Role of benoxaprofen and flunoxaprofen acyl glucuronides in covalent binding to rat plasma and liver proteins in vivo

Biochemical Pharmacology

Volumn 70, Issue 6, 2005, Pages 937-948

  Dong, Jennifer Q ^a   Liu, Jianhua ^b   Smith, Philip C ^c  

^a ALLERGAN INC   (United States)

^b PFIZER INC   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Covalent protein binding; Immunoblot; Liver protein targets; NSAIDs; Reactive acyl glucuronide; Reversible metabolism

Indexed keywords

BENOXAPROFEN; FLUNOXAPROFEN; GLUCURONIDE; LIVER PROTEIN; LONG CHAIN FATTY ACID COENZYME A LIGASE; PLASMA PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; COVALENT BOND; DRUG DETERMINATION; DRUG EXPOSURE; DRUG PROTEIN BINDING; IMMUNOCHEMISTRY; LIVER TOXICITY; MALE; METABOLITE; NONHUMAN; PLASMA; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZOXAZOLES; BLOOD PROTEINS; GLUCURONIDES; LIVER; MALE; PROPIONIC ACIDS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 23744450319     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.05.026     Document Type: Article

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