Serum response factor: Discovery, biochemistry, biological roles and implications for tissue injury healing

Journal of Physiology and Pharmacology

Volumn 53, Issue 2, 2002, Pages 147-157

  Chai, J ^a   Tarnawski, Andrzej S ^a  

^a VA LONG BEACH HEALTHCARE SYSTEM   (United States)

Author keywords

c fos gene; Serum response element; Serum response factor; Transcription factor

Indexed keywords

ACTIN; ACTIVATING TRANSCRIPTION FACTOR 6; ANTIOXIDANT; CALCIUM; MYOGENIC FACTOR; MYOSIN; SERUM RESPONSE FACTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SP1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VIRUS PROTEIN;

CALCIUM CELL LEVEL; CELL DIFFERENTIATION; CELL GROWTH; GENE OVEREXPRESSION; HEART FAILURE; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; IMMEDIATE EARLY GENE; MOUSE; MUSCLE DEVELOPMENT; MUSCLE FUNCTION; NONHUMAN; ONCOGENE C FOS; PROTO ONCOGENE; REVIEW; SERUM RESPONSIVE ELEMENT; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION; TISSUE INJURY; TRANSGENICS; ULCER HEALING; ULTRAVIOLET RADIATION; WOUND HEALING;

ANIMALS; HUMANS; SERUM RESPONSE ELEMENT; SERUM RESPONSE FACTOR; WOUND HEALING;

EID: 0036295848     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (68)

