메뉴 건너뛰기




Volumn 12, Issue 4, 2007, Pages 591-603

Emerging pharmacotherapies for diabetic macular edema

Author keywords

Bevacizumab; Diabetic retinopathy; Macular edema; Ranibizumab; VEGF

Indexed keywords

AMFENAC; ATORVASTATIN; BEVACIZUMAB; BEVASIRANIB SODIUM; CORTICOSTEROID; DEXAMETHASONE; DICLOFENAC; FLUOCINOLONE ACETONIDE; GLYCOLIC ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LACTIC ACID; LIPID; MIDOSTAURIN; NEPAFENAC; NONSTEROID ANTIINFLAMMATORY AGENT; OCTREOTIDE; PEGAPTANIB; PEGVISOMANT; PEPTIDE HORMONE RECEPTOR BLOCKING AGENT; PLACEBO; PROTEIN KINASE C INHIBITOR; RANIBIZUMAB; RUBOXISTAURIN; SMALL INTERFERING RNA; TRIAMCINOLONE ACETONIDE; UNCLASSIFIED DRUG; VASCULOTROPIN INHIBITOR; VEGF TRAP;

EID: 36549086584     PISSN: 14728214     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728214.12.4.591     Document Type: Review
Times cited : (16)

References (116)
  • 1
    • 2342466734 scopus 로고    scopus 로고
    • Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030
    • WILD S, ROGLIC G, GREEN A et al.: Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care (2004) 27(5):1047-1053.
    • (2004) Diabetes Care , vol.27 , Issue.5 , pp. 1047-1053
    • WILD, S.1    ROGLIC, G.2    GREEN, A.3
  • 2
    • 36549042040 scopus 로고    scopus 로고
    • RYAN SJ, HINTON DR, SCHACHAT AP et al.: Retina (4th Edition). Elsevier Mosby.
    • RYAN SJ, HINTON DR, SCHACHAT AP et al.: Retina (4th Edition). Elsevier Mosby.
  • 3
    • 33947508401 scopus 로고    scopus 로고
    • MEYER CH: Current treatment approaches in diabetic macular edema. Ophthalmologica (2007) 221(2):118-131. • In this comprehensive paper the author overviews the various therapeutic approaches for diabetic macular edema, while the pathogenesis of the disease has been deeply discussed and correlated to the emerging treatments.
    • MEYER CH: Current treatment approaches in diabetic macular edema. Ophthalmologica (2007) 221(2):118-131. • In this comprehensive paper the author overviews the various therapeutic approaches for diabetic macular edema, while the pathogenesis of the disease has been deeply discussed and correlated to the emerging treatments.
  • 4
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Basic science and clinical progress
    • FERRARA N: Vascular endothelial growth factor: basic science and clinical progress. Endocr. Rev. (2004) 25:581-611.
    • (2004) Endocr. Rev , vol.25 , pp. 581-611
    • FERRARA, N.1
  • 5
    • 33646175396 scopus 로고    scopus 로고
    • HOW does vitrectomy afFect diabetic macular edema?
    • STEFANSSON E, LANDERS MB: HOW does vitrectomy afFect diabetic macular edema? Am. J. Ophthalmol. (2006) 141:984.
    • (2006) Am. J. Ophthalmol , vol.141 , pp. 984
    • STEFANSSON, E.1    LANDERS, M.B.2
  • 6
    • 0034798467 scopus 로고    scopus 로고
    • The therapeutic effects of retinal laser treatment and vitrectomy: A theory based on oxygen and vascular physiology
    • STEFANSSON E: The therapeutic effects of retinal laser treatment and vitrectomy: a theory based on oxygen and vascular physiology. Acta Ophthalmol. Scand. (2001) 79:435-440.
    • (2001) Acta Ophthalmol. Scand , vol.79 , pp. 435-440
    • STEFANSSON, E.1
  • 7
    • 0028234334 scopus 로고
    • Early vitrectomy for progressive diabetic proliferations covering the macula
    • GREWING R, MESTER U: Early vitrectomy for progressive diabetic proliferations covering the macula. Br. J. Ophthalmol. (1994) 78:433-436.
    • (1994) Br. J. Ophthalmol , vol.78 , pp. 433-436
    • GREWING, R.1    MESTER, U.2
  • 8
    • 0023814808 scopus 로고    scopus 로고
    • NASRALLAH FP, JALKH AE, VANCOPPENROLLE F et al.: The role of the vitteous in diabetic macular edema. Ophthalmology (1988) 95:1335-1339. • This is one of the earliest publications to describe the role of the vitreous in the pathogenesis of diabetic macular edema.
    • NASRALLAH FP, JALKH AE, VANCOPPENROLLE F et al.: The role of the vitteous in diabetic macular edema. Ophthalmology (1988) 95:1335-1339. • This is one of the earliest publications to describe the role of the vitreous in the pathogenesis of diabetic macular edema.
  • 9
    • 0030997154 scopus 로고    scopus 로고
    • Association between the short-term natural history of diabetic macular edema and the vitteomacular relationship in Type 2 diabetes mellitus
    • HIKICHI T, FUJIO N, AKIBA Y et al.: Association between the short-term natural history of diabetic macular edema and the vitteomacular relationship in Type 2 diabetes mellitus. Ophthalmology (1997) 104:473-478.
    • (1997) Ophthalmology , vol.104 , pp. 473-478
    • HIKICHI, T.1    FUJIO, N.2    AKIBA, Y.3
  • 10
    • 0000204649 scopus 로고
    • A modification of the Airlie House classification of diabetic retinopathy
    • DIABETIC RETINOPATHY STUDY RESEARCH GROUP
    • DIABETIC RETINOPATHY STUDY RESEARCH GROUP: A modification of the Airlie House classification of diabetic retinopathy. Report 7. Invest. Ophthalmol. Vis. Sci. (1981) 21:210-226.
    • (1981) Invest. Ophthalmol. Vis. Sci , vol.21 , pp. 210-226
  • 11
    • 0034108888 scopus 로고    scopus 로고
    • Comparison between optical coherence tomography and fundus fluorescein angiography for the detection of cystoids macular edema in patients with uveitis
    • ANTCLIFF RJ, STANFORD MR, CHAUHAN DS et al.: Comparison between optical coherence tomography and fundus fluorescein angiography for the detection of cystoids macular edema in patients with uveitis. Ophthalmology (2000) 107:593-599.
    • (2000) Ophthalmology , vol.107 , pp. 593-599
    • ANTCLIFF, R.J.1    STANFORD, M.R.2    CHAUHAN, D.S.3
  • 12
    • 36549082456 scopus 로고    scopus 로고
    • EARLY TREATMENT DIABETIC RETINOPATHY STUDY RESEARCH GROUP: Photocoagulation for diabetic macular edema. ETDRS report No 4. Int. Ophthalmol. Clin. (1987) 27:254-264. • In this trial report the group released some of the key results of the very important trial named ETDRS.
    • EARLY TREATMENT DIABETIC RETINOPATHY STUDY RESEARCH GROUP: Photocoagulation for diabetic macular edema. ETDRS report No 4. Int. Ophthalmol. Clin. (1987) 27:254-264. • In this trial report the group released some of the key results of the very important trial named ETDRS.
  • 13
    • 0021748399 scopus 로고
    • The Wisconsin epidemiologic study of diabetic retinopathy
    • KLEIN R, KLEIN BEK, MOSS SE et al.: The Wisconsin epidemiologic study of diabetic retinopathy. Ophthalmology (1984) 91:1464-1474.
    • (1984) Ophthalmology , vol.91 , pp. 1464-1474
    • KLEIN, R.1    KLEIN, B.E.K.2    MOSS, S.E.3
  • 14
    • 0027370108 scopus 로고    scopus 로고
    • THE DIABETES CONTROL AND COMPLICATIONS TRIAL RESEARCH GROUP: The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med. (1993) 329:977-986. • In this trial report the group released some of the results of the trial named DCCT that demonstrate the efficacy of tight blood glucose to prevent diabetic retinopathy.
