Preparation and characterization of carboxymethyl chitosan and β-cyclodextrin microspheres by spray drying

Drying Technology

Volumn 26, Issue 1, 2008, Pages 108-115

  Zhang, Wei Fen ^a,b   Chen, Xi Guang ^a   Li, Pi Wu ^a,c   Liu, Cheng Sheng ^a   He, Qiang Zhi ^c  

^a OCEAN UNIVERSITY OF CHINA   (China)

^b Department of Pharmaceutics   (Chile)

^c Shandong Academy of Food and Fermentation Industries   (China)

Author keywords

Carboxymethyl chitosan; Drug release; Microspheres; Theophylline

Indexed keywords

CHARACTERIZATION; CHITIN; CYCLODEXTRINS; DRUG DELIVERY; ENCAPSULATION; MICROSPHERES; PARTICLE SIZE ANALYSIS; PERMEATION; TOXICITY;

CARBOXYMETHYL CHITOSAN; DRUG RELEASE; ENCAPSULATION EFFICIENCY; PERMEATION RATE;

SPRAY DRYING;

CHARACTERIZATION; CHITIN; CYCLODEXTRINS; DRUG DELIVERY; ENCAPSULATION; MICROSPHERES; PARTICLE SIZE ANALYSIS; PERMEATION; SPRAY DRYING; TOXICITY;

EID: 37849041993     PISSN: 07373937     EISSN: 15322300     Source Type: Journal    
DOI: 10.1080/07373930701781736     Document Type: Article

References (38)

