Features of nuclear architecture that influence gene expression in higher eukaryotes: Confronting the enigma of epigenetics

Journal of Cellular Biochemistry

Volumn 80, Issue SUPPL. 35, 2000, Pages 69-77

  Sotolongo, Barbara ^a   Ward, W Steven ^a  

^a UNIVERSITY OF HAWAII   (United States)

Author keywords

Chromatin domains; DNA loops; Gene expression; Nuclear dynamics; Nuclear structure

Indexed keywords

CELL NUCLEUS; CHROMATIN; CHROMOSOMAL LOCALIZATION; DNA STRUCTURE; EUKARYOTE; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENETIC RECOMBINATION; MOLECULAR DYNAMICS; NUCLEIC ACID STRUCTURE; PRIORITY JOURNAL; PROTEIN DOMAIN; REGULATOR GENE; REVIEW; ANIMAL; CHROMOSOME; GENE EXPRESSION REGULATION; HUMAN; METABOLISM; PROTEIN TERTIARY STRUCTURE;

TRANSCRIPTION FACTOR;

ANIMALS; CELL NUCLEUS; CHROMATIN; CHROMOSOMES; GENE EXPRESSION REGULATION; HUMANS; LOCUS CONTROL REGION; PROTEIN STRUCTURE, TERTIARY; TRANSCRIPTION FACTORS;

EID: 37649026054     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (45)

1. The MAR-binding protein SATB1 orchestrates temporal and spatial expression of multiple genes during T-cell development
2. Stopped at the border: Boundaries and insulators
3. The protein CTCF is required for the enhancer blocking activity of vertebrate insulators
4. β-globin gene switching and DNase I sensitivity of the endogenous β-globin locus in mice do not require the locus control region
5. Going the distance: A current view of enhancer action
6. Transcriptional augmentation: Modulation of gene expression by scaffold/matrix attached regions (S/MAR elements)
7. The transgeneticists toolbox
8. Transcriptional behaviour of LCR enhancer elements integrated at the same chromosomal locus by recombinase-mediated cassette exchange
9. The Drosophila polycomb protein interacts with nucleosomal core particles in vitro via its repression domain
10. Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin
11. Epigenetic inheritance of active chromatin after removal of main transactivator
12. The organization of replication and transcription
13. Random activation of a transgene under the control of a hybrid hCD2 locus control region/Ig enhancer regulatory element
14. Looping, linking and chromatin activity: New insights into β-globin locus regulation
15. The β-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse β-globin locus
16. Locus control regions and epigenetic chromatin modifiers
17. Analysis of mammalian cis-regulatory DNA elements by homologous recombination
18. A functional enhancer suppresses silencing of a transgene and prevents its localization close to centromeric heterochromatin
19. Contacts in context: Promoter specificity and macromolecular interactions in transcription
20. Intergenic transcription and developmental remodeling of chromatin subdomains in the human β-globin locus
21. Position-independent, high-level expression of the human β-globin gene in transgenic mice
22. Do LCRs open chromatin domains?
23. Chromatin domains and nuclear compartments: Establishing sites of gene expression in eukaryotic nuclei
24. Replicon clusters are stable units of chromosome structure: Evidence that nuclear organization contributes to the efficient activation and propagation of S-phase in human cells
25. The balance sheet for transcription: An analysis of nuclear RNA metabolism in mammalian cells
26. Extension of chromatin accessibility by nuclear matrix attachment regions
27. Eukaryotic transcription: An interlaced network of transcription factors and chromatin-modifying machines
28. A group of scs elements function as domain boundaries in an enhancer-blocking assay
29. Quantitation of RNA polymerase II and its transcription factors in an HeLa cell: Little soluble holoenzyme but significant amounts of polymerase attached to the nuclear substructure
30. Probes for chromatin accessibility in the Drosophila bithorax complex respond differently to polycomb-mediated repression
31. The glucocorticoid receptor: Rapid exchange with regulatory sites in living cells
32. An Fgf mutant allelic series generated by Cre- and Flp-mediated recombination
33. Boundaries that demarcate structural and functional domains of chromatin
34. The cellular organization of gene expression
35. Human matrix attachment regions insulate transgene expression from chromosomal position effects in Drosophila melanogaster
36. Silence across the border
37. A single erythroid specific DNase I super-hypersensitive site activates high levels of human β-globin gene expression in transgenic mice
38. Duplication and maintenance of heterochromatin domains
39. Gene targeting the myf-5 locus with nlacZ reveals expression of this myogenic factor in mature skeletal muscle fibres as well as early embryonic muscle
40. Dividing the empire: Boundary chromatin elements delimit the territory of enhancers
41. Pre-selection of integration sites imparts repeatable transgene expression
42. Transcription complex stability and chromatin dynamics in vivo
43. Position effects on eukaryotic gene expression
44. Alterations of nucleosome structure as a mechanism of transcriptional regulation
45. Visualization of chromosomal domains with boundary element-associated factor BEAF-32