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Volumn 56, Issue , 2008, Pages 229-256

Topical Microbicides: A Promising Approach for Controlling the AIDS Pandemic via Retroviral Zinc Finger Inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

GAG PROTEIN; NCP7 PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; TOPICAL ANTIINFECTIVE AGENT; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

EID: 37349074474     PISSN: 10543589     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1054-3589(07)56008-4     Document Type: Review
Times cited : (20)

References (92)
  • 1
    • 0034685755 scopus 로고    scopus 로고
    • Inactivation of HIV-1 nucleocapsid protein p7 by pyridinioalkanoyl thioesters. Characterization of reaction products and proposed mechanism of action
    • Basrur V., Song Y., Mazur S.J., Higashimoto Y., Turpin J.A., Rice W.G., Inman J.K., and Appella E. Inactivation of HIV-1 nucleocapsid protein p7 by pyridinioalkanoyl thioesters. Characterization of reaction products and proposed mechanism of action. J. Biol. Chem. 275 (2000) 14890-14897
    • (2000) J. Biol. Chem. , vol.275 , pp. 14890-14897
    • Basrur, V.1    Song, Y.2    Mazur, S.J.3    Higashimoto, Y.4    Turpin, J.A.5    Rice, W.G.6    Inman, J.K.7    Appella, E.8
  • 2
    • 0022695021 scopus 로고
    • Potential metal-binding domains in nucleic acid binding proteins
    • Berg J.M. Potential metal-binding domains in nucleic acid binding proteins. Science 232 (1986) 485-487
    • (1986) Science , vol.232 , pp. 485-487
    • Berg, J.M.1
  • 3
    • 0027496344 scopus 로고
    • Specific binding of human immunodeficiency virus type 1 gag polyprotein and nucleocapsid protein to viral RNAs detected by RNA mobility shift assays
    • Berkowitz R.D., Luban J., and Goff S.P. Specific binding of human immunodeficiency virus type 1 gag polyprotein and nucleocapsid protein to viral RNAs detected by RNA mobility shift assays. J. Virol. 67 (1993) 7190-7200
    • (1993) J. Virol. , vol.67 , pp. 7190-7200
    • Berkowitz, R.D.1    Luban, J.2    Goff, S.P.3
  • 4
    • 27144532234 scopus 로고    scopus 로고
    • Cellulose acetate 1,2-benzenedicarboxylate protects against challenge with pathogenic X4 and R5 simian/human immunodeficiency virus
    • Boadi T., Schneider E., Chung S., Tsai L., Gettie A., Ratterree M., Blanchard J., Neurath A.R., and Cheng-Mayer C. Cellulose acetate 1,2-benzenedicarboxylate protects against challenge with pathogenic X4 and R5 simian/human immunodeficiency virus. AIDS 19 (2005) 1587-1594
    • (2005) AIDS , vol.19 , pp. 1587-1594
    • Boadi, T.1    Schneider, E.2    Chung, S.3    Tsai, L.4    Gettie, A.5    Ratterree, M.6    Blanchard, J.7    Neurath, A.R.8    Cheng-Mayer, C.9
  • 5
    • 0037223701 scopus 로고    scopus 로고
    • 2+ fingers are required for efficient reverse transcription, initial integration processes, and protection of newly synthesized viral DNA
    • 2+ fingers are required for efficient reverse transcription, initial integration processes, and protection of newly synthesized viral DNA. J. Virol. 77 (2003) 1469-1480
    • (2003) J. Virol. , vol.77 , pp. 1469-1480
    • Buckman, J.S.1    Bosche, W.J.2    Gorelick, R.J.3
  • 7
    • 85136367975 scopus 로고    scopus 로고
    • CDC statement on study results of product containing nonoxynol-9
    • Centers for Disease Control and Prevention
    • Centers for Disease Control and Prevention. CDC statement on study results of product containing nonoxynol-9. JAMA 284 (2000) 1376
    • (2000) JAMA , vol.284 , pp. 1376
  • 8
    • 22944453688 scopus 로고    scopus 로고
    • Factors affecting sexual transmission of HIV-1: Current evidence and implications for prevention
    • Chan D.J. Factors affecting sexual transmission of HIV-1: Current evidence and implications for prevention. Curr. HIV Res. 3 (2005) 223-241
    • (2005) Curr. HIV Res. , vol.3 , pp. 223-241
    • Chan, D.J.1
  • 9
    • 0034003762 scopus 로고    scopus 로고
    • Spectroscopic characterization of Co(II)-, Ni(II)-, and Cd(II)-substituted wild-type and non-native retroviral-type zinc finger peptides
    • Chen X., Chu M., and Giedroc D.P. Spectroscopic characterization of Co(II)-, Ni(II)-, and Cd(II)-substituted wild-type and non-native retroviral-type zinc finger peptides. J. Biol. Inorg. Chem. 5 (2000) 93-101
