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Volumn 36, Issue 11-12, 2004, Pages 859-866

GIP as a potential therapeutic agent?

Author keywords

Gastric inhibitory polypeptide; GIP; Insulin secretion; Obesity; Type 2 diabetes

Indexed keywords

GASTRIC INHIBITORY POLYPEPTIDE; GASTROINTESTINAL HORMONE; GLUCAGON LIKE PEPTIDE 1; GLUCOSE DEPENDENT INSULINOTROPIC POLYPEPTIDE RECEPTOR AGONIST; GLUCOSE DEPENDENT INSULINOTROPIC POLYPEPTIDE RECEPTOR ANTAGONIST; HORMONE RECEPTOR BLOCKING AGENT; HORMONE RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG;

EID: 12244270387     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-826176     Document Type: Review
Times cited : (44)

References (118)
  • 1
    • 0014811685 scopus 로고
    • Further purification of a polypeptide demonstrating enterogastrone activity
    • Brown JC, Mutt V, Pederson RA. Further purification of a polypeptide demonstrating enterogastrone activity. J Physiol 1970; 209: 57-64
    • (1970) J Physiol , vol.209 , pp. 57-64
    • Brown, J.C.1    Mutt, V.2    Pederson, R.A.3
  • 2
    • 0015103223 scopus 로고
    • A gastric inhibitory polypeptide II. The complete amino acid sequence
    • Brown JC, Dryburgh JR. A gastric inhibitory polypeptide II. The complete amino acid sequence. Can J Biochem 1971; 49: 867-872
    • (1971) Can J Biochem , vol.49 , pp. 867-872
    • Brown, J.C.1    Dryburgh, J.R.2
  • 3
    • 0015015451 scopus 로고
    • A Gastric Inhibitory Polypeptide. I. The amino acid composition and the tryptic peptides
    • Brown JC. A Gastric Inhibitory Polypeptide. I. The amino acid composition and the tryptic peptides. Can J Biochem 1971; 49: 255-261
    • (1971) Can J Biochem , vol.49 , pp. 255-261
    • Brown, J.C.1
  • 4
    • 0015311027 scopus 로고
    • Inhibition of histamine-, pentagastrin-, and insulin-stimulated canine gastric secretion by pure 'gastric inhibitory polypeptide'
    • Pederson RA, Brown JC. Inhibition of histamine-, pentagastrin-, and insulin-stimulated canine gastric secretion by pure 'gastric inhibitory polypeptide'. Gastroenterology 1972; 62: 393-400
    • (1972) Gastroenterology , vol.62 , pp. 393-400
    • Pederson, R.A.1    Brown, J.C.2
  • 5
    • 0026472575 scopus 로고
    • Lack of effect of synthetic human gastric inhibitory polypeptide and glucagon-like peptide 1 [7-36 amide] infused at near-physiological concentrations on pentagastrin-stimulated gastric acid secretion in normal human subjects
    • Nauck MA, Bartels E, Ørskov C, Ebert R, Creutzfeldt W. Lack of effect of synthetic human gastric inhibitory polypeptide and glucagon-like peptide 1 [7-36 amide] infused at near-physiological concentrations on pentagastrin-stimulated gastric acid secretion in normal human subjects. Digestion 1992; 52: 214-221
    • (1992) Digestion , vol.52 , pp. 214-221
    • Nauck, M.A.1    Bartels, E.2    Ørskov, C.3    Ebert, R.4    Creutzfeldt, W.5
  • 7
    • 0015791989 scopus 로고
    • Stimulation of insulin secretion by gastric inhibitory polypeptide in man
    • Dupré J, Ross SA, Watson D, Brown JC. Stimulation of insulin secretion by gastric inhibitory polypeptide in man. J Clin Endocrinol Metab 1973; 37: 826-828
    • (1973) J Clin Endocrinol Metab , vol.37 , pp. 826-828
    • Dupré, J.1    Ross, S.A.2    Watson, D.3    Brown, J.C.4
  • 8
    • 0022385480 scopus 로고
    • Stimulation of insulin release in isolated rat islets by GIP in physiological concentrations and its relation to cyclic AMP content
    • Siegel EG, Creutzfeldt W. Stimulation of insulin release in isolated rat islets by GIP in physiological concentrations and its relation to cyclic AMP content. Diabetologia 1985; 28: 857-861
    • (1985) Diabetologia , vol.28 , pp. 857-861
    • Siegel, E.G.1    Creutzfeldt, W.2
  • 9
    • 0017189728 scopus 로고
    • The insulinotropic action of gastric inhibitory polypeptide in the perfused rat pancreas
    • Pederson RA, Brown JC. The insulinotropic action of gastric inhibitory polypeptide in the perfused rat pancreas. Endocrinology 1976; 99: 780-785
    • (1976) Endocrinology , vol.99 , pp. 780-785
    • Pederson, R.A.1    Brown, J.C.2
  • 10
    • 0023955686 scopus 로고
    • Immunoreactive gastric inhibitory polypeptide
    • Krarup T. Immunoreactive gastric inhibitory polypeptide. Endocrine Reviews 1988; 9: 122-133
    • (1988) Endocrine Reviews , vol.9 , pp. 122-133
    • Krarup, T.1
  • 11
    • 0022461548 scopus 로고
    • Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses
    • Nauck MA, Homberger E, Siegel EG, Allen RC, Eaton RP, Ebert R et al. Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses. J Clin Endocrinol Metab 1986; 63: 492-498
    • (1986) J Clin Endocrinol Metab , vol.63 , pp. 492-498
    • Nauck, M.A.1    Homberger, E.2    Siegel, E.G.3    Allen, R.C.4    Eaton, R.P.5    Ebert, R.6
  • 12
    • 0018138396 scopus 로고
    • Interaction of gastric inhibitory polypeptide, glucose, and arginine on insulin and glucagon secreton from the perfused rat pancreas
    • Pederson RA, Brown JC. Interaction of gastric inhibitory polypeptide, glucose, and arginine on insulin and glucagon secreton from the perfused rat pancreas. Endocrinol 1978; 103: 610-615
    • (1978) Endocrinol , vol.103 , pp. 610-615
    • Pederson, R.A.1    Brown, J.C.2
  • 13
    • 0038574573 scopus 로고    scopus 로고
    • Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia
    • Meier JJ, Gallwitz B, Siepmann N, Holst JJ, Deacon CF, Schmidt WE et al. Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia. Diabetologia 2003; 46: 798-801
    • (2003) Diabetologia , vol.46 , pp. 798-801
    • Meier, J.J.1    Gallwitz, B.2    Siepmann, N.3    Holst, J.J.4    Deacon, C.F.5    Schmidt, W.E.6
