Radioprotection of 4-hydroxy-3,5-dimethoxybenzaldehyde (VND3207) in culture cells is associated with minimizing DNA damage and activating Akt

European Journal of Pharmaceutical Sciences

Volumn 33, Issue 1, 2008, Pages 52-59

  Zheng, Hong ^a,b   Chen, Zhi Wu ^b   Wang, Lin ^a   Wang, Si Ying ^b   Yan, Yu Qian ^a   Wu, Ke ^a   Xu, Qin Zhi ^a   Zhang, Shi Meng ^a   Zhou, Ping Kun ^a  

^a BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

^b ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Akt; DNA repair; DNA PKcs; Free radical; Radioprotection; Vanillin derivative

Indexed keywords

DNA; DNA DEPENDENT PROTEIN KINASE; DOUBLE STRANDED DNA; GLYCOGEN SYNTHASE KINASE 3BETA; HYDROXYL RADICAL; PLASMID DNA; PROTEIN KINASE B; RADIOPROTECTIVE AGENT; SUPEROXIDE; SYRINGALDEHYDE; UNCLASSIFIED DRUG; VANILLIN; VANILLIN DERIVATIVE; VND 3207;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; ELECTRON SPIN RESONANCE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FIBROBLAST; GAMMA RADIATION; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL; PRIORITY JOURNAL; RADIATION PROTECTION; SURVIVAL;

ANTIOXIDANTS; APOPTOSIS; BENZALDEHYDES; CELL LINE; CELL SURVIVAL; CELLS, CULTURED; COMET ASSAY; DNA BREAKS, DOUBLE-STRANDED; DNA BREAKS, SINGLE-STRANDED; DNA DAMAGE; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; FLOW CYTOMETRY; HUMANS; LYMPHOCYTES; MALE; MOLECULAR STRUCTURE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RADIATION-PROTECTIVE AGENTS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION;

EID: 36849022109     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2007.09.006     Document Type: Article

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