1. Gavini, E., Hegge, A. B., Rassu, G., Sanna, V., Testa, C., Pirisino, G., Karlsen, J. and Giunchedi, P. (2006) Nasal administration of carbamazepine using chitosan microspheres: In vitro/in vivo studies. International Journal of Pharmaceutics, 307, pp. 9-15.
2. Huang, Y. C., Yeh, M. K. and Chiang, C. H. (2002) Formulation factors in preparing BTM-chitosan microspheres by spray drying method. International Journal of Pharmaceutics, 242, pp. 239-242.
3. Wang, Y. L., Wang, Y. P., Yang, J., Pfeffer, R., Dave, R. and Michniak, B. (2006) The application of a supercritical antisolvent process for sustained drug delivery. Powder Technology, 164, pp. 94-102.
4. Fu, J., Fiegel, J., Krauland, E. and Hanes, J. (2002) New polymeric carriers for controlled drug delivery following inhalation or injection. Biomaterials, 23, pp. 4425-4433.
5. Oneda, F. and Ré, M. I. (2003) The effect of formulation variables on the dissolution and physical properties of spray-dried microspheres containing organic salts. Powder Technology, 130, pp. 377-384.
6. Sinha, V. R., Singla, A. K., Wadhavan, S., Kaushik, R., Kumria, R., Bansal, K. and Dhawan, S. (2004) Chitosan microspheres as a potential carrier for drugs. International Journal of Pharmaceutics, 274, pp. 1-33.
7. Zeng, X. M., Martin, G. P. and Marriott, C. (1995) The controlled delivery of drugs to the lung. International Journal of Pharmaceutics, 124, pp. 149-164.
8. Berger, J., Reist, M., Mayer, J. M., Felt, O., Peppas, N. A. and Gurny, R. (2004) Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications. European Journal of Pharmaceutics and Biopharmaceutics, 57, pp. 19-34.
9. Chellat, F., Tabrizian, M., Dumitriu, S., Chornet, E., Rivard, C. H. and Yahia, L. (2000) Study of biodegradation behavior of chitosan-xanthan microspheres in simulated physiological media. Journal of Biomedical Materials Research, 53, pp. 592-599.
10. Bogataj, M., Mrhar, A., Grabnar, I., Rajtman, Z., Bukovec, P., Srcic, S. and Urleb, U. (2000) The influence of magnesium stearate on the characteristic of mucoadhesive microspheres. Journal of Microencapsulation, 17, pp. 499-508.
11. Liu, C. S., Desai, K. G. H., Tang, X. X. and Chen, X. G. (2006) Drug release kinetics of spray-dried chitosan microspheres. Drying Technology, 24, pp. 769-776.
12. Desai, K. G. H. and Park, H. J. (2005) Recent developments in microencapsulation of food ingredients. Drying Technology, 23, pp. 1361-1394.
13. Pavanetto, F., Genta, I., Giunchedi, P. and Conti, B. (1993) Evaluation of spray drying as a method for polylactide and polylactide-co-glycolide microsphere preparation. Journal of Microencapsulation, 10, pp. 487-497.
14. He, P., Davis, S. S. and Illum, L. (1999) Sustained release chitosan microspheres prepared by spray drying methods. Journal of Microencapsulation, 16, pp. 343-355.
15. He, P., Davis, S. S. and Illum, L. (1999) Chitosan microspheres prepared by spray drying. International Journal of Pharmaceutics, 187, pp. 53-65.
16. Asada, M., Takahashi, H., Okamoto, H., Tanino, H. and Danjo, K. (2004) Theophylline particle design using chitosan by the spray drying. International Journal of Pharmaceutics, 270, pp. 167-174.
17. Takeuchi, H., Yasuji, T., Hino, T., Yamamoto, H. and Kawashima, Y. (1998) Spray-dried composite particles of lactose and sodium alginate for direct tabletting and controlled releasing. International Journal of Pharmaceutics, 174, pp. 91-100.
18. Aiedeh, K. and Taha, M. O. (2001) Synthesis of iron-crosslinked chitosan succinate and iron-crosslinked hydroxamated chitosan succinate and their in vitro evaluation as potential matrix materials for oral theophylline sustained-release beads. European Journal of Pharmaceutical Sciences, 13, pp. 159-168.
19. Patel, V. R. and Amiji, M. M. (1996) Preparation and characterization of freeze-dried chitosan-poly (ethylene oxide) hydrogels for site-specific antibiotic delivery in the stomach. Pharmaceutical Research, 13, pp. 588-593.
20. Puttipipatkhachorn, S., Nunthanid, J., Yamamoto, K. and Peck, G. E. (2001) Drug physical state and drug-polymer interaction on drug release from chitosan matrix films. Journal of Controlled Release, 75, pp. 143-153.
21. Oungbho, K. and Müller, B. W. (1997) Chitosan sponges as sustained release drug carriers. International Journal of Pharmaceutics, 156, pp. 229-237.
22. Ganza-González, A., Anguiano-Igea, S., Otero-Espinar, F. J. and Mández, J. B. (1999) Chitosan and chondroitin microspheres for oral-administration controlled release of metoclopramide. European Journal of Pharmaceutical Biopharmaceutics, 48, pp. 149-155.
23. Li, Z., Zhuang, X. P., Liu, X. F., Guan, Y. L. and Yao, K. D. (2002) Study on antibacterial O-carboxymethylated chitosan/cellulose blend film from LiCl/N, N-dimethylacetamide solution. Polymer, 43, pp. 1541-1547.
24. Kennedy, R., Costain, D. J., MeAlister, V. C. and Lee, T. D. G. (1996) Prevention of experimental postoperative peritoneal adhesions by N,O-carboxymethyl chitosan. Surgery, 120, pp. 866-870.
25. Muzzarelli, R. A. A., Mattioli-Belmonte, M., Pugnaloni, A. and Biagini, G. (1999) Chitin and Chitinases, pp. 260-261. Basel, Birkhauser Verlag
26. Chen, S. C., Wu, Y. C., Mi, F. L., Lin, Y. H., Yu, L. C. and Sung, H. W. (2004) A novel pH-sensitive hydrogel composed of N, O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery. Journal Controlled Release, 96, pp. 285-300.
27. Kinnarinen, T., Jarho, P., Järvinen, K. and Järvinen, T. (2003) Pullmonary deposition of a budesonide/γ-cyclodextrin complex in vitro. Journal of Controlled Release, 90, pp. 197-205.
28. Cerchiara, T., Luppi, B., Bigucci, F. and Zecchi, V. (2003) Effect of chitosan on progesterone release from hydroxypropyl-β-cyclodextrin complexes. International Journal of Pharmaceutics, 258, pp. 209-215.
29. Fernandes, C. M. and Veiga, F. J. B. (2002) Effect of the hydrophobic nature of triacetyl-β-cyclodextrin on the complexation with nicardipine hydrochloride: Physicochemical and dissolution properties of the kneaded and spray-dried complexes. Chemical & Pharmaceutical Bulletin, 50, pp. 1597-1602.
30. Filipovic-Grcic, J., Becirevic-Lacan, M., Skalko, N. and Jalsenjak, I. (1996) Chitosan microspheres of nifedipine and nifedipine-cyclodextrin inclusion complexes. International Journal of Pharmaceutics, 135, pp. 183-190.
31. Fukaya, H., Iimura, A., Hoshiko, K., Fuyumuro, T., Noji, S. and Nabeshima, T. (2003) A cyclosporine A/maltosyl-alpha-cyclodextrin complex for inhalation therapy of asthma. Respiratory Journal, 22, pp. 213-219.
32. Marques, H.M. Carbral, Hadgraft, J., Kellaway, I. W. and Pugh, W. J. (1990) Studies of cyclodextrin inclusion complexes: Molecular modeling and 1H-NMR evidence for the sabutamol-β-cyclodextrin complex. International Journal of Pharmaceutics, 63, pp. 267-274.
33. Finnerty, J. P., Lee, C., Wilson, S., Madden, J. and Holgate, S. T. (1996) Effects of theophylline on inflammatory cells and cytokines in asthmatic subjects: A placebo-controlled parallel group study. European Respiratory Journal, 9, pp. 1672-1677.
34. Tohda, Y., Muraki, M., Iwanaga, T., Kubo, H., Fukuoka, M. and Nakajima, S. (1998) The effect of theophylline on blood and sputum eosinophils and ECP in patients with bronchial asthma. International Journal Immunopharmacology, 20, pp. 173-181.
35. Li, H. P., He, G. J. and Yi, X. H. (2000) Effect of aminophylline aerosol on airway mucosa of normal and asthmatic guinea pigs. Shanghai Medical Journal, 23, pp. 465-469.
36. Corrigan, D. O., Healy, A. M. and Corrigan, O. I. (2006) Preparation and release of salbutamol from chitosan and chitosan co-spray dried compacts and multiparticulates. European Journal of Pharmaceutical Biopharmaceutics, 62, pp. 295-305.
37. Chan, H. K. and Chew, N. Y. K. (2003) Novel alternative methods for the delivery of drugs for the treatment of asthma. Advanced Drug Delivery Reviews, 55, pp. 793-805.
38. Merkus, F. W. H. M., Verhoef, J. C., Marttin, E., Romeijn, S. G., van der Kuy, P. H. M., Hermens, W. A. J. J. and Schipper, N. G. M. (1999) Cyclodextrins in nasal drug delivery. Advanced Drug Delivery Reviews, 36, pp. 41-57.