-
1
-
-
0037202189
-
Renal cancer: cytogenetic and molecular genetic aspects
-
Meloni-Ehrig A.M. Renal cancer: cytogenetic and molecular genetic aspects. Am. J. Med. Genet. 115 (2002) 164-172
-
(2002)
Am. J. Med. Genet.
, vol.115
, pp. 164-172
-
-
Meloni-Ehrig, A.M.1
-
3
-
-
13844273087
-
PI3K-Akt pathway: its functions and alterations in human cancer
-
Osaki M., Oshimura M., and Ito H. PI3K-Akt pathway: its functions and alterations in human cancer. Apoptosis 9 (2004) 667-676
-
(2004)
Apoptosis
, vol.9
, pp. 667-676
-
-
Osaki, M.1
Oshimura, M.2
Ito, H.3
-
4
-
-
4544299668
-
Focus on kidney cancer
-
Linehan W.M., and Zbar B. Focus on kidney cancer. Cancer Cell 6 (2004) 223-228
-
(2004)
Cancer Cell
, vol.6
, pp. 223-228
-
-
Linehan, W.M.1
Zbar, B.2
-
5
-
-
0030869787
-
Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element
-
Mazure N.M., Chen E.Y., Laderoute K.R., and Giaccia A.J. Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element. Blood 90 (1997) 3322-3331
-
(1997)
Blood
, vol.90
, pp. 3322-3331
-
-
Mazure, N.M.1
Chen, E.Y.2
Laderoute, K.R.3
Giaccia, A.J.4
-
6
-
-
0035477438
-
Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3′-kinase/Akt signaling pathway
-
Blancher C., Moore J.W., Robertson N., and Harris A.J. Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3′-kinase/Akt signaling pathway. Cancer Res. 61 (2001) 7349-7355
-
(2001)
Cancer Res.
, vol.61
, pp. 7349-7355
-
-
Blancher, C.1
Moore, J.W.2
Robertson, N.3
Harris, A.J.4
-
7
-
-
4043171462
-
Upstream and downstream of mTOR
-
Hay N., and Sonenberg N. Upstream and downstream of mTOR. Genes Dev. 18 (2004) 1926-1945
-
(2004)
Genes Dev.
, vol.18
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
8
-
-
4644239258
-
Genetic basis of cancer of the kidney: disease-specific approaches to therapy
-
Linehan W.M., Vasselli J., Srinivasan R., Walther M.M., Merino M., Choyke P., Vocke C., Schmidt L., Isaacs J.S., Glenn G., Toro J., Zbar B., Bottaro D., and Neckers L. Genetic basis of cancer of the kidney: disease-specific approaches to therapy. Clin. Cancer Res. 10 (2004) 6282S-6289S
-
(2004)
Clin. Cancer Res.
, vol.10
-
-
Linehan, W.M.1
Vasselli, J.2
Srinivasan, R.3
Walther, M.M.4
Merino, M.5
Choyke, P.6
Vocke, C.7
Schmidt, L.8
Isaacs, J.S.9
Glenn, G.10
Toro, J.11
Zbar, B.12
Bottaro, D.13
Neckers, L.14
-
9
-
-
0033551070
-
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
-
Cantley L.C., and Neel N.G. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 4240-4245
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 4240-4245
-
-
Cantley, L.C.1
Neel, N.G.2
-
10
-
-
0000227612
-
PTEN/MMAC1/TEP1 in signal transduction and tumorigenesis
-
Besson A., Robbins S.M., and Yong V.W. PTEN/MMAC1/TEP1 in signal transduction and tumorigenesis. Eur. J. Biochem. 263 (1999) 605-611
-
(1999)
Eur. J. Biochem.
