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Volumn 40, Issue 6, 2007, Pages 899-910

RGS protein specificity towards Gq- and Gi/o-mediated ERK 1/2 and Akt activation, in vitro

Author keywords

Akt; ERK 1 2; Muscarinic GPCR specifity; R4 RGS proteins

Indexed keywords


EID: 36949010806     PISSN: 12258687     EISSN: 02191024     Source Type: Journal    
DOI: 10.5483/bmbrep.2007.40.6.899     Document Type: Article
Times cited : (46)

References (55)
  • 1
    • 1042266676 scopus 로고    scopus 로고
    • Differential contribution of GTPase activation and effector antagonism to the inhibitory Effect of RGS Proteins on Gq-mediated Signaling in vivo
    • Anger, T., Zhang, W. and Mende, U. (2004) Differential contribution of GTPase activation and effector antagonism to the inhibitory Effect of RGS Proteins on Gq-mediated Signaling in vivo. J. Biol. Chem. 279, 3906-3915.
    • (2004) J. Biol. Chem , vol.279 , pp. 3906-3915
    • Anger, T.1    Zhang, W.2    Mende, U.3
  • 2
    • 0029861417 scopus 로고    scopus 로고
    • The GTPase-activating protein RGS4 stabilizes the transition state for nucleotide hydrolysis
    • Berman, D. M., Kozasa, T. and Gilman, A. G. (1996) The GTPase-activating protein RGS4 stabilizes the transition state for nucleotide hydrolysis. J. Biol. Chem. 271, 27209-27212.
    • (1996) J. Biol. Chem , vol.271 , pp. 27209-27212
    • Berman, D.M.1    Kozasa, T.2    Gilman, A.G.3
  • 3
    • 0042703386 scopus 로고    scopus 로고
    • 2 in vascular smooth muscle cells: Potential involvement in vascular disease (review)
    • 2 in vascular smooth muscle cells: potential involvement in vascular disease (review). Int. J. Mol. Med. 11, 229-234.
    • (2003) Int. J. Mol. Med , vol.11 , pp. 229-234
    • Blanc, A.1    Pandey, N.R.2    Srivastava, A.K.3
  • 4
    • 0034624060 scopus 로고    scopus 로고
    • Dual regulation of Akt/protein kinase B by heterotrimeric G protein subunits
    • Bommakanti, R. K., Vinayak, S. and Simonds, W. F. (2000) Dual regulation of Akt/protein kinase B by heterotrimeric G protein subunits. J. Biol. Chem. 275, 38870-38876.
    • (2000) J. Biol. Chem , vol.275 , pp. 38870-38876
    • Bommakanti, R.K.1    Vinayak, S.2    Simonds, W.F.3
  • 5
    • 0037810249 scopus 로고    scopus 로고
    • Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: Potential targeting for therapeutic intervention
    • Chang, F., Steelman, L. S., Lee, J. T., Shelton, J. G., Navolanic, P. M., Blalock, W. L., Franklin, R. A. and McCubrey, J. A. (2003b) Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention. Leukemia 17, 1263-1293.
    • (2003) Leukemia , vol.17 , pp. 1263-1293
    • Chang, F.1    Steelman, L.S.2    Lee, J.T.3    Shelton, J.G.4    Navolanic, P.M.5    Blalock, W.L.6    Franklin, R.A.7    McCubrey, J.A.8
  • 7
    • 0031006273 scopus 로고    scopus 로고
    • Chatterjee, T. K., Eapen, A. K. and Fisher, R. A. (1997) A truncated form of RGS3 negatively regulates G protein-coupled receptor stimulation of adenylyl cyclase and phosphoinositide phospholipase C. J. Biol. Chem. 272, 15481-15487.
    • Chatterjee, T. K., Eapen, A. K. and Fisher, R. A. (1997) A truncated form of RGS3 negatively regulates G protein-coupled receptor stimulation of adenylyl cyclase and phosphoinositide phospholipase C. J. Biol. Chem. 272, 15481-15487.
  • 8
    • 0030933718 scopus 로고    scopus 로고
    • Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast
    • Chen, C., Zheng, B., Han, J. and Lin, S. C. (1997) Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast. J. Biol. Chem. 272, 8679-8685.
