-
1
-
-
0029049553
-
A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
-
Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 10:111-113.
-
(1995)
Nat Genet
, vol.10
, pp. 111-113
-
-
Frosst, P.1
Blom, H.J.2
Milos, R.3
-
2
-
-
0023696435
-
Intermediate homocysteinemia: A thermolabile variant of methylenetetrahydrofolate reductase
-
Kang SS, Zhou J, Wong PW, et al. Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase. Am J Hum Genet 1988; 43:414-421.
-
(1988)
Am J Hum Genet
, vol.43
, pp. 414-421
-
-
Kang, S.S.1
Zhou, J.2
Wong, P.W.3
-
3
-
-
0031757389
-
Plasma homocysteine levels related to interactions between folate status and methylenetetrahydrofolate reductase: A study in 52 healthy subjects
-
Zittoun J, Tonetti C, Bories D, et al. Plasma homocysteine levels related to interactions between folate status and methylenetetrahydrofolate reductase: a study in 52 healthy subjects. Metabolism 1998; 47:1413-1418.
-
(1998)
Metabolism
, vol.47
, pp. 1413-1418
-
-
Zittoun, J.1
Tonetti, C.2
Bories, D.3
-
4
-
-
0033846460
-
Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene
-
Stern LL, Mason JB, Selhub J, et al. Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene. Cancer Epidemiol Biomarkers Prev 2000; 9:849-853.
-
(2000)
Cancer Epidemiol Biomarkers Prev
, vol.9
, pp. 849-853
-
-
Stern, L.L.1
Mason, J.B.2
Selhub, J.3
-
5
-
-
0037117501
-
A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status
-
Friso S, Choi SW, Girelli D, et al. A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci U S A 2002; 99:5606-5611.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 5606-5611
-
-
Friso, S.1
Choi, S.W.2
Girelli, D.3
-
6
-
-
0030615085
-
Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer
-
Ma J, Stampfer MJ, Giovannucci E, et al. Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Res 1997; 57:1098-1102.
-
(1997)
Cancer Res
, vol.57
, pp. 1098-1102
-
-
Ma, J.1
Stampfer, M.J.2
Giovannucci, E.3
-
7
-
-
0029855024
-
A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer
-
Chen J, Giovannucci E, Kelsey K, et al. A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer. Cancer Res 1996; 56:4862-4864.
-
(1996)
Cancer Res
, vol.56
, pp. 4862-4864
-
-
Chen, J.1
Giovannucci, E.2
Kelsey, K.3
-
8
-
-
18144436225
-
677T mutation of the MTHFR gene in adenomas and colorectal cancer in a population sample from the Northeastern Mexico. Preliminary results
-
Delgado-Enciso I, Martinez-Garza SG, Rojas-Martinez A, et al. 677T mutation of the MTHFR gene in adenomas and colorectal cancer in a population sample from the Northeastern Mexico. Preliminary results. Rev Gastroenterol Mex 2001; 66:32-37.
-
(2001)
Rev Gastroenterol Mex
, vol.66
, pp. 32-37
-
-
Delgado-Enciso, I.1
Martinez-Garza, S.G.2
Rojas-Martinez, A.3
-
9
-
-
0033370552
-
Colorectal adenomas and the C677T MTHFR polymorphism: Evidence for gene-environment interaction?
-
Ulrich CM, Kampman E, Bigler J, et al. Colorectal adenomas and the C677T MTHFR polymorphism: evidence for gene-environment interaction? Cancer Epidemiol Biomarkers Prev 1999; 8:659-668.
-
(1999)
Cancer Epidemiol Biomarkers Prev
, vol.8
, pp. 659-668
-
-
Ulrich, C.M.1
Kampman, E.2
Bigler, J.3
-
10
-
-
0035785560
-
The methylenetetrahydrofolate reductase (MTHFR) gene in colorectal cancer: Role in tumor development and significance of allelic loss in tumor progression
-
Ryan BM, Molloy AM, McManus R, et al. The methylenetetrahydrofolate reductase (MTHFR) gene in colorectal cancer: role in tumor development and significance of allelic loss in tumor progression. Int J Gastrointest Cancer 2001; 30:105-111.