    • THE DIABETES CONTROL AND COMPLICATIONS TRIAL RESEARCH GROUP: The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med. (1993) 329:977-986. • In this trial report the group released some of the results of the trial named DCCT that demonstrate the efficacy of tight blood glucose to prevent diabetic retinopathy.
  • 15
    • 0032511583 scopus 로고    scopus 로고
    • intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with Type 2 diabetes
    • UK PROSPECTIVE DIABETES STUDY GROUP
    • UK PROSPECTIVE DIABETES STUDY GROUP: intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with Type 2 diabetes. Lancet (1998) 352:837-853.
    • (1998) Lancet , vol.352 , pp. 837-853
  • 16
    • 0022347471 scopus 로고
    • Photocoagulation for DME early treatment diabetic retinopathy study
    • EARLY TREATMENT DIABETIC RETINOPATHY STUDY RESEARCH GROUP
    • EARLY TREATMENT DIABETIC RETINOPATHY STUDY RESEARCH GROUP: Photocoagulation for DME early treatment diabetic retinopathy study report number 1. Arch. Ophthalmol. (1985) 103:1796-1806.
    • (1985) Arch. Ophthalmol , vol.103 , pp. 1796-1806
  • 17
    • 0021263352 scopus 로고
    • Macular edema: A complication of diabetic retinopathy
    • FERRIS FL, PATZ A: Macular edema: a complication of diabetic retinopathy. Surv. Ophthalmol. (1984) 28(Suppl.):452-461.
    • (1984) Surv. Ophthalmol , vol.28 , Issue.SUPPL. , pp. 452-461
    • FERRIS, F.L.1    PATZ, A.2
  • 18
    • 0021013753 scopus 로고
    • Diabetic maculopathy: A critical review highlighting diffuse macular edema
    • BRESNICK GH: Diabetic maculopathy: a critical review highlighting diffuse macular edema. Ophthalmology (1983) 90:1301-1317.
    • (1983) Ophthalmology , vol.90 , pp. 1301-1317
    • BRESNICK, G.H.1
  • 19
    • 0022508965 scopus 로고
    • Modified grid argon (blue-green) laser photocoagulation for diffuse diabetic macular edema
    • OLK RJ: Modified grid argon (blue-green) laser photocoagulation for diffuse diabetic macular edema. Ophthalmology (1986) 93:938-950.
    • (1986) Ophthalmology , vol.93 , pp. 938-950
    • OLK, R.J.1
  • 20
    • 33646510067 scopus 로고    scopus 로고
    • Vitrectomy for diabetic macular edema with and without internal limiting membrane removal
    • LAM RF, LAI WW, CHAN WM et al.: Vitrectomy for diabetic macular edema with and without internal limiting membrane removal. Ophthalmologica (2006) 220:206.
    • (2006) Ophthalmologica , vol.220 , pp. 206
    • LAM, R.F.1
  • 21
    • 33646175396 scopus 로고    scopus 로고
    • How does vitrectomy affect diabetic macular edema?
    • STEFANSSON E, LANDERS MB: How does vitrectomy affect diabetic macular edema? Am. J. Ophthalmol. (2006) 141:984.
    • (2006) Am. J. Ophthalmol , vol.141 , pp. 984
    • STEFANSSON, E.1    LANDERS, M.B.2
  • 22
    • 34250181353 scopus 로고    scopus 로고
    • Long-term outcomes of pats plana vitrectomy with internal limiting membrane removal in diabetic macular edema
    • YANYALI A, HOROZOGLU F, CELIK E et al.: Long-term outcomes of pats plana vitrectomy with internal limiting membrane removal in diabetic macular edema. Retina (2007) 27(5):557-566.
    • (2007) Retina , vol.27 , Issue.5 , pp. 557-566
    • YANYALI, A.1    HOROZOGLU, F.2    CELIK, E.3
  • 23
    • 34249991499 scopus 로고    scopus 로고
    • Results of visual acuity and foveal thickness in diabetic macular edema after vitrectomy
    • SHIMONAGANO Y, MAKIUCHI R, MIYAZAKI M et al.: Results of visual acuity and foveal thickness in diabetic macular edema after vitrectomy. Jpn J. Ophthalmol. (2007) 51:204-209.
    • (2007) Jpn J. Ophthalmol , vol.51 , pp. 204-209
    • SHIMONAGANO, Y.1    MAKIUCHI, R.2    MIYAZAKI, M.3
  • 24
    • 33750688891 scopus 로고    scopus 로고
    • Visual acuity comparison of vitrectomy with and without internal limiting membrane removal in the treatment of diabetic macular edema
    • BAHADIR M, ERTAN A, MERTOGLU O: Visual acuity comparison of vitrectomy with and without internal limiting membrane removal in the treatment of diabetic macular edema. Int. Ophthalmol. (2005) 6(1-2):3-8.
    • (2005) Int. Ophthalmol , vol.6 , Issue.1-2 , pp. 3-8
    • BAHADIR, M.1    ERTAN, A.2    MERTOGLU, O.3
  • 25
    • 23744447253 scopus 로고    scopus 로고
    • Vitrectomy for persistent diffuse diabetic macular edema
    • STOLBA U, BINDER S, GRUBER D et al.: Vitrectomy for persistent diffuse diabetic macular edema. Am. J. Ophthalmol. (2005) 140(2):295-301.
    • (2005) Am. J. Ophthalmol , vol.140 , Issue.2 , pp. 295-301
    • STOLBA, U.1    BINDER, S.2    GRUBER, D.3
  • 26
    • 0036323373 scopus 로고    scopus 로고
    • Hydrocortisone decreases retinal endothelial cell water and solute flux coincident with increased content and decreased phosphorylation of occluding
    • ANTONETTI DA, WOLPERT EB, DEMAIO L et al.: Hydrocortisone decreases retinal endothelial cell water and solute flux coincident with increased content and decreased phosphorylation of occluding. J. Neurochem. (2002) 80:667-677.
    • (2002) J. Neurochem , vol.80 , pp. 667-677
    • ANTONETTI, D.A.1    WOLPERT, E.B.2    DEMAIO, L.3
  • 27
    • 12744266491 scopus 로고    scopus 로고
    • Corticosteroids inhibit VEGF-induced vascular leakage in a rabbit model of blood-retinal and blood-aqueous barrier breakdown
    • EDELMAN JL, LUTZ D, CASTRO MR: Corticosteroids inhibit VEGF-induced vascular leakage in a rabbit model of blood-retinal and blood-aqueous barrier breakdown. Exp. Eye Res. (2005) 80:249-258.
    • (2005) Exp. Eye Res , vol.80 , pp. 249-258
    • EDELMAN, J.L.1    LUTZ, D.2    CASTRO, M.R.3
  • 28
    • 0344196834 scopus 로고    scopus 로고
    • Intravitreal triamcinolone does not alter basal vascular endothelial growth factor mRNA expression in rat retina
    • GAO H, QIAO X, GAO R et al.: Intravitreal triamcinolone does not alter basal vascular endothelial growth factor mRNA expression in rat retina. Vision Res. (2004) 44:349-356.
    • (2004) Vision Res , vol.44 , pp. 349-356
    • GAO, H.1    QIAO, X.2    GAO, R.3
  • 29
    • 10044242430 scopus 로고    scopus 로고
    • Vitreous levels of vascular endothelial growth factor and stromal-derived factot 1 in patients with diabetic retinopathy and cystoid macular edema before and after intraocular injection of triamcinolone
    • BROOKS HL, CABALLERO S, NEWELL CK et al.: Vitreous levels of vascular endothelial growth factor and stromal-derived factot 1 in patients with diabetic retinopathy and cystoid macular edema before and after intraocular injection of triamcinolone. Arch. Ophthalmol. (2004) 122:1801- 1807.
