Inducible Mouse Model of Chronic Intestinal Pseudo-Obstruction by Smooth Muscle-Specific Inactivation of the SRF Gene

Gastroenterology

Volumn 133, Issue 6, 2007, Pages 1960-1970

  Mericskay, Mathias ^a,b   Blanc, Jocelyne ^a,b   Tritsch, Eva ^a,b   Moriez, Raphael ^c,d,e   Aubert, Philippe ^c,d,e   Neunlist, Michel ^c,d,e   Feil, Robert ^f   Li, Zhenlin ^a,b  

^a SORBONNE UNIVERSITÉ   (France)

^b CNRS   (France)

^c INSERM   (France)

^d UNIVERSITÉ DE NANTES   (France)

^e NANTES UNIVERSITY HOSPITAL   (France)

^f UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CARBACHOL; CRE RECOMBINASE; MYOSIN; SERUM RESPONSE FACTOR; SMOOTHELIN; TAMOXIFEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; BLADDER; CACHEXIA; CELL SPECIFICITY; CONTROLLED STUDY; DEATH; DISEASE COURSE; DOWN REGULATION; ELECTROSTIMULATION; EX VIVO STUDY; GASTROINTESTINAL TRACT; GENE EXPRESSION; GENE INACTIVATION; INTESTINE; INTESTINE CONTRACTION; INTESTINE MOTILITY; INTESTINE MUSCLE; INTESTINE PSEUDOOBSTRUCTION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SMOOTH MUSCLE; SMOOTH MUSCLE CONTRACTION;

EID: 36549005596     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2007.09.010     Document Type: Article

References (31)

1. Small J.V., and Gimona M. The cytoskeleton of the vertebrate smooth muscle cell. Acta Physiol Scand 164 (1998) 341-348
2. Miano J.M. Serum response factor: toggling between disparate programs of gene expression. J Mol Cell Cardiol 35 (2003) 577-593
3. Chai J., and Tarnawski A.S. Serum response factor: discovery, biochemistry, biological roles and implications for tissue injury healing. J Physiol Pharmacol 53 (2002) 147-157
4. Treisman R., Alberts A.S., and Sahai E. Regulation of SRF activity by Rho family GTPases. Cold Spring Harb Symp Quant Biol 63 (1998) 643-651
5. Arsenian S., Weinhold B., Oelgeschlager M., et al. Serum response factor is essential for mesoderm formation during mouse embryogenesis. EMBO J 17 (1998) 6289-6299
6. Miano J.M., Ramanan N., Georger M.A., et al. Restricted inactivation of serum response factor to the cardiovascular system. Proc Natl Acad Sci U S A 101 (2004) 17132-17137
7. Parlakian A., Tuil D., Hamard G., et al. Targeted inactivation of serum response factor in the developing heart results in myocardial defects and embryonic lethality. Mol Cell Biol 24 (2004) 5281-5289
8. Li S., Czubryt M.P., McAnally J., et al. Requirement for serum response factor for skeletal muscle growth and maturation revealed by tissue-specific gene deletion in mice. Proc Natl Acad Sci U S A 102 (2005) 1082-1087
9. Charvet C., Houbron C., Parlakian A., et al. New role for serum response factor in postnatal skeletal muscle growth and regeneration via the interleukin 4 and insulin-like growth factor 1 pathways. Mol Cell Biol 26 (2006) 6664-6674
10. Alberti S., Krause S.M., Kretz O., et al. Neuronal migration in the murine rostral migratory stream requires serum response factor. Proc Natl Acad Sci U S A 102 (2005) 6148-6153
11. Ramanan N., Shen Y., Sarsfield S., et al. SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability. Nat Neurosci 8 (2005) 759-767
12. Parlakian A., Charvet C., Escoubet B., et al. Temporally controlled onset of dilated cardiomyopathy through disruption of the SRF gene in adult heart. Circulation 112 (2005) 2930-2939
13. Chai J., Baatar D., and Tarnawski A. Serum response factor promotes re-epithelialization and muscular structure restoration during gastric ulcer healing. Gastroenterology 126 (2004) 1809-1818
14. Chai J., Norng M., Tarnawski A.S., et al. A critical role of serum response factor in myofibroblast differentiation during experimental oesophageal ulcer healing in rat. Gut 56 (2007) 621-630
15. Latasa M.U., Couton D., Charvet C., et al. Delayed liver regeneration in mice lacking liver serum response factor. Am J Physiol Gastrointest Liver Physiol 292 (2007) G996-G1001
16. Miralles F., Hebrard S., Lamotte L., et al. Conditional inactivation of the murine serum response factor in the pancreas leads to severe pancreatitis. Lab Invest 86 (2006) 1020-1036
17. Kuhbandner S., Brummer S., Metzger D., et al. Temporally controlled somatic mutagenesis in smooth muscle. Genesis 28 (2000) 15-22
18. Duband J.L., Gimona M., Scatena M., et al. Calponin and SM 22 as differentiation markers of smooth muscle: spatiotemporal distribution during avian embryonic development. Differentiation 55 (1993) 1-11
19. Connor F.L., and Di Lorenzo C. Chronic intestinal pseudo-obstruction: assessment and management. Gastroenterology 130 (2006) S29-S36
20. Rensen S.S., Niessen P.M., Long X., et al. Contribution of serum response factor and myocardin to transcriptional regulation of smoothelins. Cardiovasc Res 70 (2006) 136-145
21. Boesten L.S., Zadelaar S.M., De Clercq S., et al. Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated caspase-3-independent cell death. Cell Death Differ 13 (2006) 2089-2098
22. Knowles C.H., Silk D.B., Darzi A., et al. Deranged smooth muscle α-actin as a biomarker of intestinal pseudo-obstruction: a controlled multinational case series. Gut 53 (2004) 1583-1589
23. Schratt G., Philippar U., Berger J., et al. Serum response factor is crucial for actin cytoskeletal organization and focal adhesion assembly in embryonic stem cells. J Cell Biol 156 (2002) 737-750
24. Miralles F., Posern G., Zaromytidou A.I., et al. Actin dynamics control SRF activity by regulation of its coactivator MAL. Cell 113 (2003) 329-342
25. Zhang J.C., Kim S., Helmke B.P., et al. Analysis of SM22α-deficient mice reveals unanticipated insights into smooth muscle cell differentiation and function. Mol Cell Biol 21 (2001) 1336-1344
26. Niessen P., Rensen S., van Deursen J., et al. Smoothelin-a is essential for functional intestinal smooth muscle contractility in mice. Gastroenterology 129 (2005) 1592-1601
27. Wedel T., Van Eys G.J., Waltregny D., et al. Novel smooth muscle markers reveal abnormalities of the intestinal musculature in severe colorectal motility disorders. Neurogastroenterol Motil 18 (2006) 526-538
28. Morano I., Chai G.X., Baltas L.G., et al. Smooth-muscle contraction without smooth-muscle myosin. Nat Cell Biol 2 (2000) 371-375
29. Mao J., Yuan H., Xie W., et al. Specific involvement of G proteins in regulation of serum response factor-mediated gene transcription by different receptors. J Biol Chem 273 (1998) 27118-27123
30. Wang L., Liu H.W., McNeill K.D., et al. Mechanical strain inhibits airway smooth muscle gene transcription via protein kinase C signaling. Am J Respir Cell Mol Biol 31 (2004) 54-61
31. Yang Y., Beqaj S., Kemp P., et al. Stretch-induced alternative splicing of serum response factor promotes bronchial myogenesis and is defective in lung hypoplasia. J Clin Invest 106 (2000) 1321-1330