-
(2001)
Int J Gastrointest Cancer
, vol.30
, pp. 105-111
-
-
Ryan, B.M.1
Molloy, A.M.2
McManus, R.3
-
11
-
-
0033869703
-
Riboflavin as a determinant of plasma total homocysteine: Effect modification by the methylenetetrahydrofolate reductase C677T polymorphism
-
Hustad S, Ueland PM, Vollset SE, et al. Riboflavin as a determinant of plasma total homocysteine: effect modification by the methylenetetrahydrofolate reductase C677T polymorphism. Clin Chem 2000; 46:1065-1071.
-
(2000)
Clin Chem
, vol.46
, pp. 1065-1071
-
-
Hustad, S.1
Ueland, P.M.2
Vollset, S.E.3
-
12
-
-
0024426567
-
Deoxyuridylate effects on thymidylate synthase-5-fluorodeoxyuridylate- folate ternary complex formation
-
Spears CP, Hayes AA, Shahinian AH. et al. Deoxyuridylate effects on thymidylate synthase-5-fluorodeoxyuridylate- folate ternary complex formation. Biochem Pharmacol 1989; 38:2985-2993.
-
(1989)
Biochem Pharmacol
, vol.38
, pp. 2985-2993
-
-
Spears, C.P.1
Hayes, A.A.2
Shahinian, A.H.3
-
13
-
-
0021219342
-
Thymidylate synthetase inhibition in malignant tumors and normal liver of patients given intravenous 5-fluorouracil
-
Spears CP, Gustavsson BG, Mitchell MS, et al. Thymidylate synthetase inhibition in malignant tumors and normal liver of patients given intravenous 5-fluorouracil. Cancer Res 1984; 44:4144-4150.
-
(1984)
Cancer Res
, vol.44
, pp. 4144-4150
-
-
Spears, C.P.1
Gustavsson, B.G.2
Mitchell, M.S.3
-
14
-
-
0037990003
-
Methylenetetrahydrofolate reductase polymorphism in advanced colorectal cancer: A novel genomic predictor of clinical response to fluoropyrimidine-based chemotherapy
-
Cohen V, Panet-Raymond V, Sabbaghian N, et al. Methylenetetrahydrofolate reductase polymorphism in advanced colorectal cancer: a novel genomic predictor of clinical response to fluoropyrimidine-based chemotherapy. Clin Cancer Res 2003; 9:1611-1615.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 1611-1615
-
-
Cohen, V.1
Panet-Raymond, V.2
Sabbaghian, N.3
-
15
-
-
0024808080
-
Folylpolyglutamate synthesis and role in the regulation of one-carbon metabolism
-
Shane B. Folylpolyglutamate synthesis and role in the regulation of one-carbon metabolism. Vitam Horm 1989; 45:263-335.
-
(1989)
Vitam Horm
, vol.45
, pp. 263-335
-
-
Shane, B.1
-
16
-
-
0026597828
-
Intracellular metabolism of 5-formyl tetrahydrofolate in human breast and colon cell lines
-
Boarman DM, Allegra CJ. Intracellular metabolism of 5-formyl tetrahydrofolate in human breast and colon cell lines. Cancer Res 1992; 52:36-44.
-
(1992)
Cancer Res
, vol.52
, pp. 36-44
-
-
Boarman, D.M.1
Allegra, C.J.2
-
17
-
-
33947093786
-
Effect of 5, 10-methylenetetrahydrofolate on the dissociation of 5-fluoro-2′-deoxyuridylate from thymidylate synthetase: Evidence for an ordered mechanism
-
Danenberg PV, Danenberg KD. Effect of 5, 10-methylenetetrahydrofolate on the dissociation of 5-fluoro-2′-deoxyuridylate from thymidylate synthetase: evidence for an ordered mechanism. Biochemistry 1978; 17:4018-4024.
