Synaptically-released zinc inhibits N-methyl-D-aspartate receptor activation at recurrent mossy fiber synapses

Brain Research

Volumn 910, Issue 1-2, 2001, Pages 205-207

  Molnár, Peter ^a   Nadler, J Victor ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Epilepsy; Granule cell; Hippocampus; Mossy fibers; NMDA receptor; Zinc

Indexed keywords

AMPA RECEPTOR; GLUTAMIC ACID; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PILOCARPINE; ZINC;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHELATION; CONTROLLED STUDY; DRUG MECHANISM; EXCITATORY POSTSYNAPTIC POTENTIAL; GRANULE CELL; HIPPOCAMPUS; MEMBRANE POTENTIAL; MOSSY FIBER; NONHUMAN; PRIORITY JOURNAL; RAT; SYNAPSE;

ANIMALS; CHELATING AGENTS; EXCITATORY AMINO ACID ANTAGONISTS; GABA ANTAGONISTS; MOSSY FIBERS, HIPPOCAMPAL; MUSCARINIC AGONISTS; PATCH-CLAMP TECHNIQUES; PILOCARPINE; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPSES; SYNAPTIC TRANSMISSION; ZINC;

EID: 0035839170     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02720-2     Document Type: Article

References (17)

1. Selective release of endogenous zinc from the hippocampal mossy fibers in situ
2. 2+ from brain tissue during activity
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5. Subunit-specific enhancement of glutamate receptor responses by zinc
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7. A receptor function in dentate granule and CA1 neurons
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10. Mossy fiber-granule cell synapses in the normal and epileptic rat dentate gyrus studied with minimal laser photostimulation
11. A receptors in the pilocarpine model of epilepsy
12. Recurrent mossy fiber pathway in rat dentate gyrus: Synaptic currents evoked in presence and absence of seizure-induced growth
13. High-affinity zinc inhibition of NMDA NR1-NR2A receptors
14. Physiological unmasking of new glutamatergic pathways in the dentate gyrus of hippocampal slices from kainate-induced epileptic rats
15. Mossy fiber synaptic reorganization in the epileptic human temporal lobe
16. The actions of synaptically released zinc at hippocampal mossy fiber synapses
17. Electrographic seizures and new recurrent excitatory circuits in the dentate gyrus of hippocampal slices from kainate-treated epileptic rat