Nitrogen-appended N-alkylsulfonamides as inhibitors of γ-secretase

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 1, 2008, Pages 175-178

  Bergstrom, Carl P ^a   Sloan, Charles P ^a   Wang, Henry H ^a   Parker, Michael F ^a   Smith, David W ^a   Zheng, Ming ^a   Hansel, Steven B ^a   Polson, Craig T ^a   Barber, Lauren E ^a   Bursuker, Isia ^a   Guss, Valerie L ^a   Corsa, Jason A ^a   Barten, Donna M ^a   Felsenstein, Kevin M ^a   Roberts, Susan B ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Secretase; Alzheimer's disease; Aryl sulfonamides

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; HETEROCYCLIC COMPOUND; IMIDAZOLE DERIVATIVE; PYRAZOLE DERIVATIVE; SULFONAMIDE; TETRAZOLE DERIVATIVE; TRIAZOLE DERIVATIVE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DEGENERATIVE DISEASE; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION; TRANSGENIC MOUSE;

ALKYLATION; AMINES; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; AZOLES; BRAIN; HYDROPHOBICITY; INHIBITORY CONCENTRATION 50; MICE; MICE, TRANSGENIC; PEPTIDE FRAGMENTS; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

MUS MUSCULUS;

EID: 37549048203     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.10.105     Document Type: Article

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