Effect of Mouriri pusa extracts on experimentally induced gastric lesions in rodents: Role of endogenous sulfhydryls compounds and nitric oxide in gastroprotection

Journal of Ethnopharmacology

Volumn 107, Issue 3, 2006, Pages 431-441

  Andreo, Marcio Adriano ^a   Ballesteros, Kátia Verônica Rodríguez ^a   Hiruma Lima, Clélia Akiko ^a   Machado da Rocha, Lúcia Regina ^a   Souza Brito, Alba Regina Monteiro ^b   Vilegas, Wagner ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Antiulcerogenic activity; Flavonoids; Melastomataceae; Mouriri pusa; Tannins

Indexed keywords

ALCOHOL; DICHLOROMETHANE; EPICATECHIN; FLAVONOID; HYDROCHLORIC ACID; METHANOL; MOURIRI PUSA EXTRACT; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; ORGANIC COMPOUND; PHENOL DERIVATIVE; PLANT EXTRACT; TANNIN; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAZIL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG ISOLATION; GASTROINTESTINAL DISEASE; MALE; MELASTOMATACEAE; MOURIRI PUSA; MOUSE; NONHUMAN; PHYTOCHEMISTRY; PLANT LEAF; PYLORUS LIGATION; RAT; RODENT; STOMACH LESION; STOMACH PROTECTION; STOMACH ULCER; STRESS; TRADITIONAL MEDICINE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTI-ULCER AGENTS; BRAZIL; ENZYME INHIBITORS; ETHANOL; ETHYLMALEIMIDE; GASTRIC ACID; GASTRIC ACIDITY DETERMINATION; GASTRIC MUCOSA; GASTROINTESTINAL MOTILITY; HYDROCHLORIC ACID; MALE; MEDICINE, TRADITIONAL; MELASTOMATACEAE; MICE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PLANT EXTRACTS; PLANT LEAVES; PYLORUS; RATS; RATS, WISTAR; STOMACH ULCER; STRESS; STRESS, PHYSIOLOGICAL; SULFHYDRYL COMPOUNDS; SULFHYDRYL REAGENTS;

ANIMALIA; MELASTOMATACEAE; MOURIRI; PUSA; RODENTIA;

EID: 33748526513     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2006.04.001     Document Type: Article

References (77)

