Colorectal carcinomas with microsatellite instability display increased thymidylate synthase gene expression levels

Clinical Colorectal Cancer

Volumn 6, Issue 10, 2007, Pages 720-727

  Odin, Elisabeth ^a   Wettergren, Yvonne ^a   Nilsson, Staffan ^b   Carlsson, Göran ^a   Gustavsson, Bengt ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^b CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

Author keywords

DNA methylation; Microsatellite instability; Mismatch repair genes; Polymerase chain reaction

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FOLIC ACID; GENOMIC DNA; PTEROPTIN; THYMIDYLATE SYNTHASE;

ADULT; AGED; ARTICLE; CANCER GRADING; CANCER STAGING; CANCER SURVIVAL; COLORECTAL CARCINOMA; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE EXPRESSION; GENE SEQUENCE; GENOTYPE; HUMAN; MALE; MICROSATELLITE INSTABILITY; MICROSATELLITE MARKER; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; TUMOR DIFFERENTIATION;

EID: 36849029114     PISSN: 15330028     EISSN: None     Source Type: Journal    
DOI: 10.3816/CCC.2007.n.042     Document Type: Article

References (57)

1. Veigl ML, Kasturi L, Olechnowicz J, et al. Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers. Proc Natl Acad Sci U S A 1998; 95:8698-702.
2. Cravo ML, Albuquerque CM, Salazar de Sousa L, et al. Microsatellite instability in non-neoplastic mucosa of patients with ulcerative colitis: effect of folate supplementation. Am J Gastroenterol 1998; 93:2060-4.
3. Kawakami K, Ruszkiewicz A, Bennett G, et al. The folate pool in colorectal cancers is associated with DNA hypermethylation and with a polymorphism in methylenetetrahydrofolate reductase. Clin Cancer Res 2003; 9:5860-5.
4. Fenech M, Rinaldi J. The relationship between micronuclei in human lymphocytes and plasma levels of vitamin C, vitamin E, vitamin B12 and folic acid. Carcinogenesis 1994; 15:1405-11.
5. James SJ, Basnakian AG, Miller BJ. In vitro folate deficiency induces deoxynucleotide pool imbalance, apoptosis, and mutagenesis in Chinese hamster ovary cells. Cancer Res 1994; 54:5075-80.
6. Wickramasinghe SN, Fida S. Bone marrow cells from vitamin B12-and folate-deficient patients misincorporate uracil into DNA. Blood 1994; 83:1656-61.
7. Blount BC, Mack MM, Wehr CM, et al. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci U S A 1997; 94:3290-5.
8. Choi SW, Mason JB. Folate and carcinogenesis: an integrated scheme. J Nutr 2000; 130:129-32.
9. Davis CD, Uthus EO. DNA methylation, cancer susceptibility, and nutrient interactions. Exp Biol Med (Maywood) 2004; 229:988-95.
10. Sirotnak FM, Tolner B. Carrier-mediated membrane transport of folates in mammalian cells. Annu Rev Nutr 1999; 19:91-122.
11. Scott J, Weir D. Folate/vitamin B12 inter-relationships. Essays Biochem 1994; 28:63-72.
12. Odin E, Wettergren Y, Nilsson S, et al. Altered gene expression of folate enzymes in adjacent mucosa is associated with outcome of colorectal cancer patients. Clin Cancer Res 2003; 9:6012-9.
13. Odin E, Wettergren Y, Carlsson G, et al. Expression and clinical significance of methylenetetrahydrofolate reductase in patients with colorectal cancer. Clin Colorectal Cancer 2006; 5:344-9.
14. Kawakami K, Salonga D, Park JM, et al. Different lengths of a polymorphic repeat sequence in the thymidylate synthase gene affect translational efficiency but not its gene expression. Clin Cancer Res 2001; 7:4096-101.
15. Edler D, Glimelius B, Hallstrom M, et al. Thymidylate synthase expression in colorectal cancer: a prognostic and predictive marker of benefit from adjuvant fluorouracil-based chemotherapy. J Clin Oncol 2002; 20:1721-8.