-
(1978)
Biochemistry
, vol.17
, pp. 4018-4024
-
-
Danenberg, P.V.1
Danenberg, K.D.2
-
18
-
-
0024578676
-
Effect of polyglutamylation of 5,10-methylenetetrahydrofolate on the binding of 5-fluoro-2′-deoxyuridylate to thymidylate synthase purified from a human colon adenocarcinoma xenograft
-
Radparvar S, Houghton PJ, Houghton JA. Effect of polyglutamylation of 5,10-methylenetetrahydrofolate on the binding of 5-fluoro-2′-deoxyuridylate to thymidylate synthase purified from a human colon adenocarcinoma xenograft. Biochem Pharmacol 1989; 38:335-342.
-
(1989)
Biochem Pharmacol
, vol.38
, pp. 335-342
-
-
Radparvar, S.1
Houghton, P.J.2
Houghton, J.A.3
-
19
-
-
0346103806
-
Altered gene expression of folate enzymes in adjacent mucosa is associated with outcome of colorectal cancer patients
-
Odin E, Wettergren Y, Nilsson S, et al. Altered gene expression of folate enzymes in adjacent mucosa is associated with outcome of colorectal cancer patients. Clin Cancer Res 2003; 9:6012-6019.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 6012-6019
-
-
Odin, E.1
Wettergren, Y.2
Nilsson, S.3
-
20
-
-
0029655379
-
Field effect of human colon carcinoma on normal mucosa: Relevance of carcinoembryonic antigen expression
-
Jothy S, Slesak B, Harlozinska A, et al. Field effect of human colon carcinoma on normal mucosa: relevance of carcinoembryonic antigen expression. Tumour Biol 1996; 17:58-64.
-
(1996)
Tumour Biol
, vol.17
, pp. 58-64
-
-
Jothy, S.1
Slesak, B.2
Harlozinska, A.3
-
21
-
-
0023099309
-
Abnormal pattern of cell proliferation in the entire colonic mucosa of patients with colon adenoma or cancer
-
Terpstra OT, van Blankenstein M, Dees J, et al. Abnormal pattern of cell proliferation in the entire colonic mucosa of patients with colon adenoma or cancer. Gastroenterology 1987; 92:704-708.
-
(1987)
Gastroenterology
, vol.92
, pp. 704-708
-
-
Terpstra, O.T.1
van Blankenstein, M.2
Dees, J.3
-
22
-
-
0019445663
-
Colon epithelium. IV. Human colon carcinogenesis. Changes in human colon mucosa adjacent to and remote from carcinomas of the colon
-
Shamsuddin AK, Weiss L, Phelps PC, et al. Colon epithelium. IV. Human colon carcinogenesis. Changes in human colon mucosa adjacent to and remote from carcinomas of the colon. J Natl Cancer Inst 1981; 66:413-419.
-
(1981)
J Natl Cancer Inst
, vol.66
, pp. 413-419
-
-
Shamsuddin, A.K.1
Weiss, L.2
Phelps, P.C.3
-
23
-
-
0030277195
-
Folate: Effects on carcinogenesis and the potential for cancer chemoprevention
-
1727-1736, discussion 1743-1744
-
Mason JB, Levesque T. Folate: effects on carcinogenesis and the potential for cancer chemoprevention. Oncology (Williston Park) 1996; 10:1727-1736, 1742-1743; discussion 1743-1744.
-
(1996)
Oncology (Williston Park)
, vol.10
, pp. 1742-1743
-
-
Mason, J.B.1
Levesque, T.2
-
25
-
-
78651051453
-
The prognostic significance of direct extension of carcinoma of the colon and rectum
-
Astler V, Coller F. The prognostic significance of direct extension of carcinoma of the colon and rectum. Ann Surg 1954; 139:846-852.
