Skin targeted DNA vaccine delivery using electroporation in rabbits II. Safety

International Journal of Pharmaceutics

Volumn 308, Issue 1-2, 2006, Pages 61-68

  Medi, Babu M ^a   Singh, Jagdish ^a  

^a NORTH DAKOTA STATE UNIVERSITY   (United States)

Author keywords

DNA vaccine; Electroporation; Safety; Skin

Indexed keywords

DNA VACCINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ELECTROPORATION; ERYTHEMA; GENE DELIVERY SYSTEM; GENE TARGETING; GENE TRANSFER; METHODOLOGY; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; RABBIT; SAFETY; SKIN; SKIN EDEMA; SKIN IRRITATION; SKIN PERMEABILITY; SKIN STRUCTURE; SKIN WATER LOSS; TARGET CELL;

ANIMALS; DRUG DELIVERY SYSTEMS; EDEMA; ELECTROPORATION; ERYTHEMA; GENE THERAPY; RABBITS; SAFETY; SKIN; TIME FACTORS; VACCINES, DNA; WATER LOSS, INSENSIBLE;

EID: 30744434386     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2005.10.035     Document Type: Article

References (35)

1. B. Abdallah, L. Sachs, and B.A. Demeneix Non-viral gene transfer: applications in developmental biology and gene therapy Biol. Cell. 8 1995 1 7
2. K. Abrams, J.D. Harvell, D. Shriner, P. Wertz, H. Maibach, H.I. Maibach, and S.J. Rehfeld Effect of organic solvents on in vitro human skin water barrier function J. Invest. Dermatol. 101 1993 609 613
3. H. Aihara, and J. Miyazaki Gene transfer into muscle by electroporation in vivo Nat. Biotechnol. 16 1998 867 870
4. M.A. Chattergoon, V. Saulino, J.P. Shames, J. Stein, L.J. Montaner, and D.B. Weiner Co-immunization with plasmid IL-12 generates a strong T-cell memory response in mice Vaccine 22 2004 1744 1750
5. Y.H. Chow, W.L. Huang, W.K. Chi, Y.D. Chu, and M.H. Tao Improvement of hepatitis B virus DNA vaccines by plasmids coexpressing hepatitis B surface antigen and interleukin-2 J. Virol. 7 1997 169 178
6. H.L. Davis, M.L. Michel, and R.G. Whalen Use of plasmid DNA for direct gene transfer and immunization Ann. N. Y. Acad. Sci. 772 1995 21 29
7. N.A. Doria-Rose, and N.L. Haigwood DNA vaccine strategies: candidates for immune modulation and immunization regimens Methods 31 2003 207 216
8. J.H. Draize, G. Woodard, and H.O. Calvery Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes J. Pharmacol. Exp. Ther. 82 1944 377 390
9. J. Glasspool-Malone, S. Somiari, J.J. Drabick, and R.W. Malone Efficient nonviral cutaneous transfection Mol. Ther. 2 2000 140 146
10. H. Herweijer, and J.A. Wolff Progress and prospects: naked DNA gene transfer and therapy Gene Ther. 10 2003 453 458
11. P.A. Khavari Therapeutic gene delivery to the skin Mol. Med. Today 3 1997 533 538
12. L.M. Lagging, K. Meyer, D. Hoft, M. Houghton, R.B. Belshe, and R. Ray Immune responses to plasmid DNA encoding the hepatitis C virus core protein J. Virol. 69 1995 5859 5863
13. P. Lefesvre, J. Attema, and D.A. Bekkum Comparison of efficacy and toxicity between electroporation and adenoviral gene transfer BMC Mol. Biol. 3 2002 12
14. H. Loffler, C. Pirker, J. Aramaki, P.J. Frosch, R. Happle, and I. Effendy Evaluation of skin susceptibility to irritancy by routine patch testing with sodium lauryl sulfate Eur. J. Dermatol. 11 2001 416 419
15. H. Ma, and S.L. Diamond Nonviral gene therapy and its delivery systems Curr. Pharm. Biotechnol. 2 2001 1 17
16. H.I. Maibach, R. Bronaugh, R. Guy, E. Turr, D. Wilson, S. Jacques, and D. Chaing Noninvasive techniques for determining skin function V.A. Drill P. Lazar Cutaneous Toxicity 1984 Raven Press New York 63 97
