Protection of oligodeoxynucleotides against nuclease degradation through association with self-assembling peptides

Biomaterials

Volumn 29, Issue 8, 2008, Pages 1099-1108

  Wang, M ^a   Adikane, H V ^a,b   Duhamel, J ^a   Chen, P ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

^b NATIONAL CHEMICAL LABORATORY   (India)

Author keywords

Aggregate; Centrifugation; Fluorescence resonance energy transfer (FRET); Nuclease resistance; Oligonucleotide; Self assembling peptide

Indexed keywords

FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET); NUCLEASE RESISTANCE; SELF ASSEMBLING PEPTIDES;

DEGRADATION; ENZYME ACTIVITY; ESCHERICHIA COLI; PEPTIDES; SELF ASSEMBLY; ULTRAVIOLET SPECTROSCOPY;

OLIGONUCLEOTIDES;

EXONUCLEASE; NUCLEASE; OLIGODEOXYNUCLEOTIDE DERIVATIVE; PEPTIDE DERIVATIVE; PEPTIDE EAK16II; PEPTIDE EAK16IV; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CENTRIFUGATION; CONCENTRATION (PARAMETERS); ESCHERICHIA COLI; FLUORESCENCE RESONANCE ENERGY TRANSFER; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; ULTRAVIOLET SPECTROSCOPY;

DEOXYRIBONUCLEASES; ESCHERICHIA COLI; EXODEOXYRIBONUCLEASES; FLUORESCENCE RESONANCE ENERGY TRANSFER; HYDROGEN-ION CONCENTRATION; OLIGODEOXYRIBONUCLEOTIDES; OLIGOPEPTIDES; POLY C; POLY G; PROTEIN BINDING; SPECTROPHOTOMETRY, ULTRAVIOLET;

ESCHERICHIA COLI;

EID: 37349049075     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2007.10.049     Document Type: Article

References (22)

1. Stein C., Benimetskaya L., and Mani S. Antisense strategies for oncogene inactivation. Semin Oncol 32 (2005) 563-572
2. Crooke S.T. Therapeutic applications of oligonucleotides. Biotechnology 10 (1992) 882-886
3. Wang H., Prasad G., Buolamwini J.K., and Zhang R. Antisense anticancer oligonucleotide therapeutics. Curr Cancer Drug Targets 1 (2001) 177-196
4. Zhao H., Peng P., Longley C., Zhang Y., Borowski V., Mehlig M., et al. Delivery of G3139 using releasable PEG-linkers: impact on pharmacokinetic profile and anti-tumor efficacy. J Control Rel 119 (2007) 143-152
5. Garcia-Chaumont C., Seksek O., Grzybowska J., Borowski E., and Bolard J. Delivery systems for antisense oligonucleotides. Pharm Therap 87 (2000) 255-277
6. Crooke S.T. Progress in antisense technology: the end of the beginning. Methods Enzymol 313 (2000) 3-45
7. Ghosh M.K., Cohen J.S., Dahl O., and Ghosh K. Evaluation of some properties of a phosphorodithioate oligodeoxyribonucleotide for antisense application. Nucleic Acids Res 21 (1993) 5761-5766
8. Pavid A.D. Peptide nucleic acids: versatile tools for gene therapy strategies. Adv Drug Del Rev 44 (2000) 81-95
9. Hogrefe R.I. An antisense oligonucleotide primer. Antisense Nucleic Acid Drug Del 9 (1999) 351-357
10. Remaut K., Lucas B., Braeckmans K., Sanders N.N., De Smedt S.C., and Demeester J. FRET-FCS as a tool to evaluate the stability of oligonucleotide drugs after intracellular delivery. J Control Rel 103 (2005) 259-271
11. Parekh H.S., Marano R.J., Rakoczy E.P., Blanchfield J., and Toth I. Synthesis of a library of polycationic lipid core dendrimers and their evaluation in the delivery of an oligonucleotide with hVEGF inhibition. Bioorg Med Chem 14 (2006) 4775-4780
12. Park T.G., Jeong J.H., and Kim S.W. Current status of polymeric gene delivery systems. Adv Drug Del Rev 58 (2006) 467-486
13. Thierry A.R., Abes S., Resina S., Travo A., Richard J.P., et al. Comparison of basic peptides- and lipid-based strategies for the delivery of splice correcting oligonucleotides. Biochim Biophys Acta 1758 (2006) 364-374
14. Wang M., Law M., Duhamel J., and Chen P. Interaction of a self-assembling peptide with oligonucleotides: complexation and aggregation. Biophys J 93 (2007) 2477-2490
15. Zhang S., Lockshin C., Cook R., and Rich A. Unusually stable β-sheet formation of an ionic self-complementary oligopeptide. Biopolymers 34 (1994) 663-672
16. Uchiyama H., Hirano K., Kashiwasake-J M., and Taira K. Detection of undegraded oligonucleotides in vivo by fluorescence resonance energy transfer. J Biol Chem 271 (1996) 380-384
17. Akinrimisi E.O., Sander C., and Ts'o P.O.P. Properties of helical polycytidylic acid. Biochemistry 2 (1963) 340-344
18. Bolumar T., Sanz T.Y., Aristoy M.C., and Toldra F. Purification and characterization of a prolyl aminopeptidase from debaryomyces hansenii. Appl Environ Microbiol 69 (2003) 227-232
19. Moyer R.W., and Rothe C.T. Role of the T5 gene D15 nuclease in the generation of nicked bacteriophage T5 DNA. J Virol 24 (1977) 177-193
20. Lehninger A.L. Principles of biochemistry (1993)
21. Agrawal S. Importance of nucleotide sequence and chemical modifications of antisense oligonucleotides. Biochim Biophys Acta 1489 (1999) 53-68
22. Woon-Soo K., Izumi H., and Woo-Sik K. Aging characteristics of protein precipitates produced by polyelectrolyte precipitation in turbulently agitated reactor. Chem Eng Sci 57 (2002) 4077-4085