    • (2000) J. Biol. Inorg. Chem. , vol.5 , pp. 93-101
    • Chen, X.1    Chu, M.2    Giedroc, D.P.3
  • 11
    • 17644382251 scopus 로고    scopus 로고
    • Amplified HIV transmission and new approaches to HIV prevention
    • Cohen M.S., and Pilcher C.D. Amplified HIV transmission and new approaches to HIV prevention. J. Infect. Dis. 191 (2005) 1391-1393
    • (2005) J. Infect. Dis. , vol.191 , pp. 1391-1393
    • Cohen, M.S.1    Pilcher, C.D.2
  • 12
    • 33748109942 scopus 로고    scopus 로고
    • Innate host defense of human vaginal and cervical mucosae
    • Cole A.M. Innate host defense of human vaginal and cervical mucosae. Curr. Top. Microbiol. Immunol. 306 (2006) 199-230
    • (2006) Curr. Top. Microbiol. Immunol. , vol.306 , pp. 199-230
    • Cole, A.M.1
  • 13
    • 0034033172 scopus 로고    scopus 로고
    • Development of an in vitro organ culture model to study transmission of HIV-1 in the female genital tract
    • Collins K.B., Patterson B.K., Naus G.J., Landers D.V., and Gupta P. Development of an in vitro organ culture model to study transmission of HIV-1 in the female genital tract. Nat. Med. 6 (2000) 475-479
    • (2000) Nat. Med. , vol.6 , pp. 475-479
    • Collins, K.B.1    Patterson, B.K.2    Naus, G.J.3    Landers, D.V.4    Gupta, P.5
  • 14
    • 33746646763 scopus 로고    scopus 로고
    • Vaginal microbicides: Detecting toxicities in vivo that paradoxically increase pathogen transmission
    • Cone R.A., Hoen T., Wong X., Abusuwwa R., Anderson D.J., and Moench T.R. Vaginal microbicides: Detecting toxicities in vivo that paradoxically increase pathogen transmission. BMC Infect. Dis. 6 (2006) 90
    • (2006) BMC Infect. Dis. , vol.6 , pp. 90
    • Cone, R.A.1    Hoen, T.2    Wong, X.3    Abusuwwa, R.4    Anderson, D.J.5    Moench, T.R.6
  • 15
    • 17344367520 scopus 로고    scopus 로고
    • Association between culturable human immunodeficiency virus type 1 (HIV-1) in semen and HIV-1 RNA levels in semen and blood: Evidence for compartmentalization of HIV-1 between semen and blood
    • Coombs R.W., Speck C.E., Hughes J.P., Lee W., Sampoleo R., Ross S.O., Dragavon J., Peterson G., Hooton T.M., Collier A.C., Corey L., Koutsky L., et al. Association between culturable human immunodeficiency virus type 1 (HIV-1) in semen and HIV-1 RNA levels in semen and blood: Evidence for compartmentalization of HIV-1 between semen and blood. J. Infect. Dis. 177 (1998) 320-330
    • (1998) J. Infect. Dis. , vol.177 , pp. 320-330
    • Coombs, R.W.1    Speck, C.E.2    Hughes, J.P.3    Lee, W.4    Sampoleo, R.5    Ross, S.O.6    Dragavon, J.7    Peterson, G.8    Hooton, T.M.9    Collier, A.C.10    Corey, L.11    Koutsky, L.12
  • 16
    • 0023055867 scopus 로고
    • Amino acid sequence homology in gag region of reverse transcribing elements and the coat protein gene of cauliflower mosaic virus
    • Covey S.N. Amino acid sequence homology in gag region of reverse transcribing elements and the coat protein gene of cauliflower mosaic virus. Nucleic Acids Res. 14 (1986) 623-633
    • (1986) Nucleic Acids Res. , vol.14 , pp. 623-633
    • Covey, S.N.1
  • 17
    • 0346025452 scopus 로고    scopus 로고
    • Clinical development of microbicides for the prevention of HIV infection
    • D'Cruz O.J., and Uckun F.M. Clinical development of microbicides for the prevention of HIV infection. Curr. Pharm. Des. 10 (2004) 315-336
    • (2004) Curr. Pharm. Des. , vol.10 , pp. 315-336
    • D'Cruz, O.J.1    Uckun, F.M.2
  • 18
    • 0032506295 scopus 로고    scopus 로고
    • The role of nucleocapsid of HIV-1 in virus assembly
    • Dawson L., and Yu X.F. The role of nucleocapsid of HIV-1 in virus assembly. Virology 251 (1998) 141-157
    • (1998) Virology , vol.251 , pp. 141-157
    • Dawson, L.1    Yu, X.F.2
  • 20
    • 29744459673 scopus 로고    scopus 로고
    • Microbicides to prevent HIV transmission: Overcoming obstacles to chemical barrier protection
    • Dhawan D., and Mayer K.H. Microbicides to prevent HIV transmission: Overcoming obstacles to chemical barrier protection. J. Infect. Dis. 193 (2006) 36-44
    • (2006) J. Infect. Dis. , vol.193 , pp. 36-44
    • Dhawan, D.1    Mayer, K.H.2
  • 21
    • 7244257490 scopus 로고    scopus 로고