    • (2004) Arch. Ophthalmol , vol.122 , pp. 1801-1807
    • BROOKS, H.L.1    CABALLERO, S.2    NEWELL, C.K.3
  • 30
    • 26944440532 scopus 로고    scopus 로고
    • Post-transcriptional and non-genomic effects of glucocorticoids
    • STELLATO C: Post-transcriptional and non-genomic effects of glucocorticoids. Proc. Am. Thorac. Soc. (2004) 1:255-263.
    • (2004) Proc. Am. Thorac. Soc , vol.1 , pp. 255-263
    • STELLATO, C.1
  • 32
    • 0029620301 scopus 로고
    • Exudative macular degeneration and intravitreal triamcinolone. A pilot study
    • PENFOLD PL, GYORY JF, HUNYOR AB, BILLSON FA: Exudative macular degeneration and intravitreal triamcinolone. A pilot study. Aust. NZ J. Ophthalmol. (1995) 23(4):293-298.
    • (1995) Aust. NZ J. Ophthalmol , vol.23 , Issue.4 , pp. 293-298
    • PENFOLD, P.L.1    GYORY, J.F.2    HUNYOR, A.B.3    BILLSON, F.A.4
  • 33
    • 0036240895 scopus 로고    scopus 로고
    • Intravitreal triamcinolone for refractory diabetic macular edema
    • MARTIDIS A, DUKER JS, GREENBERG PB et al.: Intravitreal triamcinolone for refractory diabetic macular edema. Ophthalmology (2002) 109(5):920-927.
    • (2002) Ophthalmology , vol.109 , Issue.5 , pp. 920-927
    • MARTIDIS, A.1    DUKER, J.S.2    GREENBERG, P.B.3
  • 34
    • 0037247376 scopus 로고    scopus 로고
    • JONAS JB, KREISSIG I, SOFKER A et al.: Intravitreal injection of triamcinolone for diffuse diabetic macular edema. Arch. Ophthalmol. (2003) 121(1):57-61. •• This paper demonstrate the positive role of the cristaline steroid triamcinolone to treat diffuse macular edema.
    • JONAS JB, KREISSIG I, SOFKER A et al.: Intravitreal injection of triamcinolone for diffuse diabetic macular edema. Arch. Ophthalmol. (2003) 121(1):57-61. •• This paper demonstrate the positive role of the cristaline steroid triamcinolone to treat diffuse macular edema.
  • 35
    • 26844521532 scopus 로고    scopus 로고
    • Intravitreal triamcinolone acetonide for diabetic macular edema
    • CHIEH JJ, ROTH DB, LIU M et al.: Intravitreal triamcinolone acetonide for diabetic macular edema. Retina (2005) 25(7):828-834.
    • (2005) Retina , vol.25 , Issue.7 , pp. 828-834
    • CHIEH, J.J.1    ROTH, D.B.2    LIU, M.3
  • 36
    • 0842267262 scopus 로고    scopus 로고
    • Intravitreal triamcinolone acetonide for diabetic diffuse macular edema. Preliminary results of a prospective controlled trial
    • MASSIN P, AUDREN F, HAOUCHINE B et al.: Intravitreal triamcinolone acetonide for diabetic diffuse macular edema. Preliminary results of a prospective controlled trial. Ophthalmology (2004) 111:218-224.
    • (2004) Ophthalmology , vol.111 , pp. 218-224
    • MASSIN, P.1    AUDREN, F.2    HAOUCHINE, B.3
  • 37
    • 34250163917 scopus 로고    scopus 로고
    • Early versus late intravitreal triamcinolone acetonide for macular edema associated with branch retinal vein occlusion
    • OH JY, SEO JH, AHN JK et al.: Early versus late intravitreal triamcinolone acetonide for macular edema associated with branch retinal vein occlusion. Korean J. Ophthalmol. (2007) 21(1):18-20.
    • (2007) Korean J. Ophthalmol , vol.21 , Issue.1 , pp. 18-20
    • OH, J.Y.1    SEO, J.H.2    AHN, J.K.3
  • 38
    • 33846994055 scopus 로고    scopus 로고
    • Intraocular triamcinolone acetonide for pseudophakic cystoid macular edema: Optical coherence tomography and multifocal electroretinography study
    • KOUTSANDREA C, MOSCHOS MM, BROUZAS D et al.: Intraocular triamcinolone acetonide for pseudophakic cystoid macular edema: optical coherence tomography and multifocal electroretinography study. Retina (2007) 27(2):159-164.
    • (2007) Retina , vol.27 , Issue.2 , pp. 159-164
    • KOUTSANDREA, C.1    MOSCHOS, M.M.2    BROUZAS, D.3
  • 39
    • 33846535809 scopus 로고    scopus 로고
    • Intravitreal triamcinolone acetonide for the treatment of immune recovery uveitis macular edema
    • MORRISON VL, KOZAK I, LABREE LD et al.: Intravitreal triamcinolone acetonide for the treatment of immune recovery uveitis macular edema. Ophthalmology (2007) 114(2):334-339.
    • (2007) Ophthalmology , vol.114 , Issue.2 , pp. 334-339
    • MORRISON, V.L.1    KOZAK, I.2    LABREE, L.D.3
  • 40
    • 33846805832 scopus 로고    scopus 로고
    • Intraocular triamcinolone acetonide for macular edema due to CRVO. A multifocal-ERG and OCT study
    • MOSCHOS MM, BROUZAS D, LOUKIANOU E et al.: Intraocular triamcinolone acetonide for macular edema due to CRVO. A multifocal-ERG and OCT study. Doc. Ophthalmol. (2007) 114(1):1-7.
    • (2007) Doc. Ophthalmol , vol.114 , Issue.1 , pp. 1-7
    • MOSCHOS, M.M.1    BROUZAS, D.2    LOUKIANOU, E.3
  • 41
    • 33747623255 scopus 로고    scopus 로고
    • Intravitreal triamcinolone for refractory diabetic macular edema: Two-year results of a double-masked, placebo-controlled, randomized clinical trial
    • GILLIES MC, SUTTER FK, SIMPSON JM et al.: Intravitreal triamcinolone for refractory diabetic macular edema: two-year results of a double-masked, placebo-controlled, randomized clinical trial. Ophthalmology (2006) 113(9):1533-1538.
    • (2006) Ophthalmology , vol.113 , Issue.9 , pp. 1533-1538
    • GILLIES, M.C.1    SUTTER, F.K.2    SIMPSON, J.M.3
  • 42
    • 33846845026 scopus 로고    scopus 로고
    • A prospective randomized trial of different doses of intravitreal triamcinolone for diabetic macular oedema
    • LAM DS, CHAN CK, MOHAMED S et al.: A prospective randomized trial of different doses of intravitreal triamcinolone for diabetic macular oedema. Br. J. Ophthalmol. (2007) 91(2):199-203.
    • (2007) Br. J. Ophthalmol , vol.91 , Issue.2 , pp. 199-203
    • LAM, D.S.1    CHAN, C.K.2    MOHAMED, S.3
  • 43
    • 26844431631 scopus 로고    scopus 로고
    • Intravitreal triamcinolone compared with macular laser grid photocoagulation for the treatment of cystoid macular edema
    • AVITABILE T, LONGO A, REIBALDI A: Intravitreal triamcinolone compared with macular laser grid photocoagulation for the treatment of cystoid macular edema. Am. J. Ophthalmol. (2005) 140:695-702.
    • (2005) Am. J. Ophthalmol , vol.140 , pp. 695-702
    • AVITABILE, T.1    LONGO, A.2    REIBALDI, A.3
  • 44
    • 33144463314 scopus 로고    scopus 로고
    • Severe steroid-induced glaucoma following intravitreal injection of triamcinolone acetonide
    • QUIRAM PA, GONZALES CR, SCHWARTZ SD: Severe steroid-induced glaucoma following intravitreal injection of triamcinolone acetonide. Am. J. Ophthalmol. (2006) 141(3):580-582.