, vol.263
, pp. 605-611
-
-
Besson, A.1
Robbins, S.M.2
Yong, V.W.3
-
11
-
-
0033539945
-
PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein
-
Paramio J.M., Navarro M., Segrelles C., Gomez-Casero E., and Jorcano J.L. PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein. Oncogene 18 (1999) 7462-7468
-
(1999)
Oncogene
, vol.18
, pp. 7462-7468
-
-
Paramio, J.M.1
Navarro, M.2
Segrelles, C.3
Gomez-Casero, E.4
Jorcano, J.L.5
-
12
-
-
33646706052
-
Oncogenic PI3K and its role in cancer
-
Samuels Y., and Ericson K. Oncogenic PI3K and its role in cancer. Curr. Opin. Oncol. 18 (2006) 77-82
-
(2006)
Curr. Opin. Oncol.
, vol.18
, pp. 77-82
-
-
Samuels, Y.1
Ericson, K.2
-
13
-
-
20144387695
-
PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma
-
Saal L.H., Holm K., Maurer M., Memeo L., Su T., Wang X., Yu J.S., Malmstrom P.O., Mansukhani M., Enoksson J., Hibshoosh H., Borge A., and Parsons R. PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. Cancer Res. 65 (2005) 2554-2559
-
(2005)
Cancer Res.
, vol.65
, pp. 2554-2559
-
-
Saal, L.H.1
Holm, K.2
Maurer, M.3
Memeo, L.4
Su, T.5
Wang, X.6
Yu, J.S.7
Malmstrom, P.O.8
Mansukhani, M.9
Enoksson, J.10
Hibshoosh, H.11
Borge, A.12
Parsons, R.13
-
14
-
-
13144249184
-
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
-
Suzuki A., de la Pompa J.L., Stambolic V., Elia A.J., Sasaki T., del B.B., Ho A., Wakeham A., Itie A., Khoo W., Fukumoto M., and Mak T.W. High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr. Biol. 8 (1998) 1169-1178
-
(1998)
Curr. Biol.
, vol.8
, pp. 1169-1178
-
-
Suzuki, A.1
de la Pompa, J.L.2
Stambolic, V.3
Elia, A.J.4
Sasaki, T.5
del, B.B.6
Ho, A.7
Wakeham, A.8
Itie, A.9
Khoo, W.10
Fukumoto, M.11
Mak, T.W.12
-
15
-
-
33745172528
-
The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice
-
Chen M.L., Xu P.Z., Peng X.D., Chen W.S., Guzman G., Yang X., Di Cristofano A., Pandolfi P.P., and Hay N. The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice. Genes Dev. 20 (2006) 1569-1574
-
(2006)
Genes Dev.
, vol.20
, pp. 1569-1574
-
-
Chen, M.L.1
Xu, P.Z.2
Peng, X.D.3
Chen, W.S.4
Guzman, G.5
Yang, X.6
Di Cristofano, A.7
Pandolfi, P.P.8
Hay, N.9
-
16
-
-
0035878552
-
Allelic loss at 10q23.3 but lack of mutation of PTEN/MMAC1 in chromophobe renal cell carcinoma
-
Sukosd F., Digon B., Fischer J., Pietsch T., and Kovacs G. Allelic loss at 10q23.3 but lack of mutation of PTEN/MMAC1 in chromophobe renal cell carcinoma. Cancer Genet. Cytogenet. 128 (2001) 161-163
-
(2001)
Cancer Genet. Cytogenet.
, vol.128
, pp. 161-163
-
-
Sukosd, F.1
Digon, B.2
Fischer, J.3
Pietsch, T.4
Kovacs, G.5
-
17
-
-
0036568448
-
Loss of tumor suppressor protein PTEN during renal carcinogenesis
-
Brenner W., Farber G., Herget T., Lehr H.A., Hengstler J.G., and Thuroff J.W. Loss of tumor suppressor protein PTEN during renal carcinogenesis. Int. J. Cancer 99 (2002) 53-57
-
(2002)
Int. J. Cancer
, vol.99
, pp. 53-57
-
-
Brenner, W.1
Farber, G.2
Herget, T.3
Lehr, H.A.4
Hengstler, J.G.5
Thuroff, J.W.6
-
18
-
-
0242330122
-
Expression of PTEN in renal cell carcinoma and its relation to tumor behavior and growth
-
Lee S.J., Kim S.H., Kim B.Y., Lee C.M., and Park S.C. Expression of PTEN in renal cell carcinoma and its relation to tumor behavior and growth. J. Surg. Oncol. 84 (2003) 166-172
-
(2003)