    • (1997) J. Biol. Chem , vol.272 , pp. 8679-8685
    • Chen, C.1    Zheng, B.2    Han, J.3    Lin, S.C.4
  • 9
    • 0036765564 scopus 로고    scopus 로고
    • Characterization and comparison of RGS2 and RGS4 as GTPase-activating proteins for m2 muscarinic receptor-stimulated G(i)
    • Cladman, W. and Chidiac, P. (2002) Characterization and comparison of RGS2 and RGS4 as GTPase-activating proteins for m2 muscarinic receptor-stimulated G(i). Mol. Pharmacol. 62, 654-659.
    • (2002) Mol. Pharmacol , vol.62 , pp. 654-659
    • Cladman, W.1    Chidiac, P.2
  • 10
    • 0028240869 scopus 로고
    • Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits
    • Crespo, P., Xu, N., Simonds, W. F. and Gutkind, J. S. (1994) Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits. Nature 369, 418-420.
    • (1994) Nature , vol.369 , pp. 418-420
    • Crespo, P.1    Xu, N.2    Simonds, W.F.3    Gutkind, J.S.4
  • 12
    • 0033015220 scopus 로고    scopus 로고
    • Gq signaling in cardiac adaptation and maladaptation
    • Dorn, G. W., 2nd and Brown J. H. (1999) Gq signaling in cardiac adaptation and maladaptation. Trends Cardiovasc Med. 9, 26-34.
    • (1999) Trends Cardiovasc Med , vol.9 , pp. 26-34
    • Dorn 2nd, G.W.1    Brown, J.H.2
  • 13
    • 0033033440 scopus 로고    scopus 로고
    • Low- and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice
    • Dorn, G. W., 2nd, Tepe, N. M., Lorenz, J. N., Koch, W. J. and Liggett, S. B. (1999) Low- and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice. Proc. Natl. Acad. Sci. USA 96, 6400-6405.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 6400-6405
    • Dorn 2nd, G.W.1    Tepe, N.M.2    Lorenz, J.N.3    Koch, W.J.4    Liggett, S.B.5
  • 14
    • 0030029727 scopus 로고    scopus 로고
    • Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family
    • Druey, K. M., Blumer, K. J., Kang, V. H. and Kehrl, J. H. (1996) Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family. Nature 379, 742-746.
    • (1996) Nature , vol.379 , pp. 742-746
    • Druey, K.M.1    Blumer, K.J.2    Kang, V.H.3    Kehrl, J.H.4
  • 15
    • 0034647493 scopus 로고    scopus 로고
    • Regulator of G protein signaling RGS3T is localized to the nucleus and induces apoptosis
    • Dulin, N. O., Pratt, P., Tiruppathi, C., Niu, J., Voyno-Yasenetskaya, T. and Dunn, M. J. (2000) Regulator of G protein signaling RGS3T is localized to the nucleus and induces apoptosis. J. Biol. Chem. 275, 21317-21323.
    • (2000) J. Biol. Chem , vol.275 , pp. 21317-21323
    • Dulin, N.O.1    Pratt, P.2    Tiruppathi, C.3    Niu, J.4    Voyno-Yasenetskaya, T.5    Dunn, M.J.6
  • 17
    • 0141680396 scopus 로고    scopus 로고
    • MAPK regulation of gene expression in airway smooth muscle
    • Gerthoffer, W. T. and Singer, C. A. (2003) MAPK regulation of gene expression in airway smooth muscle. Respir Physiol. Neurobiol. 137, 237-250.
    • (2003) Respir Physiol. Neurobiol , vol.137 , pp. 237-250
    • Gerthoffer, W.T.1    Singer, C.A.2
  • 18
    • 0029282131 scopus 로고
    • Nobel Lecture. G proteins and regulation of adenylyl cyclase
    • Gilman, A. G. (1995) Nobel Lecture. G proteins and regulation of adenylyl cyclase. Biosci. Rep. 15, 65-97.
    • (1995) Biosci. Rep , vol.15 , pp. 65-97
    • Gilman, A.G.1
  • 19
    • 33746843994 scopus 로고    scopus 로고
    • Regulation of cardiomyocyte signaling by RGS proteins: Differential selectivity towards G proteins and susceptibility to regulation
    • Hao, J., Michalek, C., Zhang, W., Zhu, M., Xu, X. and Mende, U. (2006) Regulation of cardiomyocyte signaling by RGS proteins: differential selectivity towards G proteins and susceptibility to regulation. J. Mol. Cell. Cardiol. 41, 51-61.