    • (2006) Am. J. Ophthalmol , vol.141 , Issue.3 , pp. 580-582
    • QUIRAM, P.A.1    GONZALES, C.R.2    SCHWARTZ, S.D.3
  • 45
    • 1842556483 scopus 로고    scopus 로고
    • Intractable glaucoma following intravitreal triamcinolone in central retinal vein occlusion
    • KAUSHIK S, GUPTA V, GUPTA A et al.: Intractable glaucoma following intravitreal triamcinolone in central retinal vein occlusion. Am. J. Ophthalmol. (2004) 137(4):758-760.
    • (2004) Am. J. Ophthalmol , vol.137 , Issue.4 , pp. 758-760
    • KAUSHIK, S.1    GUPTA, V.2    GUPTA, A.3
  • 46
    • 30344444276 scopus 로고    scopus 로고
    • Argon laser trabeculoplasty for intractable glaucoma following intravitreal triamcinolone
    • VIOLA F, MORESCALCHI F, STAURENGHI G: Argon laser trabeculoplasty for intractable glaucoma following intravitreal triamcinolone. Arch. Ophthalmol. (2006) 124(1):133-134.
    • (2006) Arch. Ophthalmol , vol.124 , Issue.1 , pp. 133-134
    • VIOLA, F.1    MORESCALCHI, F.2    STAURENGHI, G.3
  • 47
    • 7544232838 scopus 로고    scopus 로고
    • Intravitreal triamcinolone acetonide and intraocular pressure
    • SMITHEN LM, OBER MD, MARANAN L et al.: Intravitreal triamcinolone acetonide and intraocular pressure. Am. J. Ophthalmol. (2004) 138(5):740-743.
    • (2004) Am. J. Ophthalmol , vol.138 , Issue.5 , pp. 740-743
    • SMITHEN, L.M.1    OBER, M.D.2    MARANAN, L.3
  • 48
    • 33645290250 scopus 로고    scopus 로고
    • Cataract formation and other complications of intravitreal triamcinolone for macular edema
    • THOMPSON JT: Cataract formation and other complications of intravitreal triamcinolone for macular edema. Am. J. Ophthalmol. (2006) 141(4):629-637.
    • (2006) Am. J. Ophthalmol , vol.141 , Issue.4 , pp. 629-637
    • THOMPSON, J.T.1
  • 49
    • 23844554479 scopus 로고    scopus 로고
    • Acute endophthalmitis incidence: Intravitreal Triamcinolone
    • WESTFALL AC, OSBORN A, KUHL D et ai.: Acute endophthalmitis incidence: intravitreal Triamcinolone. Arch. Ophthalmol. (2005) 123(8):1075-1077.
    • (2005) Arch. Ophthalmol , vol.123 , Issue.8 , pp. 1075-1077
    • WESTFALL, A.C.1    OSBORN, A.2    KUHL, D.3    et ai4
  • 50
    • 10744233542 scopus 로고    scopus 로고
    • Acute endophthalmitis following intravitreal triamcinolone acetonide injection
    • MOSHFEGHI DM, KAISER PK, SCOTT IU et al.: Acute endophthalmitis following intravitreal triamcinolone acetonide injection. Am. J. Ophthalmol. (2003) 136(5):791-796.
    • (2003) Am. J. Ophthalmol , vol.136 , Issue.5 , pp. 791-796
    • MOSHFEGHI, D.M.1    KAISER, P.K.2    SCOTT, I.U.3
  • 51
    • 0025874961 scopus 로고
    • Toxicity of high-dose intravitreal dexamethasone
    • NABIH M, PEYMAN GA, TAWAKOL ME et al.: Toxicity of high-dose intravitreal dexamethasone. Int. Ophthalmol. (1991) 15:233-235.
    • (1991) Int. Ophthalmol , vol.15 , pp. 233-235
    • NABIH, M.1    PEYMAN, G.A.2    TAWAKOL, M.E.3
  • 52
    • 0026515817 scopus 로고
    • Evaluation of the retinal toxicity and pharmacokinetics of dexamethasone after intravitreal injection
    • KWAK HW, D'AMICO DJ: Evaluation of the retinal toxicity and pharmacokinetics of dexamethasone after intravitreal injection. Arch. Ophthalmol. (1992) 110:259-266.
    • (1992) Arch. Ophthalmol , vol.110 , pp. 259-266
    • KWAK, H.W.1    D'AMICO, D.J.2
  • 53
    • 0026385872 scopus 로고
    • Effect of intravitreal dexamethasone on ocular histopathology in a rabbit model of endophthalmitis
    • MAXWELL DP Jr, BRENT BD, DIAMOND JG et al.: Effect of intravitreal dexamethasone on ocular histopathology in a rabbit model of endophthalmitis. Ophthalmology (1991) 98:1370-1375.
    • (1991) Ophthalmology , vol.98 , pp. 1370-1375
    • MAXWELL Jr, D.P.1    BRENT, B.D.2    DIAMOND, J.G.3
  • 54
    • 33947275043 scopus 로고    scopus 로고
    • Randomized controlled study of an intravitreous dexamethasone drug delivery system in patients with persistent macular edema
    • KUPPERMANN BD, BLUMENKRANZ MS, HALLER JA et al.: Randomized controlled study of an intravitreous dexamethasone drug delivery system in patients with persistent macular edema. Arch. Ophthalmol. (2007) 125(3):309-317.
    • (2007) Arch. Ophthalmol , vol.125 , Issue.3 , pp. 309-317
    • KUPPERMANN, B.D.1    BLUMENKRANZ, M.S.2    HALLER, J.A.3
  • 55
    • 16844362809 scopus 로고    scopus 로고
    • FLUOCINOLONE ACETONIDE OPHTHALMIC-BAUSCH & LOMB: Fluocinolone acetonide envision TD implant. Drugs RD (2005) 6:116-119.
    • FLUOCINOLONE ACETONIDE OPHTHALMIC-BAUSCH & LOMB: Fluocinolone acetonide envision TD implant. Drugs RD (2005) 6:116-119.
  • 56
    • 58149274997 scopus 로고    scopus 로고
    • Fluocinolone acetonide intravitreal implant to treat diabetic macular edema: 3-year results of a multi-center clinical trial
    • FLUOCINOLONE ACETONIDE IMPLANT STUDY GROUP:, Abstract
    • FLUOCINOLONE ACETONIDE IMPLANT STUDY GROUP: Fluocinolone acetonide intravitreal implant to treat diabetic macular edema: 3-year results of a multi-center clinical trial. Invest. Ophthalmol. Vis. Sci. (2006) 47:E5442 (Abstract).
    • (2006) Invest. Ophthalmol. Vis. Sci , vol.47
  • 57
    • 0028123090 scopus 로고
    • Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy
    • ADAMIS AP, MILLER JW, BERNAL MT et al.: Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am. J. Ophthalmol. (1994) 118:445-450.
    • (1994) Am. J. Ophthalmol , vol.118 , pp. 445-450
    • ADAMIS, A.P.1    MILLER, J.W.2    BERNAL, M.T.3
  • 58
    • 0027942607 scopus 로고    scopus 로고
    • AIELLO LP, AVERY RL, ARRIGG et al.: Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N. Engl. J. Med. (1994) 331:1480-1487. • This pioneer report describes the enhanced levels of VEGF in the vitreous of diabetic patients.
    • AIELLO LP, AVERY RL, ARRIGG PG et al.: Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N. Engl. J. Med. (1994) 331:1480-1487. • This pioneer report describes the enhanced levels of VEGF in the vitreous of diabetic patients.