J. Surg. Oncol.
, vol.84
, pp. 166-172
-
-
Lee, S.J.1
Kim, S.H.2
Kim, B.Y.3
Lee, C.M.4
Park, S.C.5
-
19
-
-
0036097950
-
Intragenic PTEN/MMAC1 loss of heterozygosity in conventional (clear-cell) renal cell carcinoma is associated with poor patient prognosis
-
Velickovic M., Delahunt B., McIver B., and Grebe S.K. Intragenic PTEN/MMAC1 loss of heterozygosity in conventional (clear-cell) renal cell carcinoma is associated with poor patient prognosis. Mod. Pathol. 15 (2002) 479-485
-
(2002)
Mod. Pathol.
, vol.15
, pp. 479-485
-
-
Velickovic, M.1
Delahunt, B.2
McIver, B.3
Grebe, S.K.4
-
20
-
-
0035839614
-
Akt is activated in response to an apoptotic signal
-
Tang D., Okada H., Ruland J., Liu L., Stambolic V., Mak T.W., and Ingrama J. Akt is activated in response to an apoptotic signal. J. Biol. Chem. 276 (2001) 30461-30466
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 30461-30466
-
-
Tang, D.1
Okada, H.2
Ruland, J.3
Liu, L.4
Stambolic, V.5
Mak, T.W.6
Ingrama, J.7
-
21
-
-
2342565881
-
Advances in protein kinase B signalling: AKTion on multiple fronts
-
Brazil D.P., Yang Z.Z., and Hemmings B.A. Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem. Sci. 29 (2004) 233-242
-
(2004)
Trends Biochem. Sci.
, vol.29
, pp. 233-242
-
-
Brazil, D.P.1
Yang, Z.Z.2
Hemmings, B.A.3
-
22
-
-
0037304479
-
Elevated Akt activation and its impact on clinicopathological features of renal cell carcinoma
-
Horiguchi A., Oya M., Uchida A., Marumo K., and Murai M. Elevated Akt activation and its impact on clinicopathological features of renal cell carcinoma. J. Urol. 169 (2003) 710-713
-
(2003)
J. Urol.
, vol.169
, pp. 710-713
-
-
Horiguchi, A.1
Oya, M.2
Uchida, A.3
Marumo, K.4
Murai, M.5
-
23
-
-
33845478597
-
Regulation of Imaginal Disc Growth by Tumor-Suppressor Genes in Drosophila
-
Hariharan I.K., and Bilder D. Regulation of Imaginal Disc Growth by Tumor-Suppressor Genes in Drosophila. Annu. Rev. Genet. 40 (2006) 335-361
-
(2006)
Annu. Rev. Genet.
, vol.40
, pp. 335-361
-
-
Hariharan, I.K.1
Bilder, D.2
-
24
-
-
0037086001
-
Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB
-
Stocker H., Andjelkovic M., Oldham S., Laffargue M., Wymann M.P., Hemmings B.A., and Hafen E. Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB. Science 295 (2002) 2088-2091
-
(2002)
Science
, vol.295
, pp. 2088-2091
-
-
Stocker, H.1
Andjelkovic, M.2
Oldham, S.3
Laffargue, M.4
Wymann, M.P.5
Hemmings, B.A.6
Hafen, E.7
-
26
-
-
33746154235
-
Genetic background controls tumor development in PTEN-deficient mice
-
Freeman D., Lesche R., Kertesz N., Wang S., Li G., Gao J., Groszer M., Martinez-Diaz H., Rozengurt N., Thomas G., Liu X., and Wu H. Genetic background controls tumor development in PTEN-deficient mice. Cancer Res. 66 (2006) 6492-6496
-
(2006)
Cancer Res.
