Metabolic therapy for early treatment of age-related macular degeneration;Metabolikus terápia az idoskori makuladegeneráció korai kezelésére

Orvosi Hetilap

Volumn 148, Issue 48, 2007, Pages 2259-2268

  Fehér, Janos ^a,d   Kovács, Bálint ^b   Kovács, Illés ^c   Schvöller, Mónika ^b   Corrado Balacco, Gabrielli ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF PÉCS   (Hungary)

^c SEMMELWEIS UNIVERSITY   (Hungary)

^d NONE   (Italy)

Author keywords

Acetyl L carnitine; Age related macular degeneration; Coenzyme Q10; Mitochondrium; Omega 3 fatty acids

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA TOCOPHEROL; ASCORBIC ACID; BETA CAROTENE; LEVACECARNINE; OMEGA 3 FATTY ACID; PLACEBO; REACTIVE OXYGEN METABOLITE; UBIDECARENONE; ZINC;

ANTIOXIDANT ACTIVITY; ARTICLE; CLINICAL TRIAL; DISEASE COURSE; DISEASE SEVERITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG CHOICE; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; DRUG SAFETY; EARLY INTERVENTION; HUMAN; HUNGARY; LIPID METABOLISM; OUTCOME ASSESSMENT; PHOTORECEPTOR; PIGMENT EPITHELIUM; PILOT STUDY; RETINA MACULA AGE RELATED DEGENERATION; TREATMENT DURATION; VISUAL ACUITY; VISUAL FIELD DEFECT; VISUAL IMPAIRMENT;

EID: 37349115563     PISSN: 00306002     EISSN: 17886120     Source Type: Journal    
DOI: 10.1556/OH.2007.28250     Document Type: Article

References (50)