-
(1954)
Ann Surg
, vol.139
, pp. 846-852
-
-
Astler, V.1
Coller, F.2
-
27
-
-
0001554828
-
The classification of cancer of the rectum
-
Dukes C. The classification of cancer of the rectum. J Pathol 1932; 35:323-332.
-
(1932)
J Pathol
, vol.35
, pp. 323-332
-
-
Dukes, C.1
-
29
-
-
85030734780
-
-
ABI PRISM 7700 Sequence Detection Systems [User Bulletin #2]. Foster City, CA: Applied Biosystems
-
ABI PRISM 7700 Sequence Detection Systems [User Bulletin #2]. Foster City, CA: Applied Biosystems; 1997:1-36.
-
(1997)
, pp. 1-36
-
-
-
30
-
-
33244497326
-
-
TaqMan Universal PCR Master mix, Biosystems A
-
TaqMan Universal PCR Master mix, Biosystems A. 1998.
-
(1998)
-
-
-
31
-
-
0024327653
-
Relationship of reduced folate changes to inhibition of DNA synthesis induced by methotrexate in L1210 cells in vivo
-
Priest DG, Bunni M, Sirotnak FM. Relationship of reduced folate changes to inhibition of DNA synthesis induced by methotrexate in L1210 cells in vivo. Cancer Res 1989; 49:4204-4209.
-
(1989)
Cancer Res
, vol.49
, pp. 4204-4209
-
-
Priest, D.G.1
Bunni, M.2
Sirotnak, F.M.3
-
32
-
-
0024200997
-
Methods for thymidylate synthase pharmacodynamics: Serial biopsy, free and total TS, FdUMP and dUMP, and H4PteGlu and CH2-H4PteGlu assays
-
Spears CP, Gustavsson BG. Methods for thymidylate synthase pharmacodynamics: serial biopsy, free and total TS, FdUMP and dUMP, and H4PteGlu and CH2-H4PteGlu assays. Adv Exp Med Biol 1988; 244:97-106.
-
(1988)
Adv Exp Med Biol
, vol.244
, pp. 97-106
-
-
Spears, C.P.1
Gustavsson, B.G.2
-
34
-
-
33845382806
-
Nonparametric estimation from incomplete observations
-
Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958; 53:457-481.
-
(1958)
J Am Stat Assoc
, vol.53
, pp. 457-481
-
-
Kaplan, E.L.1
Meier, P.2
-
35
-
-
0032573077
-
A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells
-
Bagley PJ, Selhub J. A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells. Proc Natl Acad Sci U S A 1998; 95:13217-13220.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 13217-13220
-
-
Bagley, P.J.1
Selhub, J.2
-
36
-
-
0346103808
-
The folate pool in colorectal cancers is associated with DNA hypermethylation and with a polymorphism in methylenetetrahydrofolate reductase
-
Kawakami K, Ruszkiewicz A, Bennett G, et al. The folate pool in colorectal cancers is associated with DNA hypermethylation and with a polymorphism in methylenetetrahydrofolate reductase. Clin Cancer Res 2003; 9:5860-5865.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 5860-5865
-
-
Kawakami, K.1
Ruszkiewicz, A.2
Bennett, G.3
-
37
-
-
0002641374
-
Modulation of thymidylate synthase expression by dietary folic acid induced DNA hypomethylation in a mouse model tumor
-
Pfeiderer, Rokos, eds. Berlin: Blackwell Scientific
-
Priest DG, Raghunathan K, Liu Y, et al. Modulation of thymidylate synthase expression by dietary folic acid induced DNA hypomethylation in a mouse model tumor. In: Pfeiderer, Rokos, eds. Chemistry and Biology of Pteridines and Folates. Berlin: Blackwell Scientific; 1997:387-392.
