Induction of potent Th1-type immune responses from a novel DNA vaccine for West Nile virus New York isolate (WNV-NY1999)

Journal of Infectious Diseases

Volumn 184, Issue 7, 2001, Pages 809-816

  Yang, Joo Sung ^a   Kim, J Joseph ^b   Hwang, Daniel ^a   Choo, Andrew Y ^a   Dang, Kesen ^a   Maguire, Henry ^a   Kudchodkar, Sagar ^a   Ramanathan, Mathura P ^a   Weiner, David B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Viral Genomix   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; DNA VACCINE; GAMMA INTERFERON; IMMUNOGLOBULIN G; INTERLEUKIN 2; MACROPHAGE INFLAMMATORY PROTEIN 1; PLASMID DNA; RANTES; VIRUS VACCINE;

ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; UNITED STATES; VACCINATION; VIRUS CAPSID; VIRUS INFECTION; VIRUS ISOLATION; WEST NILE FLAVIVIRUS;

ANIMALS; ANTIGENS, VIRAL; CAPSID; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; MICE; MICE, INBRED BALB C; MUSCLES; T-LYMPHOCYTES, CYTOTOXIC; TH1 CELLS; VACCINES, DNA; VIRAL VACCINES; WEST NILE FEVER; WEST NILE VIRUS;

EID: 0035479182     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/323395     Document Type: Article

References (23)

1. Twelve die of West Nile virus in Israel
2. Guidelines for surveillance, prevention, control of West Nile virus infection: United States
3. Update: West Nile-like virus encephalitis: New York
4. Identification of a Kunjin/West Nile-like flavivirus in brains of patients with New York encephalitis
5. Origin of the West Nile virus responsible for an outbreak of encephalitis in the northeastern United States
6. Isolation of West Nile virus from mosquitoes, crows, and a Cooper's hawk in Connecticut
7. Migratory birds and spread of West Nile virus in the Western Hemisphere
8. Ribavirin inhibits West Nile virus replication and cytopathic effect in neural cells
9. DNA vaccines
10. Genetic vaccines
11. Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine
12. Vaccination of seronegative volunteers with a human immunodeficiency virus type 1 env/rev DNA vaccine induces antigen-specific proliferation and lymphocyte production of beta-chemokines
13. CD8 positive T cells controls antigen-specific immune responses through the expression of chemokines
14. Engineering of in vivo immune responses to DNA immunization via co-delivery of costimulatory molecule genes
15. Macrophage-colony stimulating factor (M-CSF) can modulate immune responses and attract dendritic cells in vivo
16. Specific immune induction following DNA-based immunization through in vivo transfection and activation of macrophages
17. Lymphokine control of in vivo immunoglobulin isotype selection
18. Selective in vitro growth of T lymphocytes from normal human bone marrows
19. - T cells
20. Targeted antigen delivery to antigen-presenting cells including dendritic cells by engineered Fas-mediated apoptosis
21. CD86 (B7-2) can function to drive MHC-restricted antigen-specific cytotoxic T lymphocyte responses in vivo
22. Update: West Nile virus activity: Northeastern United States, January-August 7, 2000