    • Preclinical assessment of the proinflammatory potential of microbicide candidates
    • Doncel G.F., Chandra N., and Fichorova R.N. Preclinical assessment of the proinflammatory potential of microbicide candidates. J. Acquir. Immune Defic. Syndr. 37 Suppl. 3 (2004) S174-S180
    • (2004) J. Acquir. Immune Defic. Syndr. , vol.37 , Issue.SUPPL. 3
    • Doncel, G.F.1    Chandra, N.2    Fichorova, R.N.3
  • 22
    • 0037980414 scopus 로고    scopus 로고
    • Shifts in condom use following microbicide introduction: Should we be concerned
    • Foss A.M., Vickerman P.T., Heise L., and Watts C.H. Shifts in condom use following microbicide introduction: Should we be concerned. AIDS 17 (2003) 1227-1237
    • (2003) AIDS , vol.17 , pp. 1227-1237
    • Foss, A.M.1    Vickerman, P.T.2    Heise, L.3    Watts, C.H.4
  • 23
    • 0036079966 scopus 로고    scopus 로고
    • The enigma of dendritic cell-immunodeficiency virus interplay
    • Frank I., and Pope M. The enigma of dendritic cell-immunodeficiency virus interplay. Curr. Mol. Med. 2 (2002) 229-248
    • (2002) Curr. Mol. Med. , vol.2 , pp. 229-248
    • Frank, I.1    Pope, M.2
  • 25
    • 33746680413 scopus 로고    scopus 로고
    • AIDS anniversaries in 2006 mark the time to deliver
    • Gayle H.D. AIDS anniversaries in 2006 mark the time to deliver. Lancet 368 (2006) 425-427
    • (2006) Lancet , vol.368 , pp. 425-427
    • Gayle, H.D.1
  • 26
    • 0034034688 scopus 로고    scopus 로고
    • Parameters of human immunodeficiency virus infection of human cervical tissue and inhibition by vaginal virucides
    • Greenhead P., Hayes P., Watts P.S., Laing K.G., Griffin G.E., and Shattock R.J. Parameters of human immunodeficiency virus infection of human cervical tissue and inhibition by vaginal virucides. J. Virol. 74 (2000) 5577-5586
    • (2000) J. Virol. , vol.74 , pp. 5577-5586
    • Greenhead, P.1    Hayes, P.2    Watts, P.S.3    Laing, K.G.4    Griffin, G.E.5    Shattock, R.J.6
  • 27
    • 0033803461 scopus 로고    scopus 로고
    • Zinc finger structures in the human immunodeficiency virus type 1 nucleocapsid protein facilitate efficient minus- and plus-strand transfer
    • Guo J., Wu T., Anderson J., Kane B.F., Johnson D.G., Gorelick R.J., Henderson L.E., and Levin J.G. Zinc finger structures in the human immunodeficiency virus type 1 nucleocapsid protein facilitate efficient minus- and plus-strand transfer. J. Virol. 74 (2000) 8980-8988
    • (2000) J. Virol. , vol.74 , pp. 8980-8988
    • Guo, J.1    Wu, T.2    Anderson, J.3    Kane, B.F.4    Johnson, D.G.5    Gorelick, R.J.6    Henderson, L.E.7    Levin, J.G.8
  • 28
    • 0036226153 scopus 로고    scopus 로고
    • Subtle alterations of the native zinc finger structures have dramatic effects on the nucleic acid chaperone activity of human immunodeficiency virus type 1 nucleocapsid protein
    • Guo J., Wu T., Kane B.F., Johnson D.G., Henderson L.E., Gorelick R.J., and Levin J.G. Subtle alterations of the native zinc finger structures have dramatic effects on the nucleic acid chaperone activity of human immunodeficiency virus type 1 nucleocapsid protein. J. Virol. 76 (2002) 4370-4378
    • (2002) J. Virol. , vol.76 , pp. 4370-4378
    • Guo, J.1    Wu, T.2    Kane, B.F.3    Johnson, D.G.4    Henderson, L.E.5    Gorelick, R.J.6    Levin, J.G.7
  • 29
    • 0030837431 scopus 로고    scopus 로고
    • High viral load in semen of human immunodeficiency virus type 1-infected men at all stages of disease and its reduction by therapy with protease and nonnucleoside reverse transcriptase inhibitors
    • Gupta P., Mellors J., Kingsley L., Riddler S., Mandaleshwar K.S., Schreiber S., Cronin M., and Rinaldo C.R. High viral load in semen of human immunodeficiency virus type 1-infected men at all stages of disease and its reduction by therapy with protease and nonnucleoside reverse transcriptase inhibitors. J. Virol. 71 (1997) 6271-6275
    • (1997) J. Virol. , vol.71 , pp. 6271-6275
    • Gupta, P.1    Mellors, J.2    Kingsley, L.3    Riddler, S.4    Mandaleshwar, K.S.5    Schreiber, S.6    Cronin, M.7    Rinaldo, C.R.8
  • 30
    • 25844482131 scopus 로고    scopus 로고
    • Perils at mucosal front lines for HIV and SIV and their hosts
    • Haase A.T. Perils at mucosal front lines for HIV and SIV and their hosts. Nat. Rev. Immunol. 5 (2005) 783-792