  • 59
    • 0027962667 scopus 로고
    • Detection of vascular endothelial growth factor messenger RNA and vascular endothelial growth factor-like activity in proliferative diabetic retinopathy
    • MALECAZE F, CLAMENS S, SIMORRE-PINATEL V et al.: Detection of vascular endothelial growth factor messenger RNA and vascular endothelial growth factor-like activity in proliferative diabetic retinopathy. Arch. Ophthalmol. (1994) 112:1476-1482.
    • (1994) Arch. Ophthalmol , vol.112 , pp. 1476-1482
    • MALECAZE, F.1    CLAMENS, S.2    SIMORRE-PINATEL, V.3
  • 60
    • 0036179104 scopus 로고    scopus 로고
    • Pathologic features of vascular endothelial growth factor-induced retinopathy in the nonhuman primate
    • TOLENTINO MJ, MCLEOD DS, TAOMOTO M et al.: Pathologic features of vascular endothelial growth factor-induced retinopathy in the nonhuman primate. Am. J. Ophthalmol. (2002) 133:373-385.
    • (2002) Am. J. Ophthalmol , vol.133 , pp. 373-385
    • TOLENTINO, M.J.1    MCLEOD, D.S.2    TAOMOTO, M.3
  • 61
    • 0029803087 scopus 로고    scopus 로고
    • Intravitreous injections of vascular endothelial growth factor produce retinal ischemia and microangiopathy in an adult primate
    • TOLENTINO MJ, MILLER JW, GRAGOUDAS ES et al.: Intravitreous injections of vascular endothelial growth factor produce retinal ischemia and microangiopathy in an adult primate. Ophthalmology (1996) 103:1820-1828.
    • (1996) Ophthalmology , vol.103 , pp. 1820-1828
    • TOLENTINO, M.J.1    MILLER, J.W.2    GRAGOUDAS, E.S.3
  • 62
    • 0034854865 scopus 로고    scopus 로고
    • VEGF-initiated bloodretinal barrier breakdown in early diabetes
    • QAUM T, XU Q, JOUSSEN AM et al.: VEGF-initiated bloodretinal barrier breakdown in early diabetes. Invest. Ophthalmol. Vis. Sci. (2001) 42:2408-2413.
    • (2001) Invest. Ophthalmol. Vis. Sci , vol.42 , pp. 2408-2413
    • QAUM, T.1    XU, Q.2    JOUSSEN, A.M.3
  • 64
    • 7444240909 scopus 로고    scopus 로고
    • VEGF165b, an inhibitory vascular endothelial growth factor splice variant: Mechanism of action, in vivo effect on angiogenesis and endogenous protein expression
    • WOOLARD J, WANG WY, BEVAN HS et al.: VEGF165b, an inhibitory vascular endothelial growth factor splice variant: mechanism of action, in vivo effect on angiogenesis and endogenous protein expression. Cancer Res. (2004) 64(21):7822-7835.
    • (2004) Cancer Res , vol.64 , Issue.21 , pp. 7822-7835
    • WOOLARD, J.1    WANG, W.Y.2    BEVAN, H.S.3
  • 65
    • 34547119296 scopus 로고    scopus 로고
    • Emerging therapies for the treatment of neovascular age-related macular degeneration and diabetic macular edema
    • EMERSON MV, LAUER AK: Emerging therapies for the treatment of neovascular age-related macular degeneration and diabetic macular edema. BioDrugs (2007) 21(4):245-257.
    • (2007) BioDrugs , vol.21 , Issue.4 , pp. 245-257
    • EMERSON, M.V.1    LAUER, A.K.2
  • 66
    • 25844513658 scopus 로고    scopus 로고
    • Macugen diabetic retinopathy study group: A Phase II randomized double-masked trial of pegaptanib, an antivascular endothelial gtowth factor aptamer, for diabetic macular edema
    • CUNNINGHAM ET Jr, ADAMIS AP, ALTAWEEL M et al.: Macugen diabetic retinopathy study group: a Phase II randomized double-masked trial of pegaptanib, an antivascular endothelial gtowth factor aptamer, for diabetic macular edema. Ophthalmology (2005) 112:1747-1757.
    • (2005) Ophthalmology , vol.112 , pp. 1747-1757
    • CUNNINGHAM Jr, E.T.1    ADAMIS, A.P.2    ALTAWEEL, M.3
  • 67
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • HURWITZ H, FEHRENBACHER L, NOVOTNY W et al.: Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N. Engl. J. Med. (2004) 350(23):2335-2342.
    • (2004) N. Engl. J. Med , vol.350 , Issue.23 , pp. 2335-2342
    • HURWITZ, H.1    FEHRENBACHER, L.2    NOVOTNY, W.3
  • 68
    • 23044505200 scopus 로고    scopus 로고
    • Optical coherence tomography findings after an intravitreal injection of bevacizumab (Avastin) for neovascular age-related macular degeneration
    • ROSENFELD PJ, MOSHFEGHI AA, PULIAFITO CA: Optical coherence tomography findings after an intravitreal injection of bevacizumab (Avastin) for neovascular age-related macular degeneration. Ophthal. Surg. Lasers Imaging (2005) 36(4):331-335.
    • (2005) Ophthal. Surg. Lasers Imaging , vol.36 , Issue.4 , pp. 331-335
    • ROSENFELD, P.J.1    MOSHFEGHI, A.A.2    PULIAFITO, C.A.3
  • 69
    • 23044440795 scopus 로고    scopus 로고
    • Optical coherence tomography findings after an intravitreal injection of bevacizumab (Avastin) for macular edema from central retinal vein occlusion
    • ROSENFELD PJ, FUNG AE, PULIAFITO CA: Optical coherence tomography findings after an intravitreal injection of bevacizumab (Avastin) for macular edema from central retinal vein occlusion. Ophthal. Surg. Lasers Imaging (2005) 36(4):336-339.
    • (2005) Ophthal. Surg. Lasers Imaging , vol.36 , Issue.4 , pp. 336-339
    • ROSENFELD, P.J.1    FUNG, A.E.2    PULIAFITO, C.A.3
  • 70
    • 33646447443 scopus 로고    scopus 로고
    • Regression of retinal and iris neovascularization after intravitreal bevacizumab (Avastin) treatment
    • AVERY RL: Regression of retinal and iris neovascularization after intravitreal bevacizumab (Avastin) treatment. Retina (2006) 26(3):352-354.
    • (2006) Retina , vol.26 , Issue.3 , pp. 352-354
    • AVERY, R.L.1
  • 71
    • 33749470397 scopus 로고    scopus 로고
    • Bilateral CRAO and CRVO from thrombotic thrombocytopenic purpura: OCT findings and treatment with triamcinolone acetonide and bevacizumab
    • SCHWARTZ SG, HICKEY M, PULIAFITO CA: Bilateral CRAO and CRVO from thrombotic thrombocytopenic purpura: OCT findings and treatment with triamcinolone acetonide and bevacizumab. Ophthalmic. Surg. Lasers Imaging (2006) 37(5):420-422.
    • (2006) Ophthalmic. Surg. Lasers Imaging , vol.37 , Issue.5 , pp. 420-422
    • SCHWARTZ, S.G.1    HICKEY, M.2    PULIAFITO, C.A.3
  • 72
    • 33646443430 scopus 로고    scopus 로고
    • Intravitreal bevacizumab (Avastin) for refractory pseudophakic cystoid macular edema
    • MASON JO, ALBERT MA, VAIL R: Intravitreal bevacizumab (Avastin) for refractory pseudophakic cystoid macular edema. Retina (2006) 26(3):356-357.
    • (2006) Retina , vol.26 , Issue.3 , pp. 356-357
    • MASON, J.O.1    ALBERT, M.A.2    VAIL, R.3
  • 73
    • 33845745774 scopus 로고    scopus 로고
    • Intravitreal bevacizumab (Avastin) therapy for persistent diffuse diabetic macular edema
    • HARITOGLOU C, KOOK D, NEUBAUER A: Intravitreal bevacizumab (Avastin) therapy for persistent diffuse diabetic macular edema. Retina (2006) 26(9):999-1005.
