Pharmacological profiling of chemokine receptor-directed compounds using high-content screening

Journal of Biomolecular Screening

Volumn 13, Issue 1, 2008, Pages 40-53

  Haasen, Dorothea ^a,b   Merk, Susanne ^a   Seither, Peter ^a   Martyres, Domnic ^a   Hobbie, Silke ^a   Heilker, Ralf ^a  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

CCR2B; CCR3; ERK phosphorylation; High content screening; Internalization

Indexed keywords

CALCIUM; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR2B; CHEMOKINE RECEPTOR CCR3; EOTAXIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MONOCYTE CHEMOTACTIC PROTEIN 1; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CHO CELL; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FEMALE; FLUORESCENCE MICROSCOPY; HIGH CONTENT SCREENING; IMAGE ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ANIMALS; CHEMOKINE CCL11; CHEMOKINE CCL2; CHO CELLS; CRICETINAE; CRICETULUS; DRUG EVALUATION, PRECLINICAL; HUMANS; MAP KINASE SIGNALING SYSTEM; RECEPTORS, CCR2; RECEPTORS, CCR3; RECEPTORS, CHEMOKINE; RECOMBINANT PROTEINS; TRANSFECTION;

CRICETULUS GRISEUS;

EID: 37749023097     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057107312128     Document Type: Article

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