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 783-792
    • Haase, A.T.1
  • 31
    • 1642298257 scopus 로고    scopus 로고
    • Mechanistic insights into the kinetics of HIV-1 nucleocapsid protein-facilitated tRNA annealing to the primer binding site
    • Hargittai M.R., Gorelick R.J., Rouzina I., and Musier-Forsyth K. Mechanistic insights into the kinetics of HIV-1 nucleocapsid protein-facilitated tRNA annealing to the primer binding site. J. Mol. Biol. 337 (2004) 951-968
    • (2004) J. Mol. Biol. , vol.337 , pp. 951-968
    • Hargittai, M.R.1    Gorelick, R.J.2    Rouzina, I.3    Musier-Forsyth, K.4
  • 32
    • 0141703218 scopus 로고    scopus 로고
    • CD8 + T cell-mediated CXC chemokine receptor 4-simian/human immunodeficiency virus suppression in dually infected rhesus macaques
    • Harouse J.M., Buckner C., Gettie A., Fuller R., Bohm R., Blanchard J., and Cheng-Mayer C. CD8 + T cell-mediated CXC chemokine receptor 4-simian/human immunodeficiency virus suppression in dually infected rhesus macaques. Proc. Natl. Acad. Sci. USA 100 (2003) 10977-10982
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 10977-10982
    • Harouse, J.M.1    Buckner, C.2    Gettie, A.3    Fuller, R.4    Bohm, R.5    Blanchard, J.6    Cheng-Mayer, C.7
  • 33
    • 0032560189 scopus 로고    scopus 로고
    • Anti-HIV agents that selectively target retroviral nucleocapsid protein zinc fingers without affecting cellular zinc finger proteins
    • Huang M., Maynard A., Turpin J.A., Graham L., Janini G.M., Covell D.G., and Rice W.G. Anti-HIV agents that selectively target retroviral nucleocapsid protein zinc fingers without affecting cellular zinc finger proteins. J. Med. Chem. 41 (1998) 1371-1381
    • (1998) J. Med. Chem. , vol.41 , pp. 1371-1381
    • Huang, M.1    Maynard, A.2    Turpin, J.A.3    Graham, L.4    Janini, G.M.5    Covell, D.G.6    Rice, W.G.7
  • 38
    • 33748990336 scopus 로고    scopus 로고
    • Which topical microbicides for blocking HIV-1 transmission will work in the real world?
    • Klasse P.J., Shattock R.J., and Moore J.P. Which topical microbicides for blocking HIV-1 transmission will work in the real world?. PLoS Med. 3 (2006) e351
    • (2006) PLoS Med. , vol.3
    • Klasse, P.J.1    Shattock, R.J.2    Moore, J.P.3
  • 39
    • 0027258736 scopus 로고
    • Interactions between HIV-1 nucleocapsid protein and viral DNA may have important functions in the viral life cycle
    • Lapadat-Tapolsky M., De Rocquigny H., Van Gent D., Roques B., Plasterk R., and Darlix J.-L. Interactions between HIV-1 nucleocapsid protein and viral DNA may have important functions in the viral life cycle. Nucleic Acids Res. 21 (1993) 831-839
    • (1993) Nucleic Acids Res. , vol.21 , pp. 831-839
    • Lapadat-Tapolsky, M.1    De Rocquigny, H.2    Van Gent, D.3    Roques, B.4    Plasterk, R.5    Darlix, J.-L.6
  • 41
    • 33646342770 scopus 로고    scopus 로고
    • Microbicides and other topical strategies to prevent vaginal transmission of HIV
    • Lederman M.M., Offord R.E., and Hartley O. Microbicides and other topical strategies to prevent vaginal transmission of HIV. Nat. Rev. Immunol. 6 (2006) 371-382
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 371-382
    • Lederman, M.M.1    Offord, R.E.2    Hartley, O.3
  • 43
    • 0029797081 scopus 로고    scopus 로고
    • Biophysical characterization of zinc ejection from HIV nucleocapsid protein by anti-HIV 2,2′-dithiobis[benzamides] and benzisothiazolones
    • Loo J.A., Holler T.P., Sanchez J., Gogliotti R., Maloney L., and Reily M.D. Biophysical characterization of zinc ejection from HIV nucleocapsid protein by anti-HIV 2,2′-dithiobis[benzamides] and benzisothiazolones. J. Med. Chem. 39 (1996) 4313-4320
    • (1996) J. Med. Chem. , vol.39 , pp. 4313-4320
    • Loo, J.A.1    Holler, T.P.2    Sanchez, J.3    Gogliotti, R.4    Maloney, L.5    Reily, M.D.6
  • 44
    • 33646891072 scopus 로고    scopus 로고
    • Cellulose acetate 1,2-benzenedicarboxylate inhibits infection by cell-free and cell-associated primary HIV-1 isolates
    • Lu H., Zhao Q., Wallace G., Liu S., He Y., Shattock R., Neurath A.R., and Jiang S. Cellulose acetate 1,2-benzenedicarboxylate inhibits infection by cell-free and cell-associated primary HIV-1 isolates. AIDS Res. Hum. Retrov. 22 (2006) 411-418
