Synthesis and biological evaluation of benzamides and benzamidines as selective inhibitors of VEGFR tyrosine kinases

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 19, 2006, Pages 5127-5131

  Nakamura, Hiroyuki ^a   Sasaki, Yusuke ^a   Uno, Masaharu ^a   Yoshikawa, Tomohiro ^a   Asano, Toru ^a   Ban, Hyun Seung ^a   Fukazawa, Hidesuke ^b   Shibuya, Masabumi ^c   Uehara, Yoshimasa ^b  

^a GAKUSHUIN UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Benzamides; Benzamidines; Inhibitor; VEGFR tyrosine kinases; VEGFR 1; VEGFR 2

Indexed keywords

2 AMINOBENZAMIDE; 2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; AAL 993; AMIDE; BENZAMIDE DERIVATIVE; BENZAMIDINE DERIVATIVE; PROTEIN TYROSINE KINASE INHIBITOR; SALICYCLAMIDE; UNCLASSIFIED DRUG; VANDETANIB; VASCULOTROPIN C; VASCULOTROPIN INHIBITOR; VATALANIB;

ANTIANGIOGENIC ACTIVITY; ARTICLE; AUTOPHOSPHORYLATION; DRUG DETERMINATION; DRUG INHIBITION; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY;

ANIMALS; BENZAMIDES; BENZAMIDINES; HUMANS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 33747372852     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.07.075     Document Type: Article

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