, vol.66
, pp. 6492-6496
-
-
Freeman, D.1
Lesche, R.2
Kertesz, N.3
Wang, S.4
Li, G.5
Gao, J.6
Groszer, M.7
Martinez-Diaz, H.8
Rozengurt, N.9
Thomas, G.10
Liu, X.11
Wu, H.12
-
27
-
-
13044250465
-
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
-
Podsypanina K., Ellenson L.H., Nemes A., Gu J., Tamura M., Yamada K.M., Cordon-Cardo C., Catoretti G., Fisher P.E., and Parsons R. Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 1563-1568
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 1563-1568
-
-
Podsypanina, K.1
Ellenson, L.H.2
Nemes, A.3
Gu, J.4
Tamura, M.5
Yamada, K.M.6
Cordon-Cardo, C.7
Catoretti, G.8
Fisher, P.E.9
Parsons, R.10
-
28
-
-
0034234268
-
High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice
-
Stambolic V., Tsao M.S., Macpherson D., Suzuki A., Chapman W.B., and Mak T.W. High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice. Cancer Res. 60 (2000) 3605-3611
-
(2000)
Cancer Res.
, vol.60
, pp. 3605-3611
-
-
Stambolic, V.1
Tsao, M.S.2
Macpherson, D.3
Suzuki, A.4
Chapman, W.B.5
Mak, T.W.6
-
29
-
-
13144249184
-
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
-
Suzuki A., de la Pompa J.L., Stambolic V., Elia A.J., Sasaki T., del Barco Barrantes I., Ho A., Wakeham A., Itie A., Khoo W., Fukumoto M., and Mak T.W. High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr. Biol. 8 (1998) 1169-1178
-
(1998)
Curr. Biol.
, vol.8
, pp. 1169-1178
-
-
Suzuki, A.1
de la Pompa, J.L.2
Stambolic, V.3
Elia, A.J.4
Sasaki, T.5
del Barco Barrantes, I.6
Ho, A.7
Wakeham, A.8
Itie, A.9
Khoo, W.10
Fukumoto, M.11
Mak, T.W.12
-
30
-
-
33644513730
-
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis
-
Cully M., You H., Levine A.J., and Mak T.W. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat. Rev., Cancer 6 (2006) 184-192
-
(2006)
Nat. Rev., Cancer
, vol.6
, pp. 184-192
-
-
Cully, M.1
You, H.2
Levine, A.J.3
Mak, T.W.4
-
31
-
-
21344446791
-
Akt activation in renal cell carcinoma: contribution of a decreased PTEN expression and the induction of apoptosis by an Akt inhibitor
-
Hara S., Oya M., Mizuno R., Horiguchi A., Marumo K., and Murai M. Akt activation in renal cell carcinoma: contribution of a decreased PTEN expression and the induction of apoptosis by an Akt inhibitor. Ann. Oncol. 16 (2005) 928-933
-
(2005)
Ann. Oncol.
, vol.16
, pp. 928-933
-
-
Hara, S.1
Oya, M.2
Mizuno, R.3
Horiguchi, A.4
Marumo, K.5
Murai, M.6
-
32
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov D.D., Guertin D.A., Ali S.M., and Sabatini D.M. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307 (2005) 1098-1101
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
33
-
-
0031001041
-
TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta
-
Li D.M., and Sun H. TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta. Cancer Res. 57 (1997) 2124-2129
-
(1997)
Cancer Res.