    • (2006) AIDS Res. Hum. Retrov. , vol.22 , pp. 411-418
    • Lu, H.1    Zhao, Q.2    Wallace, G.3    Liu, S.4    He, Y.5    Shattock, R.6    Neurath, A.R.7    Jiang, S.8
  • 45
    • 0035857417 scopus 로고    scopus 로고
    • Reactivity of zinc finger cores: Analysis of protein packing and electrostatic screening
    • Maynard A.T., and Covell D.G. Reactivity of zinc finger cores: Analysis of protein packing and electrostatic screening. J. Am. Chem. Soc. 123 (2001) 1047-1058
    • (2001) J. Am. Chem. Soc. , vol.123 , pp. 1047-1058
    • Maynard, A.T.1    Covell, D.G.2
  • 46
    • 0038447097 scopus 로고    scopus 로고
    • Human cellular nucleic acid-binding protein Zn2 + fingers support replication of human immunodeficiency virus type 1 when they are substituted in the nucleocapsid protein
    • McGrath C.F., Buckman J.S., Gagliardi T.D., Bosche W.J., Coren L.V., and Gorelick R.J. Human cellular nucleic acid-binding protein Zn2 + fingers support replication of human immunodeficiency virus type 1 when they are substituted in the nucleocapsid protein. J. Virol. 77 (2003) 8524-8531
    • (2003) J. Virol. , vol.77 , pp. 8524-8531
    • McGrath, C.F.1    Buckman, J.S.2    Gagliardi, T.D.3    Bosche, W.J.4    Coren, L.V.5    Gorelick, R.J.6
  • 48
    • 0037276929 scopus 로고    scopus 로고
    • Target cells in vaginal HIV transmission
    • Miller C.J., and Shattock R.J. Target cells in vaginal HIV transmission. Microbes Infect. 5 (2003) 59-67
    • (2003) Microbes Infect. , vol.5 , pp. 59-67
    • Miller, C.J.1    Shattock, R.J.2
  • 50
    • 0036095739 scopus 로고    scopus 로고
    • A tight-binding mode of inhibition is essential for anti-human immunodeficiency virus type 1 virucidal activity of nonnucleoside reverse transcriptase inhibitors
    • Motakis D., and Parniak M.A. A tight-binding mode of inhibition is essential for anti-human immunodeficiency virus type 1 virucidal activity of nonnucleoside reverse transcriptase inhibitors. Antimicrob. Agents Chemother. 46 (2002) 1851-1856
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 1851-1856
    • Motakis, D.1    Parniak, M.A.2
  • 51
    • 2942627489 scopus 로고    scopus 로고
    • Cellulose acetate phthalate, a common pharmaceutical excipient, inactivates HIV-1 and blocks the coreceptor binding site on the virus envelope glycoprotein gp120
    • Neurath A.R., Strick N., Li Y.-Y., and Debnath A.K. Cellulose acetate phthalate, a common pharmaceutical excipient, inactivates HIV-1 and blocks the coreceptor binding site on the virus envelope glycoprotein gp120. BMC Infect. Dis. 1 (2001) 17
    • (2001) BMC Infect. Dis. , vol.1 , pp. 17
    • Neurath, A.R.1    Strick, N.2    Li, Y.-Y.3    Debnath, A.K.4
  • 52
    • 2942622122 scopus 로고    scopus 로고
    • Anti-HIV-1 activity of cellulose acetate phthalate: Synergy with soluble CD4 and induction of dead-end gp41 six-helix bundles
    • Neurath A.R., Strick N., Jiang S., Li Y.-Y., and Debnath A.K. Anti-HIV-1 activity of cellulose acetate phthalate: Synergy with soluble CD4 and induction of dead-end gp41 six-helix bundles. BMC Infect. Dis. 2 (2002) 6
    • (2002) BMC Infect. Dis. , vol.2 , pp. 6
    • Neurath, A.R.1    Strick, N.2    Jiang, S.3    Li, Y.-Y.4    Debnath, A.K.5
  • 53
    • 2442642818 scopus 로고    scopus 로고
    • Water dispersible microbicidal cellulose acetate phthalate film
    • Neurath A.R., Strick N., and Li Y.-Y. Water dispersible microbicidal cellulose acetate phthalate film. BMC Infect. Dis. 3 (2003) 27
    • (2003) BMC Infect. Dis. , vol.3 , pp. 27
    • Neurath, A.R.1    Strick, N.2    Li, Y.-Y.3
  • 54
    • 0029077099 scopus 로고
    • The activity of candidate virucidal agents, low pH and genital secretions against HIV-1 in vitro
    • O'Connor T.J., Kinchington D., Kangro H.O., and Jeffries D.J. The activity of candidate virucidal agents, low pH and genital secretions against HIV-1 in vitro. Int. J. STD AIDS 6 (1995) 267-272
    • (1995) Int. J. STD AIDS , vol.6 , pp. 267-272
    • O'Connor, T.J.1    Kinchington, D.2    Kangro, H.O.3    Jeffries, D.J.4
  • 56
    • 1842429076 scopus 로고    scopus 로고
    • Macaca fascicularis vs. Macaca nemestrina as a model for topical microbicide safety studies