16. Popat S, Matakidou A, Houlston RS. Thymidylate synthase expression and prognosis in colorectal cancer: a systematic review and meta-analysis. J Clin Oncol 2004; 22:529-36.
17. Hamilton SR, Aaltonen L, eds. WHO Classification of Tumors. Pathology and Genetics of Tumours of the Digestive System. Lyon, France: IARC Press; 2000.
18. Dukes C. The classification of cancer of the rectum. J Pathol 1932; 35:323-32.
19. Astler V, Coller F. The prognostic significance of direct extension of carcinoma of the colon and rectum. Ann Surg 1954; 139:846-52.
20. Beart RW, Jr, van Heerden J, Beahrs O. Evolution in the pathologic staging of carcinoma of the colon. Surg Gynecol Obstet 1978; 146:257-9.
21. Boland CR, Thibodeau SN, Hamilton SR, et al. A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 1998; 58:5248-57.
22. Lecomte T, Ferraz JM, Zinzindohoue F, et al. Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy. Clin Cancer Res 2004; 10:5880-8.
23. Iacopetta B, Grieu F, Joseph D, et al. A polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracil. Br J Cancer 2001; 85:827-30.
24. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate- phenol-chloroform extraction. Anal Biochem 1987; 162:156-9.
25. Horikoshi T, Danenberg KD, Stadlbauer TH, et al. Quantitation of thymidylate synthase, dihydrofolate reductase, and DT- diaphorase gene expression in human tumors using the polymerase chain reaction. Cancer Res 1992; 52:108-16.
26. JMP [computer program]. Statistical Discovery Software. Version 4. SAS Institute; 2000.
27. Cunningham JM, Christensen ER, Tester DJ, et al. Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability. Cancer Res 1998; 58:3455-60.
28. Kohonen-Corish MR, Daniel JJ, te Riele H, et al. Susceptibility of Msh2-deficient mice to inflammation-associated colorectal tumors. Cancer Res 2002; 62:2092-7.
29. Michael-Robinson JM, Reid LE, Purdie DM, et al. Proliferation, apoptosis, and survival in high-level microsatellite instability sporadic colorectal cancer. Clin Cancer Res 2001; 7:2347-56.
30. Gafa R, Maestri I, Matteuzzi M, et al. Sporadic colorectal adenocarcinomas with high-frequency microsatellite instability. Cancer 2000; 89:2025-37.
31. Thibodeau SN, Bren G, Schaid D. Microsatellite instability in cancer of the proximal colon. Science 1993; 260:816-9.
32. Guidoboni M, Gafa R, Viel A, et al. Microsatellite instability and high content of activated cytotoxic lymphocytes identify colon cancer patients with a favorable prognosis. Am J Pathol 2001; 159:297-304.
33. Wright CM, Dent OF, Barker M, et al. Prognostic significance of extensive microsatellite instability in sporadic clinicopathological stage C colorectal cancer. Br J Surg 2000; 87:1197-202.
34. Ricciardiello L, Ceccarelli C, Angiolini G, et al. High thymidylate synthase expression in colorectal cancer with microsatellite instability: implications for chemotherapeutic strategies. Clin Cancer Res 2005; 11:4234-40.
35. Banerjea A, Ahmed S, Hands RE, et al. Colorectal cancers with microsatellite instability display mRNA expression signatures characteristic of increased immunogenicity. Mol Cancer 2004; 3:21.
36. Ropponen KM, Eskelinen MJ, Lipponen PK, et al. Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal cancer. J Pathol 1997; 182:318-24.
37. Takemoto N, Konishi F, Yamashita K, et al. The correlation of microsatellite instability and tumor-infiltrating lymphocytes in hereditary non-polyposis colorectal cancer (HNPCC) and sporadic colorectal cancers: the significance of different types of lymphocyte infiltration. Jpn J Clin Oncol 2004; 34:90-8.