    • (2006) J. Mol. Cell. Cardiol , vol.41 , pp. 51-61
    • Hao, J.1    Michalek, C.2    Zhang, W.3    Zhu, M.4    Xu, X.5    Mende, U.6
  • 20
    • 0031017573 scopus 로고    scopus 로고
    • RGS4 and GAIP are GTPase-activating proteins for Gq alpha and block activation of phospholipase C beta by gamma-thio-GTP-Gq alpha
    • Hepler, J. R., Berman, D. M., Gilman, A. G. and Kozasa, T. (1997) RGS4 and GAIP are GTPase-activating proteins for Gq alpha and block activation of phospholipase C beta by gamma-thio-GTP-Gq alpha. Proc. Natl. Acad. Sci. USA 94, 428-432.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 428-432
    • Hepler, J.R.1    Berman, D.M.2    Gilman, A.G.3    Kozasa, T.4
  • 23
    • 0036733358 scopus 로고    scopus 로고
    • Cellular regulation of RGS proteins: Modulators and integrators of G protein signaling
    • Hollinger, S. and Hepler, J. R. (2002) Cellular regulation of RGS proteins: modulators and integrators of G protein signaling. Pharmacol. Rev. 54, 527-559.
    • (2002) Pharmacol. Rev , vol.54 , pp. 527-559
    • Hollinger, S.1    Hepler, J.R.2
  • 24
    • 0035853775 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase. differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells
    • Igarashi, J., Bernier, S. G. and Michel, T. (2001) Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase. differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells. J. Biol. Chem. 276, 12420-12426.
    • (2001) J. Biol. Chem , vol.276 , pp. 12420-12426
    • Igarashi, J.1    Bernier, S.G.2    Michel, T.3
  • 25
    • 0033555886 scopus 로고    scopus 로고
    • Use of a sandwich enzyme-linked immunosorbent assay strategy to study mechanisms of G protein-coupled receptor assembly
    • Jakubik, J. and Wess, J. (1999) Use of a sandwich enzyme-linked immunosorbent assay strategy to study mechanisms of G protein-coupled receptor assembly. J. Biol. Chem. 274, 1349-1358.
    • (1999) J. Biol. Chem , vol.274 , pp. 1349-1358
    • Jakubik, J.1    Wess, J.2
  • 26
    • 0037081441 scopus 로고    scopus 로고
    • Muscarinic receptor subtype determines vulnerability to oxidative stress in COS-7 cells
    • Joseph, J. A., Fisher, D. R. and Strain, J. (2002) Muscarinic receptor subtype determines vulnerability to oxidative stress in COS-7 cells. Free Radic. Biol. Med. 32, 153-161.
    • (2002) Free Radic. Biol. Med , vol.32 , pp. 153-161
    • Joseph, J.A.1    Fisher, D.R.2    Strain, J.3
  • 27
    • 0031737333 scopus 로고    scopus 로고
    • Cardiac myocytes express mRNA for ten RGS proteins: Changes in RGS mRNA expression in ventricular myocytes and cultured atria
    • Kardestuncer, T., Wu, H., Lim, A. L. and Neer, E. J. (1998) Cardiac myocytes express mRNA for ten RGS proteins: changes in RGS mRNA expression in ventricular myocytes and cultured atria. FEBS Lett. 438, 285-288.
    • (1998) FEBS Lett , vol.438 , pp. 285-288
    • Kardestuncer, T.1    Wu, H.2    Lim, A.L.3    Neer, E.J.4
  • 28
    • 0028085776 scopus 로고
    • Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling
    • Koch, W. J., Hawes, B. E., Inglese, J., Luttrell, L. M. and Lefkowitz, R. J. (1994) Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling. J. Biol. Chem. 269, 6193-6197.
    • (1994) J. Biol. Chem , vol.269 , pp. 6193-6197
    • Koch, W.J.1    Hawes, B.E.2    Inglese, J.3    Luttrell, L.M.4    Lefkowitz, R.J.5
  • 29
    • 0036238817 scopus 로고    scopus 로고
    • The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia
    • Lee, J. T., Jr. and McCubrey, J. A. (2002) The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia. Leukemia 16, 486-507.
    • (2002) Leukemia , vol.16 , pp. 486-507
    • Lee Jr., J.T.1    McCubrey, J.A.2
  • 30
    • 0033840564 scopus 로고    scopus 로고
    • Activation of extracellular signal-regulated kinase (ERK) and Akt by human serotonin 5-HT(1B) receptors in transfected BE(2)-C neuroblastoma cells is inhibited by RGS4
    • Leone, A. M., Errico, M., Lin, S. L. and Cowen, D. S. (2000) Activation of extracellular signal-regulated kinase (ERK) and Akt by human serotonin 5-HT(1B) receptors in transfected BE(2)-C neuroblastoma cells is inhibited by RGS4. J. Neurochem. 75, 934-938.
