Cyclooxygenase-1 participates in selected vasodilator responses of the cerebral circulation

Circulation Research

Volumn 88, Issue 6, 2001, Pages 600-608

  Niwa, Kiyoshi ^a   Haensel, Cindy ^a   Ross, M Elizabeth ^a   Iadecola, Costantino ^a,b  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Cerebral blood flow; Endothelium dependent vasodilators; Laser Doppler flowmetry

Indexed keywords

5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; ACETYLCHOLINE; BRADYKININ; CALCIMYCIN; CARBON 14; CHLORALOSE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; IODOPHENAZONE; PROSTANOID; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; URETHAN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BLOOD VESSEL TONE; BRAIN BLOOD FLOW; BRAIN CIRCULATION; BRAIN MICROCIRCULATION; CONTROLLED STUDY; HYPERCAPNIA; LASER FLOWMETER; MALE; NONHUMAN; PRIORITY JOURNAL; SOMATOSENSORY CORTEX; VASODILATATION; VIBRISSA;

EID: 0035970509     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.88.6.600     Document Type: Article

References (46)

1. Biochemistry of prostaglandin endoperoxide H synthase-1 and synthase-2 and their differential susceptibility to nonsteroidal anti-inflammatory drugs
2. Cyclooxygenases 1 and 2
3. Cyclooxygenase-2: Molecular biology, pharmacology, and neurobiology
4. COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex
5. Factors involved in the physiological regulation of the cerebral circulation
6. Prostanoids: Intrinsic modulators of cerebral circulation
7. Regulation of the cerebral circulation: Role of endothelium and potassium channels
8. Hydroxyl radical mediates the endothelium-dependent relaxation produced by bradykinin in mouse cerebral arterioles
9. Calcium ionophore and acetylcholine dilate arterioles on the mouse brain by different mechanisms
10. Inhibition of prostaglandin synthesis and the response of baboon cerebral circulation to carbon dioxide
11. The effect of indomethacin on the blood flow-metabolism couple in the brain under normal, hypercapnic and hypoxic conditions
12. Effects of indomethacin upon cerebral hemodynamics of newborn pigs
13. Inhibitory effect of indomethacin on prostacyclin receptor-mediated cerebral vascular responses
14. Indomethacin in submicromolar concentrations inhibits cyclic AMP-dependent protein kinase
15. Differential effect of three cyclooxygenase inhibitors on human cerebral blood flow velocity and carbon dioxide reactivity
16. Prostaglandin and human CBF control: Effect of aspirin and indomethacin
17. Effects of indomethacin and diclofenac on cerebral blood flow in hypercapnic conscious rats
18. Indomethacin abolishes cerebral blood flow increases in response to acetazolamide-induced extracellular acidosis: A mechanism for its effect on hypercapnia?
19. Pharmacological analysis of cyclooxygenase-1 in inflammation
20. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
21. + channels
22. Cyclooxygenase-2 contributes to functional hyperemia in whisker-barrel cortex
23. A β1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation
24. Principles and methods for measurement of cerebral blood flow: Experimental methods
25. Measurement of local cerebral blood flow with iodo(C14)antipyrine
26. SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein
27. Exogenous A β1-40 reproduces cerebrovascular alterations resulting from amyloid precursor protein overexpression in mice
28. Cerebrovascular hypoxic and autoregulatory responses during reduced brain metabolism
29. Gene-targeting studies of mammalian behavior: Is it the mutation or the background genotype?
30. Differences in endothelium-dependent cerebral dilation by bradykinin and acetylcholine
31. The role of NO in cerebrovascular regulation and stroke
32. 2 and bicarbonate on pial vessels
33. 2 action on cat pial arterioles
34. SIN-1 reverses attenuation of hypercapnic cerebrovasodilation by nitric oxide synthase inhibitors
35. 2 reactivity of cerebral arterioles is restored by vasodilator prostaglandin
36. Does nitric oxide mediate the increases in cerebral blood flow elicited by hypercapnia?
37. Cerebrovascular alteration in mice lacking neuronal nitric oxide synthase gene expression
38. L-NNA-sensitive regional cerebral blood flow augmentation during hypercapnia in type III NOS mutant mice
39. Distribution and characterization of cyclooxygenase immunoreactivity in the ovine brain
40. Vasodilation of cat cerebral arterioles by prostaglandins D2, E2, G2, and I2
41. Prostanoids and pial arteriolar diameter in hypotensive newborn pigs
42. Mechanisms of cerebral vasodilation by superoxide, hydrogen peroxide, and peroxynitrite
43. + channels in cerebral vasodilatation induced by increases in cyclic GMP and cyclic AMP in the rat
44. ATP-sensitive potassium channels may participate in the coupling of neuronal activity and cerebrovascular tone
45. Role of cGMP versus 20-HETE in the vasodilator response to nitric oxide in rat cerebral arteries
46. cGMP-dependent protein kinase activates Ca-activated K channels in cerebral artery smooth muscle cells