Stretch-induced alternative splicing of serum response factor promotes bronchial myogenesis and is defective in lung hypoplasia

Journal of Clinical Investigation

Volumn 106, Issue 11, 2000, Pages 1321-1330

  Yang, Yan ^a   Beqaj, Safedin ^a   Kemp, Paul ^b   Ariel, Ilana ^c   Schuger, Lucia ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ISOPROTEIN; MUSCLE PROTEIN; SERUM RESPONSE FACTOR; TRANSCRIPTION FACTOR;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRONCHUS MUSCLE; CELL DIFFERENTIATION; EXON; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG ALVEOLUS CELL; LUNG ALVEOLUS EPITHELIUM; LUNG HYPOPLASIA; LUNG PRESSURE; MESENCHYME CELL; MOUSE; MUSCLE DEVELOPMENT; MUSCLE STRETCHING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS;

EID: 0033653955     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI8893     Document Type: Article

References (32)

1. Cellular distribution of smooth muscle actins during mammalian embryogenesis: Expression of the α-vascular but not the γ-enteric isoform in differentiating striated myocytes
2. Smooth muscle actin expression during rat gut development and induction in fetal skin fibroblastic cells associated with intestinal embryonic epithelium
3. Expression of fibronectin, the integrin α5, and α-smooth muscle actin in heart and lung development
4. Molecular analysis of smooth muscle development in the mouse
5. SM22α, a marker of adult smooth muscle, is expressed in multiple myogenic lineages during embryogenesis
6. Increased elastin expression in experimental granulomatous lung disease
7. Smooth muscle markers in developing rat lung
8. Myosin isoform expression in developing and remodeling rat lung
9. Smooth muscle myosin heavy chain exclusively marks the smooth muscle lineage during mouse embryogenesis
10. Role of laminin polymerization at the epithelial mesenchymal interface in bronchial myogenesis
11. Differentiation of smooth muscle cell precursors is determined by the cell's shape
12. Laminin α-2 chain expression is controlled by the cell shape and is required for normal myogenesis
13. Feral breathing movements
14. Organization and myogenic restricted expression of the murine serum response factor gene. A role for auroregularion
15. A serum response factor-dependent transcriptional regulatory program identifies distinct smooth muscle cell sublineages
16. The developmentally regulated expression of serum response factor plays a key role in the control of smooth muscle-specific genes
17. Dominant negative murine serum response factor: Alternative splicing within the activation domain inhibits transactivation of serum response factor binding targets
18. Four isoforms of serum response factor that increase or inhibit smooth-muscle-specific promoter activity
19. Laminin α1 chain synthesis in the mouse developing lung: Requirement for epithelial-mesenchymal contact and possible role in bronchial smooth muscle development
20. Bronchial smooth muscle hypoplasia in mouse embryonic lungs exposed to a laminin β1 chain antisense oligonucleotide
21. Feral lung development, tests for maturation, induction of maturation, and treatment
22. Mechanical strain and collagen potentiate mitogenic activity of angiotensin II in vascular smooth muscle cells
23. Strain increases airway smooth muscle cell proliferation
24. Experimental pulmonary hypoplasia and oligohydramnion: Relative contributions of lung fluid and feral breathing movements
25. Prematurity and the developing lung
26. Experimental fetal tracheal ligation reverses the structural and physiological effects of pulmonary hypoplasia in congenital diaphragmatic hernia
27. Sustained alterations in postnatal respiratory function following sub-optimal intrauterine conditions
28. Effects of mechanical factors on growth and maturation of the lung in fetal sheep
29. Continuous intrapulmonary distention with perfluorocarbon accelerates neonatal (but nor adult) lung growth
30. Current management of congenital diaphragmatic hernia
31. Developmental changes in tropoelastin gene expression in the rat lung studied by in situ hybridization
32. Failure of elastin development in hypoplastic lungs associated with oligohydramnios: An electron microscopic study