    • Patton D.L., Sweeney Y.C., Tsai C.C., and Hillier S.L. Macaca fascicularis vs. Macaca nemestrina as a model for topical microbicide safety studies. J. Med. Primatol. 33 (2004) 105-108
    • (2004) J. Med. Primatol. , vol.33 , pp. 105-108
    • Patton, D.L.1    Sweeney, Y.C.2    Tsai, C.C.3    Hillier, S.L.4
  • 57
    • 10644268549 scopus 로고    scopus 로고
    • Anti-HIV drug development-an overview
    • Pereira C.F., and Paridaen J.T.M.L. Anti-HIV drug development-an overview. Curr. Pharm. Des. 10 (2004) 4005-4037
    • (2004) Curr. Pharm. Des. , vol.10 , pp. 4005-4037
    • Pereira, C.F.1    Paridaen, J.T.M.L.2
  • 59
    • 0037625131 scopus 로고    scopus 로고
    • Transmission, acute HIV-1 infection and the quest for strategies to prevent infection
    • Pope M., and Haase A.T. Transmission, acute HIV-1 infection and the quest for strategies to prevent infection. Nat. Med. 9 (2003) 847-852
    • (2003) Nat. Med. , vol.9 , pp. 847-852
    • Pope, M.1    Haase, A.T.2
  • 60
    • 0030863628 scopus 로고    scopus 로고
    • T lymphocytes and macrophages but not motile spermatozoa, are a significant source of human immunodeficiency virus in semen
    • Quayle A.J., Xu C., Mayer K.H., and Anderson D.J. T lymphocytes and macrophages but not motile spermatozoa, are a significant source of human immunodeficiency virus in semen. J. Infect. Dis 176 (1997) 960-968
    • (1997) J. Infect. Dis , vol.176 , pp. 960-968
    • Quayle, A.J.1    Xu, C.2    Mayer, K.H.3    Anderson, D.J.4
  • 61
    • 0033609448 scopus 로고    scopus 로고
    • Structural investigation on the requirement of CCHH zinc finger type in nucleocapsid protein of human immunodeficiency virus 1
    • Ramboarina S., Morellet N., Fournie-Zaluski M.C., and Roques B.P. Structural investigation on the requirement of CCHH zinc finger type in nucleocapsid protein of human immunodeficiency virus 1. Biochemistry 38 (1999) 9600-9607
    • (1999) Biochemistry , vol.38 , pp. 9600-9607
    • Ramboarina, S.1    Morellet, N.2    Fournie-Zaluski, M.C.3    Roques, B.P.4
  • 65
    • 0028257964 scopus 로고
    • Inhibition of human immunodeficiency virus infection by agents that interfere with thiol-disulfide interchange upon virus-receptor interaction
    • Ryser H.J.J., Levy E.M., Mandel R., and DiSciullo G.J. Inhibition of human immunodeficiency virus infection by agents that interfere with thiol-disulfide interchange upon virus-receptor interaction. Proc. Natl. Acad. Sci. USA 91 (1994) 4559-4563
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 4559-4563
    • Ryser, H.J.J.1    Levy, E.M.2    Mandel, R.3    DiSciullo, G.J.4
  • 66
    • 0035371167 scopus 로고    scopus 로고
    • A human immunodeficiency virus transgenic mouse model for assessing interventions that block microbial-induced proviral expression
    • Schito M.L., Kennedy P.E., Kowal R., Berger E.A., and Sher A. A human immunodeficiency virus transgenic mouse model for assessing interventions that block microbial-induced proviral expression. J. Infect. Dis. 183 (2001) 1592-1600
    • (2001) J. Infect. Dis. , vol.183 , pp. 1592-1600
    • Schito, M.L.1    Kennedy, P.E.2    Kowal, R.3    Berger, E.A.4    Sher, A.5
  • 67
    • 0345269262 scopus 로고    scopus 로고
    • In vivo antiviral activity of novel human immunodeficiency virus type 1 nucleocapsid p7 zinc finger inhibitors in a transgenic murine model
    • Schito M.L., Goel A., Song Y., Inman J.K., Fattah R.J., Rice W.G., Turpin J.A., Sher A., and Appella E. In vivo antiviral activity of novel human immunodeficiency virus type 1 nucleocapsid p7 zinc finger inhibitors in a transgenic murine model. AIDS Res. Hum. Retrov. 19 (2003) 91-101
    • (2003) AIDS Res. Hum. Retrov. , vol.19 , pp. 91-101
    • Schito, M.L.1    Goel, A.2    Song, Y.3    Inman, J.K.4    Fattah, R.J.5    Rice, W.G.6    Turpin, J.A.7    Sher, A.8    Appella, E.9
  • 69
    • 0037161291 scopus 로고    scopus 로고
    • Affinities of packaging domain loops in HIV-1 RNA for the nucleocapsid protein
    • Shubsda M.F., Paoletti A.C., Hudson B.S., and Borer P.N. Affinities of packaging domain loops in HIV-1 RNA for the nucleocapsid protein. Biochemistry 41 (2002) 5276-5282
    • (2002) Biochemistry , vol.41 , pp. 5276-5282
    • Shubsda, M.F.1    Paoletti, A.C.2    Hudson, B.S.3    Borer, P.N.4