    • (2000) J. Neurochem , vol.75 , pp. 934-938
    • Leone, A.M.1    Errico, M.2    Lin, S.L.3    Cowen, D.S.4
  • 31
    • 0042750799 scopus 로고    scopus 로고
    • Akt and PI 3-kinase signaling in cardiomyocyte hypertrophy and survival
    • Matsui, T., Nagoshi, T. and Rosenzweig, A. (2003) Akt and PI 3-kinase signaling in cardiomyocyte hypertrophy and survival. Cell Cycle 2, 220-223.
    • (2003) Cell Cycle , vol.2 , pp. 220-223
    • Matsui, T.1    Nagoshi, T.2    Rosenzweig, A.3
  • 32
    • 0035871046 scopus 로고    scopus 로고
    • RGS2 blocks slow muscarinic inhibition of N-type Ca(2+) channels reconstituted in a human cell line
    • Melliti, K., Meza, U. and Adams, B. A. (2001) RGS2 blocks slow muscarinic inhibition of N-type Ca(2+) channels reconstituted in a human cell line. J. Physiol. 532, 337-347.
    • (2001) J. Physiol , vol.532 , pp. 337-347
    • Melliti, K.1    Meza, U.2    Adams, B.A.3
  • 33
    • 0032563295 scopus 로고    scopus 로고
    • Activation of Akt/protein kinase B by G protein-coupled receptors. A role for alpha and beta gamma subunits of heterotrimeric G proteins acting through phosphatidylinositol-3-OH kinasegamma
    • Murga, C., Laguinge, L., Wetzker, R., Cuadrado, A. and Gutkind, J. S. (1998) Activation of Akt/protein kinase B by G protein-coupled receptors. A role for alpha and beta gamma subunits of heterotrimeric G proteins acting through phosphatidylinositol-3-OH kinasegamma. J. Biol. Chem. 273, 19080-19085.
    • (1998) J. Biol. Chem , vol.273 , pp. 19080-19085
    • Murga, C.1    Laguinge, L.2    Wetzker, R.3    Cuadrado, A.4    Gutkind, J.S.5
  • 34
    • 0028860268 scopus 로고
    • Heterotrimeric G proteins: Organizers of transmembrane signals
    • Neer, E. J. (1995) Heterotrimeric G proteins: organizers of transmembrane signals. Cell 80, 249-257.
    • (1995) Cell , vol.80 , pp. 249-257
    • Neer, E.J.1
  • 35
    • 0037057801 scopus 로고    scopus 로고
    • The nuclear phosphoinositide 3-kinase/AKT pathway: A new second messenger system
    • Neri, L. M., Borgatti, P., Capitani, S. and Martelli, A. M. (2002) The nuclear phosphoinositide 3-kinase/AKT pathway: a new second messenger system. Biochim. Biophys. Acta 1584, 73-80.
    • (2002) Biochim. Biophys. Acta , vol.1584 , pp. 73-80
    • Neri, L.M.1    Borgatti, P.2    Capitani, S.3    Martelli, A.M.4
  • 37
    • 0034672063 scopus 로고    scopus 로고
    • Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells
    • Ogier-Denis, E., Pattingre, S., El Benna, J. and Codogno, P. (2000) Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells. J. Biol. Chem. 275, 39090-39095.
    • (2000) J. Biol. Chem , vol.275 , pp. 39090-39095
    • Ogier-Denis, E.1    Pattingre, S.2    El Benna, J.3    Codogno, P.4
  • 38
    • 0033779101 scopus 로고    scopus 로고
    • Structure, function, and control of phosphoinositide-specific phospholipase C
    • Rebecchi, M. J. and Pentyala, S. N. (2000) Structure, function, and control of phosphoinositide-specific phospholipase C. Physiol. Rev. 80, 1291-1335.
    • (2000) Physiol. Rev , vol.80 , pp. 1291-1335
    • Rebecchi, M.J.1    Pentyala, S.N.2
  • 39
    • 0038048211 scopus 로고    scopus 로고
    • Role of MAP kinase in tumor progression and invasion
    • Reddy, K. B., Nabha, S. M. and Atanaskova, N. (2003) Role of MAP kinase in tumor progression and invasion. Cancer Metastasis Rev. 22, 395-403
    • (2003) Cancer Metastasis Rev , vol.22 , pp. 395-403
    • Reddy, K.B.1    Nabha, S.M.2    Atanaskova, N.3
  • 40
    • 0034192097 scopus 로고    scopus 로고
    • RGS molecule expression in murine B lymphocytes and ability to down-regulate chemotaxis to lymphoid chemokines
    • Reif, K. and Cyster, J. G. (2000) RGS molecule expression in murine B lymphocytes and ability to down-regulate chemotaxis to lymphoid chemokines. J. Immunol. 164, 4720-4729.