1. Zarbin, M. A.: Current concepts in the pathogenesis of age-related macular degeneration. Arch Ophthalmol., 2004, 122, 598-614.
2. Feigl, B., Brown, B., Lovie-Kitchin, J. és mtsa: Functional loss in early age-related maculopathy: the ischaemia postreceptoral hypothesis. Eye, 2007, 21, 689-696. Epub., 2006, May 5.
3. Roth, F., Bindewald, A., Holz, F. G.: Keypathophysiologic pathways in age-related macular disease. Graefes Arch. Clin. Exp. Ophthalmol., 2004, 242, 710-716. Epub., 2004, Aug. 10.
4. Bhutto, I. A., McLeod, D. S., Hasegawa, T. és mtsai: Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration. Exp. Eye Res., 2006, 82, 99-110. Epub., 2005, Jul. 12.
5. Shen, J. K., Dong, A., Hackett S. F. és mtsai: Oxidative damage in age-related macular degeneration. Histol. Histopathol., 2007, 22, 1301-1308.
6. AREDS report 8. A Randomized, Placebo-Controlled, clinical Trial of High-Dose Supplementation with Vitamins C and E, Beta Carotene and Zinc for Age-related Macular Degeneration and Vision loss. Arch. Ophthalmol., 2001, 119, 1417-1436.
7. Arora, S., Musadiq, M., Mukherji, S. és mtsa: Eye nutrient products for age-related macular degeneration: what do they contain? Eye, 2004, 18, 470-473.
8. Feher J., Papale, A., Mannino, G. és mtsai: Mitotropic compounds for the treatment of age-related macular degeneration. The metabolic approach and a pilot study. Ophthalmologica, 2003, 217, 351-357.
9. Feher J., Kovacs B., Kovacs I. és mtsai: Improvement of visual functions and fundus alterations in early age-related macular degeneration treated with a combination of acetyl-L-carnitine, n-3 fatty acids, and coenzyme Q10. Ophthalmologica, 2005, 219, 154-166.
10. Bird, A. C., Bressler, N. M., Bressler, S. B. és mtsai: An international classification and grading system for age-related maculopathy and age-related macular degeneration. The International ARM Epidemiological Study Group. Surv. Ophthalmol., 1995, 39, 367-374.
11. Seddon, J. M., Sharma, S., Adelman, R. A.: Evaluation of the Clinical Age-Related Maculopathy Staging System. Ophthalmology, 2006, 113, 260-266.
12. Wang, J. J., Mitchell, P., Smith, W. és mtsa: Bilateral involvement by age related maculopathy lesions in a population. Br. J. Ophthalmol., 1998, 82, 743-747.
13. King, A., Gottlieb, E., Brooks, D. G. és mtsai: Mitochondria-derived reactive oxygen species mediate blue light-induced death of retinal pigment epitheial cells. Photochem. Photobiol., 2004, 79, 470-475.
14. Seddon, J. M., Ajani, U. A., Sperduto, R. D. és mtsai: Dietary carotenoids, vitamins A, C and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group. JAMA, 1994, 272, 1413-1420.
15. Mares-Perlman, J. A., Klein, R., Klein, B. E. és mtsai: Association of zinc and antioxidant nutrients with age-related maculopathy. Arch. Ophthalmol., 1996, 114, 991-997.
16. Vanden Langenberg, G. M., Mares-Perlman, J. A., Klein, R. és mtsai: Associations between antioxidant and zinc intake and the 5-year incidence of early age-related maculopathy in the Beaver Dam Eye Study. Am. J. Epidemiol., 1998, 148, 204-214.
17. Flood, V., Smith, W., Wang, J. J. és mtsai: Dietary antioxidant intake and incidence of early age-related maculopathy: the Blue Mountains Eye Study. Ophthalmology, 2002, 109, 2272-2278.
18. van Leeuwen, R., Boekhoorn, S., Vingerling, J. R. és mtsai: Dietary intake of antioxidants and risk of age-related macular degeneration. JAMA, 2005, 294, 3101-3107.
19. Gaynes, B. I.: AREDS misses on safety. Arch. Ophthalmol., 2003, 121, 416-417.
20. Seigel, D.: AREDS investigators distort findings. Arch. Ophthalmol., 2002, 120, 100-101.
21. Omenn, G. S., Goodman, G. E., Thornquist, M. D. és mtsai: Risk factors for lung cancer and for intervention effects in CARET, the Beta-Carotene and Retinol Efficacy Trial. J. Natl. Cancer Inst., 1996, 88, 1550-1559.
22. Goodman, G. E., Thornquist, M. D., Balmes, J. és mtsai: The Beta-Carotene and Retinol Efficacy Trial: incidence of lung cancer and cardiovascular disease mortality during 6-year follow-up after stopping beta-carotene and retinol supplements. J. Natl. Cancer Inst., 2004, 96, 1743-1750.
23. Albanes, D., Heinonen, O. P., Taylor, P. R. és mtsai: Alpha-Tocopherol and beta-carotene supplements and lung cancer incidence in the alpha-tocopherol, beta-carotene cancer prevention study: effects of base-line characteristics and study compliance. J. Natl. Cancer Inst., 1996, 88, 1560-1570.
24. Miller, E. R., Pastor-Barriuso, R., Dalal, D. és mtsai: Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann. Intern. Med., 2005, 142, 37-46. Epub., 2004, Nov. 10.
