Differential modulation of hepatic very low-density lipoprotein secretion by triacylglycerol-rich lipoproteins derived from different oleic-acid rich dietary oils

British Journal of Nutrition

Volumn 99, Issue 1, 2008, Pages 29-36

  Perona, Javier S ^a   Avella, Michael ^b   Botham, Kathleen M ^b   Ruiz Gutierrez, Valentina ^a  

^a INSTITUTO DE LA GRASA   (Spain)

^b ROYAL VETERINARY COLLEGE   (United Kingdom)

Author keywords

Liver; PPAR ; Triacylglycerol rich lipoprotein; Virgin olive oil; VLDL

Indexed keywords

APOLIPOPROTEIN B; DIACYLGLYCEROL ACYLTRANSFERASE; EDIBLE OIL; MESSENGER RNA; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; OLEIC ACID; OLIVE OIL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; SUNFLOWER OIL; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ATHEROGENIC DIET; CONTROLLED STUDY; DIETARY INTAKE; HUMAN; HUMAN EXPERIMENT; INTRACELLULAR TRANSPORT; LIPID ANALYSIS; LIPID COMPOSITION; LIPID METABOLISM; LIPID STORAGE; LIPOPROTEIN SECRETION; LIVER CELL; MALE; NONHUMAN; NORMAL HUMAN; PROTEIN EXPRESSION; PROTEIN ISOLATION; RAT;

ADULT; ANIMALS; CELLS, CULTURED; CHROMATOGRAPHY, LIQUID; DIETARY FATS, UNSATURATED; DOUBLE-BLIND METHOD; FATTY ACIDS; HEPATOCYTES; HUMANS; LIPOPROTEINS; LIPOPROTEINS, VLDL; LIVER; MALE; OLEIC ACID; PLANT OILS; RATS; RATS, WISTAR; TRIGLYCERIDES;

HELIANTHUS; RATTUS;

EID: 37349085739     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114507793868     Document Type: Article

References (27)

