Gene expression profiles during the activation of rat hepatic stellate cells evaluated by cDNA microarray

Archives of Pharmacal Research

Volumn 30, Issue 11, 2007, Pages 1410-1418

  Sun, Wook Woo ^a,c   Hwang, Kwan Ik ^a   Chung, Myeon Woo ^a   Sun, Kyung Jin ^a   Bang, Syrie ^a   Sung, Ho Lee ^b   Sung, Hee Lee ^c   Hye, Joo Chung ^a   Dong, Hwan Sohn ^c  

^a Korea Food and Drug Administration   (South Korea)

^b College of Medicine   (South Korea)

^c Wonkwang University   (South Korea)

Author keywords

DNA chip; DNA microarray; Gene expression; Hepatic fibrosis; Hepatic stellate cell

Indexed keywords

EID: 36849024948     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf02977365     Document Type: Article

References (33)

1. Cassiman, D., Roskams, T., van Pelt, J., Libbrecht, L., Aertsen, P., Crabbe, T., Vankelecom, H., and Denef, C., Alpha B-crystallin expression in human and rat hepatic stellate cells. J. Hepatol., 35, 200-207 (2001).
2. Eng, F. J. and Friedman, S. L., Fibrogenesis I. New insights into hepatic stellate cell activation: the simple becomes complex. Am. J. Physiol. Gastrointest Liver Physiol., 279, G7-G11 (2000).
3. Friedman, S. L., Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N. Engl. J. Med., 328, 1828-1835 (1993).
4. Friedman, S. L., Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J. Biol. Chem., 275, 2247-2250 (2000).
5. Friedman, S. L., Roll, F. J., Boyles, J., and Bissell, D. M., Hepatic lipocytes: the principal collagen-producing cells of normal rat liver. Proc. Natl. Acad. Sci. U.S.A., 82, 8681-8685 (1985).
6. Galli, A., Crabb, D. W., Ceni, E., Salzano, R., Mello, T., Svegliati-Baroni, G., Ridolfi, F., Trozzi, L., Surrenti, C., and Casini, A., Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro. Gastroenterology, 122, 1924-1940 (2002).
7. Ge, X., Penney, L. C., van de Rijn, I., and Tanner, M. E., Active site residues and mechanism of UDP-glucose dehydrogenase. Eur. J. Biochem., 271, 14-22 (2004).
8. Gressner, A. M., Cytokines and cellular crosstalk involved in the activation of fat-storing cells. J. Hepatol., 22, 28-36 (1995).
9. Gressner, A. M., The cell biology of liver fibrogenesis - an imbalance of proliferation, growth arrest and apoptosis of myofibroblasts. Cell Tissue Res., 292, 447-452 (1998).
10. Gressner, A. M. and Bachem, M. G. Cellular sources of non-collagenous matrix proteins: role of fat-storing cells in fibrogenesis. Semin Liver Dis., 10, 30-46 (1990).
11. Hedenfalk, I., Duggan, D., Chen, Y., Radmacher, M., Bittner, M., Simon, R., Meltzer, P., Gusterson, B., Esteller, M., Kallioniemi, O. P., et al., Gene-expression profiles in hereditary breast cancer. N. Engl. J. Med., 344, 539-548 (2001).
12. Ikeda, K., Kawada, N., Wang, Y. Q., Kadoya, H., Nakatani, K., Sato, M., and Kaneda, K., Expression of cellular prion protein in activated hepatic stellate cells. Am. J. Pathol., 153, 1695-1700 (1998)..
13. Kawada, N., The hepatic perisinusoidal stellate cell. Histol. Histopathol, 12, 1069-1080 (1997).
14. Knittel, T., Schuppan, D., Meyer zum Buschenfelde, K. H., and Ramadori, G., Differential expression of collagen types I, III, and IV by fat-storing (Ito) cells in vitro. Gastroenterology, 102, 1724-1735 (1992).
15. Kristensen, D. B., Kawada, N., Imamura, K., Miyamoto, Y., Tateno, C., Seki, S., Kuroki, T., and Yoshizato, K., Proteome analysis of rat hepatic stellate cells. Hepatology, 32, 268-277 (2000).
16. Lang, A., Schrum, L. W., Schoonhoven, R., Tuvia, S., Solis-Herruzo, J. A., Tsukamoto, H., Brenner, D. A., and Rippe, R. A., Expression of small heat shock protein alphaB-crystallin is induced after hepatic stellate cell activation. Am. J. Physiol. Gastrointest Liver Physiol., 279, G1333-1342 (2000).
