3′-Azido-2′,3′-dideoxynucleoside 5′-triphosphates inhibit telomerase activity in vitro, and the corresponding nucleosides cause telomere shortening in human HL60 cells

Nucleic Acids Research

Volumn 35, Issue 21, 2007, Pages 7140-7149

  Liu, Xiaohong ^a   Takahashi, Hazuki ^a   Harada, Yoko ^a   Ogawara, Tsukasa ^a   Ogimura, Yuta ^a   Mizushina, Yoshiyuku ^b   Saneyoshi, Mineo ^a   Yamaguchi, Toyofumi ^a  

^a TEIKYO UNIVERSITY OF SCIENCE   (Japan)

^b KOBE GAKUIN UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3' AZIDO 2',3' DIDEOXY 2 AMINOADENOSINE 5' TRIPHOSPHATE; 3' AZIDO 2',3' DIDEOXY 6 THIOGUANOSINE 5' TRIPHOSPHATE; 3' AZIDO 2',3' DIDEOXYADENOSINE 5' TRIPHOSPHATE; 3' AZIDO 2',3' DIDEOXYGUANOSINE 5' TRIPHOSPHATE; 3' AZIDO 2',3' DIDEOXYNUCLEOSIDE 5' TRIPHOSPHATE; ANTINEOPLASTIC AGENT; DNA DIRECTED DNA POLYMERASE ALPHA; DNA DIRECTED DNA POLYMERASE DELTA; ENZYME INHIBITOR; GENOMIC DNA; NUCLEOSIDE; TELOMERASE; UNCLASSIFIED DRUG; 2',3' DIDEOXYADENOSINE; 2',3' DIDEOXYNUCLEOSIDE DERIVATIVE; 3' AZIDO 2',3' DIDEOXYGUANOSINE; 3' AZIDO 2,6 DIAMINOPURINE 2',3' DIDEOXYRIBOSIDE; 3'-AZIDO-2',3'-DIDEOXYGUANOSINE; 3'-AZIDO-2,6-DIAMINOPURINE-2',3'-DIDEOXYRIBOSIDE; DIDEOXYNUCLEOTIDE; DNA; DRUG DERIVATIVE; ZIDOVUDINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL STRAIN HL 60; CONTROLLED STUDY; DRUG POTENCY; ENZYME INHIBITION; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; SOUTHERN BLOTTING; STRUCTURE ACTIVITY RELATION; TELOMERE; CELL PROLIFERATION; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM;

ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; DIDEOXYADENOSINE; DIDEOXYNUCLEOSIDES; DIDEOXYNUCLEOTIDES; DNA; ENZYME INHIBITORS; HELA CELLS; HL-60 CELLS; HUMANS; TELOMERASE; TELOMERE; ZIDOVUDINE;

EID: 37549065493     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkm859     Document Type: Article

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