  • 14
    • 0031930530 scopus 로고    scopus 로고
    • Gastric inhibitory polypeptide and effects of glycation on glucose transport and metabolism in isolated mouse abdominal muscle
    • O'Harte FP, Gray AM, Flatt PR. Gastric inhibitory polypeptide and effects of glycation on glucose transport and metabolism in isolated mouse abdominal muscle. J Endocrinol 1998; 156: 237-243
    • (1998) J Endocrinol , vol.156 , pp. 237-243
    • O'Harte, F.P.1    Gray, A.M.2    Flatt, P.R.3
  • 15
    • 0025273277 scopus 로고
    • Lack of effect of gastric inhibitory polypeptide on hepatic and extrahepatic insulin action
    • Service FJ, Heiling VJ, Go VLW, Rizza RA. Lack of effect of gastric inhibitory polypeptide on hepatic and extrahepatic insulin action. J Clin Endocrinol Metab 1990; 70: 1398-1402
    • (1990) J Clin Endocrinol Metab , vol.70 , pp. 1398-1402
    • Service, F.J.1    Heiling, V.J.2    Go, V.L.W.3    Rizza, R.A.4
  • 16
    • 0018672563 scopus 로고
    • Gastric inhibitory polypeptide enhance lipoprotein lipase activity in cultured preadipocytes
    • Eckel RH, Fujimoto WY, Brunzell JD. Gastric inhibitory polypeptide enhance lipoprotein lipase activity in cultured preadipocytes. Diabetes 1979; 28: 1141-1142
    • (1979) Diabetes , vol.28 , pp. 1141-1142
    • Eckel, R.H.1    Fujimoto, W.Y.2    Brunzell, J.D.3
  • 17
    • 0020552646 scopus 로고
    • Gastric inhibitory polypeptide enhancement of the insulin effect on fatty acid incorporation into adipose tissue in the rat
    • Beck B, Max JP. Gastric inhibitory polypeptide enhancement of the insulin effect on fatty acid incorporation into adipose tissue in the rat. Regul Pept 1983; 7: 3-8
    • (1983) Regul Pept , vol.7 , pp. 3-8
    • Beck, B.1    Max, J.P.2
  • 18
    • 0023494098 scopus 로고
    • Hypersensitivity of adipose tissue to gastric inhibitory polypeptide action in obese Zucker rat
    • Beck B, Max JP. Hypersensitivity of adipose tissue to gastric inhibitory polypeptide action in obese Zucker rat. Cell Mol Biol 1987; 33: 555-562
    • (1987) Cell Mol Biol , vol.33 , pp. 555-562
    • Beck, B.1    Max, J.P.2
  • 19
    • 0025808278 scopus 로고
    • Effect of the entero-pancreatic hormones, gastric inhibitory polypeptide and glucagon-like polypeptide-1(7-36) amide, on fatty acid synthesis in explants of rat adipose tissue
    • Oben J, Morgan L, Fletcher J, Marks V. Effect of the entero-pancreatic hormones, gastric inhibitory polypeptide and glucagon-like polypeptide-1(7-36) amide, on fatty acid synthesis in explants of rat adipose tissue. J Endocrinol 1991; 130: 267-272
    • (1991) J Endocrinol , vol.130 , pp. 267-272
    • Oben, J.1    Morgan, L.2    Fletcher, J.3    Marks, V.4
  • 20
    • 0019407932 scopus 로고
    • Effect of gastric inhibitory polypeptide on plasma levels of chylomicron triglycerides in dogs
    • Wasada T, McCorkle K, Harris V, Kawai K, Howard B, Linger RH. Effect of gastric inhibitory polypeptide on plasma levels of chylomicron triglycerides in dogs. J Clin Invest 1981; 68: 1107-1110
    • (1981) J Clin Invest , vol.68 , pp. 1107-1110
    • Wasada, T.1    McCorkle, K.2    Harris, V.3    Kawai, K.4    Howard, B.5    Linger, R.H.6
  • 21
    • 0035008535 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic hormone potentiates the hyopglyacemic effect of glibenclamide in healthy volunteers: Evidence for an effect on insulin extraction
    • Kindmark H, Pigon J, Efendic S. Glucose-dependent insulinotropic hormone potentiates the hyopglyacemic effect of glibenclamide in healthy volunteers: evidence for an effect on insulin extraction. J Clin Endocrinol Metab 2001; 86: 2015-2019
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 2015-2019
    • Kindmark, H.1    Pigon, J.2    Efendic, S.3
  • 22
    • 0037447762 scopus 로고    scopus 로고
    • The reduction in hepatic insulin clearance after oral glucose is not mediated by gastric Inhibitory polypeptide (GIP)
    • Meier JJ, Gallwitz B, Siepmann N, Holst JJ, Deacon CF, Schmidt WE et al. The reduction in hepatic insulin clearance after oral glucose is not mediated by gastric Inhibitory polypeptide (GIP). Regul Peptides 2003; 113: 95-100
    • (2003) Regul Peptides , vol.113 , pp. 95-100
    • Meier, J.J.1    Gallwitz, B.2    Siepmann, N.3    Holst, J.J.4    Deacon, C.F.5    Schmidt, W.E.6
  • 23
    • 0036022670 scopus 로고    scopus 로고
    • Gastric inhibitory polypeptide analogues: Do they have a therapeutic role in diabetes mellitus similar to that of glucagon-like Peptide-1?
    • Holst JJ. Gastric inhibitory polypeptide analogues: do they have a therapeutic role in diabetes mellitus similar to that of glucagon-like Peptide-1? BioDrugs 2002; 16: 175-181
    • (2002) BioDrugs , vol.16 , pp. 175-181
    • Holst, J.J.1
  • 24
    • 0037334355 scopus 로고    scopus 로고
    • GIP or not GIP? That is the question
    • Kieffer TJ. GIP or not GIP? That is the question. Trends Pharmacol Sci 2003; 24: 110-112
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 110-112
    • Kieffer, T.J.1
  • 25
    • 0041592594 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide analogues and their therapeutic potential for the treatment of obesity-diabetes
    • Gault VA, Flatt PR, O'Harte FP. Glucose-dependent insulinotropic polypeptide analogues and their therapeutic potential for the treatment of obesity-diabetes. Biochem Biophys Res Commun 2003; 308: 207-213
    • (2003) Biochem Biophys Res Commun , vol.308 , pp. 207-213
    • Gault, V.A.1    Flatt, P.R.2    O'Harte, F.P.3
  • 26
    • 0344010130 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide (GIP): Anti-diabetic and anti-obesity potential?