17. Lee, S. H., Seo, G. S., Park, Y. N., Yoo, T. M., and Sohn, D. H., Effects and regulation of osteopontin in rat hepatic stellate cells. Biochem. Pharmacol., 68, 2367-2378 (2004).
18. Li, D. and Friedman, S. L., Liver fibrogenesis and the role of hepatic stellate cells: new insights and prospects for therapy. J. Gastroenterol Hepatol., 14, 618-633 (1999).
19. Liu, C., Gaca, M. D., Swenson, E. S., Vellucci, V. F., Reiss, M., and Wells, R. G., Smads 2 and 3 are differentially activated by transforming growth factor-beta (TGF-beta ) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Smads in activated cells is TGF-beta-independent. J. Biol. Chem., 278, 11721-11728 (2003).
20. Liu, X. J., Yang, L., Luo, F. M., Wu, H. B., and Qiang, Q., Association of differentially expressed genes with activation of mouse hepatic stellate cells by high-density cDNA microarray. World. J. Gastroenterol., 10, 1600-1607 (2004).
21. Liu, X. J., Yang, L., Mao, Y. Q., Wang, Q., Huang, M. H., Wang, Y. P., and Wu, H. B., Effects of the tyrosine protein kinase inhibitor genistein on the proliferation, activation of cultured rat hepatic stellate cells. World J. Gastroenterol., 8, 739-745 (2002).
22. Mann, D. A. and Smart, D. E., Transcriptional regulation of hepatic stellate cell activation. Gut, 50, 891-896 (2002).
23. Nielsen, T. O., West, R. B., Linn, S. C., Alter, O., Knowling, M. A., O'Connell, J. X., Zhu, S., Fero, M., Sherlock, G., Pollack, J. R. et al., Molecular characterisation of soft tissue tumours: a gene expression study. Lancet, 359, 1301-1307 (2002).
24. Pinzani, M., Novel insights into the biology and physiology of the Ito cell. Pharmacol. Ther., 66, 387-412 (1995).
25. Pinzani, M. and Gentilini, P., Biology of hepatic stellate cells and their possible relevance in the pathogenesis of portal hypertension in cirrhosis. Semin Liver Dis., 19, 397-410 (1999).
26. Pinzani, M. and Marra, F., Cytokine receptors and signaling in hepatic stellate cells. Semin Liver Dis., 21, 397-416 (2001).
27. Ramadori, G., The stellate cell (Ito-cell, fat-storing cell, lipocyte, perisinusoidal cell) of the liver. New insights into pathophysiology of an intriguing cell. Virchows Arch. B. Cell Pathol. Incl. Mol. Pathol., 61, 147-158 (1991).
28. Ratziu, V., Lalazar, A., Wong, L., Dang, Q., Collins, C., Shaulian, E., Jensen, S., and Friedman, S. L., Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis. Proc. Natl. Acad. Sci. U.S.A., 95, 9500-9505 (1998).
29. Svegliati-Baroni, G., Ridolfi, F., Di Sario, A., Casini, A., Marucci, L., Gaggiotti, G., Orlandoni, P., Macarri, G., Perego, L., Benedetti, A. et al., Insulin and insulin-like growth factor-1 stimulate proliferation and type I collagen accumulation by human hepatic stellate cells: differential effects on signal transduction pathways. Hepatology, 29, 1743-1751 (1999).
30. van 't Veer, L. J., Dai, H., van de Vijver, M. J., He, Y. D., Hart, A. A., Mao, M., Peterse, H. L., van der Kooy, K., Marton, M. J., Witteveen, A. T. et al., Gene expression profiling predicts clinical outcome of breast cancer. Nature, 415, 530-536 (2002).
31. van de Vijver, M. J., He, Y. D., van't Veer, L. J., Dai, H., Hart, A. A., Voskuil, D. W., Schreiber, G. J., Peterse, J. L., Roberts, C., Marton, M. J. et al., A gene-expression signature as a predictor of survival in breast cancer. N. Engl. J. Med., 347, 1999-2009 (2002).
32. Woo, S. W., Lee, S. H., Kang, H. C., Park, E. J., Zhao, Y. Z., Kim, Y. C., and Sohn, D. H., Butein suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture. J. Pharm. Pharmacol., 55, 347-352 (2003).
33. Woo, S. W., Nan, J. X., Lee, S. H., Park, E. J., Zhao, Y. Z., and Sohn, D. H., Aloe emodin suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture. Pharmacol. Toxicol., 90, 193-198 (2002).