTRATION; MOUSE; NONHUMAN; OCHROBACTRUM ANTHROPI; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, CD45; BACTERIA; CD4-POSITIVE T-LYMPHOCYTES; COLITIS; COLON; GERM-FREE LIFE; INTESTINAL MUCOSA; MICE; MICE, SCID; NITRIC OXIDE SYNTHASE TYPE II; T-LYMPHOCYTE SUBSETS;

EID: 38049058331     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.20262     Document Type: Article

References (40)

1. Strober W, Fuss IJ, Blumberg RS. The immunology of mucosal models of inflammation. Annu Rev Immunol. 2002;20:495-549.
2. Jiang HQ, Kushnir N, Thurnheer MC, et al. Monoassociation of SCID mice with Helicobacter muridarum, but not four other enterics, provokes IBD upon receipt of T cells. Gastroenterology. 2002;122:1346-1354.
3. Phillips MW, Lee A. Isolation and characterization of a spiral bacterium from the crypts of rodent gastrointestinal tracts. Appl Environ Microbiol. 1983;45:675-683.
4. Dijkstra G, Moshage H, van Dullemen HM, et al. Expression of nitric oxide synthases and formation of nitrotyrosine and reactive oxygen species in inflammatory bowel disease. J Pathol. 1998;186:416-421.
5. Naumann M. Nuclear factor-kappa B activation and innate immune response in microbial pathogen infection. Biochem Pharmacol. 2000; 60:1109-1114.
6. Vos TA, Gouw AS, Klok PA, et al. Differential effects of nitric oxide synthase inhibitors on endotoxin-induced liver damage in rats. Gastroenterology. 1997;113:1323-1333.
7. Scanziani E, Simpson KW, Monestiroli S, et al. Histological and immunohistochemical detection of different Helicobacter species in the gastric mucosa of cats. J Vet Diagn Invest. 2001;13:3-12.
8. Xie QW, Kashiwabara Y, Nathan C. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J Biol Chem. 1994; 269:4705-4708.
9. Comalada M, Camuesco D, Sierra S, et al. In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-kappaB pathway. Eur J Immunol. 2005;35:584-592.
10. Jobin C, Haskill S, Mayer L, et al. Evidence for altered regulation of 1 kappa B alpha degradation in human colonic epithelial cells. J Immunol. 1997;158:226-234.
11. Witthoft T, Eckmann L, Kim JM, et al. Enteroinvasive bacteria directly activate expression of iNOS and NO production in human colon epithelial cells. Am J Physiol. 1998;275:G564-G571.
12. Schesser K, Spiik AK, Dukuzumuremyi JM, et al. The yopJ locus is required for Yersinia-mediated inhibition of NF-kappaB activation and cytokine expression: YopJ contains a eukaryotic SH2-like domain that is essential for its repressive activity. Mol Microbiol. 1998;28:1067-1079.
13. Neurath MF, Pettersson S, Meyer Zum Buschenfelde KH, et al. Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice. Nat Med. 1996;2:998-1004.
14. Dijkstra G, Moshage H, Jansen PL. Blockade of NF-kappaB activation and donation of nitric oxide: new treatment options in inflammatory bowel disease? Scand J Gastroenterol Suppl. 2002;37-41.
15. Chen LW, Egan L, Li ZW, et al. The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med. 2003;9:575-581.
16. Grisham MB, Pavlick KP, Laroux FS, et al. Nitric oxide and chronic gut inflammation: controversies in inflammatory bowel disease. J Investig Med. 2002;50:272-283.
17. Camuesco D, Comalada M, Rodriguez-Cabezas ME, et al. The intestinal anti-inflammatory effect of quercitrin is associated with an inhibition in iNOS expression. Br J Pharmacol. 2004;143:908-918.
18. Hogaboam CM, Jacobson K, Collins SM, et al. The selective beneficial effects of nitric oxide inhibition in experimental colitis. Am J Physiol. 1995;268:G673-684.
19. Rachmilewitz D, Karmeli F, Okon E, et al. Experimental colitis is ameliorated by inhibition of nitric oxide synthase activity. Gut. 1995; 37:247-255.
