A randomly coiled, high-molecular-weight polypeptide exhibits increased paracellular diffusion in Vitro and in Situ relative to the highly ordered α-helix conformer

Pharmaceutical Research

Volumn 22, Issue 2, 2005, Pages 245-254

  Salamat Miller, Nazila ^a,b   Chittchang, Montakarn ^a   Mitra, Ashim K ^a   Johnston, Thomas P ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^b UNIVERSITY OF KANSAS   (United States)

Author keywords

Molecular geometry; Paracellular diffusion; Polypeptide; Secondary structure

Indexed keywords

POLY DEXTRO GLUTAMIC ACID; POLY DEXTRO LYSINE; POLYPEPTIDE; UNCLASSIFIED DRUG;

ALPHA HELIX; ANIMAL EXPERIMENT; ARTICLE; CELL TRANSPORT; DIFFUSION; DIFFUSION COEFFICIENT; DRUG ABSORPTION; HUMAN; HUMAN CELL; HYDRODYNAMICS; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PH; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; RAT;

ANIMALS; CACO-2 CELLS; CELL MEMBRANE; DIFFUSION; HUMANS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; MALE; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 16244385465     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11095-004-1192-4     Document Type: Article

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