    • Gault VA, O'Harte FP, Flatt PR. Glucose-dependent insulinotropic polypeptide (GIP): anti-diabetic and anti-obesity potential? Neuropeptides 2003; 37: 253-263
    • (2003) Neuropeptides , vol.37 , pp. 253-263
    • Gault, V.A.1    O'Harte, F.P.2    Flatt, P.R.3
  • 27
    • 0032587206 scopus 로고    scopus 로고
    • 2-terminally modified gastric inhibitory polypeptide exhibits amino-peptidase resistance and enhanced antihyperglycemic activity
    • 2-terminally modified gastric inhibitory polypeptide exhibits amino-peptidase resistance and enhanced antihyperglycemic activity. Diabetes 1999; 48: 758-765
    • (1999) Diabetes , vol.48 , pp. 758-765
    • O'Harte, F.P.1    Mooney, M.H.2    Flatt, P.R.3
  • 28
    • 0036317496 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV-resistant [D-Ala(2)]glucose-dependent insulinotropic polypeptide (GIP) improves glucose tolerance in normal and obese diabetic rats
    • Hinke SA, Gelling RW, Pederson RA, Manhart S, Nian C, Dernuth HU et al. Dipeptidyl peptidase IV-resistant [D-Ala(2)]glucose-dependent insulinotropic polypeptide (GIP) improves glucose tolerance in normal and obese diabetic rats. Diabetes 2002; 51: 652-661
    • (2002) Diabetes , vol.51 , pp. 652-661
    • Hinke, S.A.1    Gelling, R.W.2    Pederson, R.A.3    Manhart, S.4    Nian, C.5    Dernuth, H.U.6
  • 29
    • 0002101277 scopus 로고    scopus 로고
    • GIP analogues substituted at Ala2 exhibit improved plasma stability and insulin-releasing activity
    • Gault VA, Harriott P, Flatt PR, O'Harte FPM. GIP analogues substituted at Ala2 exhibit improved plasma stability and insulin-releasing activity (abstract). Diabetologia 2001; 44 (Suppl. 1): A195
    • (2001) Diabetologia , vol.44 , Issue.SUPPL. 1
    • Gault, V.A.1    Harriott, P.2    Flatt, P.R.3    O'Harte, F.P.M.4
  • 30
    • 0036844953 scopus 로고    scopus 로고
    • Enhanced cAMP generation and insulin-releasing potency of two novel Tyr1-modified enzyme-resistant forms of glucose dependent insulinotropic polypeptide is associated with significant antihyperglycaemic activity in spontaneous obesity-diabetes
    • Gault VA, Flatt PR, Bailey CJ, Harriott P, Greer B, Mooney MH et al. Enhanced cAMP generation and insulin-releasing potency of two novel Tyr1-modified enzyme-resistant forms of glucose dependent insulinotropic polypeptide is associated with significant antihyperglycaemic activity in spontaneous obesity-diabetes. Biochem J 2002; 367: 913-920
    • (2002) Biochem J , vol.367 , pp. 913-920
    • Gault, V.A.1    Flatt, P.R.2    Bailey, C.J.3    Harriott, P.4    Greer, B.5    Mooney, M.H.6
  • 31
    • 0037261678 scopus 로고    scopus 로고
    • DPP IV resistance and insulin releasing activity of a novel di-substituted analogue of glucose-dependent insulinotropic polypeptide, (Ser2-Asp13)GIP
    • Gault VA, Irwin N, Harriott P, Flatt PR, O'Harte FP DPP IV resistance and insulin releasing activity of a novel di-substituted analogue of glucose-dependent insulinotropic polypeptide, (Ser2-Asp13)GIP. Cell Biol Int 2003; 27: 41-46
    • (2003) Cell Biol Int , vol.27 , pp. 41-46
    • Gault, V.A.1    Irwin, N.2    Harriott, P.3    Flatt, P.R.4    O'Harte, F.P.5
  • 32
    • 0037253460 scopus 로고    scopus 로고
    • Improved biological activity of Gly2- and Ser2-substituted analogues of glucose-dependent insulinotrophic polypeptide
    • Gault VA, Flatt PR, Harriott P, Mooney MH, Bailey CJ, O'Harte FP. Improved biological activity of Gly2- and Ser2-substituted analogues of glucose-dependent insulinotrophic polypeptide. J Endocrinol 2003; 176: 133-141
    • (2003) J Endocrinol , vol.176 , pp. 133-141
    • Gault, V.A.1    Flatt, P.R.2    Harriott, P.3    Mooney, M.H.4    Bailey, C.J.5    O'Harte, F.P.6
  • 33
    • 0038818982 scopus 로고    scopus 로고
    • Degradation, cyclic adenosine monophosphate production, insulin secretion, and glycemic effects of two novel N-terminal Ala2-substituted analogs of glucose-dependent insulinotropic polypeptide with preserved biological activity in vivo
    • Gault VA, O'Harte FP, Harriott P, Flatt PR. Degradation, cyclic adenosine monophosphate production, insulin secretion, and glycemic effects of two novel N-terminal Ala2-substituted analogs of glucose-dependent insulinotropic polypeptide with preserved biological activity in vivo. Metabolism 2003; 52: 679-687
    • (2003) Metabolism , vol.52 , pp. 679-687
    • Gault, V.A.1    O'Harte, F.P.2    Harriott, P.3    Flatt, P.R.4
  • 34
    • 0036383414 scopus 로고    scopus 로고
    • Improved stability, insulin-releasing activity and antidiabetic potential of two novel N-terminal analogues of gastric inhibitory polypeptide: N-acetyl-GIP and pGlu-GIP
    • O'Harte FP, Gault VA, Parker JC, Harriott P, Mooney MH, Bailey CJ et al. Improved stability, insulin-releasing activity and antidiabetic potential of two novel N-terminal analogues of gastric inhibitory polypeptide: N-acetyl-GIP and pGlu-GIP. Diabetologia 2002; 45: 1281-1291
    • (2002) Diabetologia , vol.45 , pp. 1281-1291
    • O'Harte, F.P.1    Gault, V.A.2    Parker, J.C.3    Harriott, P.4    Mooney, M.H.5    Bailey, C.J.6
  • 35
    • 0036289106 scopus 로고    scopus 로고
    • Characterization of the cellular and metabolic effects of a novel enzyme-resistant antagonist of glucose-dependent insulinotropic polypeptide
    • Gault VA, O'Harte FP, Harriott P, Flatt PR. Characterization of the cellular and metabolic effects of a novel enzyme-resistant antagonist of glucose-dependent insulinotropic polypeptide. Biochem Biophys Res Commun 2002; 290: 1420-1426
    • (2002) Biochem Biophys Res Commun , vol.290 , pp. 1420-1426
    • Gault, V.A.1    O'Harte, F.P.2    Harriott, P.3    Flatt, P.R.4
  • 36
    • 0036068322 scopus 로고    scopus 로고
    • Inhibition of gastric inhibitory polypeptide signaling prevents obesity
    • Miyawaki K, Yamada Y, Ban N, Ihara Y, Tsukiyama K, Zhou H et al. Inhibition of gastric inhibitory polypeptide signaling prevents obesity. Nat Med 2002; 8: 738-742
    • (2002) Nat Med , vol.8 , pp. 738-742
    • Miyawaki, K.1    Yamada, Y.2    Ban, N.3    Ihara, Y.4    Tsukiyama, K.5    Zhou, H.6
  • 37
    • 33845344395 scopus 로고
    • Plasma insulin response to oral and intravenous glucose administration
    • Elrick H, Stimmler L, Hlad CJ, Arai Y. Plasma insulin response to oral and intravenous glucose administration. J Clin Endocrinol Metab 1964; 24: 1076-1082
    • (1964) J Clin Endocrinol Metab , vol.24 , pp. 1076-1082
    • Elrick, H.1    Stimmler, L.2    Hlad, C.J.3    Arai, Y.4
  • 38