1. Redgrave TG (1983) Formation and metabolism of chylomicrons. Int Rev Physiol 28, 103-130.
2. Mamo JC & Wheeler JR (1994) Chylomicrons or their remnants penetrate rabbit thoracic aorta as efficiently as do smaller macromolecules, including low-density lipoprotein, high-density lipoprotein, and, albumin. Coron Artery Dis 5, 695-705.
3. Grieve DJ, Avella MA, Elliott J & Botham KM (1998) The influence of chylomicron remnants on endothelial cell function in the isolated perfused rat aorta. Atherosclerosis 139, 273-281.
4. Napolitano M, Avella M, Botham KM & Bravo E (2003) Chylomicron remnant induction of lipid accumulation in J774 macrophages is associated with up-regulation of triacylglycerol synthesis which is not dependent on oxidation of the particles. Biochim Biophys Acta 1631, 255-264.
5. Batt KV, Avella M, Moore EH, Jackson B, Suckling KE & Botham KM (2004) Differential effects of low-density lipoprotein and chylomicron remnants on lipid accumulation in human macrophages. Exp Biol Med (Maywood) 229, 528-537.
6. Wang CS, Hartsuck J & McConathy WJ (1992) Structure and functional properties of lipoprotein lipase. Biochim Biophys Acta 1123, 1-17.
7. Zeng BJ, Mortimer BC, Martins IJ, Seydel U & Redgrave TG (1998) Chylomicron remnant uptake is regulated by the expression and function of heparan sulfate proteoglycan in hepatocytes. J Lipid Res 39 845-860.
8. Rohlmann A, Gotthardt M, Hammer RE & Herz J (1998) Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants. J Clin Invest 101, 689-695.
9. Lambert MS, Avella MA, Berhane Y, Shervill E & Botham KM (2001) The fatty acid composition of chylomicron remnants influences their binding and internalization by isolated hepatocytes. Eur J Biochem 268 3983-3992.
10. Zheng X, Avella M & Botham, KM (2001) Comparison of the effects of dietary n-3 and n-6 polyunsaturated fatty acids on very low-density lipoprotein secretion when delivered to hepatocytes in chylomicron remnants. Biochem J 357, 481-487.
11. Gibbons GF, Wiggins D, Brown AM & Hebbachi AM (2004). Synthesis and function of hepatic very-low-density lipoprotein. Biochem Soc Trans 32, 59-64.
12. Keys A, Menotti A, Karvonen MJ, et al. (1986) The diet and 15-year death rate in the seven countries study. Am J Epidemiol 124, 903-915.
13. Abia R, Pacheco YM, Perona JS, Montero E, Muriana FJ & Ruiz-Gutierrez V (2001) The metabolic availability of dietary triacylglycerols from two high oleic oils during the postprandial period does not depend on the amount of oleic acid ingested by healthy men. J Nutr 131, 59-65.
14. Perona JS, Martinez-Gonzalez J, Sanchez-Dominguez JM, Badimon L & Ruiz-Gutierrez V. (2004) The unsaponifiable fraction of virgin olive oil in chylomicrons from men improves the balance between vasoprotective and prothrombotic factors released by endothelial cells. J Nutr 134 3284-3289.
15. Perona JS, Avella M, Botham KM & Ruiz-Gutierrez V (2006) Uptake of triacylglycerol-rich lipoproteins of differing triacyl-glycerol molecular species and unsaponifiable content by liver cells. Br J Nutr 95, 889-897.
16. Ruiz-Gutierrez V, Perona JS, Pacheco YM, Muriana FJ & Villar J (1999) Incorporation of dietary triacylglycerols from olive oil and high-oleic sunflower oil into VLDL triacylglycerols of hypertensive patients. Eur J Clin Nutr 53, 687-693.
17. Folch J, Lees M & Sloane-Stanley GH (1957) A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226, 497-509.
18. Perona JS & Ruiz-Gutierrez V (2004) Quantification of major lipid classes in human triacylglycerol-rich lipoproteins by high-performance liquid chromatography with evaporative light-scattering detection. J Sep Sci 27, 653-659.
19. Ruiz-Gutierrez V, Montero E & Villar J (1992) Determination of fatty acid and triacylglycerol composition of human adipose tissue. J Chromatogr 581, 171-178.
20. Perona JS & Ruiz-Gutiérrez V (1999) Characterization of the triacylglycerol molecular species of fish oil by reversed-phase high-performance liquid chromatography. J Liquid Chromatogr Rel Technol 22, 1699-1714.
21. Ford RP, Botham KM, Suckling KE & Boyd GS (1985) The effect of a rat plasma high-density lipoprotein subfraction on the synthesis of bile salts by rat hepatocyte monolayers. FEBS Lett 179, 177-180.
22. Isusi E, Aspichueta. P, Liza M, Hernandez ML, Diaz C, Hernandez G, Martinez MJ & Ochoa B (2000) Short- and long-term effects of atorvastatin, lovastatin and simvastatin on the cellular metabolism of cholesteryl esters and VLDL secretion in rat hepatocytes. Atherosclerosis 153, 283-294.
23. Hussain M (2000) A proposed model for the assembly of chylomicrons. Atherosclerosis 148, 1-15.
24. Abia R, Pacheco YM, Montero E, Ruiz-Gutierrez V & Muriana FJ (2003) Distribution of fatty acids from dietary oils into phospholipid classes of triacylglycerol-rich lipoproteins in healthy subjects. Life Sci 72, 1643-1654.
25. Linden D, Lindberg K, Oscarsson J, Claesson C, Asp L, Li L, Gustafsson M, Boren J & Olofsson SO (2002) Influence of peroxisome proliferator-activated receptor alpha agonists on the intracellular turnover and secretion of apolipoprotein (Apo) B-100 and ApoB-48. J Biol Chem 277, 23044-23053.
26. Ameen C, Edvardsson U, Ljungberg A, Asp L, Akerblad P, Tuneld A, Olofsson SO, Einden D & Oscarsson J (2005) Activation of peroxisome proliferator-activated receptor alpha increases the expression and activity of microsomal triglyceride transfer protein in the liver. J Biol Chem 280, 1224-1229.
27. Packard CJ, Munro A, Lorimer AR, Gotto AM & Shepherd J (1984) Metabolism of apolipoprotein B in large triglyceride-rich very low density lipoproteins of normal and hypertriglyceridemic subjects. J Clin Invest 74, 2178-2192.