    • (2000) J. Immunol , vol.164 , pp. 4720-4729
    • Reif, K.1    Cyster, J.G.2
  • 41
    • 0034927336 scopus 로고    scopus 로고
    • Regulation of phosphoinositide-specific phospholipase C
    • Rhee, S. G. (2001) Regulation of phosphoinositide-specific phospholipase C. Annu. Rev. Biochem. 70, 281-312.
    • (2001) Annu. Rev. Biochem , vol.70 , pp. 281-312
    • Rhee, S.G.1
  • 42
    • 0033783132 scopus 로고    scopus 로고
    • GTPase-activating proteins for heterotrimeric G proteins: Regulators of G protein signaling (RGS) and RGS-like proteins
    • Ross, E. M. and Wilkie, T. M. (2000) GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins. Annu. Rev. Biochem. 69, 795-827.
    • (2000) Annu. Rev. Biochem , vol.69 , pp. 795-827
    • Ross, E.M.1    Wilkie, T.M.2
  • 43
    • 0035968293 scopus 로고    scopus 로고
    • Regulator of G-protein signaling 3 (RGS3) inhibits Gbeta1gamma 2-induced inositol phosphate production, mitogen-activated protein kinase activation, and Akt activation
    • Shi, C. S., Lee, S. B., Sinnarajah, S., Dessauer, C. W., Rhee, S. G. and Kehrl, J. H. (2001) Regulator of G-protein signaling 3 (RGS3) inhibits Gbeta1gamma 2-induced inositol phosphate production, mitogen-activated protein kinase activation, and Akt activation. J. Biol. Chem. 276, 24293-24300.
    • (2001) J. Biol. Chem , vol.276 , pp. 24293-24300
    • Shi, C.S.1    Lee, S.B.2    Sinnarajah, S.3    Dessauer, C.W.4    Rhee, S.G.5    Kehrl, J.H.6
  • 44
    • 0037188941 scopus 로고    scopus 로고
    • Role of Akt signaling in vascular homeostasis and angiogenesis
    • Shiojima, I. and Walsh, K. (2002) Role of Akt signaling in vascular homeostasis and angiogenesis. Circ. Res. 90, 1243-1250.
    • (2002) Circ. Res , vol.90 , pp. 1243-1250
    • Shiojima, I.1    Walsh, K.2
  • 45
    • 0037400975 scopus 로고    scopus 로고
    • A pivotal role for ERK in the oncogenic behaviour of malignant melanoma?
    • Smalley, K. S. (2003) A pivotal role for ERK in the oncogenic behaviour of malignant melanoma? Int. J. Cancer 104, 527-532.
    • (2003) Int. J. Cancer , vol.104 , pp. 527-532
    • Smalley, K.S.1
  • 46
    • 15944429694 scopus 로고    scopus 로고
    • Regulation of the extracellular signal-regulated kinase pathway in adult myocardium: Differential roles of G(q/11), Gi and G(12/13) proteins in signalling by alpha1-adrenergic, endothelin-1 and thrombin-sensitive protease-activated receptors
    • Snabaitis, A. K., Muntendorf, A., Wieland, T. and Avkiran, M. (2005) Regulation of the extracellular signal-regulated kinase pathway in adult myocardium: differential roles of G(q/11), Gi and G(12/13) proteins in signalling by alpha1-adrenergic, endothelin-1 and thrombin-sensitive protease-activated receptors. Cell Signal. 17, 655-664.
    • (2005) Cell Signal , vol.17 , pp. 655-664
    • Snabaitis, A.K.1    Muntendorf, A.2    Wieland, T.3    Avkiran, M.4
  • 48
    • 0033567291 scopus 로고    scopus 로고
    • The stress-activated protein kinase pathways
    • Tibbles, L. A. and Woodgett, J. R. (1999) The stress-activated protein kinase pathways. Cell Mol. Life Sci. 5, 1230-1254.