    • 0023836241 scopus 로고
    • Incretin effect due to increased secretion and decreased clearance of insulin in normal humans
    • Shuster LT, Go VLW, Rizza RA, O'Brien PC, Service FJ. Incretin effect due to increased secretion and decreased clearance of insulin in normal humans. Diabetes 1988; 37: 200-203
    • (1988) Diabetes , vol.37 , pp. 200-203
    • Shuster, L.T.1    Go, V.L.W.2    Rizza, R.A.3    O'Brien, P.C.4    Service, F.J.5
  • 39
    • 0018758893 scopus 로고
    • The incretin concept today
    • Creutzfeldt W. The incretin concept today. Diabetologia 1979; 16: 75-85
    • (1979) Diabetologia , vol.16 , pp. 75-85
    • Creutzfeldt, W.1
  • 40
    • 0021864130 scopus 로고
    • New developments in the incretin concept
    • Creutzfeldt W, Ebert R. New developments in the incretin concept. Diabetologia 1985; 28: 565-573
    • (1985) Diabetologia , vol.28 , pp. 565-573
    • Creutzfeldt, W.1    Ebert, R.2
  • 41
    • 0022617246 scopus 로고
    • Reduced incretin effect in Type 2 (non-insulin-dependent) diabetes
    • Nauck M, Stöckmann F, Ebert R, Creutzfeldt W. Reduced incretin effect in Type 2 (non-insulin-dependent) diabetes. Diabetologia 1986; 29: 46-54
    • (1986) Diabetologia , vol.29 , pp. 46-54
    • Nauck, M.1    Stöckmann, F.2    Ebert, R.3    Creutzfeldt, W.4
  • 42
  • 43
    • 0021983672 scopus 로고
    • Effects of intravenously infused porcine GIP on serum insulin, plasma C-peptide, and pancreatic polypeptide in non-insulin-dependent diabetes in the fasting state
    • Amland PF, Jorde R, Aanderup S, Burhol PG, Giercksky K-E. Effects of intravenously infused porcine GIP on serum insulin, plasma C-peptide, and pancreatic polypeptide in non-insulin-dependent diabetes in the fasting state. Scand J Gastroenterol 1985; 20: 315-320
    • (1985) Scand J Gastroenterol , vol.20 , pp. 315-320
    • Amland, P.F.1    Jorde, R.2    Aanderup, S.3    Burhol, P.G.4    Giercksky, K.-E.5
  • 44
    • 0023092790 scopus 로고
    • The insulinotropic effect of gastric inhibitory polypeptide in non-insulin dependent diabetes
    • Jorde R, Burhol PG. The insulinotropic effect of gastric inhibitory polypeptide in non-insulin dependent diabetes. Ital J Gastroenterol 1987; 19: 76-78
    • (1987) Ital J Gastroenterol , vol.19 , pp. 76-78
    • Jorde, R.1    Burhol, P.G.2
  • 45
    • 0023179206 scopus 로고
    • Effect of porcine gastric inhibitory polypeptide on β-cell function in Type I and Type II diabetes mellitus
    • Krarup T, Saurbrey N, Moody AJ, Kühl C, Madsbad S. Effect of porcine gastric inhibitory polypeptide on β-cell function in Type I and Type II diabetes mellitus. Metabolism 1988; 36: 677-682
    • (1988) Metabolism , vol.36 , pp. 677-682
    • Krarup, T.1    Saurbrey, N.2    Moody, A.J.3    Kühl, C.4    Madsbad, S.5
  • 46
    • 0027391607 scopus 로고
    • Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus
    • Nauck MA, Heimesaat MM, Ørskov C, Holst JJ, Ebert R, Creutzfeldt W. Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J Clin Invest 1993; 91: 301-307
    • (1993) J Clin Invest , vol.91 , pp. 301-307
    • Nauck, M.A.1    Heimesaat, M.M.2    Ørskov, C.3    Holst, J.J.4    Ebert, R.5    Creutzfeldt, W.6
  • 47
    • 0035512742 scopus 로고    scopus 로고
    • Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes
    • Meier JJ, Hücking K, Holst JJ, Deacon C, Schmiegel W, Nauck MA. Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes. Diabetes 2001; 50: 2497-2504
    • (2001) Diabetes , vol.50 , pp. 2497-2504
    • Meier, J.J.1    Hücking, K.2    Holst, J.J.3    Deacon, C.4    Schmiegel, W.5    Nauck, M.A.6
  • 48
    • 0036373430 scopus 로고    scopus 로고
    • Defective amplification of the late phase insulin response to glucose by GIP in obese type II diabetic patients
    • Vilsbøll T, Krarup T, Madsbad S, Holst JJ. Defective amplification of the late phase insulin response to glucose by GIP in obese type II diabetic patients. Diabetologia 2002; 45: 1111-1119
    • (2002) Diabetologia , vol.45 , pp. 1111-1119
    • Vilsbøll, T.1    Krarup, T.2    Madsbad, S.3    Holst, J.J.4
  • 50
    • 0001095690 scopus 로고    scopus 로고
    • Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients
    • Vilsbøll T, Krarup T, Deacon CF, Madsbad S, Holst JJ. Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients. Diabetes 2001; 50: 609-613
    • (2001) Diabetes , vol.50 , pp. 609-613
    • Vilsbøll, T.1    Krarup, T.2    Deacon, C.F.3    Madsbad, S.4    Holst, J.J.5
  • 51
    • 0017047498 scopus 로고
    • Gastric inhibitory polypeptide (GIP) in maturity-onset diabetes mellitus
    • Crockett SE, Mazzaferri EL, Cataland S. Gastric inhibitory polypeptide (GIP) in maturity-onset diabetes mellitus. Diabetes 1976; 25: 931-935
    • (1976) Diabetes , vol.25 , pp. 931-935
    • Crockett, S.E.1    Mazzaferri, E.L.2    Cataland, S.3
  • 52
    • 0017377640 scopus 로고
    • Hypersecretion of gastric inhibitory polypeptide following oral glucose in diabetes mellitus
    • Ross SA, Brown JC, Dupré J. Hypersecretion of gastric inhibitory polypeptide following oral glucose in diabetes mellitus. Diabetes 1977; 26: 525-529
    • (1977) Diabetes , vol.26 , pp. 525-529
    • Ross, S.A.1    Brown, J.C.2    Dupré, J.3
  • 53
    • 0024397993 scopus 로고
    • The glucose dependent insulinotropic polypeptide response to oral glucose and mixed meals is increased in patients with type 2 (non-insulin-dependent) diabetes mellitus
    • Jones IR, Owens DR, Luzio S, Williams S, Hayes TM. The glucose dependent insulinotropic polypeptide response to oral glucose and mixed meals is increased in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1989; 32: 668-677
    • (1989) Diabetologia , vol.32 , pp. 668-677
    • Jones, I.R.1    Owens, D.R.2    Luzio, S.3    Williams, S.4    Hayes, T.M.5
  • 54
    • 0031781959 scopus 로고    scopus 로고
    • Discovery of amino acid variants in the human glucose-dependent insulinotropic polypeptide (GIP) receptor: The impact on the pancreatic beta cell response and functional expression studies in Chinese hamster fibroblast cells
    • Amlind K, Ambye L, Urhammer SA, Hansen T, Echwald SM, Holst JJ et al. Discovery of amino acid variants in the human glucose-dependent insulinotropic polypeptide (GIP) receptor: the impact on the pancreatic beta cell response and functional expression studies in Chinese hamster fibroblast cells. Diabetologia 1998; 41: 1194-1198
    • (1998) Diabetologia , vol.41 , pp. 1194-1198
    • Amlind, K.1    Ambye, L.2    Urhammer, S.A.3    Hansen, T.4    Echwald, S.M.5    Holst, J.J.6
