Chromatin modification of Apaf-1 restricts the apoptotic pathway in mature neurons

Journal of Cell Biology

Volumn 179, Issue 5, 2007, Pages 825-832

  Wright, Kevin M ^a   Smith, Michelle I ^a,b   Farrag, Lila ^a   Deshmukh, Mohanish ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE INHIBITOR; CELL DNA; CYTOCHROME C; ETOPOSIDE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; MESSENGER RNA; TRANSCRIPTION FACTOR E2F1; TRICHOSTATIN A;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL MATURATION; CHROMATIN STRUCTURE; CONTROLLED STUDY; DNA DAMAGE; ENZYME RELEASE; MOLECULAR BIOLOGY; MOUSE; NERVE CELL; NERVE CELL DIFFERENTIATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; UPREGULATION;

ANIMALS; APOPTOSIS; APOPTOSOMES; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CELL CYCLE PROTEINS; CHROMATIN; CYTOCHROMES C; DNA DAMAGE; INHIBITOR OF APOPTOSIS PROTEINS; MICE; NEURONS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 36849041089     PISSN: 00219525     EISSN: 00219525     Source Type: Journal    
DOI: 10.1083/jcb.200708086     Document Type: Article

References (34)

1. Becker, E.B., and A. Bonni. 2005. Beyond proliferation - cell cycle control of neuronal survival and differentiation in the developing mammalian brain. Semin. Cell Dev. Biol. 16:439-448.
2. Benn, S.C., and C.J. Woolf. 2004. Adult neuron survival strategies-slamming on the brakes. Nat. Rev. Neurosci. 5:686-700.
3. Besirli, C.G., T.L. Deckwerth, R.J. Crowder, R.S. Freeman, and E.M. Johnson Jr. 2003. Cytosine arabinoside rapidly activates Bax-dependent apoptosis and a delayed Bax-independent death pathway in sympathetic neurons. Cell Death Differ. 10:1045-1058.
4. Biswas, S.C., D.X. Liu, and L.A. Greene. 2005. Bim is a direct target of a neuronal E2F-dependent apoptotic pathway. J. Neurosci. 25:8349-8358.
5. Blomgren, K., C. Zhu, U. Hallin, and H. Hagberg. 2003. Mitochondria and ischemic reperfusion damage in the adult and in the developing brain. Biochem. Biophys. Res. Commun. 304:551-559.
6. Boatright, K.M., and G.S. Salvesen. 2003. Mechanisms of caspase activation. Curr. Opin. Cell Biol. 15:725-731.
7. Bolden, J.E., M.J. Peart, and R.W. Johnstone. 2006. Anticancer activities of histone deacetylase inhibitors. Nat. Rev. Drug Discov. 5:769-784.
8. Boutillier, A.L., E. Trinh, and J.P. Loeffler. 2003. Selective E2F-dependent gene transcription is controlled by histone deacetylase activity during neuronal apoptosis. J. Neurochem. 84:814-828.
9. Deshmukh, M., and E.M. Johnson Jr. 1998. Evidence of a novel event during neuronal death: development of competence-to-die in response to cytoplasmic cytochrome c. Neuron. 21:695-705.
10. Donovan, M., and T.G. Cotter. 2002. Caspase-independent photoreceptor apoptosis in vivo and differential expression of apoptotic protease activating factor-1 and caspase-3 during retinal development. Cell Death Differ. 9:1220-1231.
11. Easton, R.M., T.L. Deckwerth, P.A. Sh, and E.M. Johnson Jr. 1997. Analysis of the mechanism of loss of trophic factor dependence associated with neuronal maturation: A phenotype indistinguishable from BAX deletion. J. Neurosci. 17:9656-9666.
12. Fischle, W., Y. Wang, and C.D. Allis. 2003. Histone and chromatin cross-talk. Curr. Opin. Cell Biol. 15:172-183.
13. Fortin, A., S.P. Cregan, J.G. MacLaurin, N. Kushwaha, E.S. Hickman, C.S. Thompson, A. Hakim, P.R. Albert, F. Cecconi, K. Helin, et al. 2001. APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death. J. Cell Biol. 155:207-216.
14. Greene, L.A., S.C. Biswas, and D.X. Liu. 2004. Cell cycle molecules and vertebrate neuron death: E2F at the hub. Cell Death Differ. 11:49-60.