17. B.M. Medi, and J. Singh In vivo cutaneous gene delivery using electroporation Proc. Contr. Rel. Soc. 2003 abstract # 611
18. B.M. Medi, S. Hoselton, B.R. Marepalli, and J. Singh Skin targeted DNA vaccine delivery using electroporation in rabbits. I. Efficacy Int. J. Pharm. 294 2005 53 63
19. L.M. Mir, L.F. Glass, G. Sersa, J. Teissie, C. Domenge, D. Miklavcic, M.J. Jaroszeski, S. Orlowski, D.S. Reintgen, Z. Rudolf, M. Belehradek, R. Gilbert, M.P. Rols, J. Belehradek Jr., J.M. Bachaud, R. DeConti, B. Stabuc, M. Cemazar, P. Coninx, and R. Heller Effective treatment of cutaneous and subcutaneous malignant tumors by electrochemotherapy Br. J. Cancer 77 1998 2336 2342
20. E. Raz, D.A. Carson, S.E. Parker, T.B. Parr, A.M. Abai, G. Aichinger, S.H. Gromkowski, M. Singh, D. Lew, M.A. Yankauckas, S.M. Baird, and G.H. Rhodes Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses Proc. Natl. Acad. Sci. U.S.A. 91 1994 9519 9523
21. M.S. Roberts, and K.A. Walters The relationship between structure and barrier function of skin M.S. Roberts K.A. Walters Dermal Absorption and Toxicity Assessment 1998 Marcel Dekker New York 1 42
22. A. Rougier, A. Goldberg, and H.I. Maibach In vitro skin toxicology: irritation Phototoxicity and Sensitization 1994 Mary and Liebert New York
23. N. Sekkat, Y.N. Kalia, and R.H. Guy Biophysical study of porcine ear skin in vitro and its comparison to human skin in vivo J. Pharm. Sci. 91 2002 2376 2381
24. G. Sersa, B. Stabuc, M. Cemazar, D. Miklavcic, and Z. Rudolf Electrochemotherapy with cisplatin: clinical experience in malignant melanoma patients Clin. Cancer Res. 6 2000 863 867
25. J. Singh, M. Gross, B. Sage, H.T. Davis, and H.I. Maibach Regional variations in skin barrier function and cutaneous irritation due to iontophoresis in human subjects Food Chem. Toxicol. 39 2001 1079 1086
26. I.K. Srivastava, and A.L. Margaret Gene vaccines Ann. Inter. Med. 38 2003 550 559
27. H. Tanojo, E. Boelsma, H.E. Junginger, M. Ponec, and H.E. Bodde In vivo human skin barrier modulation by topical application of fatty acids Skin Pharmacol. Appl. Skin Physiol. 11 1998 87 97
28. T. Tuting, W.J. Storkus, and J.D. Falo DNA immunization targeting the skin: molecular control of adaptive immunity J. Invest. Dermatol. 111 1998 183 188
29. J.B. Ulmer, J.J. Donnelly, S.E. Parker, G.H. Rhodes, P.L. Felgner, V.J. Dwarki, S.H. Gromkowski, R.R. Deck, C.M. DeWitt, and A. Friedman Heterologous protection against influenza by injection of DNA encoding a viral protein Science 259 1993 1745 1749
30. I.M. Verma, and N. Somia Gene therapy-promises, problems and prospects Nature 389 1997 239 242
31. I.M. Verma A tumultuous year for gene therapy Mol. Ther. 2 2000 415 416
32. R.G. Whalen DNA vaccines for emerging infectious diseases: what if? Emerg. Infect. Dis. 2 1996 168 175
33. I.R. Williams, and T.S. Kupper Immunity at the surface: homeostatic mechanisms of the skin immune system Life Sci. 58 1996 1485 1507
34. J.A. Wolff, R.W. Malone, P. Williams, W. Chong, G. Acsadi, A. Jani, and P.L. Felgner Direct gene transfer into mouse muscle in vivo Science 247 1990 1465 1468
35. L. Zhang, E. Nolan, S. Kreitschitz, and D.P. Rabussay Enhanced delivery of naked DNA to the skin by non-invasive in vivo electroporation Biochim. Biophys. Acta 1572 2002 1 9