  • 55
    • 10544249875 scopus 로고    scopus 로고
    • Identification of two missense mutations in the GIP receptor gene: A functional study and association analysis with NIDDM: No evidence of association with Japanese NIDDM subjects
    • Kubota A, Yamada Y, Hayami T, Yasuda K, Ihara Y, Kagimoto S et al. Identification of two missense mutations in the GIP receptor gene: a functional study and association analysis with NIDDM: no evidence of association with Japanese NIDDM subjects. Diabetes 1996; 45: 1701-1705
    • (1996) Diabetes , vol.45 , pp. 1701-1705
    • Kubota, A.1    Yamada, Y.2    Hayami, T.3    Yasuda, K.4    Ihara, Y.5    Kagimoto, S.6
  • 56
    • 0030876081 scopus 로고    scopus 로고
    • The pathogenesis of NIDDM involves a defective expression of the GIP receptor
    • Holst JJ, Gromada J, Nauck MA. The pathogenesis of NIDDM involves a defective expression of the GIP receptor. Diabetologia 1997; 40: 984-986
    • (1997) Diabetologia , vol.40 , pp. 984-986
    • Holst, J.J.1    Gromada, J.2    Nauck, M.A.3
  • 57
    • 0035041250 scopus 로고    scopus 로고
    • Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats
    • Lynn PC, Pamir N, Ng EH, McIntosh CH, Kieffeŕ TJ, Pederson RA. Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats. Diabetes 2001; 50: 1004-1011
    • (2001) Diabetes , vol.50 , pp. 1004-1011
    • Lynn, P.C.1    Pamir, N.2    Ng, E.H.3    McIntosh, C.H.4    Kieffeŕ, T.J.5    Pederson, R.A.6
  • 58
    • 0037268159 scopus 로고    scopus 로고
    • A novel pathway for regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta cells
    • Lynn FC, Thompson SA, Pospisilik JA, Ehses JA, Hinke SA, Pamir N et al. A novel pathway for regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta cells. Faseb J 2003; 17: 91-93
    • (2003) Faseb J , vol.17 , pp. 91-93
    • Lynn, F.C.1    Thompson, S.A.2    Pospisilik, J.A.3    Ehses, J.A.4    Hinke, S.A.5    Pamir, N.6
  • 59
    • 0037098963 scopus 로고    scopus 로고
    • Gastric inhibitory polypeptide (GIP): The neglected incretin revisited
    • Meier JJ, Nauck MA, Schmidt WE, Gallwitz B. Gastric inhibitory polypeptide (GIP): the neglected incretin revisited. Regul Peptides 2002; 107: 1-13
    • (2002) Regul Peptides , vol.107 , pp. 1-13
    • Meier, J.J.1    Nauck, M.A.2    Schmidt, W.E.3    Gallwitz, B.4
  • 61
    • 0026505012 scopus 로고
    • Comparison of the effect of GIP and GLP-1 (7-36amide) on insulin release from rat pancreatic islets
    • Siegel EG, Schulze A, Schmidt WE, Creutzfeldt W. Comparison of the effect of GIP and GLP-1 (7-36amide) on insulin release from rat pancreatic islets. Eur J Clin Invest 1992; 22: 154-157
    • (1992) Eur J Clin Invest , vol.22 , pp. 154-157
    • Siegel, E.G.1    Schulze, A.2    Schmidt, W.E.3    Creutzfeldt, W.4
  • 62
    • 0016583468 scopus 로고
    • Gastric inhibitory polypeptide. Its physiologic release and insulinotropic action in the dog
    • Pederson RA, Schubert HE, Brown JC. Gastric inhibitory polypeptide. Its physiologic release and insulinotropic action in the dog. Diabetes 1975; 24: 1050-1056
    • (1975) Diabetes , vol.24 , pp. 1050-1056
    • Pederson, R.A.1    Schubert, H.E.2    Brown, J.C.3
  • 63
    • 0007866067 scopus 로고    scopus 로고
    • Glucose intolerance caused by a defect in the entero-insular axis: A study in gastric inhibitory polypeptide receptor knockout mice
    • Miyawaki K, Yamada Y, Yano H, Niwa H, Ban N, Ihara Y et al. Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice. Proc Natl Acad Sci 1999; 96: 14843-14847
    • (1999) Proc Natl Acad Sci , vol.96 , pp. 14843-14847
    • Miyawaki, K.1    Yamada, Y.2    Yano, H.3    Niwa, H.4    Ban, N.5    Ihara, Y.6
  • 65
    • 0027419106 scopus 로고
    • Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations
    • Nauck MA, Bartels E, Ørskov C, Ebert R, Creutzfeldt W. Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations. J Clin Endocrinol Metab 1993; 76: 912-917
    • (1993) J Clin Endocrinol Metab , vol.76 , pp. 912-917
    • Nauck, M.A.1    Bartels, E.2    Ørskov, C.3    Ebert, R.4    Creutzfeldt, W.5
  • 66
    • 0345737203 scopus 로고    scopus 로고
    • Similar insulin secretory response to a GIP bolus injection at euglycemia in first-degree relatives of patients with type 2 diabetes and control subjects
    • Meier JJ, Nauck MA, Siepmann N, Greulich M, Holst JJ, Deacon CF et al. Similar insulin secretory response to a GIP bolus injection at euglycemia in first-degree relatives of patients with type 2 diabetes and control subjects. Metabolism 2003; 52: 1579-1585
    • (2003) Metabolism , vol.52 , pp. 1579-1585
    • Meier, J.J.1    Nauck, M.A.2    Siepmann, N.3    Greulich, M.4    Holst, J.J.5    Deacon, C.F.6
  • 67
    • 0024424884 scopus 로고
    • Insulinotropic properties of synthetic human gastric inhibitory polypeptide in man; interactions with glucose, phenylalanine, and cholezystokinin-8
    • Nauck M, Schmidt WE, Ebert R, Strietzel J, Cantor P, Hoffmann G et al. Insulinotropic properties of synthetic human gastric inhibitory polypeptide in man; interactions with glucose, phenylalanine, and cholezystokinin-8. J Clin Endocrinol Metab 1989; 69: 654-662
    • (1989) J Clin Endocrinol Metab , vol.69 , pp. 654-662
    • Nauck, M.1    Schmidt, W.E.2    Ebert, R.3    Strietzel, J.4    Cantor, P.5    Hoffmann, G.6
  • 68
    • 0029074964 scopus 로고
    • Pharmacokinetic, insulinotropic, and glucagonostatic properties of GLP-1 [7-;36 amide] after subcutaneous injection in healthy volunteers. Dose-response-relationships
    • Ritzel R, Ørskov C, Holst JJ, Nauck MA. Pharmacokinetic, insulinotropic, and glucagonostatic properties of GLP-1 [7-;36 amide] after subcutaneous injection in healthy volunteers. Dose-response-relationships. Diabetologia 1995; 38: 720-725
    • (1995) Diabetologia , vol.38 , pp. 720-725
    • Ritzel, R.1    Ørskov, C.2    Holst, J.J.3    Nauck, M.A.4
  • 69
    • 0037850667 scopus 로고    scopus 로고
    • Effect on glycemic control of exenatide (synthetic exendin-4) additive to existing metformin and/or sulfonylurea treatment in patients with type 2 diabetes
    • Fineman MS, Bicsak TA, Shen LZ, Taylor K, Gaines E, Varns A et al. Effect on glycemic control of exenatide (synthetic exendin-4) additive to existing metformin and/or sulfonylurea treatment in patients with type 2 diabetes. Diabetes Care 2003; 26: 2370-2377
    • (2003) Diabetes Care , vol.26 , pp. 2370-2377
    • Fineman, M.S.1    Bicsak, T.A.2    Shen, L.Z.3    Taylor, K.4    Gaines, E.5    Varns, A.6
