Advanced glycation end products, oxidative stress and metalloproteinases are altered in the cerebral microvasculature during aging

Current Neurovascular Research

Volumn 4, Issue 4, 2007, Pages 228-234

  Safciuc, Florentina ^a   Constantin, Alina ^a   Manea, Adrian ^a   Nicolae, Manuela ^a   Popov, Doina ^a   Raicu, Monica ^a   Alexandru, Dorin ^a   Constantinescu, Elena ^a  

^a INSTITUTE OF CELLULAR BIOLOGY AND PATHOLOGY NICOLAE SIMIONESCU   (Romania)

Author keywords

Antioxidant enzymes; Brain aging; Metalloproteinases; Microvessels; Oxidative stress; Protein carbonyls

Indexed keywords

ADVANCED GLYCATION END PRODUCT; GELATINASE A; GELATINASE B; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; SUPEROXIDE DISMUTASE;

AGING; ARTICLE; BRAIN MICROCIRCULATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; MALE; MICROSCOPY; MICROVASCULATURE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SPECTROPHOTOMETRY;

EID: 36549064271     PISSN: 15672026     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720207782446351     Document Type: Article

References (42)

1. Agarwal, R, Gupta, A, Shukla, GS. (1999) Developmental pattern of reactive oxygen species generation and antioxidative defense machinery in rat cerebral microvessels. Int J Dev Neurosci 17: 673-679.
2. Annuk, M, Zilmer, M, Lind, L, Linse, T, Feulstrom, B. (2001) Oxidative stress and endothelial function in chronic renal failure. J Am Soc Nephrol 12: 2747-2752.
3. Butterfield, DA, Perluigi, M, Sultana, R. (2006) Oxidative stress in Alzheimer's disease brain: New insights from redox proteomics. Eur J Pharmacol 545: 39-50.
4. Çakatay, U, Telci, A, Kayalì, R, Tekeli, F, Akçay, T, Sivas, A. (2001) Relation of oxidative protein damage and nitro tyrosine levels in the aging rat brain. Exp Gerontol 36: 221-229.
5. Castegna, A, Aksenov, M, Thongboonkerd, V, Klein, JB, Pierce, WM, Booze, R, Markesbery, WR, Butterfield, DA. (2002) Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase-related protein 2, a-enolase and heat shock cognate 71. J Neurochem 82: 1524-1532.
6. Crack, PJ, Cimdins, K, Ali, U, Hertzog, PJ, Iannello, RC. (2005) Lack of glutathione peroxidase-1 exacerbates Abeta-mediated neurotoxicity in cortical neurons. J Neural Transm 113: 645-657.
7. Dalle-Donne, I, Scaloni, A, Giustarini, D, Cavarra, E, Tell, G, Lungarella, G, Colombo, R, Rossi, R, Milzani, A. (2005) Proteins as biomarkers of oxidative/nitrosative stress in diseases: the contribution of redox proteomics. Mass Spectrom Rev 24: 55-99.
8. De la Torre, JC, Mussivand, T. (1993) Can disturbed brain microcirculation cause Alzheimer's disease? Neurol Res 15: 146-153.
9. Farkas, E, Luiten, PGM. (2001) Cerebral microvascular pathology in aging and Alzheimer's disease. Prog Neurobiol 64: 575-611.
10. Galis, ZS. (1999) Physiological and pathological remodeling of vascular matrix by matrix metalloproteinases. Acad Med Kinki Univ 24: 45-53.
11. Golden, TR, Hinerfeld, DA, Melov, S. (2002) Oxidative stress and aging: beyond correlation. Aging Cell 1: 117-123.
12. Grammas, P, Moore, P, Weigel, PH. (1999) Microvessels from Alzheimer's disease brains kill neurons in vitro. Am J Pathol 154: 337-342.
13. Grammas, P, Ovase, R. (2001) Inflammatory factors are elevated in brain microvessels in Alzheimer's disease. Neurobiol Aging 22: 837-842.
14. Gu, Z, Kaul, M, Yan, B, Kridel, SJ, Cui, J, Strongin, A, Smith, JW, Liddington, RC, Lipton, SA. (2002) S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death. Science 297: 1186-1190.
15. Joseph, JA, Shukitt-Hale, B, Denisova, NA, Bielinski, D, Martin, A, McEwen, JJ, Bickford, PC. (1999) Reversals of Age-Related Declines in Neuronal Signal Transduction, Cognitive, and Motor Behavioral Deficits with Blueberry, Spinach, or Strawberry Dietary Supplementation. J Neurosci 19: 8114-8121.
16. Kudo, T, Imaizumi, K, Tanimukai, H, Katayama, T, Sato, N, Nakamura, Y, Tanaka, T, Kashiwagi, Y, Jinno, Y, Tohyama, M, Takeda, M. (2000) Are cerebrovascular factors involved in Alzheimer's disease? Neurobiol Aging 21: 215-224.
17. Labat-Robert, J. (2004) Cell-matrix interactions in aging: role of receptors and matricryptins. Ageing Res Rev 3: 233-247.
18. Levin, ED. (2005) Extracellular superoxide dismutase (EC-SOD) quenches free radicals and attenuates age-related cognitive decline: opportunities for novel drug development in aging. Curr Alzheimer Res 2:191-196.