1. Agrawal P.K. Carbon 13 NMR of Flavonoids (1989), Elsevier, Amsterdam p. 564
2. Allen A., Cunliffe W.J., Pearson J.P., Sellers L.A., and Ward R. Studies on gastrointestinal mucus. Scandinavian Journal of Gastroenterology 93 (1984) S101-S113
3. Allen A., and Flemstrom G. Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin. American Journal Physiology Cell 288 (2005) C1-C19
4. Almeida, S.P., Proença, C.E.B., Sano, S.M., Ribeiro, J.F., 1998. Cerrado: espécies vegetais úteis. EMBRAPA, Planaltina, Distrito Federal, pp. 38-39.
5. Arrieta J., Benitez J., Flores E., Castillo C., and Navarrete A. Purification of gastroprotective triterpenoids from the stem bark of Amphipterygium adstringens; role of prostaglandins, sulfhydryls, nitric oxide and capsaicin-sensitive neurons. Planta Medica 69 (2003) 905-909
6. Avila J.R., Of La it Ballasts C.A., Martín M.J., Motilva V., Luque I., Delgado D., Esteban J., and Herrerias J.R. Roll of endogenous sulphydryls and neutrophil infiltration in the pathogenesis of gastric mucosal injury induced by piroxicam in rats. Inflammation Research 45 (1996) 83-88
7. Azuma K., Ippoushi K., Nakayama M., Ito H., Higashio H., and Terao J. Absoption of chlorogenic acid and caffeic acid in rats after oral administration. Journal of Agricultural Food Chemistry 48 (2000) 5496-5500
8. Borrelli F., and Izzo A.A. The plant kingdom as a source of anti-ulcer remedies. Phytotherapy Research 14 (2000) 581-591
9. Brodie D.A. The mechanism of gastric hyperacidity produced by pylorus ligation in the rat. American Journal of Digestion Disease 11 (1966) 231-241
10. Calderon A.I., Angehofer C.K., Pezzuto J.M., Farnsworth N.R., Foster R., Condit R., Gupta M.P., and Soejarto D.D. Forest plot as a tool to demonstrate the pharmaceutical potential of plants in tropical forest of Panamá. Economic Botany 54 (2000) 278-294
11. Cao G., Sofic E., and Prior R.L. Antioxidant and prooxidant behaviour of flavonoids: structure-activity relationships. Free Radical Biology and Medicine 22 (1997) 749-760
12. Chandranath S.I., Bastaki S.M., and Singh J. A comparative study on the activity of lansoprazole, omeprazole and PD-136450 on acidified ethanol- and indomethacin-induced gastric lesions in the rat. Clinical Experimental Pharmacology and Physiology 29 (2002) 173-180
13. Corrêa M.P. Dicionário de Planta úteis do Brasil e das Exóticas Cultivadas (1984), Imprensa National, Rio de Janeiro pp. 538-541
14. Fauconneau B., Waffo-Téguo P., Huguet F., Barrier L., Decendit A., and Merillon J.M. Comparative study of radical scavenger and antioxidant properties of phenolic compounds from Vitis vinifera cell cultures using in vitro tests. Life Sciences 61 (1997) 2103-2110
15. Fejes S., Blazovics A., Lugasi A., Lemberkovics E., Petri G., and Kery A. In vitro antioxidant activity of Anthriscus cerefolium L. (Hoffm.) extracts. Journal of Ethnopharmacology 69 (2000) 259-265
16. Frankel S., and Berenbaum M. Effects of light on antioxidant content of foliage in a tropical forest community. Biotropica 31 (1999) 422-429
17. Garner A. Adaptation in the pharmaceutical industry, with particular reference to gastrointestinal drugs and diseases. Review. Scandinavian Journal of Gastroenterology 193 (1992) S83-S89
18. Gong D.H., Turner B., Bhaskar K.R., and Lamont J.T. Lipid binding to gastric mucin: protective effect against oxygen radicals. American Journal of Physiology 259 (1990) G681-G686
19. Gonzalez F.G., and Di Stasi L.C. Anti-ulcerogenic and analgesic activities of the leaves of Wilbrandia ebracteata in mice. Phytomedicine 9 (2002) 125-134
20. Gracioso J.S., Vilegas W., Hiruma-Lima C.A., and Souza Brito A.R. Effects of tea from Turnera ulmifolia L. on mouse gastric mucosa support the Turneraceae as a new source of antiulcerogenic drugs. Biological Pharmaceutical Bulletin 25 (2002) 487-491