, vol.57
, pp. 2124-2129
-
-
Li, D.M.1
Sun, H.2
-
34
-
-
0032574718
-
Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression
-
Whang Y.E., Wu X., Suzuki H., Reiter R.E., Tran C., Vessella R.L., Said J.W., Isaacs W.B., and Sawyers C.J. Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 5246-5250
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 5246-5250
-
-
Whang, Y.E.1
Wu, X.2
Suzuki, H.3
Reiter, R.E.4
Tran, C.5
Vessella, R.L.6
Said, J.W.7
Isaacs, W.B.8
Sawyers, C.J.9
-
36
-
-
7144223432
-
PTEN mutations in gliomas and glioneuronal tumors
-
Duerr E.M., Rollbrocker B., Hayashi Y., Peters N., Meyer-Puttlitz B., Louis D.N., Schramm J., Wiestler O.D., Parsons R., Eng C., and von Deimling A. PTEN mutations in gliomas and glioneuronal tumors. Oncogene 16 (1998) 2259-2264
-
(1998)
Oncogene
, vol.16
, pp. 2259-2264
-
-
Duerr, E.M.1
Rollbrocker, B.2
Hayashi, Y.3
Peters, N.4
Meyer-Puttlitz, B.5
Louis, D.N.6
Schramm, J.7
Wiestler, O.D.8
Parsons, R.9
Eng, C.10
von Deimling, A.11
-
37
-
-
2342631914
-
The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif
-
Walker S.M., Leslie N.R., Perera N.M., Batty I.H., and Downes C.P. The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif. Biochem. J. 379 (2004) 301-307
-
(2004)
Biochem. J.
, vol.379
, pp. 301-307
-
-
Walker, S.M.1
Leslie, N.R.2
Perera, N.M.3
Batty, I.H.4
Downes, C.P.5
-
38
-
-
0033615538
-
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association
-
Lee J.O., Yang H., Georgescu M.M., Di Cristofano A., Maehama T., Shi Y., Dixon J., Pandolfi P., and Pavletich N.P. Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell 99 (1999) 323-334
-
(1999)
Cell
, vol.99
, pp. 323-334
-
-
Lee, J.O.1
Yang, H.2
Georgescu, M.M.3
Di Cristofano, A.4
Maehama, T.5
Shi, Y.6
Dixon, J.7
Pandolfi, P.8
Pavletich, N.P.9
-
39
-
-
17644371347
-
Functions and mechanisms of redox regulation of cystein-based phosphatase
-
Salmeen A., and Barford D. Functions and mechanisms of redox regulation of cystein-based phosphatase. Antioxid. Redox Signal. 7 (2005) 560-577
-
(2005)
Antioxid. Redox Signal.
, vol.7
, pp. 560-577
-
-
Salmeen, A.1
Barford, D.2
-
40
-
-
20244365801
-
DJ-1, a novel regulator of the tumor suppressor PTEN
-
Kim R.H., Peters M., Jang Y., Shi W., Pintilie M., Fletcher G.C., DeLuca C., Liepa J., Zhou L., Snow B., Binari R.C., Manoukian A.S., Bray M.R., Liu F.F., Tsao M.S., and Mak T.W. DJ-1, a novel regulator of the tumor suppressor PTEN. Cancer Cell 7 (2005) 263-273
-
(2005)
Cancer Cell
, vol.7
, pp. 263-273
-
-
Kim, R.H.1
Peters, M.2
Jang, Y.3
Shi, W.4
Pintilie, M.5
Fletcher, G.C.6
DeLuca, C.7
Liepa, J.8
Zhou, L.9
Snow, B.10
Binari, R.C.11
Manoukian, A.S.12
Bray, M.R.13
Liu, F.F.14
Tsao, M.S.15
Mak, T.W.16
-
41
-
-
17744399699
-
PTEN/MMAC1/TEP1 mutations in human primary renal-cell carcinomas and renal carcinoma cell lines
-
Kondo K., Yao M., Kobayashi K., Ota S., Yoshida M., Kaneko S., Baba M., Sakai N., Kishida T., Kawakami S., Uemura H., Nagashima Y., Nakatani Y., and Hosaka M. PTEN/MMAC1/TEP1 mutations in human primary renal-cell carcinomas and renal carcinoma cell lines. Int. J. Cancer 91 (2001) 219-224
-
(2001)
Int. J. Cancer
, vol.91
, pp. 219-224
-
-
Kondo, K.1
Yao, M.2
Kobayashi, K.3
Ota, S.4
Yoshida, M.5
Kaneko, S.6
Baba, M.7
Sakai, N.8
Kishida, T.9
Kawakami, S.10
Uemura, H.11
Nagashima, Y.12
Nakatani, Y.13
Hosaka, M.14
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