Oxygen consumption of human peripheral blood mononuclear cells in severe human sepsis

Critical Care Medicine

Volumn 35, Issue 12, 2007, Pages 2702-2708

  Belikova, Ioulia ^a   Lukaszewicz, Anne Claire ^a   Faivre, Valerie ^a   Damoisel, Charles ^a   Singer, Mervyn ^b   Payen, Didier ^a  

^a HÔPITAL LARIBOISIÈRE   (France)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Energetic failure; Human leukocyte antigen DR; Immune suppression; Mitochondria; Peripheral blood mononuclear cells; Sepsis

Indexed keywords

ADENOSINE DIPHOSPHATE; HLA DR ANTIGEN;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; BIOENERGY; CLINICAL ARTICLE; CONTROLLED STUDY; EX VIVO STUDY; FEMALE; HLA SYSTEM; HUMAN; LEUKOCYTE ACTIVATION; MALE; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SEPSIS; SEPTIC SHOCK;

EID: 36448993710     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000295593.25106.C4     Document Type: Article

References (35)

1. Munoz C, Carlet J, Fitting C, et al: Dysregulation of in vitro cytokine production by monocytes during sepsis. J Clin Invest 1991; 88:1747-1754
2. Marie C, Muret J, Fitting C, et al: Reduced ex vivo interleukin-8 production by neutrophils in septic and nonseptic systemic inflammatory response syndrome. Blood 1998; 91:3439-3446
3. Payen D, Faivre V, Lukaszewicz AC, et al: Assessment of immunological status in the critically ill. Minerva Anestesiol 2000; 66:351-357
4. Caille V, Chiche JD, Nciri N, et al: Histocompatibility leukocyte antigen-D related expression is specifically altered and predicts mortality in septic shock but not in other causes of shock. Shock 2004; 22:521-526
5. Docke WD, Randow F, Syrbe U, et al: Monocyte deactivation in septic patients: Restoration by IFN-gamma treatment. Nat Med 1997; 3:678-681
6. Le Tulzo Y, Pangault C, Amiot L, et al: Monocyte human leukocyte antigen-DR transcriptional downregulation by cortisol during septic shock. Am J Respir Crit Care Med 2004; 169:1144-1151
7. Kuhnke A, Burmester GR, Krauss S, et al: Bioenergetics of immune cells to assess rheumatic disease activity and efficacy of glucocorticoid treatment. Ann Rheum Dis 2003; 62:133-139
8. Gnaiger E: Bioenergetics at low oxygen: Dependence of respiration and phosphorylation on oxygen and adenosine diphosphate supply. Respir Physiol 2001; 128:277-297
9. Chance B, Williams GR: Respiratory enzymes in oxidative phosphorylation. I. Kinetics of oxygen utilization. J Biol Chem 1955; 217:383-393
10. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992; 20:864-874
11. Drapier JC, Bouton C: Modulation by nitric oxide of metalloprotein regulatory activities. Bioessays 1996; 18:549-556
12. Giovannoni G, Land JM, Keir G, et al: Adaptation of the nitrate reductase and Griess reaction methods for the measurement of serum nitrate plus nitrite levels. Ann Clin Biochem 1997; 34:193-198
13. King CJ, Tytgat S, Delude RL, et al: Ileal mucosal oxygen consumption is decreased in endotoxemic rats but is restored toward normal by treatment with aminoguanidine. Crit Care Med 1999; 27:2518-2524
14. Merlo-Pich M, Deleonardi G, Biondi A, et al: Methods to detect mitochondrial function. Exp Gerontol 2004; 39:277-281
15. Slater EC: The mechanism of action of the respiratory inhibitor antimycin. Biochim Biophys Acta 1973; 301:129-154
16. Nagamune H, Fukushima Y, Takada J, et al: The lipophilic weak base (Z)-5-methyl-2-[2-(1-naphthyl)ethenyl]-4-piperidinopyridine (AU-1421) is a potent protonophore type cationic uncoupler of oxidative phosphorylation in mitochondria. Biochim Biophys Acta 1993; 1141:231-237
17. Pinsky MR: Dysregulation of the immune response in severe sepsis. Am J Med Sci 2004; 328:220-229
18. Medzhitov R, Janeway C Jr: Innate immunity. N Engl J Med 2000; 343:338-344
19. Tapfer H, Liigant A, Simovart HE, et al: Dissemination of bacteria in multiple organs associated with apoptosis and macrophage activity in different stages of experimental sepsis. Scand J Surg 2003; 92:163-170
20. Munford RS, Pugin J: Normal responses to injury prevent systemic inflammation and can be immunosuppressive. Am J Respir Crit Care Med 2001; 163:316-321
21. Cheadle WG, Hershman MJ, Wellhausen SR, et al: HLA-DR antigen expression on peripheral blood monocytes correlates with surgical infection. Am J Surg 1991; 161:639-645
22. Monneret G, Elmenkouri N, Bohe J, et al: Analytical requirements for measuring monocytic human lymphocyte antigen DR by flow cytometry: Application to the monitoring of patients with septic shock. Clin Chem 2002; 48:1589-1592
23. Fumeaux T, Pugin J: Role of interleukin-10 in the intracellular sequestration of human leukocyte antigen-DR in monocytes during septic shock. Am J Respir Crit Care Med 2002; 166:1475-1482
24. Chinnaiyan AM, Huber-Lang M, Kumar-Sinha C, et al: Molecular signatures of sepsis: Multiorgan gene expression profiles of systemic inflammation. Am J Pathol 2001; 159: 1199-1209
25. Buttgereit F, Burmester GR, Brand MD: Bioenergetics of immune functions: Fundamental and therapeutic aspects. Immunol Today 2000; 21:192-199
26. Brealey D, Brand M, Hargreaves I, et al: Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet 2002; 360:219-223
27. Brealey D, Karyampudi S, Jacques TS, et al: Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure. Am J Physiol Regul Integr Comp Physiol 2004; 286:R491-R497
28. Crouser ED, Julian MW, Blaho DV, et al: Endotoxin-induced mitochondrial damage correlates with impaired respiratory activity. Crit Care Med 2002; 30:276-284
29. Frost MT, Wang Q, Moncada S, et al: Hypoxia accelerates nitric oxide- dependent inhibition of mitochondrial complex I in activated macrophages. Am J Physiol Regul Integr Comp Physiol 2005; 288:R394-R400
30. Gergely P Jr, Niland B, Gonchoroff N, et al: Persistent mitochondrial hyperpolarization, increased reactive oxygen intermediate production, and cytoplasmic alkalinization characterize altered IL-10 signaling in patients with systemic lupus erythematosus. J Immunol 2002; 169:1092-1101
31. Calvano SE, Xiao W, Richards DR, et al: A network-based analysis of systemic inflammation in humans. Nature 2005; 437:1032-1037
32. Singer M, De Santis V, Vitale D, et al: Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation. Lancet 2004; 364:545-548
33. Duan S, Hajek P, Lin C, et al: Mitochondrial outer membrane permeability change and hypersensitivity to digitonin early in staurosporine-induced apoptosis. J Biol Chem 2003; 278:1346-1353
34. Adrie C, Bachelet M, Vayssier-Taussat M, et al: Mitochondrial membrane potential and apoptosis peripheral blood monocytes in severe human sepsis. Am J Respir Crit Care Med 2001; 164:389-395
35. Stegmayr BG, Banga R, Berggren L, et al: Plasma exchange as rescue therapy in multiple organ failure including acute renal failure. Crit Care Med 2003; 31:1730-1736