25. Pearson, P., Lewis, S. A., Britton, J. és mtsai: The pro-oxidant activity of high-dose vitamin E supplements in vivo. BioDrugs, 2006, 20, 271-273.
26. Bairati, I., Meyer, F., Jobin, E. és mtsai: Antioxidant vitamins supplementation and mortality: a randomized trial in head and neck cancer patients. Int. J. Cancer, 2006, 119, 2221-2224.
27. Bjelakovic, G., Nikolova, D., Gluud, L. L. és mtsai: Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA, 2007, 297, 842-857.
28. Hayden, K. M., Welsh-Bohmer, K. A., Wengreen, H. J. és mtsai: Risk of mortality with vitamin E supplements: the Cache County study. Am. J. Med., 2007, 120, 180-184.
29. Marchioli, R., Levantesi, G., Macchia, A. és mtsai: Vitamin E increases the risk of developing heart failure after myocardial infarction: Results from the GISSI-Prevenzione trial. J. Cardiovasc. Med. (Hagerstown), 2006, 7, 347-350.
30. Klein, R., Klein, B. E., Knudtson, M. D. és mtsai: Subclinical atherosclerotic cardiovascular disease and early age-related macular degeneration in a multiracial cohort: the Multiethnic Study of Atherosclerosis. Arch. Ophthalmol., 2007, 125, 534-543.
31. Tan, J. S., Mitchell, P., Smith, W. és mtsa: Cardiovascular risk factors and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study. Ophthalmology, 2007, 114, 1143-1150. Epub., 2007, Feb. 1.
32. Mares-Perlman, J. A., Fisher, A. I., Klein, R. és mtsai: Lutein and zeaxanthin in the diet and serum and their relation to age-related maculopathy in the Third National Health and Nutrition Examination Survey. Am. J. Epidemiol., 2001, 153, 424-432.
33. Seddon, J. M., Ajani, U. A., Sperduto, R. D. és mtsai: Dietary carotenoids, vitamins A, C and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group. JAMA, 1994, 272, 1413-1420.
34. Cho, E., Seddon, J. M., Rosner, B. és mtsai: Prospective study of intake of fruits, vegetables, vitamins, and carotenoids and risk of age-related maculopathy. Arch. Ophthalmol., 2004, 122, 883-892.
35. Davies, N. P., Morland, A. B.: Macular pigments: their characteristics and putative role. Prog. Retin. Eye Res., 2004, 23, 533-559.
36. Beatty, S., Murray, I. J., Henson, D. B és mtsai: Macular pigment and risk for age-related macular degeneration in subjects from a Northern European population. Invest. Ophthalmol. Vis. Sci., 2001, 42, 439-446.
37. Ciulla, T. A., Hammond, B. R.: Macular pigment density and aging, assessed in the normal elderly and those with cataracts and age-related macular degeneration. Am. J. Ophthalmol., 2004, 138, 582-587.
38. Mozaffarieh, M., Sacu, S., Wedrich, A.: The role of the carotenoids, lutein and zeaxanthin, in protecting against age-related macular degeneration: a review based on controversial evidence. Nutr. J., 2003, 2, 20-28.
39. Trumbo, P. R., Ellwood, K. C.: Lutein and zeaxanthin intakes and risk of age-related macular degeneration and cataracts: an evaluation using the Food and Drug Administration's evidence-based review system for health claims. Am. J. Clin. Nutr., 2006, 84, 971-974.
40. Kabagambe, E. K., Furtado, J., Baylin, A. és mtsa: Some dietary and adipose tissue carotenoids are associated with the risk of nonfatal acute myocardial infarction in Costa Rica. J. Nutr., 2005, 135, 1763-1769.
41. Algvere, P. V., Marshall, J., Seregard, S.: Age-related maculopathy and the impact of blue light hazard. Acta Ophthalmol. Scand., 2006, 84, 4-15.
42. Suzuki, M., Kamei, M., Itabe, H. és mtsai: Oxidized phospholipids in the macula increase with age and in eyes with age-related macular degeneration. Mol. Vis., 2007, 13, 772-778.
43. Feher, J., Kovacs, I., Artico, M. és mtsai: Mitochondrial alterations of retinal pigment epithelium in age-related macular degeneration. Neurobiol. Aging, 2006, 27, 983-93. Epub., 2005, Jun. 23.
44. Pepe, S.: Effect of dietary polyunsaturated fatty acids on age-related changes in cardiac mitochondrial membranes. Exp. Gerontol., 2005, 40, 751-758.
45. Simopoulos, A. P.: Essential fatty acids in health and chronic disease. Am. J. Clin. Nutr., 1999, 70 (Suppl. 3.), 560S-569S.
46. Turunen, M., Olsson, J., Dallner, G.: Metabolism and function of coenzyme Q. Biochim. Biophys. Acta, 2004, 1660, 171-199.
47. Ames, B. N., Liu, J.: Delaying the mitochondrial decay of aging with acetylcarnitine. Ann. N. Y. Acad. Sci., 2004, 1033, 108-116.
48. Feher J., Schvoller M., Kovacs B. és mtsai: Long Term Improvement of Early AMD Treated With Phototrop™: Prospective Case Studies ARVO. Abstract, 2007, 5113, B261.
49. Dorrell, M., Uusitalo-Jarvinen, H., Aguilar, E. és mtsa: Ocular neovascularization: basic mechanisms and therapeutic advances. Surv. Ophthalmol., 2007, 52 (Suppl. 1.), S3-19.
50. Age-Related Eye Diseases Study, 2. www.areds2.org