Parametric images of benzodiazepine receptor concentration using a partial-saturation injection

Journal of Cerebral Blood Flow and Metabolism

Volumn 17, Issue 3, 1997, Pages 343-355

  Delforge, Jacques ^a,b   Spelle, L ^a   Bendriem, B ^a   Samson, Y ^a   Syrota, A ^a  

^a SERVICE HOSPITALIER FRÉDÉRIC JOLIOT   (France)

^b DIF   (France)

Author keywords

Benzodiazepine receptor; Flumazemil; Parametric image; PET; Quantification

Indexed keywords

BENZODIAZEPINE RECEPTOR; CARBON 11; FLUMAZENIL;

ANALYTIC METHOD; ARTICLE; BRAIN; COMPARTMENT MODEL; HUMAN; IMAGING; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SCATCHARD PLOT;

EID: 0030939401     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199703000-00011     Document Type: Article

References (19)

1. d values with positron emission tomography. Eur J Pharmacol 213:107-115
2. Bendriem B, Trebossen R, Frouin V, Lamer O, Brulon V, Syrota A (1992) Evaluation of a PET scanner in 2D and 3D acquisition mode. In: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vol 13 (Moucci JP, Plonsev R, Coatrieux JL, Laxminarayan S, eds) pp 1837-1840
3. Blomqvist G, Pauli S, Farde L, Eriksson L, Persson A, Halldin C (1990) Maps of receptor binding parameters in the human brain - a kinetic analysis of PET measurements. Eur J Nucl Med 16:257-265
4. 11C-flumazenil kinetics studied by PET: application to a critical study of the equilibrium approaches. J Cereb Blood Flow Metab 13:454-468
5. 11C-flumazenil and a single experiment protocol. J Cereb Blood Flow Metab 15:284-300
6. Delforge J, Bendriem B, Syrota A (1996a) The concept of reaction volume in the in vivo ligand-receptor model. J Nucl Med 37:118-125
7. Delforge J, Spelle L, Bendriem B, Samson Y, Bottlaender M, Papageorgiou S, Syrota A (1996b) Quantitation of the benzodiazepine receptor in human brain using a partial-saturation method. J Nucl Med 37:5-11
8. Huang SC, Barrio JR, Phelps ME (1986) Neuroreceptor assay with positron emission tomography: equilibrium versus dynamic approach. J Cereb Blood Flow Metab 6:515-521
9. Iyo M, Itoh T, Yamasaki T, Fukuda H, Inoue O, Shinotoh H, Suzuki K, Fukui S, Tateno Y (1991) Quantitative in vivo analysis of benzodiazepine binding sites in the human brain using positron emission tomography. Neuropharmacology 30:207-215
10. 11C-flumazenil: application of the steady state principle. In: Quantification of Brain Function (Uemura K, Lassen NA, Jones T, Kanno I, eds), Amsterdam, Excerpta Medica, pp 303-311
11. Lassen N (1993) Neuroreceptor quantitation in vivo by the steady-state principle using constant infusion or bolus injection of radioactive tracers. J Cereb Blood Flow Metab 12:709-716
12. 11C-flumazenil and PET: application of the steady-state principle. J Cereb Blood Flow Metab 15:152-165
13. Litton JE, Hall H, Pauli S (1994) Saturation analysis in PET-analysis of errors due to imperfect reference regions. J Cereb Blood Flow Metab 14:358-362
14. Mazière M, Hantraye P, Prenant C, Sastre J, Comar D (1984) Synthesis of ethyl 8-fluoro-5,6-dihydro-5-(11C)methyl-6-oxo-4H-imidazo(1,5-a) benzodiazepine-3-carboxylate (Ro 15-1788): a specific radioligand for in vivo study of central benzodiazepine receptors by positron emission tomography. Int J Appl Radiat Isot 35:973-978
15. Millet P, Delforge J, Mauguière F, Pappata S, Cinotti L, Frouin V, Samson Y, Bendriem B, Syrota A (1995) Parametric images of benzodiazepine receptor concentration in human brain: comparison with the distribution volume approach. J Nucl Med 36:1462-1471
16. 11C]RO 15 1788 to central type benzodiazepine receptors in human brain: Quantitative evaluation by PET. J Cereb Blood Flow Metab 8:304-313
17. 11C-RO 15-1788 binding to the human neocortex using positron emission tomography. Hum Psychopharmacol 4:21-31
18. 11C-flumazenil. J Cereb Blood Flow Metab 13:656-667
19. Savic I, Persson A, Roland P, Pauli S, Sedvall G, Widen L (1988) In vivo demonstration of reduced benzodiazepine receptor binding in human epileptic foci. Lancet 2:863-866