  • 70
    • 15944368905 scopus 로고    scopus 로고
    • Evaluating the potential impact of vaginal microbicides to reduce the risk of acquiring HIV in female sex workers
    • Smith R.J., Bodine E.N., Wilson D.P., and Blower S.M. Evaluating the potential impact of vaginal microbicides to reduce the risk of acquiring HIV in female sex workers. AIDS 19 (2005) 413-421
    • (2005) AIDS , vol.19 , pp. 413-421
    • Smith, R.J.1    Bodine, E.N.2    Wilson, D.P.3    Blower, S.M.4
  • 71
    • 0025917010 scopus 로고
    • C-terminal retroviral-type zinc finger domain from the HIV-1 nucleocapsid protein is structurally similar to the N-terminal zinc finger domain
    • South T.L., Blake P.R., Hare D.R., and Summers M.F. C-terminal retroviral-type zinc finger domain from the HIV-1 nucleocapsid protein is structurally similar to the N-terminal zinc finger domain. Biochemistry 30 (1991) 6342-6349
    • (1991) Biochemistry , vol.30 , pp. 6342-6349
    • South, T.L.1    Blake, P.R.2    Hare, D.R.3    Summers, M.F.4
  • 73
    • 0025248466 scopus 로고
    • HIV prevention: The need for methods women can use
    • Stein Z.A. HIV prevention: The need for methods women can use. Am. J. Public Health 80 (1990) 460-462
    • (1990) Am. J. Public Health , vol.80 , pp. 460-462
    • Stein, Z.A.1
  • 74
    • 0036884933 scopus 로고    scopus 로고
    • Microbicides: A new approach to preventing HIV and other sexually transmitted infections
    • Stone A. Microbicides: A new approach to preventing HIV and other sexually transmitted infections. Nat. Rev. Drug Discov. 1 (2002) 977-985
    • (2002) Nat. Rev. Drug Discov. , vol.1 , pp. 977-985
    • Stone, A.1
  • 75
    • 85086526402 scopus 로고    scopus 로고
    • HIV topical microbicides: The current development strategy is fully justified
    • Stone A.B. HIV topical microbicides: The current development strategy is fully justified. Am. J. Public Health 94 (2004) 1845-1846
    • (2004) Am. J. Public Health , vol.94 , pp. 1845-1846
    • Stone, A.B.1
  • 76
    • 0031956156 scopus 로고    scopus 로고
    • Role of the N-terminal zinc finger of human immunodeficiency virus type 1 nucleocapsid protein in virus structure and replication
    • Tanchou V., Decimo D., Pechoux C., Lener D., Rogemond V., Berthoux L., Ottmann M., and Darlix J.L. Role of the N-terminal zinc finger of human immunodeficiency virus type 1 nucleocapsid protein in virus structure and replication. J. Virol. 72 (1998) 4442-4447
    • (1998) J. Virol. , vol.72 , pp. 4442-4447
    • Tanchou, V.1    Decimo, D.2    Pechoux, C.3    Lener, D.4    Rogemond, V.5    Berthoux, L.6    Ottmann, M.7    Darlix, J.L.8
  • 78
    • 0035892148 scopus 로고    scopus 로고
    • Interactions of azodicarbonamide (ADA) species with the model zinc finger site: Theoretical support of the zinc finger domain destruction in the HIV-1 nucleocapsid protein (NCp7) by ADA
    • Topol I.A., Nemukhin A.V., Dobrogorskaya Y.I., and Burt S.K. Interactions of azodicarbonamide (ADA) species with the model zinc finger site: Theoretical support of the zinc finger domain destruction in the HIV-1 nucleocapsid protein (NCp7) by ADA. J. Phys. Chem. B 105 (2001) 11341-11350
    • (2001) J. Phys. Chem. B , vol.105 , pp. 11341-11350
    • Topol, I.A.1    Nemukhin, A.V.2    Dobrogorskaya, Y.I.3    Burt, S.K.4
  • 79
    • 2442470533 scopus 로고    scopus 로고
    • The next generation of HIV/AIDS drugs: Novel and developmental anti HIV drugs and targets
    • Turpin J.A. The next generation of HIV/AIDS drugs: Novel and developmental anti HIV drugs and targets. Expert Rev. Anti. Infect. Ther. 1 (2003) 97-128
    • (2003) Expert Rev. Anti. Infect. Ther. , vol.1 , pp. 97-128
    • Turpin, J.A.1
  • 80
    • 0029791790 scopus 로고    scopus 로고
    • Inhibitors of human immunodeficiency virus type 1 zinc fingers prevent normal processing of gag precursors and result in the release of noninfectious virus particles
    • Turpin J.A., Terpening S.J., Schaeffer C.A., Yu G., Glover C.J., Felsted R.L., Sausville E.A., and Rice W.G. Inhibitors of human immunodeficiency virus type 1 zinc fingers prevent normal processing of gag precursors and result in the release of noninfectious virus particles. J. Virol. 70 (1996) 6180-6189