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2. Serum-inducible genes
3. Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors
4. Multiple protein-binding sites in the 5′-flanking region regulate c-fos expression
5. Inducible binding of a factor to the c-fos enhancer
6. Mutation of the c-fos gene dyad symmetry element inhibits serum inducibility of transcription in vivo and the nuclear regulatory factor binding in vitro
7. Xenopus cytoskeletal actin and human c-fos gene promoters share a conserved protein-binding site
8. Signal uptake by the c-fos serum response element
9. Serum response factor is essential for mesoderm formation during mouse embryogenesis
10. Four isoforms of serum response factor that increase or inhibit smoothmuscle-specific promoter activity
11. Dominant negative murine serum response factor: Alternative splicing within the activation domain inhibits transactivation of serum response factor binding targets
12. Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element
13. The ETS-domain transcription factors Elk-1 and SAP-1 exhibit differential DNA binding specificities
14. Deficiens, a homeotic gene involved in the control of flower morphogenesis in Antirrhinum majus: The protein shows homology to transcription factors
15. The Drosophila SRF homolog is expressed in a subset of tracheal cells and maps within a genomic region required for tracheal development
16. Identification of transcriptional activation and inhibitory domains in serum response factor (SRF) by using GAL4-SRF constructs
17. Calcium and growth factor pathways of cfos transcriptional activation require distinct upstream regulatory sequences
18. Collaborative roles for c-Jun N-terminal kinase, c-Jun, serum response factor, and Sp1 in calcium-regulated myocardial gene expression
19. L-type voltage-sensitive calcium channel activation stimulates gene expression by a serum response factor-dependent pathway
20. The hepatitis B virus (HBV) pX transactivates the c-fos promoter through multiple cis-acting elements
21. Serum response factor has functional roles both in indirect binding to the CArG box and in the transcriptional activation function of human T-cell leukemia virus type I Tax
22. Growth and differentiation of C2 myogenic cells are dependent on serum response factor
23. Expression and activity of serum response factor is required for expression of the muscle-determining factor MyoD in both dividing and differentiating mouse C2C12 myoblasts
24. Serum response factor is required for immediate-early gene activation yet is dispensable for proliferation of embryonic stem cells
25. Cardiomyopathy in transgenic mice with cardiac-specific overexpression of serum response factor
26. Early postnatal cardiac changes and premature death in transgenic mice overexpressing a mutant form of serum response factor
27. Muscle specificity encoded by specific serum response factor-binding sites
28. Ternary complex factors: Growth factor regulated transcriptional activators
29. Mutation of serum response factor phosphorylation sites and the mechanism by which its DNA-binding activity is increased by casein kinase II
30. Physiological control of smooth muscle-specific gene expression through regulated nuclear translocation of serum response factor
31. Two pathways for serum regulation of the c-fos serum response element require specific sequence elements and a minimal domain of serum response factor
32. The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF
33. Structure and mapping of the fosB gene. FosB downregulates the activity of the fosB promoter
34. Transcriptional regulatory elements downstream of the JunB gene
35. Detection of three protein binding sites in the serum-regulated promoter of the human gene encoding the 70-kDa heat shock protein
36. An inhibitory mutant of c-Raf-1 blocks v-Src-induced activation of the Egr-1 promoter
37. Transcriptional activation and repression by Fos are independent functions: The C terminus represses immediate-early gene expression via CArG elements
38. Promoter function and structure of the growth factor-inducible immediate early gene cyr61
39. Raf and fibroblast growth factor phosphorylate Elk1 and activate the serum response element of the immediate early gene pip92 by mitogen-activated protein kinase-independent as well as -dependent signaling pathways
40. Regulation of the human beta-actin promoter by upstream and intron domains
41. A serum response element and a binding site for NF-Y mediate the serum response of the human thrombospondin 1 gene
42. Organization of the human gene encoding the cytoskeletal protein vinculin and the sequence of the vinculin promoter
43. Kappa B site-dependent activation of the interleukin-2 receptor alpha-chain gene promoter by human c-Rel
44. Organization, sequence, chromosomal localization, and promoter identification of the mouse orphan nuclear receptor Nurr1 gene
45. Activation of the inducible orphan receptor gene nur77 by serum growth factors: Dissociation of immediate-early and delayed-early responses
46. Duplicated CArG box domains have positive and mutually dependent regulatory roles in expression of the human alpha-cardiac actin gene
47. A common factor regulates skeletal and cardiac alpha-actin gene transcription in muscle
48. The smooth muscle gamma-actin gene promoter is a molecular target for the mouse bagpipe homologue, mNkx3-1, and serum response factor
49. Suppression of Ras transformation by serum response factor
50. Alpha-myosin heavy chain gene regulation: Delineation and characterization of the cardiac muscle-specific enhancer and muscle-specific promoter
51. Multiple muscle-specific regulatory elements are associated with a DNase I hypersensitive site of the cardiac beta-myosin heavy-chain gene
52. Structure, organization, and expression of the rat cardiac myosin light chain-2 gene. Identification of a 250-base pair fragment which confers cardiac-specific expression
53. Identification of functional promoter elements in the rabbit smooth muscle myosin heavy chain gene
54. Structure and expression of the human SM22alpha gene, assignment of the gene to chromosome 11, and repression of the promoter activity by cytosine DNA methylation
55. Telokin expression in A10 smooth muscle cells requires serum response factor
56. Characterization of cis-regulating elements and trans-activating factors of the rat cardiac troponin T gene
57. Promoter elements and transcriptional control of the chicken tropomyosin gene
58. Serum response factor-dependent regulation of the smooth muscle calponin gene
59. Involvement of multiple cis elements in basal- and alpha-adrenergic agonist-inducible atrial natriuretic factor transcription. Roles for serum response elements and an SP-1-like element
60. A novel E box/AT-rich element is required for muscle-specific expression of the sarcoplasmic reticulum Ca2+-ATPase (SERCA2) gene
61. Molecular and functional analysis of the muscle-specific promoter region of the Duchenne muscular dystrophy gene
62. Different regulatory sequences control creatine kinase-M gene expression in directly injected skeletal and cardiac muscle
63. Effect of sensory nerves and CGRP on the development of caerulein-induced pancreatitis and pancreatic recovery
64. Effect of central and peripheral actions of histamine and its metabolite N-alpha methyl histamine on gastric secretion and acute gastric lesions
65. Central and peripheral neural aspects of gastroprotective and ulcer healing effects of lipopolysaccharides
66. Brain-gut axis in gastroproctection by leptin and cholecystokinin against ischemia-reperfusion induced gastric lesions
67. Sensory nerves and calcitonin gene related peptide in the effect of ischemic preconditioning on acute and chronic gastric lesions induced by ischemia-reperfusion
68. Histamine in stress ulcer prophylaxis in rats