  • 70
    • 0034838323 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide is a growth factor for beta (INS-1) cells by pleiotropic signaling
    • Trümper A, Trümper K, Trusheim H, Arnold R, Göke B, Horsch D. Glucose-dependent insulinotropic polypeptide is a growth factor for beta (INS-1) cells by pleiotropic signaling. Mol Endocrinol 2001; 15: 1559-1570
    • (2001) Mol Endocrinol , vol.15 , pp. 1559-1570
    • Trümper, A.1    Trümper, K.2    Trusheim, H.3    Arnold, R.4    Göke, B.5    Horsch, D.6
  • 71
    • 0036687655 scopus 로고    scopus 로고
    • Mechanisms of mitogenic and antiapoptotic signalling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells
    • Trümper A, Trümper K, Horsch D. Mechanisms of mitogenic and antiapoptotic signalling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells. J Endocrinol 2002; 174: 233-246
    • (2002) J Endocrinol , vol.174 , pp. 233-246
    • Trümper, A.1    Trümper, K.2    Horsch, D.3
  • 72
    • 1442350411 scopus 로고    scopus 로고
    • Secretion, degradation, and elimination of glucagon-like peptide 1 (GLP-1) and gastric inhibitory polypeptide (GIP) in patients with chronic renal insufficiency and healthy controls
    • Meier JJ, Nauck MA, Kranz D, Holst JJ, Deacon CF, Gaeckler D et al. Secretion, degradation, and elimination of glucagon-like peptide 1 (GLP-1) and gastric inhibitory polypeptide (GIP) in patients with chronic renal insufficiency and healthy controls. Diabetes 2004; 53: 654-662
    • (2004) Diabetes , vol.53 , pp. 654-662
    • Meier, J.J.1    Nauck, M.A.2    Kranz, D.3    Holst, J.J.4    Deacon, C.F.5    Gaeckler, D.6
  • 73
    • 0027215348 scopus 로고
    • Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum
    • Mentlein R, Gallwitz B, Schmidt WE. Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum. Eur J Biochem 1993; 214: 829-835
    • (1993) Eur J Biochem , vol.214 , pp. 829-835
    • Mentlein, R.1    Gallwitz, B.2    Schmidt, W.E.3
  • 74
    • 0033766716 scopus 로고    scopus 로고
    • Degradation of endogenous and exogenous gastric inhibitory polypeptide (GIP) in healthy and in Type 2 diabetic subjects as revealed using a new assay for the intact peptide
    • Deacon CF, Nauck MA, Meier JJ, Hücking K, Holst JJ. Degradation of endogenous and exogenous gastric inhibitory polypeptide (GIP) in healthy and in Type 2 diabetic subjects as revealed using a new assay for the intact peptide. J Clin Endocrinol Metab 2000; 85: 3575-3581
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 3575-3581
    • Deacon, C.F.1    Nauck, M.A.2    Meier, J.J.3    Hücking, K.4    Holst, J.J.5
  • 75
    • 1442321740 scopus 로고    scopus 로고
    • Evidence that the major degradation product of glucose-dependent insulinotropic polypeptide, GIP(3-42), is a GIP receptor antagonist in vivo
    • Gault VA, Parker JC, Harriott P, Flatt PR, O'Harte FP. Evidence that the major degradation product of glucose-dependent insulinotropic polypeptide, GIP(3-42), is a GIP receptor antagonist in vivo. J Endocrinol 2002; 175: 525-533
    • (2002) J Endocrinol , vol.175 , pp. 525-533
    • Gault, V.A.1    Parker, J.C.2    Harriott, P.3    Flatt, P.R.4    O'Harte, F.P.5
  • 76
    • 0023243048 scopus 로고
    • The effects of glucose-dependent insulinotropic polypeptide infused at physiological concentrations in normal subjects and Type 2 (non-insulin- dependent) diabetic patients on glucose tolerance and B-cell secretion
    • Jones IR, Owens DR, Moody AJ, Luzio SD, Morris T, Hayes TM. The effects of glucose-dependent insulinotropic polypeptide infused at physiological concentrations in normal subjects and Type 2 (non-insulin-dependent) diabetic patients on glucose tolerance and B-cell secretion. Diabetologia 1987; 30: 707-712
    • (1987) Diabetologia , vol.30 , pp. 707-712
    • Jones, I.R.1    Owens, D.R.2    Moody, A.J.3    Luzio, S.D.4    Morris, T.5    Hayes, T.M.6
  • 77
    • 0018074226 scopus 로고
    • The effect of endogenous Gastric Inhibitory Polypeptide on glucose-induced insulin secretion in mild diabetes
    • May JM, Williams RH. The effect of endogenous Gastric Inhibitory Polypeptide on glucose-induced insulin secretion in mild diabetes. Diabetes 1978; 27: 849-855
    • (1978) Diabetes , vol.27 , pp. 849-855
    • May, J.M.1    Williams, R.H.2
  • 78
    • 0027248866 scopus 로고
    • Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients
    • Nauck MA, Kleine N, Ørskov C, Holst JJ, Willms B, Creutzfeldt W. Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia 1993; 36: 741-744
    • (1993) Diabetologia , vol.36 , pp. 741-744
    • Nauck, M.A.1    Kleine, N.2    Ørskov, C.3    Holst, J.J.4    Willms, B.5    Creutzfeldt, W.6
  • 79
    • 0037667613 scopus 로고    scopus 로고
    • Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetes
    • Meier JJ, Gallwitz B, Salmen S, Goetze O, Holst JJ, Schmidt WE et al. Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetes. J Clin Endocrinol Metab 2003; 88: 2719-2725
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2719-2725
    • Meier, J.J.1    Gallwitz, B.2    Salmen, S.3    Goetze, O.4    Holst, J.J.5    Schmidt, W.E.6
  • 80
    • 0023758530 scopus 로고
    • Effect of truncated glucagon-like peptide-1 [proglucagon-(78-107) amide] on endocrine secretion from pig pancreas, antrum, and nonantral stomach
    • Ørskov C, Holst JJ, Nielsen OV. Effect of truncated glucagon-like peptide-1 [proglucagon-(78-107) amide] on endocrine secretion from pig pancreas, antrum, and nonantral stomach. Endocrinology 1988; 123: 2009-2013
    • (1988) Endocrinology , vol.123 , pp. 2009-2013
    • Ørskov, C.1    Holst, J.J.2    Nielsen, O.V.3
  • 83
    • 0026756184 scopus 로고
    • Gastric inhibitory polypeptide-dependent cortisol hypersecretion - A new cause of Cushing's Syndrome
    • Lacroix A, Bolté E, Tremblay J, Dupré J, Poitras P, Fournier H et al. Gastric inhibitory polypeptide-dependent cortisol hypersecretion - a new cause of Cushing's Syndrome. N Engl J Med 1992; 327: 974-980
    • (1992) N Engl J Med , vol.327 , pp. 974-980
    • Lacroix, A.1    Bolté, E.2    Tremblay, J.3    Dupré, J.4    Poitras, P.5    Fournier, H.6
  • 85
    • 0036189831 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men
    • Agersø H, Jensen LB, Elbrønd B, Rolan P, Zdravkovic M. The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men. Diabetologia 2002; 45: 195-202
    • (2002) Diabetologia , vol.45 , pp. 195-202
    • Agersø, H.1    Jensen, L.B.2    Elbrønd, B.3    Rolan, P.4    Zdravkovic, M.5
  • 86