    • (1996) J. Virol. , vol.70 , pp. 6180-6189
    • Turpin, J.A.1    Terpening, S.J.2    Schaeffer, C.A.3    Yu, G.4    Glover, C.J.5    Felsted, R.L.6    Sausville, E.A.7    Rice, W.G.8
  • 81
    • 0033552881 scopus 로고    scopus 로고
    • Synthesis and biological properties of novel pyridinioalkanoyl thiolesters (PATE) as anti-HIV-1 agents that target the viral nucleocapsid protein zinc fingers
    • Turpin J.A., Song Y., Inman J.K., Huang M., Wallqvist A., Maynard A., Covell D.G., Rice W.G., and Appella E. Synthesis and biological properties of novel pyridinioalkanoyl thiolesters (PATE) as anti-HIV-1 agents that target the viral nucleocapsid protein zinc fingers. J. Med. Chem. 42 (1999) 67-86
    • (1999) J. Med. Chem. , vol.42 , pp. 67-86
    • Turpin, J.A.1    Song, Y.2    Inman, J.K.3    Huang, M.4    Wallqvist, A.5    Maynard, A.6    Covell, D.G.7    Rice, W.G.8    Appella, E.9
  • 85
    • 33744817903 scopus 로고    scopus 로고
    • The importance of context: Model projections on how microbicide impact could be affected by the underlying epidemiologic and behavioral situation in 2 African settings
    • Vickerman P., Watts C., Delany S., Alary M., Rees H., and Heise L. The importance of context: Model projections on how microbicide impact could be affected by the underlying epidemiologic and behavioral situation in 2 African settings. Sex. Transm. Dis. 33 (2006) 397-405
    • (2006) Sex. Transm. Dis. , vol.33 , pp. 397-405
    • Vickerman, P.1    Watts, C.2    Delany, S.3    Alary, M.4    Rees, H.5    Heise, L.6
  • 86
    • 37349007932 scopus 로고    scopus 로고
    • HIV-1 nucleocapsid zinc finger inhibitors (zfi's) impede trans infection in cellular and explant models
    • April 23-26, 2006: Abstract OA25
    • Wallace G., Schito M.L., and Appella E. HIV-1 nucleocapsid zinc finger inhibitors (zfi's) impede trans infection in cellular and explant models. Microbicides (2006) April 23-26, 2006: Abstract OA25
    • (2006) Microbicides
    • Wallace, G.1    Schito, M.L.2    Appella, E.3
  • 88
    • 33845329219 scopus 로고    scopus 로고
    • Disruption of estrogen receptor DNA binding domain and related intramolecular communication restores tamoxifen sensitivity in resistant breast cancer
    • Wang L.H., Yang X.Y., Zhang X., An P., Kim H.-J., Huang J., Clarke R., Osborne C.K., Inman J.K., Appella E., and Farrar W.L. Disruption of estrogen receptor DNA binding domain and related intramolecular communication restores tamoxifen sensitivity in resistant breast cancer. Cancer Cell 10 (2006) 487-499
    • (2006) Cancer Cell , vol.10 , pp. 487-499
    • Wang, L.H.1    Yang, X.Y.2    Zhang, X.3    An, P.4    Kim, H.-J.5    Huang, J.6    Clarke, R.7    Osborne, C.K.8    Inman, J.K.9    Appella, E.10    Farrar, W.L.11
  • 89
    • 22144454301 scopus 로고    scopus 로고
    • The development of vaginal microbicides for the prevention of HIV transmission
    • Weber J., Desai K., Darbyshire J., and Programme M.D. The development of vaginal microbicides for the prevention of HIV transmission. PLoS Med. 2 (2005) 142
    • (2005) PLoS Med. , vol.2 , pp. 142
    • Weber, J.1    Desai, K.2    Darbyshire, J.3    Programme, M.D.4
  • 90
    • 0024578841 scopus 로고
    • New soluble-formazan assay for HIV-1 cytopathic effects-application to high-flux screening of synthetic and natural-products for AIDS-antiviral activity
    • Weislow O.S., Kiser R., Fine D.L., Bader J., Shoemaker R.H., and Boyd M.R. New soluble-formazan assay for HIV-1 cytopathic effects-application to high-flux screening of synthetic and natural-products for AIDS-antiviral activity. J. Natl. Cancer Inst. 81 (1989) 577-586
    • (1989) J. Natl. Cancer Inst. , vol.81 , pp. 577-586
    • Weislow, O.S.1    Kiser, R.2    Fine, D.L.3    Bader, J.4    Shoemaker, R.H.5    Boyd, M.R.6
  • 92
    • 0029013602 scopus 로고
    • Domains upstream of the protease (PR) in human immunodeficiency virus type 1 Gag-Pol influence PR autoprocessing
    • Zybarth G., and Carter C. Domains upstream of the protease (PR) in human immunodeficiency virus type 1 Gag-Pol influence PR autoprocessing. J. Virol. 69 (1995) 3878-3884
    • (1995) J. Virol. , vol.69 , pp. 3878-3884
    • Zybarth, G.1    Carter, C.2


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