    • (2006) Retina , vol.26 , Issue.9 , pp. 999-1005
    • HARITOGLOU, C.1    KOOK, D.2    NEUBAUER, A.3
  • 74
    • 33947581702 scopus 로고    scopus 로고
    • AREVALO JF, FROMOW-GUERRA J, QUIROZ-MERCADO H et al.: Pan-American collaborative retina study group. Primary intravitreal bevacizumab (Avastin) for diabetic macular edema: results from the Pan-American collaborative retina study group at 6-month follow-up. Ophthalmology (2007) 114(4):743-750. • This multi-center pan-American group reported the safe and effective application of anti-VEGF Bevacizumab in the therapy of diabetic macular edema.
    • AREVALO JF, FROMOW-GUERRA J, QUIROZ-MERCADO H et al.: Pan-American collaborative retina study group. Primary intravitreal bevacizumab (Avastin) for diabetic macular edema: results from the Pan-American collaborative retina study group at 6-month follow-up. Ophthalmology (2007) 114(4):743-750. • This multi-center pan-American group reported the safe and effective application of anti-VEGF Bevacizumab in the therapy of diabetic macular edema.
  • 75
    • 34250774079 scopus 로고    scopus 로고
    • Bevacizumab (Avastin) for diabetic macular edema in previously vitrectomized eyes
    • YANYALI A, AYTUG B, HOROZOGLU F, NOHUTCU AF: Bevacizumab (Avastin) for diabetic macular edema in previously vitrectomized eyes. Am. J. Ophthalmol. (2007) 144(1):124-126.
    • (2007) Am. J. Ophthalmol , vol.144 , Issue.1 , pp. 124-126
    • YANYALI, A.1    AYTUG, B.2    HOROZOGLU, F.3    NOHUTCU, A.F.4
  • 77
    • 33645641520 scopus 로고    scopus 로고
    • HEIER JS, ANTOSZYK AN, PAVAN PR et al.: Ranibizumab for treatment of neovascular age-related macular degeneration: a Phase I/II multicenter, controlled, multidose study. Ophthalmology (2006) 113(4):642.E1- E4. (Epub 14 February 2006).
    • HEIER JS, ANTOSZYK AN, PAVAN PR et al.: Ranibizumab for treatment of neovascular age-related macular degeneration: a Phase I/II multicenter, controlled, multidose study. Ophthalmology (2006) 113(4):642.E1- E4. (Epub 14 February 2006).
  • 78
    • 33749451356 scopus 로고    scopus 로고
    • ANCHOR study group. Ranibizumab versus verteporfin for neovascular age-related macular degeneration
    • BROWN DM, KAISER PK, MICHELS M et al.: ANCHOR study group. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N. Engl. J. Med. (2006) 355(14):1432-1444.
    • (2006) N. Engl. J. Med , vol.355 , Issue.14 , pp. 1432-1444
    • BROWN, D.M.1    KAISER, P.K.2    MICHELS, M.3
  • 79
    • 33748957021 scopus 로고    scopus 로고
    • A pilot study of multiple intravitreal injections of ranibizumab in patients with center-involving clinically significant diabetic macular edema
    • CHUN DW, HEIER JS, TOPPING TM et al.: A pilot study of multiple intravitreal injections of ranibizumab in patients with center-involving clinically significant diabetic macular edema. Ophthalmology (2006) 113(10):1706-1712.
    • (2006) Ophthalmology , vol.113 , Issue.10 , pp. 1706-1712
    • CHUN, D.W.1    HEIER, J.S.2    TOPPING, T.M.3
  • 80
    • 33845191304 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is a critical stimulus for diabetic macular edema
    • NGUYEN QD, TATLIPINAR S, SHAH SM et al.: Vascular endothelial growth factor is a critical stimulus for diabetic macular edema. Am. J. Ophthalmol. (2006) 142(6):961-969.
    • (2006) Am. J. Ophthalmol , vol.142 , Issue.6 , pp. 961-969
    • NGUYEN, Q.D.1    TATLIPINAR, S.2    SHAH, S.M.3
  • 81
    • 36549057817 scopus 로고    scopus 로고
    • NGUYEN QD, SHAH SM, HAFIZ G et al.: CLEAR-AMD 1 study group. A Phase I trial of an IV-administered vascular endothelial growth factor trap for treatment in patients with choroidal neovascularization due to age-related macular degeneration. Ophthalmology (2006) 113(9):1522.E1-1522. E14. (Epub 28 July 2006).
    • NGUYEN QD, SHAH SM, HAFIZ G et al.: CLEAR-AMD 1 study group. A Phase I trial of an IV-administered vascular endothelial growth factor trap for treatment in patients with choroidal neovascularization due to age-related macular degeneration. Ophthalmology (2006) 113(9):1522.E1-1522. E14. (Epub 28 July 2006).
  • 82
    • 33746442378 scopus 로고    scopus 로고
    • VEGF trap as a novel antiangiogenic treatment currently in clinical trials for cancer and eye diseases, and VelociGene-based discovery of the next generation of angiogenesis targets
    • RUDGE JS, THURSTON G, DAVIS S et al.: VEGF trap as a novel antiangiogenic treatment currently in clinical trials for cancer and eye diseases, and VelociGene-based discovery of the next generation of angiogenesis targets. Cold Spring Harb. Symp. Quant. Biol. (2005) 70:411-418.
    • (2005) Cold Spring Harb. Symp. Quant. Biol , vol.70 , pp. 411-418
    • RUDGE, J.S.1    THURSTON, G.2    DAVIS, S.3
  • 83
    • 36549007009 scopus 로고    scopus 로고
    • Results of a Phase I study of intravitreal VEGF trap in subjects with diabetic macular edema: The CLEAR-IT DME study
    • Abstract
    • DO DV, NGUYEN QD, BROWNING DJ et al.: Results of a Phase I study of intravitreal VEGF trap in subjects with diabetic macular edema: the CLEAR-IT DME study. Invest. Ophthalmol. Vis. Sci. (2007) 48:E1430 (Abstract).
    • (2007) Invest. Ophthalmol. Vis. Sci , vol.48
    • DO, D.V.1    NGUYEN, Q.D.2    BROWNING, D.J.3
  • 84
    • 0037184495 scopus 로고    scopus 로고
    • Molecular understanding of hyperglycemias adverse effects for diabetic complications
    • SHEETZ MJ, KING GL: Molecular understanding of hyperglycemias adverse effects for diabetic complications. JAMA (2002) 288:2579-2588.
    • (2002) JAMA , vol.288 , pp. 2579-2588
    • SHEETZ, M.J.1    KING, G.L.2
  • 85
    • 0032104245 scopus 로고    scopus 로고
    • The extended protein kinase C superfamily
    • MELLOR H, PARKER PJ: The extended protein kinase C superfamily. Biochem. J. (1998) 332:281-292.
    • (1998) Biochem. J , vol.332 , pp. 281-292
    • MELLOR, H.1    PARKER, P.J.2
  • 86
    • 0036716566 scopus 로고    scopus 로고
    • Prospects for kinase activity modulators in the treatment of diabetes and diabetic complications
    • BULLOCK WH, MAGNUSON SR, CHOI S et al.: Prospects for kinase activity modulators in the treatment of diabetes and diabetic complications. Curr. Top. Med. Chem. (2002) 2:915-938.
    • (2002) Curr. Top. Med. Chem , vol.2 , pp. 915-938
    • BULLOCK, W.H.1    MAGNUSON, S.R.2    CHOI, S.3
  • 87
    • 15644366961 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective β-isoform-selective inhibitor
    • AIELLO LP, BURSELL SE, CLERMONT A et al.: Vascular endothelial growth factor induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective β-isoform-selective inhibitor. Diabetes (1997) 46:1473-1480.