20. Ribbons KA, Currie MG, Connor JR, et al. The effect of inhibitors of inducible nitric oxide synthase on chronic colitis in the rhesus monkey. J Pharmacol Exp Ther. 1997;280:1008-1015.
21. Conner EM, Chen Y, Gronberg A. Effect of nitric oxide synthase (NOS) inhibition on dextran sulfate sodium (DSS)-induced colitis in rats and mice. Gastroenterology 1995;100:A801.
22. Pfeiffer CJ, Qiu BS. Effects of chronic nitric oxide synthase inhibition on TNB-induced colitis in rats. J Pharm Pharmacol. 1995;47:827-832.
23. McCafferty DM, Mudgett JS, Swain MG, et al. Inducible nitric oxide synthase plays a critical role in resolving intestinal inflammation. Gastroenterology. 1997;112:1022-1027.
24. Zingarelli B, Szabo C, Salzman AL. Reduced oxidative and nitrosative damage in murine experimental colitis in the absence of inducible nitric oxide synthase. Gut. 1999;45:199-209.
25. McCafferty DM, Miampamba M, Sihota E, et al. Role of inducible nitric oxide synthase in trinitrobenzene sulphonic acid induced colitis in mice. Gut. 1999;45:864-873.
26. Vallance BA, Dijkstra G, Qiu B, et al. Relative contributions of NOS isoforms during experimental colitis: endothelial-derived NOS maintains mucosal integrity. Am J Physiol Gastrointest Liver Physiol. 2004; 287:G865-G874.
27. Hokari R, Kato S, Matsuzaki K, et al. Reduced sensitivity of inducible nitric oxide synthase deficient mice to chronic colitis. Free Radic Biol Med. 2001;31:153-163.
28. Krieglstein CF, Cerwinka WH, Laroux FS, et al. Regulation of murine intestinal inflammation by reactive metabolites of oxygen and nitrogen: divergent roles of superoxide and nitric oxide. J Exp Med. 2001;194: 1207-1218.
29. Beck PL, Xavier R, Wong J, et al. Paradoxical roles of different nitric oxide synthase isoforms in colonic injury. Am J Physiol Gastrointest Liver Physiol. 2004;286:G137-G147.
30. McCafferty DM, Sihota E, Muscara M, et al. Spontaneously developing chronic colitis in IL-10/iNOS double-deficient mice. Am J Physiol Gastrointest Liver Physiol. 2000;279:G90-G99.
31. Lundberg JO, Herulf M, Olesen M, et al. Increased nitric oxide production in collagenous and lymphocytic colitis. Eur J Clin Invest. 1997;27: 869-871.
32. Perner A, Andresen L, Normark M, et al. Expression of nitric oxide synthases and effects of L-arginine and L-NMMA on nitric oxide production and fluid transport in collagenous colitis. Gut. 2001;49:387-394.
33. Wallace JL, Vergnolle N, Muscara MN, et al. Enhanced anti-inflammatory effects of a nitric oxide-releasing derivative of mesalamine in rats. Gastroenterology. 1999;117:557-566.
34. Elliott SN, McKnight W, Cirino G, et al. A nitric oxide-releasing nonsteroidal anti-inflammatory drug accelerates gastric ulcer healing in rats. Gastroenterology. 1995;109:524-530.
35. Fiorucci S, Antonelli E, Santucci L, et al. Gastrointestinal safety of nitric oxide-derived aspirin is related to inhibition of ICE-like cysteine proteases in rats. Gastroenterology. 1999;116:1089-1106.
36. Matthews JR, Botting CH, Panico M, et al. Inhibition of NF-kappaB DNA binding by nitric oxide. Nucleic Acids Res. 1996;24:2236-2242.
37. Brittain T, Blackmore R, Greenwood C, et al. Bacterial nitrite-reducing enzymes. Eur J Biochem. 1992;209:793-802.
38. Johnston JD, Harvey CJ, Menzies IS, et al. Gastrointestinal permeability and absorptive capacity in sepsis. Crit Care Med. 1996;24:1144-1149.
39. Unno N, Wang H, Menconi MJ, et al. Inhibition of inducible nitric oxide synthase ameliorates endotoxin-induced gut mucosal barrier dysfunction in rats. Gastroenterology. 1997;113:1246-1257.
40. Sorrells DL, Friend C, Koltuksuz U, et al. Inhibition of nitric oxide with aminoguanidine reduces bacterial translocation after endotoxin challenge in vivo. Arch Surg. 1996;131:1155-1163.