    • 0018095493 scopus 로고
    • Effects of ingestion of triglycéride orgalactose on secretion of Gastric Inhibitory Polypeptide and on response to intravenous glucose in normal and diabetic subjects
    • Ross SA, Dupré J. Effects of ingestion of triglycéride orgalactose on secretion of Gastric Inhibitory Polypeptide and on response to intravenous glucose in normal and diabetic subjects. Diabetes 1978; 27: 327-333
    • (1978) Diabetes , vol.27 , pp. 327-333
    • Ross, S.A.1    Dupré, J.2
  • 88
    • 0018662619 scopus 로고
    • Impaired feedback control of fat induced gastric inhibitory polypeptide (GIP) secretion by insulin in obesity and glucose intolerance
    • Ebert R, Frerichs H, Creutzfeldt W. Impaired feedback control of fat induced gastric inhibitory polypeptide (GIP) secretion by insulin in obesity and glucose intolerance. Eur J Clin Invest 1979; 9: 129-135
    • (1979) Eur J Clin Invest , vol.9 , pp. 129-135
    • Ebert, R.1    Frerichs, H.2    Creutzfeldt, W.3
  • 89
    • 0017876434 scopus 로고
    • Gastric inhibitory polypeptide (GIP) and insulin in obesity: Increased response to stimulation and defective feedback control of serum levels
    • Creutzfeldt W, Ebert R, Willms B, Frerichs H, Brown JC. Gastric inhibitory polypeptide (GIP) and insulin in obesity: Increased response to stimulation and defective feedback control of serum levels. Diabetologia 1978; 14: 15-24
    • (1978) Diabetologia , vol.14 , pp. 15-24
    • Creutzfeldt, W.1    Ebert, R.2    Willms, B.3    Frerichs, H.4    Brown, J.C.5
  • 90
    • 0020411495 scopus 로고
    • Gastric inhibitory polypeptide release after oral glucose: Relationship to glucose intolerance, diabetes mellitus and obesity
    • Salera M, Giacomoni P, Pironi L, Cornia G, Capelli M, Marini A et al. Gastric inhibitory polypeptide release after oral glucose: Relationship to glucose intolerance, diabetes mellitus and obesity. J Clin Endocrinol Metab 1982; 55: 329-336
    • (1982) J Clin Endocrinol Metab , vol.55 , pp. 329-336
    • Salera, M.1    Giacomoni, P.2    Pironi, L.3    Cornia, G.4    Capelli, M.5    Marini, A.6
  • 91
    • 0021194112 scopus 로고
    • The enteric enhancement of glucose-stimulated insulin release: The role of GIP in aging, obesity, and non-insulin-dependent diabetes mellitus
    • Elahi D, Andersen DK, Muller DC, Tobin JD, Brown JC, Andres R. The enteric enhancement of glucose-stimulated insulin release: the role of GIP in aging, obesity, and non-insulin-dependent diabetes mellitus. Diabetes 1984; 33: 950-957
    • (1984) Diabetes , vol.33 , pp. 950-957
    • Elahi, D.1    Andersen, D.K.2    Muller, D.C.3    Tobin, J.D.4    Brown, J.C.5    Andres, R.6
  • 92
    • 0009910539 scopus 로고
    • GIP-the obesity hormone
    • James WPT, Parker SW (eds.). Southampton: Duphar Medical Relations
    • Marks V. GIP-the obesity hormone. In: James WPT, Parker SW (eds.). Obesity, current approaches. Southampton: Duphar Medical Relations, 1988: 13-20
    • (1988) Obesity, Current Approaches , pp. 13-20
    • Marks, V.1
  • 93
    • 0033520869 scopus 로고    scopus 로고
    • GIP biology and fat metabolism
    • Yip RG, Wolfe MM. GIP biology and fat metabolism. Life Sci 2000; 66: 91-103
    • (2000) Life Sci , vol.66 , pp. 91-103
    • Yip, R.G.1    Wolfe, M.M.2
  • 95
    • 0028855353 scopus 로고
    • Investigations into the actions of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1(7-36)amide on lipoprotein lipase activity in explants of rat adipose tissue
    • Knapper JM, Puddicombe SM, Morgan LM, Fletcher JM. Investigations into the actions of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1(7-36)amide on lipoprotein lipase activity in explants of rat adipose tissue. J Nutr 1995; 125: 183-188
    • (1995) J Nutr , vol.125 , pp. 183-188
    • Knapper, J.M.1    Puddicombe, S.M.2    Morgan, L.M.3    Fletcher, J.M.4
  • 96
    • 0017091713 scopus 로고
    • Inhibition of action of glucagon in adipocytes by gastric inhibitory polypeptide
    • Dupré J, Greenidge N, McDonald TJ, Ross SA, Rubinstein D. Inhibition of action of glucagon in adipocytes by gastric inhibitory polypeptide. Metabolism 1976; 25: 1197-1199
    • (1976) Metabolism , vol.25 , pp. 1197-1199
    • Dupré, J.1    Greenidge, N.2    McDonald, T.J.3    Ross, S.A.4    Rubinstein, D.5
  • 97
    • 0025750777 scopus 로고
    • Effect of exogenous or endogenous gastric inhibitory polypeptide (GIP) on plasma triglyceride response in rats
    • Ebert R, Nauck M, Creutzfeldt W. Effect of exogenous or endogenous gastric inhibitory polypeptide (GIP) on plasma triglyceride response in rats. Horm Metab Res 1991; 23: 517-521
    • (1991) Horm Metab Res , vol.23 , pp. 517-521
    • Ebert, R.1    Nauck, M.2    Creutzfeldt, W.3
  • 98
    • 0020959203 scopus 로고
    • Effect of enogenous gastric inhibitory polypeptide (GIP) on the removal of triacylglycerol in dogs
    • Ohneda A, Kobayashi T, Hihei J. Effect of enogenous gastric inhibitory polypeptide (GIP) on the removal of triacylglycerol in dogs. Regul Pept 1983; 6: 25-32
    • (1983) Regul Pept , vol.6 , pp. 25-32
    • Ohneda, A.1    Kobayashi, T.2    Hihei, J.3
  • 99
    • 0021191961 scopus 로고
    • Lack of effect of exogenous or endogenous gastric inhibitory polypeptide on the elimination rate of intralipid in man
    • Jorde R, Pettersen JE, Burhol PG. Lack of effect of exogenous or endogenous gastric inhibitory polypeptide on the elimination rate of intralipid in man. Acta Med Scand 1984; 216: 19-23
    • (1984) Acta Med Scand , vol.216 , pp. 19-23
    • Jorde, R.1    Pettersen, J.E.2    Burhol, P.G.3
  • 100
    • 0037299115 scopus 로고    scopus 로고
    • Effects of the novel (Pro(3))GIP antagonist and exendin(9-39)amide on GIP- and GLP-1-induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic (ob/ob) mice: Evidence that GIP is the major physiological incretin
    • Gault VA, O'Harte FP, Harriot P, Mooney MH, Green BD, Flatt PR. Effects of the novel (Pro(3))GIP antagonist and exendin(9-39)amide on GIP- and GLP-1-induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic (ob/ob) mice: evidence that GIP is the major physiological incretin. Diabetologia 2003; 46: 222-230
    • (2003) Diabetologia , vol.46 , pp. 222-230
    • Gault, V.A.1    O'Harte, F.P.2    Harriot, P.3    Mooney, M.H.4    Green, B.D.5    Flatt, P.R.6
  • 102
    • 0021175328 scopus 로고
    • Response of adipose tissue lipoprotein lipase activity and serum lipoproteins to acute hyperinsulinaemia in men