38. Dhur A, Galan P, Hercberg S. Folate status and the immune system. Prog Food Nutr Sci 1991; 15:43-60.
39. Courtemanche C, Elson-Schwab I, Mashiyama ST, et al. Folate deficiency inhibits the proliferation of primary human CD8+ T lymphocytes in vitro. J Immunol 2004; 173:3186-92.
40. Estecio MR, Gharibyan V, Shen L, et al. LINE-1 Hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability. PLoS ONE 2007; 2:e399.
41. Okon K, Klimkowska A, Wojcik P, et al. High thymidylate synthase expression is typical for sporadic MSI-H colorectal carcinoma. Pol J Pathol 2006; 57:29-33.
42. Sinicrope FA, Rego RL, Halling KC, et al. Thymidylate synthase expression in colon carcinomas with microsatellite instability. Clin Cancer Res 2006; 12:2738-44.
43. Nomura T, Nakagawa M, Fujita Y, et al. Clinical significance of thymidylate synthase expression in bladder cancer. Int J Urol 2002; 9:368-76.
44. Nakagawa H, Nuovo GJ, Zervos EE, et al. Age-related hypermethylation of the 5′ region of MLH1 in normal colonic mucosa is associated with microsatellite-unstable colorectal cancer development. Cancer Res 2001; 61:6991-5.
45. Leichman CG, Lenz HJ, Leichman L, et al. Quantitation of intra-tumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin. J Clin Oncol 1997; 15:3223-9.
46. Santini D, Vincenzi B, Perrone G, et al. Thymidylate synthase expression in normal colonic mucosa: a predictive marker of toxicity in colorectal cancer patients receiving 5-fluorouracil-based adjuvant chemotherapy. Oncology 2004; 67:135-42.
47. Goldberg RM, Tabah-Fisch I, Bleiberg H, et al. Pooled analysis of safety and efficacy of oxaliplatin plus fluorouracil/leucovorin administered bimonthly in elderly patients with colorectal cancer. J Clin Oncol 2006; 24:4085-91.
48. Benatti P, Gafa R, Barana D, et al. Microsatellite instability and colorectal cancer prognosis. Clin Cancer Res 2005; 11:8332-40.
49. Elsaleh H, Powell B, Soontrapornchai P, et al. p53 gene mutation, microsatellite instability and adjuvant chemotherapy: impact on survival of 388 patients with Dukes' C colon carcinoma. Oncology 2000; 58:52-9.
50. Niv Y. Biologic behavior of microsatellite-unstable colorectal cancer and treatment with 5-fluorouracil. Isr Med Assoc J 2005; 7:520-4.
51. Warusavitarne J, Schnitzler M. The role of chemotherapy in microsatellite unstable (MSI-H) colorectal cancer. Int J Colorectal Dis 2007; 22:739-48.
52. Tajima A, Hess MT, Cabrera BL, et al. The mismatch repair complex hMutS alpha recognizes 5-fluorouracil-modified DNA: implications for chemosensitivity and resistance. Gastroenterology 2004; 127:1678-84.
53. Giovannetti E, Backus HH, Wouters D, et al. Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels. Br J Cancer 2007; 96:769-75.
54. Calascibetta A, Cabibi D, Martorana A, et al. Thymidylate synthase gene promoter polymorphisms are associated with TSmRNA expressions but not with microsatellite instability in colorectal cancer. Anticancer Res 2004; 24:3875-80.
55. Mandola MV, Stoehlmacher J, Zhang W, et al. A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels. Pharmacogenetics 2004; 14:319-27.
56. Pullarkat ST, Stoehlmacher J, Ghaderi V, et al. Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy. Pharmacogenomics J 2001; 1:65-70.
57. Mandola MV, Stoehlmacher J, Muller-Weeks S, et al. A novel single nucleotide polymorphism within the 5′ tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity. Cancer Res 2003; 63:2898-904.