15. Johnson, D.G., J.K. Schwarz, W.D. Cress, and J.R. Nevins. 1993. Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature. 365:349-352.
16. Konishi, Y., and A. Bonni. 2003. The E2F-Cdc2 cell-cycle pathway specifically mediates activity deprivation-induced apoptosis of postmitotic neurons. J. Neurosci. 23:1649-1658.
17. Lazarus, H.M., R.H. Herzig, G.P. Herzig, G.L. Phillips, U. Roessmann, and D.J. Fishman. 1981. Central nervous system toxicity of high-dose systemic cytosine arabinoside. Cancer. 48:2577-2582.
18. Liu, D.X., N. Nath, S.P. Chellappan, and L.A. Greene. 2005. Regulation of neuron survival and death by p130 and associated chromatin modifiers. Genes Dev. 19:719-732.
19. Mattson, M.P., and T. Magnus. 2006. Ageing and neuronal vulnerability. Nat. Rev. Neurosci. 7:278-294.
20. Moroni, M.C., E.S. Hickman, E. Lazzerini Denchi, G. Caprara, E. Colli, F. Cecconi, H. Muller, and K. Helin. 2001. Apaf-1 is a transcriptional target for E2F and p53. Nat. Cell Biol. 3:552-558.
21. Neame, S.J., L.L. Rubin, and K.L. Philpott. 1998. Blocking cytochrome c activity within intact neurons inhibits apoptosis. J. Cell Biol. 142:1583-1593.
22. Orike, N., G. Middleton, E. Borthwick, V. Buchman, T. Cowen, and A.M. Davies. 2001. Role of PI 3-kinase, Akt, and Bcl-2-related proteins in sustaining the survival of neurotrophic factor-independent adult sympathetic neurons. J. Cell Biol. 154:995-1005.
23. Padmanabhan, J., D.S. Park, L.A. Greene, and M.L. Shelanski. 1999. Role of cell cycle regulatory proteins in cerebellar granule neuron apoptosis. J. Neurosci. 19:8747-8756.
24. Park, D.S., S.E. Farinelli, and L.A. Greene. 1996. Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons. J. Biol. Chem. 271:8161-8169.
25. Potts, P.R., S. Singh, M. Knezek, C.B. Thompson, and M. Deshmukh. 2003. Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis. J. Cell Biol. 163:789-799.
26. Putcha, G.V., and E.M. Johnson Jr. 2004. Men are but worms: neuronal cell death in C elegans and vertebrates. Cell Death Differ. 11:38-48.
27. Putcha, G.V., M. Deshmukh, and E.M. Johnson Jr. 2000. Inhibition of apoptotic signaling cascades causes loss of trophic factor dependence during neuronal maturation. J. Cell Biol. 149:1011-1018.
28. Vekrellis, K., M.J. McCarthy, A. Watson, J. Whitfield, L.L. Rubin, and J. Ham. 1997. Bax promotes neuronal cell death and is downregulated during the development of the nervous system. Development. 124:1239-1249.
29. Vogelbaum, M.A., J.X. Tong, and K.M. Rich. 1998. Developmental regulation of apoptosis in dorsal root ganglion neurons. J. Neurosci. 18:8928-8935.
30. Wallace, D.M., M. Donovan, and T.G. Cotter. 2006. Histone deacetylase activity regulates apaf-1 and caspase 3 expression in the developing mouse retina. Invest. Ophthalmol. Vis. Sci. 47:2765-2772.
31. Wright, K.M., M.W. Linhoff, P.R. Potts, and M. Deshmukh. 2004. Decreased apoptosome activity with neuronal differentiation sets the threshold for strict IAP regulation of apoptosis. J. Cell Biol. 167:303-313.
32. Wright, K.M., A.E. Vaughn, and M. Deshmukh. 2007. Apoptosome dependent caspase-3 activation pathway is non-redundant and necessary for apoptosis in sympathetic neurons. Cell Death Differ. 14:625-633.
33. Yakovlev, A.G., K. Ota, G. Wang, V. Movsesyan, W.-L. Bao, K. Yoshihara, and A.I. Faden. 2001. Differential expression of apoptotic protease-activating factor-1 and caspase-3 genes and susceptibility to apoptosis during brain development and after traumatic brain injury. J. Neurosci. 21:7439-7446.
34. Yuan, J., and B.A. Yankner. 2000. Apoptosis in the nervous system. Nature. 407:802-809.