Dissemination of bacteria in multiple organs associated with apoptosis and macrophage activity in different stages of experimental sepsis

Scandinavian Journal of Surgery

Volumn 92, Issue 2, 2003, Pages 163-170

  Tapfer, Helle ^a   Liigant, A ^a   Simovart, H E ^a   Poldoja E ^a   Kokk, K ^a   Naaber, P ^a   Talvik, R ^a  

^a UNIVERSITY OF TARTU   (Estonia)

Author keywords

Apoptosis; E. coli; Macrophages; Microfoci; Sepsis

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BACTERIAL COUNT; BACTERIAL TRANSLOCATION; BACTERIOLOGY; CONTROLLED STUDY; CORRELATION ANALYSIS; ESCHERICHIA COLI; EXPERIMENTAL INFECTION; IMMUNOHISTOCHEMISTRY; INOCULATION; MACROPHAGE; MORPHOLOGY; NONHUMAN; RAT; SEPSIS;

EID: 0037595490     PISSN: 14574969     EISSN: None     Source Type: Journal    
DOI: 10.1177/145749690309200210     Document Type: Article

References (27)

1. Nuytinck HKS, Offermans XJMW, Kubat K, Goris RJA: Wholebody inflammation in trauma patients. Arch Surg 1988;123:1519-1524
2. Goris RJA: Mediators of multiple organ failure. Intensive Care Medicine 1990;16:192-196
3. Schlag G, Redl H, van Vuuren CJJ, Davies J: Hyperdynamic sepsis in baboons: II. relation of organ damage to severity of sepsis evaluated by a newly developed morphological scoring system. Circulatory Shock 1992;38:253-263
4. Rogers HW, Callery MP, Deck B, Unanune R: Listeria monocytogenes induces apoptosis of infected hepatocytes. J Immunol 1996;156:679-684
5. Hotchkiss RS, Swanson PE, Cobb JP, Jacobson A, Buchman TG, Karl IE: Apoptosis in lymphoid and parenhymal cells during sepsis: findings in normal and T- and B-cell-deficient mice. Crit Care Med 1977;25:1298-1307
6. Ayala A, Urbanich MA, Herdon CD, Chaudry IH: Is sepsisinduced apoptosis associated with macrophage dysfunction? J Trauma 1996;40:568-574
7. Ayala A, Herdon CD, Lehman DL, Ayala CA, Chaudry IH: Differential induction of apoptosis in lymphoid tissues during sepsis: variation in onset, frequency, and the nature of the mediators. Blood 1996;87:4261-4275
8. Ayala A, Herdon CD, Lehman DL, DeMaso C, Ayala CA, Chaudry IH: The induction of accelerated thymic programmed cell death during polymicrobial sepsis:control by corticosteroids but not tumor necrosis factor. Shock 1995;3:259-267
9. O'Boyle CJO, Mitchell CJ, Johnstone D, Sagar PM, Sedman PC: Microbiology of bacterial translocation in humans. Gut 1998;42:29-35
10. Naaber P, Smidt I, Tamme K, Liigant A, Tapfer H, Mikelsaar M, Talvik R: Translocation of indigenous microflora in an experimental model of sepsis. J Med Microbiol 2000;49:431-439
11. Talvik R, Liigant A, Tapfer H, Tamme K, Metsvaht T: Septic shock with disseminated microfoci in multiple organs in humans. Intensive Care Med 1998;24:73-76
12. Tamme K, Liigant A, Tapfer H, Talvik R: Bacterial dissemination and the value of blood cultures in patients who die of septic shock. J Int Med Res Medical Research 2000;28:199-206
13. Brown RC, Hopps HC: Staining of bacteria in tissue sections. Am J Clin Pathol 1973;60:234-240
14. Tapfer H, Liigant A, Talvik R, Roosaar P, Hussar Ü, Mikelsaar M, Simovart HE: Pathomorphological responses in experimental sepsis. Papers on Anthropology 1997;VII:339-350
15. Moore FA, Moore EE: Evolving concepts in the pathogenesis of postinjury multiple organ failure. Surg Clin North Am 1995;75:257-277
16. Yao YM, Lu LR, Yu Y, Liang HP, Chen JS, Shi ZG, Zhou BT, Sheng ZY: Influence of selective decontamination of the digestive tract on cell-mediated immune function and bacterial/endotoxin translocation in thermally injured rats. J Trauma 1997;42:1073-1079
17. Knisely MH, Cowley RA, Hawthorne I, Garris D: Separation of shock types. Experimental and clinical separation of hypovolemic and septic shock. Angiology 1970;21:728-744
18. Hinshaw LB: Sepsis/septic shock: participation of the microcirculation: an abbreviated review. Crit Care Med 1996;24:1072-1078
19. Baveja R, Kresge N, Ashburn JH, Keller S, Yokoyama Y, Sonin N, Zhang JX, Huynh T, Clemens MG: Potentiated hepatic microcirculatory response to endothelin-1 during polymicrobial sepsis. Shock 2002;18:415-422
20. Kujath P, Bouchard R, Shekarriz H, Eckmann C: Anticoagulation in the treatment of sepsis. Correction of microcirculation: a new approach manipulating endothelial cell function. Chirurg 2002;73:1093-1099
21. ten Cate H, Schoenmakers SH, Franco R, Timmerman JJ, Groot AP, Spek CA, Reitsma PH: Microvascular coagulopathy and disseminated intravascular coagulation. Crit Care Med 2001;29:95-97
22. Salyers AA, Whitt DD: Bacterial pathogenesis. A Molecular Approach 1994:17-23
23. Niki T, Oka T, Shiga J, Machinami R: Kupffer cells in multiple organ failure - their activation as revealed by immunohistochemistry for lysozyme, al- antichymotrypsin, and lectins. Gen Diagn Pathol 1995;141:21-27
24. Hotchkiss RS, Swanson PE, Freeman BD, Tinsley KW, Cobb JP, Matuschak GM, Buchman TG, Karl IE: Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 1999;27:1230-1235
25. Williams TE, Ayala A, Chaudry IH: Inducible macrophage apoptosis following sepsis is mediated by cysteine protease activation and nitric oxide release. J Surg Res 1997;70:113-118
26. Ayala A, Xu YX, Ayala CA, Sonefeld DE, Shannon MK, Evans TA, Chaudry IH: Increased mucosal B-lymphocyte apoptosis during polymicrobial sepsis is a fas ligand but not an endotoxin-mediated process. Blood 1998;91:1362-1372
27. Ayala A, Chung CS, Xu YX, Evans TA, Redmond KM, Chaudry IH: Increased inducible apoptosis in CD4+ T lymphocytes during polymicrobial sepsis is mediated by fas ligand and not endotoxin. Immunology 1999;97:45-55