    • (1997) Diabetes , vol.46 , pp. 1473-1480
    • AIELLO, L.P.1    BURSELL, S.E.2    CLERMONT, A.3
  • 88
    • 1842855296 scopus 로고    scopus 로고
    • Blood-retinal barrier breakdown induced by activation of protein kinase C via vasculat endothelial growth factor in streptozotocin-induced diabetic rats
    • XU X, ZHU Q, XIA X et al.: Blood-retinal barrier breakdown induced by activation of protein kinase C via vasculat endothelial growth factor in streptozotocin-induced diabetic rats. Curr. Eye Res. (2004) 28:251-256.
    • (2004) Curr. Eye Res , vol.28 , pp. 251-256
    • XU, X.1    ZHU, Q.2    XIA, X.3
  • 89
    • 8944246315 scopus 로고    scopus 로고
    • JIROUSEK M, GILLIG J, GONZALEZ C et al.: (S)-13-[(dimethylamino) methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimetheno-1H,13Hdibenzo[e,k]pyrrolo [3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-dione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C. J. Med. Chem. (1996) 39:2664-2671.
    • JIROUSEK M, GILLIG J, GONZALEZ C et al.: (S)-13-[(dimethylamino) methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimetheno-1H,13Hdibenzo[e,k]pyrrolo [3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-dione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C. J. Med. Chem. (1996) 39:2664-2671.
  • 90
    • 13344293711 scopus 로고    scopus 로고
    • Amelioration of vascular dysfunctions in diabetic rats by an oral PKC inhibitor
    • ISHII H, JIROUSEK M, KOYA D et al.: Amelioration of vascular dysfunctions in diabetic rats by an oral PKC inhibitor. Science (1996) 272:728-731.
    • (1996) Science , vol.272 , pp. 728-731
    • ISHII, H.1    JIROUSEK, M.2    KOYA, D.3
  • 91
    • 0033868806 scopus 로고    scopus 로고
    • PKC-β inhibitor (LY333531) attenuates leukocyte entrapment in retinal microcirculation of diabetic rats
    • NONAKA A, KIRYU J, TSUJIKAWA A et al.: PKC-β inhibitor (LY333531) attenuates leukocyte entrapment in retinal microcirculation of diabetic rats. Invest. Ophthalmol. Vis. Sci. (2000) 41:2702-2706.
    • (2000) Invest. Ophthalmol. Vis. Sci , vol.41 , pp. 2702-2706
    • NONAKA, A.1    KIRYU, J.2    TSUJIKAWA, A.3
  • 92
    • 0037341207 scopus 로고    scopus 로고
    • Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: Role of oxidants and protein kinase-C activation
    • ABIKO T, ABIKO A, CLERMONT A et al.: Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation. Diabetes (2003) 52:829-837.
    • (2003) Diabetes , vol.52 , pp. 829-837
    • ABIKO, T.1    ABIKO, A.2    CLERMONT, A.3
  • 93
    • 0031964664 scopus 로고    scopus 로고
    • Inhibition of intraocular neovascularization caused by retinal ischemia in pigs by PKC inhibition with LY333531
    • DANIS R, BINGAMAN D, JIROUSEK M, YANG Y: Inhibition of intraocular neovascularization caused by retinal ischemia in pigs by PKC inhibition with LY333531. Invest. Ophthalmol. Vis. Sci. (1998) 39:171-179.
    • (1998) Invest. Ophthalmol. Vis. Sci , vol.39 , pp. 171-179
    • DANIS, R.1    BINGAMAN, D.2    JIROUSEK, M.3    YANG, Y.4
  • 94
    • 21344435254 scopus 로고    scopus 로고
    • The effect of ruboxistaurin on visual loss in patients with moderately severe to vety severe nonproliferative diabetic retinopathy: Initial results of the protein kinase C β inhibitor diabetic retinopathy study (PKCDRS) multicenter randomized clinical trial
    • THE PKC-DRS STUDY GROUP
    • THE PKC-DRS STUDY GROUP: The effect of ruboxistaurin on visual loss in patients with moderately severe to vety severe nonproliferative diabetic retinopathy: initial results of the protein kinase C β inhibitor diabetic retinopathy study (PKCDRS) multicenter randomized clinical trial. Diabetes (2005) 54(7):2188-2197.
    • (2005) Diabetes , vol.54 , Issue.7 , pp. 2188-2197
  • 95
    • 33751520614 scopus 로고    scopus 로고
    • Effect of ruboxistaurin on visual loss in patients with diabetic retinopathy
    • PKC-DRS2 GROUP
    • PKC-DRS2 GROUP: Effect of ruboxistaurin on visual loss in patients with diabetic retinopathy. Ophthalmology (2006) 113(12):2221-2230.
    • (2006) Ophthalmology , vol.113 , Issue.12 , pp. 2221-2230
  • 96
    • 33947236725 scopus 로고    scopus 로고
    • Effect of ruboxistaurin in patients with diabetic macular edema: Thirty-month results of the tandomized PKC-DMES clinical trial
    • THE PKC-DMES STUDY GROUP
    • THE PKC-DMES STUDY GROUP: Effect of ruboxistaurin in patients with diabetic macular edema: thirty-month results of the tandomized PKC-DMES clinical trial. Arch. Ophthalmol. (2007) 125(3):318-324.
    • (2007) Arch. Ophthalmol , vol.125 , Issue.3 , pp. 318-324
  • 97
    • 0035281737 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of PKC412, an inhibitor of protein kinase C
    • PROPPER DJ, MCDONALD AC, MAN A et al.: Phase I and pharmacokinetic study of PKC412, an inhibitor of protein kinase C. J. Clin. Oncol. (2001) 19(5):1485-1492.
    • (2001) J. Clin. Oncol , vol.19 , Issue.5 , pp. 1485-1492
    • PROPPER, D.J.1    MCDONALD, A.C.2    MAN, A.3
  • 98
    • 1542742166 scopus 로고    scopus 로고
    • C99-PKC412-003 STUDY GROUP: Reduction of diabetic macular edema by oral administration of the kinase inhibitor PKC412
    • CAMPOCHIARO PA, C99-PKC412-003 STUDY GROUP: Reduction of diabetic macular edema by oral administration of the kinase inhibitor PKC412. Invest. Ophthalmol. Vis. Sci. (2004) 45(3):922-931.
    • (2004) Invest. Ophthalmol. Vis. Sci , vol.45 , Issue.3 , pp. 922-931
    • CAMPOCHIARO, P.A.1
  • 99
    • 0000379427 scopus 로고    scopus 로고
    • Dramatic inhibition of retinal and choroidal neovascularization by oral administration of a kinase inhibitor
    • SEO M, KWAK N, OZAKI H et al.: Dramatic inhibition of retinal and choroidal neovascularization by oral administration of a kinase inhibitor. Am. J. Pathol. (1999) 154:1743-1753.
    • (1999) Am. J. Pathol , vol.154 , pp. 1743-1753
    • SEO, M.1    KWAK, N.2    OZAKI, H.3
  • 100
    • 33847629710 scopus 로고    scopus 로고
    • Deficit of somatostatin in the vitreous fluid of patients with diabetic macular edema
    • SIMO R, CARRASCO E, FONOLLOSA A et al.: Deficit of somatostatin in the vitreous fluid of patients with diabetic macular edema. Diabetes Care (2007) 30(3):725-727.
    • (2007) Diabetes Care , vol.30 , Issue.3 , pp. 725-727
    • SIMO, R.1    CARRASCO, E.2    FONOLLOSA, A.3
  • 101
    • 0025297227 scopus 로고
    • Effect of one year continuous subcutaneous infusion of a somatostatin analogue, octreotide, on early retinopathy, metabolic control and thyroid function in Type I (insulin-dependent) diabetes mellitus
    • KIRKEGAARD C, NORGAARD K, SNORGAARD O et al.: Effect of one year continuous subcutaneous infusion of a somatostatin analogue, octreotide, on early retinopathy, metabolic control and thyroid function in Type I (insulin-dependent) diabetes mellitus. Acta Endocrinol. (Copenh) (1990) 122(6):766-772.