21. Grijalva C.V., and Novin D. The role of the hypothalamus and dorsal vagal complex in gastrointestinal function and pathophysiology. Annual New York Academic Science 597 (1990) 207-222
22. Guth P.H., Paulsen G., and Nagata H. Histologic and microcirculatory changes in alcohol-induced gastric lesions in the rats: effects of prostaglandin cytoprotection. Gastroenterology 87 (1984) 1083-1090
23. Halter F., Schmassmann A., and Peskar B.M. Cyclooxygenase 2-implications on maintenance of gastric mucosal integrity and ulcer healing: controversial issues and perspectives. Gut 49 (2001) 443-453
24. Harborne J.B. The Flavonoids: Advances in Research Since 1986 (1986), Chapman & Hall, New York p. 676
25. Hashizume T., Hirokawa K., Aibara S., Ogawa H., and Kashara A. Pharmacological and histological studies of gastric mucous lesions induced by serotonin in rats. Archieves Internationales Pharmacodynamie et Therapie 236 (1978) 96-108
26. Haslam E. Natural polyphenols (vegetable tannins) as drugs and medicines: possible modes of action. Journal of Natural Products 59 (1996) 205-215
27. Heijnen C.G.M., Haenen G.R.M.M., Van Acker F.A.A., Van der Vijgh W.J.F., and Bast A. Flavonoids as peroxynitrite scavengers: The role of the hydroxyl groups. Toxicology In Vitro 15 (2001) 3-6
28. Hiraishi H., Terano A., Ota S., Mutoh S., Sugimoto T., Hirada T., Razandi M., and Ivey K.J. Role for mucus glycoprotein in protecting cultured gastric mucosal cells against toxic oxygen metabolites. Journal Laboratory Clinical Medicine 121 (1993) 570-578
29. Hiruma-Lima C.A., Gracioso J.S., Bighetti E.J., Grassi-Kassisse D.M., Nunes D.S., and Brito A.R. Effect of essential oil obtained from Croton cajucara Benth. on gastric ulcer healing and protective factors of the gastric mucosa. Phytomedicine 9 (2002) 523-529
30. Iwai K., Onodera A., and Matsue H. Antioxidant activity and inhibitory effect of Gamazumi (Viburnum dilatatum Thumb.) on oxidative damage induced by water immersion restraint stress in rats. International Journal Food Science Nutrition 52 (2001) 443-451
31. John T.A., and Onabanjo A.O. Gastroprotective effect of an aqueous extract of Entandrophragma utile bark in experimental ethanol-induced peptic ulceration in mice and rats. Journal of Ethnopharmacology 29 (1990) 87-93
32. Kinoshita M., Kume E., and Tamaki H. Roles of prostaglandins, nitric oxide and the capsaicin-sensitive sensory nerves in gastroprotection produced by ecabet sodium. Journal of Pharmacology and Experimental Therapeutics 275 (1995) 494-501
33. Klink C.A. Relação entre o desenvolvimento agrícola e a biodiversidade. In: Pereira R.C., and Nasser L.C.B. (Eds). First International Symposium on Tropical Savannas (Proceedings). Brasília (1996) 25-27
34. Konturek P.C., Brzowski T., Sliwowski Z., Pajido R., Stachura J., Hahn E.G., and Konturek S.J. Involvement of nitric oxide and prostaglandins in gastroprotection induced by bacterial lipopolysaccharide. Scandinavian Journal of Gastroenterology 33 (1998) 691-700
35. Lee H.T., Lee Y.J., Chung S.J., and Shim C.K. Effect of prokinetic agents, cisapride and metoclopramide, on the bioavailability in humans and intestinal permeability in rats of ranitidine, and intestinal charcoal transit in rats. Research Communications in Molecular Pathology and Pharmacology 108 (2000) 311-323
36. Levine R.J. A method for rapid production of stress ulcers in rats. In: Pfeiffer C.J. (Ed). Peptic Ulcer (1971), Munksgaard, Copenhagen 92-97
37. Makris D.P., and Rossiter J.T. Comparison of quercetin and a non-orthohydroxy flavonol as antioxidants by competing in vitro oxidation reactions. Journal of Agriculture Food and Chemistry 49 (2001) 3370-3377