    • Yki-Järvinen H, Taskinen MR, Kovisto VA, Nikkila EA. Response of adipose tissue lipoprotein lipase activity and serum lipoproteins to acute hyperinsulinaemia in men. Diabetologia 1984; 27: 364-369
    • (1984) Diabetologia , vol.27 , pp. 364-369
    • Yki-Järvinen, H.1    Taskinen, M.R.2    Kovisto, V.A.3    Nikkila, E.A.4
  • 103
    • 0038121744 scopus 로고    scopus 로고
    • Both GLP-1 and GIP are insulinotropic at basal and postprandial glucose levels and contribute nearly equally to the incretin effect of a meal in healthy subjects
    • Vilsbøll T, Krarup T, Madsbad S, Holst JJ. Both GLP-1 and GIP are insulinotropic at basal and postprandial glucose levels and contribute nearly equally to the incretin effect of a meal in healthy subjects. Regul Pept 2003; 114: 115-121
    • (2003) Regul Pept , vol.114 , pp. 115-121
    • Vilsbøll, T.1    Krarup, T.2    Madsbad, S.3    Holst, J.J.4
  • 104
    • 0029834106 scopus 로고    scopus 로고
    • Postprandial stimulation of insulin release by glucose-dependent insulinotropic peptide (GIP). Effect of a specific glucose-dependent insulinotropic polypeptide receptor antagonist in the rat
    • Tseng C-C, Kieffer TJ, Jarboe LA, Usdin TB, Wolfe MM. Postprandial stimulation of insulin release by glucose-dependent insulinotropic peptide (GIP). Effect of a specific glucose-dependent insulinotropic polypeptide receptor antagonist in the rat. J Clin Invest 1996; 98: 2440-2445
    • (1996) J Clin Invest , vol.98 , pp. 2440-2445
    • Tseng, C.-C.1    Kieffer, T.J.2    Jarboe, L.A.3    Usdin, T.B.4    Wolfe, M.M.5
  • 105
  • 107
    • 0037097039 scopus 로고    scopus 로고
    • Acarbose for prevention of type 2 diabetes mellitus: The STOP-NIDDM randomised trial
    • Chiasson JL, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M. Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial. Lancet 2002; 359: 2072-2077
    • (2002) Lancet , vol.359 , pp. 2072-2077
    • Chiasson, J.L.1    Josse, R.G.2    Gomis, R.3    Hanefeld, M.4    Karasik, A.5    Laakso, M.6
  • 108
    • 0032449219 scopus 로고    scopus 로고
    • The genetic basis of type 2 diabetes mellitus: Impaired insulin secretion versus impaired insulin sensitivity
    • Gerich JE. The genetic basis of type 2 diabetes mellitus: impaired insulin secretion versus impaired insulin sensitivity. Endocrine Rev 1998; 19: 491-503
    • (1998) Endocrine Rev , vol.19 , pp. 491-503
    • Gerich, J.E.1
  • 109
    • 0026596851 scopus 로고
    • Antidiabetogenic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus
    • Gutniak MK, Holst JJ, Ørskov C, Åhren B, Efendic S. Antidiabetogenic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus. N Engl J Med 1992; 326: 1316-1322
    • (1992) N Engl J Med , vol.326 , pp. 1316-1322
    • Gutniak, M.K.1    Holst, J.J.2    Ørskov, C.3    Åhren, B.4    Efendic, S.5
  • 110
    • 0032005005 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes satiety and suppresses energy intake in humans
    • Flint A, Raben A, Astrup A, Holst JJ. Glucagon-like peptide-1 promotes satiety and suppresses energy intake in humans. J Clin Invest 1998; 101: 515-520
    • (1998) J Clin Invest , vol.101 , pp. 515-520
    • Flint, A.1    Raben, A.2    Astrup, A.3    Holst, J.J.4
  • 111
    • 0001306764 scopus 로고    scopus 로고
    • GLP-1 for six weeks reduces body weight and improves insulin sensitivity and glycemic control in patients with Type 2 diabetes
    • Zander M, Madsbad S, Holst JJ. GLP-1 for six weeks reduces body weight and improves insulin sensitivity and glycemic control in patients with Type 2 diabetes. Diabetes 2001; 50 (Suppl. 2): A31
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 2
    • Zander, M.1    Madsbad, S.2    Holst, J.J.3
  • 112
    • 0034522773 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats
    • Perfetti R, Zhou J, Doyle ME, Egan JM. Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats. Endocrinology 2000; 141: 4630-4605
    • (2000) Endocrinology , vol.141 , pp. 4630-4605
    • Perfetti, R.1    Zhou, J.2    Doyle, M.E.3    Egan, J.M.4
  • 113
    • 0037386156 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5′-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway
    • Hui H, Nourparvar A, Zhao X, Perfetti R. Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5′-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway. Endocrinology 2003; 144: 1444-1455
    • (2003) Endocrinology , vol.144 , pp. 1444-1455
    • Hui, H.1    Nourparvar, A.2    Zhao, X.3    Perfetti, R.4
  • 114
    • 0345374580 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets
    • Farilla L, Bulotta A, Hirshberg B, Li Calzi S, Khoury N, Noushmehr H et al. Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets. Endocrinology 2003; 144: 5149-5158
    • (2003) Endocrinology , vol.144 , pp. 5149-5158
    • Farilla, L.1    Bulotta, A.2    Hirshberg, B.3    Li Calzi, S.4    Khoury, N.5    Noushmehr, H.6
  • 115
    • 0022327582 scopus 로고
    • GIP increases insulin receptor affinity and cellular sensitivity in adipocytes
    • Starich GH, Bar RS, Mazzaferri EL. GIP increases insulin receptor affinity and cellular sensitivity in adipocytes. Am J Physiol 1985; 249: E603-E607
    • (1985) Am J Physiol , vol.249
    • Starich, G.H.1    Bar, R.S.2    Mazzaferri, E.L.3
  • 116
    • 0024271044 scopus 로고
    • Effects of gastric inhibitory polypeptide on glucose and lipid metabolism of isolated rat adipocytes
    • Hauner H, Glatting G, Kaminska D, Pfeiffer EF. Effects of gastric inhibitory polypeptide on glucose and lipid metabolism of isolated rat adipocytes. Ann Nutr Metab 1988; 32: 282-288
    • (1988) Ann Nutr Metab , vol.32 , pp. 282-288
    • Hauner, H.1    Glatting, G.2    Kaminska, D.3    Pfeiffer, E.F.4
  • 117
    • 12244284166 scopus 로고
    • Increased chylomicronaemia in fed rats given gastric inhibitory polypeptide antibodies
    • Kwasowski PK, Tan S, DeSilva MJ, Marks V. Increased chylomicronaemia in fed rats given gastric inhibitory polypeptide antibodies (abstract). Diabetologia 1984; 27: A300-A301
    • (1984) Diabetologia , vol.27
    • Kwasowski, P.K.1    Tan, S.2    DeSilva, M.J.3    Marks, V.4
  • 118
    • 8344260591 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide/gastric inhibitory polypeptide
    • Meier JJ, Nauck MA. Glucose-dependent insulinotropic polypeptide/ gastric inhibitory polypeptide. Best Pract Res Clin Endocrinol Metab 2004; 18: 587-606
    • (2004) Best Pract Res Clin Endocrinol Metab , vol.18 , pp. 587-606
    • Meier, J.J.1    Nauck, M.A.2


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