-
(1997)
Chemistry and Biology of Pteridines and Folates
, pp. 387-392
-
-
Priest, D.G.1
Raghunathan, K.2
Liu, Y.3
-
38
-
-
0027946745
-
DNA methylation as an intermediate biomarker in colorectal cancer: Modulation by folic acid supplementation
-
Cravo M, Fidalgo P, Pereira AD, et al. DNA methylation as an intermediate biomarker in colorectal cancer: modulation by folic acid supplementation. Eur J Cancer Prev 1994; 3:473-479.
-
(1994)
Eur J Cancer Prev
, vol.3
, pp. 473-479
-
-
Cravo, M.1
Fidalgo, P.2
Pereira, A.D.3
-
39
-
-
27744608217
-
The molecular signature of normal squamous esophageal epithelium identifies the presence of a field effect and can discriminate between patients with Barrett's esophagus and patients with Barrett's-associated adenocarcinoma
-
Brabender J, Marjoram P, Lord RV, et al. The molecular signature of normal squamous esophageal epithelium identifies the presence of a field effect and can discriminate between patients with Barrett's esophagus and patients with Barrett's-associated adenocarcinoma. Cancer Epidemiol Biomarkers Prev 2005; 14:2113-2137.
-
(2005)
Cancer Epidemiol Biomarkers Prev
, vol.14
, pp. 2113-2137
-
-
Brabender, J.1
Marjoram, P.2
Lord, R.V.3
-
40
-
-
1342268390
-
Role of polymorphisms in MTHFR and MTHFDI genes in the outcome of childhood acute lymphoblastic leukemia
-
Krajinovic M, Lemieux-Blanchard E, Chiasson S, et al. Role of polymorphisms in MTHFR and MTHFDI genes in the outcome of childhood acute lymphoblastic leukemia. Pharmacogenomics J 2004; 4:66-72.
-
(2004)
Pharmacogenomics J
, vol.4
, pp. 66-72
-
-
Krajinovic, M.1
Lemieux-Blanchard, E.2
Chiasson, S.3
-
41
-
-
0032895522
-
The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia
-
Guenther BD, Sheppard CA, Tran P, et al. The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia. Nat Struct Biol 1999; 6:359-365.
-
(1999)
Nat Struct Biol
, vol.6
, pp. 359-365
-
-
Guenther, B.D.1
Sheppard, C.A.2
Tran, P.3
-
42
-
-
0037305374
-
Effect of riboflavin status on the homocysteine-lowering effect of folate in relation to the MTHFR (C677T) genotype
-
Moat SJ, Ashfield-Watt PA, Powers HJ, et al. Effect of riboflavin status on the homocysteine-lowering effect of folate in relation to the MTHFR (C677T) genotype. Clin Chem 2003; 49:295-302.
-
(2003)
Clin Chem
, vol.49
, pp. 295-302
-
-
Moat, S.J.1
Ashfield-Watt, P.A.2
Powers, H.J.3
-
43
-
-
0042920823
-
Combined marginal folate and riboflavin status affect homocysteine methylation in cultured immortalized lymphocytes from persons homozygous for the MTHFR C677T mutation
-
Lathrop Stern L, Shane B, Bagley PJ, et al. Combined marginal folate and riboflavin status affect homocysteine methylation in cultured immortalized lymphocytes from persons homozygous for the MTHFR C677T mutation. J Nutr 2003; 133:2716-2720.
-
(2003)
J Nutr
, vol.133
, pp. 2716-2720
-
-
Lathrop Stern, L.1
Shane, B.2
Bagley, P.J.3
-
44
-
-
0030027668
-
Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations
-
Jacques PF, Bostom AG, Williams RR, et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 1996; 93:7-9.
-
(1996)
Circulation
, vol.93
, pp. 7-9
-
-
Jacques, P.F.1
Bostom, A.G.2
Williams, R.R.3
|