38. Matsuda H.I., Read Y., and Yoshikawa M. Roll of capsaicin-sensitive sensory nerves, endogenous nitric rusts, sulfhydryls, and prostaglandins in gastroprotection by Mormodin Ic, an oleanolic acid oligoglycoside, on ethanol-induced gastric mucosal lesions in rat. Life Sciences 65 (1999) 27-32
39. Mendonça R.C., Felfili J.M., Walter B.M.T., Silva M.C., Rezende A.R., Filguieras T.S., and Nogueira P.E. Flora vascular do Cerrado. In: Sano S.M., and Almeida S.P. (Eds). Cerrado Ambiente e Flora, EMBRAPA (1998), Planaltina-Distrito Federal 286-556
40. Mincis M., Chebli J.M.F., Khouri S.T., and Mincis R. Ethanol and the gastrointestinal tract. Arquieves of Gastroenterology 32 (1995) 131-136
41. Mizui T., and Doteuchi M. Effect of polyamines on acidified ethanol-induced gastric lesions in rats. Japanese Journal of Pharmacology 33 (1983) 934-945
42. Morimoto Y., Shimohara K., Oshima S., and Sukamoto T. Effects of the new anti-ulcer agent KB-5492 on experimental gastric mucosal lesions and gastric mucosal defensive factors, the compared to those of terprenone and cimetidine. Japanese Journal of Pharmacology 57 (1991) 495-505
43. Morley T. A new and an emended species of Mouriri (Melastomataceae). Novon 8 (1998) 41-44
44. Nwafor P.A., Effraim K.D., and Jacks T.W. Gastroprotective effect of aqueous extract of Khaya senegalensis bark on indomethacin-induced ulceration in rats. West African Journal of Pharmacology and Drug Research 12 (1996) 46-50
45. Olfert, E.D., Cross, B. M., McWilliam, A.A., 1993. Canadian Council on Animal Care Ottawa, Ontario, pp. 1-213.
46. Parkman H.P., Treat D.M., Knight L.C., Brown K.L., Maurer A.H., and Fisher R.S. Cholinergic effect on human gastric motility. Gut 45 (1999) 346-354
47. Peskar B.M., and Maricic N. Role of prostaglandins in gastroprotection. Digestion Disease Science 43 (1998) 23S-29S
48. Porter L.J. Tannins. In: Dey P.M., and Harborne J.B. (Eds). Method in Plants Biochemistry (1989), Academic Press, London 389
49. Puscas I., Puscas C., Coltau M., Pasca R., Towers J., Márquez M., Herrero E., Fillat O., and Ortiz J.A. Comparative study of the safety and efficacy of ebrotidine versus ranitidine and placebo in the prevention of piroxicam-induced gastroduodenal lesions. Arzneimittelforschung 47 (1997) 568-572
50. Rastogi L., Patnaik G.K., and Dikshit M. Free radicals and antioxidant status following pylorus ligation induced gastric mucosal injury in rats. Pharmacological Research 38 (1998) 125-132
51. Rates S.M.K. Plants as source of drugs. Toxicon 29 (2001) 603-613
52. Repetto M.G., and Llesuy S.F. Antioxidant properties of natural compounds used in popular medicine for gastric ulcers. Brazilian Journal of Medical and Biological Research 35 (2002) 523-534
53. Rice-Evans C.A., Miller N.J., and Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radical Biology and Medicine 20 (1996) 933-956
54. Salim A.S. Sulfhydryl-containing agents: new approach to the problem of refractory peptic ulceration. Pharmacology 46 (1993) 281-288
55. Sannomiya M., Fonseca V.B., da Silva M.A., Rocha L.R., Dos Santos L.C., Hiruma-Lima C.A., Souza Brito A.R., and Vilegas W. Flavonoids and antiulcerogenic activity from Byrsonima crassa leaves extracts. Journal of Ethnopharmacology 97 (2005) 1-6
56. Santos S.C., and Mello J.C.P. Taninos. In: Simões C.M.O., Schenkel E.P., Gosmann G., Mello J.C.P., Mentz L.A., and Petrovick P.R. (Eds). Farmacognosia: da Planta ao Medicamento (1999), Ed. da Universidade/UFRGS, Porto Alegre, Florianópolis 517-544
57. Shay H. The simple goes the uniform production of gastric ulceration in rat. Gastroenterology 5 (1945) 43-61
58. Silva E.M., Hiruma-Lima C.A., and Lolis S.F. Etnobotânica no município de Porto Nacional. Symposium of Brazilian Medicinal Plants. Cuiabá (2000) 106 (Abstract)