    • (1999) Cell Mol. Life Sci , vol.5 , pp. 1230-1254
    • Tibbles, L.A.1    Woodgett, J.R.2
  • 49
    • 0037409367 scopus 로고    scopus 로고
    • G protein-coupled receptor cross-talk: Pivotal roles of protein phosphorylation and protein-protein interactions
    • Vazquez-Prado, J., Casas-Gonzalez, P. and Garcia-Sainz, J. A. (2003) G protein-coupled receptor cross-talk: pivotal roles of protein phosphorylation and protein-protein interactions. Cell Signal 15, 549-557.
    • (2003) Cell Signal , vol.15 , pp. 549-557
    • Vazquez-Prado, J.1    Casas-Gonzalez, P.2    Garcia-Sainz, J.A.3
  • 50
    • 0037067761 scopus 로고    scopus 로고
    • Receptor-selective effects of endogenous RGS3 and RGS5 to regulate mitogen-activated protein kinase activation in rat vascular smooth muscle cells
    • Wang, Q., Liu, M., Mullah, B., Siderovski, D. P. and Neubig, R. R. (2002) Receptor-selective effects of endogenous RGS3 and RGS5 to regulate mitogen-activated protein kinase activation in rat vascular smooth muscle cells. J. Biol. Chem. 277, 24949-24958.
    • (2002) J. Biol. Chem , vol.277 , pp. 24949-24958
    • Wang, Q.1    Liu, M.2    Mullah, B.3    Siderovski, D.P.4    Neubig, R.R.5
  • 51
    • 0037305038 scopus 로고    scopus 로고
    • Regulators of G-protein signalling: Multifunctional proteins with impact on signalling in the cardiovascular system
    • Wieland, T. and Mittmann, C. (2003) Regulators of G-protein signalling: multifunctional proteins with impact on signalling in the cardiovascular system. Pharmacol. Ther. 97, 95-115.
    • (2003) Pharmacol. Ther , vol.97 , pp. 95-115
    • Wieland, T.1    Mittmann, C.2
  • 52
    • 0030611749 scopus 로고    scopus 로고
    • RGS4 inhibits Gq-mediated activation of mitogen-activated protein kinase and phosphoinositide synthesis
    • Yan, Y., Chi, P. P. and Bourne, H. R. (1997) RGS4 inhibits Gq-mediated activation of mitogen-activated protein kinase and phosphoinositide synthesis. J. Biol. Chem. 272, 11924-11927.
    • (1997) J. Biol. Chem , vol.272 , pp. 11924-11927
    • Yan, Y.1    Chi, P.P.2    Bourne, H.R.3
  • 53
    • 33646842745 scopus 로고    scopus 로고
    • Selective loss of fine tuning of Gq/11 signaling by RGS2 protein exacerbates cardiomyocyte hypertrophy
    • Zhang, W., Anger, T., Su, J., Hao, J., Xu, X., Zhu, M., Gach, A., Cui, L., Liao, R. and Mende, U. (2006) Selective loss of fine tuning of Gq/11 signaling by RGS2 protein exacerbates cardiomyocyte hypertrophy. J. Biol. Chem. 281, 5811-5820.
    • (2006) J. Biol. Chem , vol.281 , pp. 5811-5820
    • Zhang, W.1    Anger, T.2    Su, J.3    Hao, J.4    Xu, X.5    Zhu, M.6    Gach, A.7    Cui, L.8    Liao, R.9    Mende, U.10
  • 54
    • 0035951796 scopus 로고    scopus 로고
    • Reassembly of phospholipase C-beta2 from separated domains: Analysis of basal and G protein-stimulated activities
    • Zhang, W. and Neer, E. J. (2001) Reassembly of phospholipase C-beta2 from separated domains: analysis of basal and G protein-stimulated activities. J. Biol. Chem. 276, 2503-2508.
    • (2001) J. Biol. Chem , vol.276 , pp. 2503-2508
    • Zhang, W.1    Neer, E.J.2
  • 55
    • 0033613580 scopus 로고    scopus 로고
    • RGS16 attenuates galphaq-dependent p38 mitogen-activated protein kinase activation by platelet-activating factor
    • Zhang, Y., Neo, S. Y., Han, J., Yaw, L. P. and Lin, S. C. (1999) RGS16 attenuates galphaq-dependent p38 mitogen-activated protein kinase activation by platelet-activating factor. J. Biol. Chem. 274, 2851-2857.
    • (1999) J. Biol. Chem , vol.274 , pp. 2851-2857
    • Zhang, Y.1    Neo, S.Y.2    Han, J.3    Yaw, L.P.4    Lin, S.C.5


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