Anti-HIV agents that selectively target retroviral nucleocapsid protein zinc fingers without affecting cellular zinc finger proteins

Journal of Medicinal Chemistry

Volumn 41, Issue 9, 1998, Pages 1371-1381

  Huang, Mingjun ^a   Maynard, Andrew ^a   Turpin, Jim A ^a   Graham, Lisa ^a   Janini, George M ^a   Covell, David G ^a   Rice, William G ^a  

^a SAIC FREDERICK INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DITHIANE 4,5 DIOL 1,1 DIOXIDE; 2,2' DITHIOBISBENZAMIDE 1; 3 NITROSOBENZAMIDE; ANTIVIRUS AGENT; AZOFORMAMIDE; DOCKING PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NSC 624151; NSC 654077; NSC 674195; NSC 674447; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG; VIRUS NUCLEOPROTEIN; VIRUS NUCLEOPROTEIN P7; ZINC FINGER PROTEIN;

ANTIVIRAL ACTIVITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG BINDING; DRUG MECHANISM; GENE DISRUPTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MOLECULAR INTERACTION; PROTEIN STRUCTURE; VIRUS INHIBITION; VIRUS NUCLEOCAPSID; VIRUS REPLICATION;

ANIMALS; ANTI-HIV AGENTS; AZO COMPOUNDS; BENZAMIDES; BINDING SITES; CAPSID; CAPSID PROTEINS; CELL LINE; DNA-BINDING PROTEINS; ERYTHROID-SPECIFIC DNA-BINDING FACTORS; GATA1 TRANSCRIPTION FACTOR; GENE PRODUCTS, GAG; HIV-1; HOST CELL FACTOR C1; HUMANS; LIGANDS; MICE; MODELS, MOLECULAR; NITROSO COMPOUNDS; OCTAMER TRANSCRIPTION FACTOR-1; POLY(ADP-RIBOSE) POLYMERASES; SP1 TRANSCRIPTION FACTOR; SULFONES; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; VIRAL PROTEINS; VIRUS REPLICATION; ZINC FINGERS;

EID: 0032560189     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9708543     Document Type: Article

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