59. Souza Brito A.R.M. Manual de Ensaios Toxicológicos in Vivo (1995), Editora da UNICAMP, Campinas, São Paulo p. 122
60. Souza Brito A.R.M. How to study the pharmacology of medicinal plants in underdevelopment countries. Journal of Ethnopharmacology 54 (1996) 131-138
61. Stickney J.C., and Northup D.W. Effect of gastric emptying upon propulsive motility of small intestine in rat. Proceedings of The Society for Experimental Biology and Medicine 101 (1959) 582
62. Szabo S. Mechanism of mucosal injury in the stomach and duodenum: Time-sequence analysis of morphologic, functional biochemical and histochemical studies. Scandinavian Journal Gastroenterology 22 (1987) 21-28
63. Szabo S., and Vattay P. Experimental gastric and duodenal ulcers. Advances in pathogenesis. Gastroenterology Clinical North America 19 (1990) 67-85
64. Szelenyi I., and Thiemer K. Distention ulcer as a model for testing of drugs for ulcerogenic side effects. Archives of Toxicology 41 (1978) 99-105
65. Van Acker S.A.B.E., De Groot M.J., Van den Berg D.J., Tromp M.N.J.L., Den Kelder G.D.O., Van der Vijgh W.J.F., and Bast. A quantum chemical explanation of the antioxidant activity of flavonoids. Chemistry Research Toxicology 9 (1996) 1305-1312
66. Wagner H.M., Bladt S., and Zgainki E.M. Plant Drug Analysis (1984), Springer, Berlin p. 320
67. Wallace J. Mechanisms of protection and healing: current knowledge and future research. American Journal of Medicine 110 (2001) 19S-22S
68. Williams D.H., Stone M.J., Hauck P.R., and Rahman S.K. Why are secondary metabolites (natural products) biosynthesized?. Journal of Natural Products 56 6 (1989) 1189-1208
69. Yoshida T., Nakata F., and Okuda T. Tannins and related polyphenols of melastomataceous plants. VIII: Nobotanins L, M and N, trimeric hydrolyzable tannins from Tibouchina semidecandra. Chemical Pharmaceutical Bulletin 47 (1999) 824-827
70. Yoshida T., Amakura Y., Yokura N., Ito H., Isaza J.H., Ramirez S., Pelaez D.P., and Renner S.S. Oligomeric hydrolysable tannins from Tibouchina multiflora. Phytochemistry 52 (1999) 1661-1666
71. Yoshida T., Ohbayashi H., Ishihara K., Ohwashi W., Haba K., Okano Y., Shingu T., and Okuda T. Tannins and related polyphenols of melastomataceous plants: Hydrolyzable tannins from Tibouchina semidecandra Cogn. Chemical and Pharmaceutical Bulletin 39 (1991) 2233-2240
72. Yoshida T., Haba K., Nakata F., Okano Y., Shingu T., and Okuda T. Tannins and related polyphenols of melastomataceous plants 3. Nobotanin-G, nobotanin-H and nobotanin-I, dimeric hydrolyzable tannins from Heterocentron roseum. Chemical and Pharmaceutical Bulletin 40 (1992) 66-71
73. Yoshida T., Nakata F., Hosotani K., Nitta A., and Okuda T. Tannins and related polyphenols of melastomataceous plants 5. 3 new complex tannins from Melastoma malabathricum L. Chemical and Pharmaceutical Bulletin 40 (1992) 1727-1732
74. Yoshida T., Nakata F., Hosotani K., Nitta A., and Okuda T. Tannins and related polyphenols of melastomataceous plants 4. Dimeric hydrolyzable tannins from Melastoma malabathricum. Phytochemistry 31 (1992) 2829-2833
75. Yoshida T., Arioka H., Fjita T., Chen X.M., and Okuda T. Monomeric and dimeric hydrolyzable tannins from 2 melastromataceous species. Phytochemistry 37 (1994) 863-866
76. Yoshida T., Haba K., Arata R., Nakata F., Shingu T., and Okuda T. Tannins and related polyphenols of melastomataceous plants 7. Nobotanin-J and nobotanin-K, trimeric and tetrameic hydrolyzable tannins from Heterocentron roseum. Chemical and Pharmaceutical Bulletin 43 (1995) 1101-1106
77. Yoshida T., Hatano T., and Ito H. Chemistry and function of vegetable polyphenols with high molecular weights. Biofactors 13 (2000) 121-125