    • (1990) Acta Endocrinol. (Copenh) , vol.122 , Issue.6 , pp. 766-772
    • KIRKEGAARD, C.1    NORGAARD, K.2    SNORGAARD, O.3
  • 102
    • 1342345228 scopus 로고    scopus 로고
    • Sandostatin LAR for cystoid diabetic macular edema: A 1-year experience
    • HERNAEZ-ORTEGA MC, SOTO-PEDRE E, MARTIN JJ: Sandostatin LAR for cystoid diabetic macular edema: a 1-year experience. Diabetes Res. Clin. Pract. (2004) 64(1):71-72.
    • (2004) Diabetes Res. Clin. Pract , vol.64 , Issue.1 , pp. 71-72
    • HERNAEZ-ORTEGA, M.C.1    SOTO-PEDRE, E.2    MARTIN, J.J.3
  • 103
    • 0035191536 scopus 로고    scopus 로고
    • The effect of a growth hormone receptor antagonist drug on proliferative diabetic retinopathy
    • GROWTH HORMONE ANTAGONIST FOR PROLIFERATIVE DIABETIC RETINOPATHY STUDY GROUP
    • GROWTH HORMONE ANTAGONIST FOR PROLIFERATIVE DIABETIC RETINOPATHY STUDY GROUP: The effect of a growth hormone receptor antagonist drug on proliferative diabetic retinopathy. Ophthalmology (2001) 108(12):2266-2272.
    • (2001) Ophthalmology , vol.108 , Issue.12 , pp. 2266-2272
  • 104
    • 4344683381 scopus 로고    scopus 로고
    • Primary prevention of cardiovascular disease with atorvastatin in Type 2 diabetes in the collaborative atorvastatin diabetes study (CARDS): Multicentre randomised placebo-controlled trial
    • COLHOUN HM, BETTERIDGE DJ, DURRINGTON PN et al.: Primary prevention of cardiovascular disease with atorvastatin in Type 2 diabetes in the collaborative atorvastatin diabetes study (CARDS): multicentre randomised placebo-controlled trial. Lancet (2004) 364(9435):685-696.
    • (2004) Lancet , vol.364 , Issue.9435 , pp. 685-696
    • COLHOUN, H.M.1    BETTERIDGE, D.J.2    DURRINGTON, P.N.3
  • 105
    • 0026093735 scopus 로고
    • The Wisconsin epidemiologic study of diabetic retinopathy, XII: Relationship of serum cholesterol to retinopathy and hard exudates
    • KLEIN BEK, MOSS SE, KLEIN R, SURAWICZ TS: The Wisconsin epidemiologic study of diabetic retinopathy, XII: relationship of serum cholesterol to retinopathy and hard exudates. Ophthalmology (1991) 98:1261-1265.
    • (1991) Ophthalmology , vol.98 , pp. 1261-1265
    • KLEIN, B.E.K.1    MOSS, S.E.2    KLEIN, R.3    SURAWICZ, T.S.4
  • 106
    • 0029757496 scopus 로고    scopus 로고
    • Association of elevated serum lipid levels with retinal hard exudate in diabetic retinopathy. Early treatment diabetic retinopathy study (ETDRS)
    • CHEW EY, KLEIN ML, FERRIS FL III: Association of elevated serum lipid levels with retinal hard exudate in diabetic retinopathy. Early treatment diabetic retinopathy study (ETDRS) report 22. Arch. Ophthalmol. (1996) 114(9): 1079-1084.
    • (1996) Arch. Ophthalmol , vol.114 , Issue.9 , pp. 1079-1084
    • CHEW, E.Y.1    KLEIN, M.L.2    FERRIS III, F.L.3
  • 107
    • 1842608809 scopus 로고    scopus 로고
    • Lipid-lowering drug atorvastatin as an adjunct in the management of diabetic macular edema
    • GUPTA A, GUPTA V, THAPAR S, BHANSALI A: Lipid-lowering drug atorvastatin as an adjunct in the management of diabetic macular edema. Am. J. Ophthalmol. (2004) 137:675-682.
    • (2004) Am. J. Ophthalmol , vol.137 , pp. 675-682
    • GUPTA, A.1    GUPTA, V.2    THAPAR, S.3    BHANSALI, A.4
  • 109
    • 0034041303 scopus 로고    scopus 로고
    • Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: II. In vitro bioactivation and permeation of external ocular barriers
    • KE TL, GRAFF G, SPELLMAN JM, YANNI JM: Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: II. In vitro bioactivation and permeation of external ocular barriers. Inflammation (2000) 24(4):371-384.
    • (2000) Inflammation , vol.24 , Issue.4 , pp. 371-384
    • KE, T.L.1    GRAFF, G.2    SPELLMAN, J.M.3    YANNI, J.M.4
  • 110
    • 0034045508 scopus 로고    scopus 로고
    • Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: I. Assessment of anti-inflammatory efficacy
    • GAMACHE DA, GRAFF G, BRADY MT et al.: Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: I. Assessment of anti-inflammatory efficacy. Inflammation (2000) 24(4):357-370.
    • (2000) Inflammation , vol.24 , Issue.4 , pp. 357-370
    • GAMACHE, D.A.1    GRAFF, G.2    BRADY, M.T.3
  • 111
    • 33847028707 scopus 로고    scopus 로고
    • KERN TS, MILLER CM, DU Y et al.: Topical administration of nepafenac inhibits diabetes-induced retinal microvascular disease and underlying abnormalities of retinal metabolism and physiology. Diabetes (2007) 56(2):373-379. •• This ground-breaking investigative report reveals that topical drug application of an anti-inflammatory drug may influence the progression of diabetic retinopathy.
    • KERN TS, MILLER CM, DU Y et al.: Topical administration of nepafenac inhibits diabetes-induced retinal microvascular disease and underlying abnormalities of retinal metabolism and physiology. Diabetes (2007) 56(2):373-379. •• This ground-breaking investigative report reveals that topical drug application of an anti-inflammatory drug may influence the progression of diabetic retinopathy.
  • 112
    • 36549015720 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention. CDCs Diabetes Program, News and Information, Press Releases
    • http://www.cdc.gov/diabetes/news/docs/dpp.htm Centers for Disease Control and Prevention. CDCs Diabetes Program - News and Information - Press Releases - (2000).
    • (2000)
  • 113
    • 36549027918 scopus 로고    scopus 로고
    • Company Information. Press releases
    • http://www.regeneron.com/company/press_detail.asp?v_c_id=252 REGENERON: Company Information. Press releases (2006).
    • (2006)
  • 114
    • 36549005560 scopus 로고    scopus 로고
    • http://www.medicalnewstoday.com/articles/44387.php MediLexicon International Ltd. Acuity Pharmaceuticals Reports Positive Initial Phase II Results For Bevasiranib (Cand5) In Wet AMD (2007).
    • http://www.medicalnewstoday.com/articles/44387.php MediLexicon International Ltd. Acuity Pharmaceuticals Reports Positive Initial Phase II Results For Bevasiranib (Cand5) In Wet AMD (2007).
  • 115
    • 36549012266 scopus 로고    scopus 로고
    • http://www.bioadvance.com/downloads/fact-sheets/ACU_FS_0807.pdf Acuity Pharmaceuticals (2006).
    • (2006) Acuity Pharmaceuticals
  • 116
    • 36549023478 scopus 로고    scopus 로고
    • http://www.caringfordiabetes.com/ER/Conference Reports/ AAO2006__Las_Vegas/C575BhavsarFuture.cfm The Caring for Diabetes Educational Forum (2007).
    • http://www.caringfordiabetes.com/ER/Conference Reports/ AAO2006__Las_Vegas/C575BhavsarFuture.cfm The Caring for Diabetes Educational Forum (2007).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.