19. Levine, RL, Garland, D, Oliver, CN, Amici, A, Climent, I, Lenz, A-G, Ahn, BW, Shaltiel, S, Stadtman, ER. (1990) Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol 86: 464-478.
20. Levine, RL, Williams, JA, Stadtman, ER, Schacter, E. (1994) Carbonyl assay for determination of oxidatively modified proteins. Methods Enzymol 233: 346-357.
21. Lorenzl, S, Albers, DS, Relkin, N, Ngyuen, T, Hilgenberg, SL, Chirichigno, J, Cudkowicz, ME, Beal, MF. (2003) Increased plasma levels of matrix metalloproteinase-9 in patients with Alzheimer's disease. Neurochem Int 43: 191-6.
22. Lorenzl, S, Calingasan, N, Yang, L, Albers, DS, Shugama, S, Gregorio, J, Krell, HW, Chirichigno, J, Joh, T, Beal, MF. (2004) Matrix metalloproteinase-9 is elevated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice. Neuromolecular Med 5: 119-132.
23. Marlatt, M, Lee, H, Perry, G, Smith, MA, Zhu, X. (2004) Sources and mechanisms of cytoplasmic oxidative damage in Alzheimer's disease. Acta Neurobiol Exp 64: 81-87.
24. Lovell, MA, Xie, C, Markesbery, WR. (2001) Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures. Neurobiol Aging 22: 187-194.
25. Melov, S, Wolf, N, Strozyk, D, Doctrow, SR, Bush, AI. (2005) Mice transgenic for Alzheimer disease beta-amyloid develop lens cataracts that are rescued by antioxidant treatment. Free Radic Biol Med 38: 258-61.
26. Paget, C, Lecomte, M, Ruggiero, D, Wiernsperger, N, Lagarde, M. (1998) Modification of enzymatic antioxidants in retinal microvascular cells by glucose or advanced glycation end products. Free Rad Biol Med 25: 121-129.
27. Paoletti, F, Mocali, A. (1990) Determination of superoxide dismutase activity by purely chemical system based on NADPH oxidation. Methods Enzymol 186: 209-220.
28. Pardridge, WM, Eisenberg, J, Yamada, T. (1985) Rapid sequestration and degradation of somatostatin analogues by isolated brain microvessels. J Neurochem 44: 1178-1184.
29. Perry, G, Cash, AD, Smith, MA. (2002) Alzheimer disease and oxidative stress. J Biomed Biotechnol 2: 3.
30. Picklo, MJ, Montine, TJ, Amarnath, V, Neely, MD. (2002) carbonyl toxicology and alzheimer's disease. Toxicol Appl Pharmacol 184: 187-197.
31. Reddy, PH. (2006) Mitochondrial oxidative damage in aging and alzheimer's disease: implications for mitochondrially targeted antioxidant therapeutics. J Biomed Biotechnol 31372: 1-13.
32. Reiter, RJ. (1998) Oxidative damage in the central nervous system: protection by melatonin. Prog Neurobiol 56: 359-384.
33. Renaud, S, Erne, B, Fuhr, P, Said, G, Lacroix, C, Steck, AJ, Leppert, D. (2003) Matrix metalloproteinases-9 and -2 in secondary vasculitic neuropathies. Acta Neuropathol 105: 37-42.
34. Schuessel, K, Schäfer, S, Bayer, TA, Czech, C, Pradier, L, Müller-Spahn, F, Müller, WE, Eckert, A. (2005) Impaired Cu/Zn-SOD activity contributes to increased oxidative damage in APP transgenic mice. Neurobiol Dis 18: 89-99.
35. Smith, MA, Sayre, LM, Anderson, VE, Harris, PL, Beal, MF, Kowall, N, Perry, G. (1998) Cytochemical demonstration of oxidative damage in Alzheimer disease by immunochemical enhancement of the carbonyl reaction with 2,4-dinitrophenylhydrazine. J Histochem Cytochem 46:731-735.
36. Sohal, RS, Agarwal, S, Sohal, BH. (1995) Oxidative stress and aging in mongolian gerbil (Meriones unguiculatus). Mech Ageing Dev 81: 15-25.
37. Winblad, B. (2001) A bridge between brain and aging research. Brain Aging Int J 1: 3.
38. Wright, JW, Kramar, EA, Meighan, SE, Harding, JW. (2002) Extracellular matrix molecules, long-term potentiation, memory consolidation and the angiotensin system. Peptide 23: 221-246.
39. Wyss-Coray, T, Lin, C, Sanan, DA, Mucke, L, Masliah, E. (2000) Chronic overproduction of transforming growth factor-b1 by astrocytes promotes alzheimer's disease-like microvascular degeneration in transgenic mice. Am J Pathol 156: 139-150.
40. Yan, P, Hu, X, Song, H, Yin, K, Bateman, RI, Cirrito, JR, Xiao, Q, Hsu, FF, Turk, JW, Xu, J, Hsu, CY, Holtzman, DM, Lee, JM. (2006) Matrix metalloproteinase-9 degrades amyloid- fibrils in vitro and compact plaques in situ. J Biol Chem 281: 24566-24574.
41. Yin, K-J, Cirrito, RC, Yan, P, Hu, X, Xiao, Q, Pan, X, Bateman, R, Song, H, Hsu, FF, Turk, J, Xu, J, Hsu, CY, Mills, JC, Holtzman, DM, Lee, JM. (2006) Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-β peptide catabolism. J Neurosci 26: 10939-10948.
42. Zhu, Y, Carvey, PM, Ling, Z. (2006) Age-related changes in glutathione and glutathione-related enzymes in rat brain. Brain Res 1090: 35-44.