Direct Characterization of Drug Glucuronide Isomers in Human Urine by HPLC-NMR Spectroscopy: Application to the Positional Isomers of 6,11 -Dihydro-11-oxodibenz[b,e]oxepin-2-acetic Acid Glucuronide

Analytical Chemistry

Volumn 68, Issue 17, 1996, Pages 2832-2837

  Lenz, Eva M ^a   Greatbanks, David ^b   Wilson, Ian D ^b   Spraul, Manfred ^c   Hofmann, Martin ^c   Troke, Jeff ^d   Lindon, John C ^a   Nicholson, Jeremy K ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c Bruker Analytik GmbH   (Germany)

^d Hoechst Roussel   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHARACTERIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORGANIC COMPOUNDS; SEPARATION; SOLVENTS; SPECTROMETRY;

DIHYDRO OXODIBENZ OXEPIN ACETIC ACID GLUCURONIDE; HUMAN URINE; MODEL NONSTEROIDAL ANTIINFLAMMATORY DRUG; POSITIONAL GLUCORONIDE ISOMERS;

DRUG PRODUCTS;

ISOXEPAC; OXEPINE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG METABOLISM; GLUCURONIDATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE; ORAL DRUG ADMINISTRATION; URINALYSIS;

ACETIC ACIDS; ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GLUCURONATES; HUMANS; ISOMERISM; MAGNETIC RESONANCE SPECTROSCOPY; MALE;

EID: 0030248476     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac951228l     Document Type: Article

References (19)

1. Sidelmann, U. G.; Lenz, E. M.; Sanderson, P. N.; Spraul, M.; Hofmann, M.; Lindon, J. C.; Wilson, I. D.; Troke, J.; Nicholson, J. K. Anal. Chem. 1996, 68, 106-110.
2. Paul, H.; Illing, A.; Wilson, I. D. Biochem. Pharmacol. 1981, 30, 3381-3384.
3. Wilson, I. D.; Bhatti, A.; Illing, H. P. A.; Bryce, T. A.; Chamberlain, J. In Drug Metabolite Isolation and Determination; Reid, E., Leppard, J. P., Eds.; Plenum Press: New York, 1983; pp 181-187.
4. Marsh, C. A. In Glucuronic Acid Free and Combined; Dutton, G. J., Ed.; Academic Press: New York, 1966; pp 185-201.
5. King, A. R.; Dickinson, R. G. Biochem. Pharmacol. 1991, 42, 2289-2299.
6. Caldwell, A.; Hutt, A.J.; Marsh, M. V.; Sinclair, K. In Drug Metabolite Isolation and Determination; Reid, E., Leppard, J. P., Eds.; Plenum Press: New York, 1983; p 161-179.
7. Compernolle, F.; Van Hees, G. P.; Blanckaert, N.; Heirwegh, K. P. M. Biochem. J. 1978, 171, 185-201.
8. Spahn-Langguth, H.; Benet, L. Z. Drug Metab. Rev. 1992, 24, 5-48.
9. Faed, E. M.; McQueen, E. G. Clin. Exp. Pharmacol Physiol. 1978, 5, 195-198.
10. Upton, G. A.; Buskin, J. N.; Williams, R. Z.; Holford, N. H. G.; Riegelman, S.J. Chromatogr. 1980, 145, 393-40.
11. Sidelmann, U. G.; Gavaghan, C.; Carless, H. A. J.; Farrant, R. D.; Lindon, J. C.; Hansen, S. H.; Wilson, I. D.; Nicholson, J. K Anal. Chem., in press.
12. Sidelmann, U. G.; Nicholls, A. W.; Meadows, P. E.; Gilbert, J. W.; Lindon, J. C.; Wilson, I. D.; Nicholson, J. K. J. Chromatogr. 1996, 728, 377-385.
13. Sidelmann, U. G.; Gavaghan, C.; Carless, H. A. J.; Spraul, M.; Hofmann, M., Lindon, J. C.; Wilson, I. D.; Nicholson, J. K. Anal. Chem. 1995, 67, 3401-3404.
14. Spraul, M.; Hofmann, M.; Wilson, I. D.; Lenz, E. M.; Nicholson, J. K.; Lindon, J. C. J. Pharm. Biomed. Anal. 1993, 11, 1009-1015.
15. Wilson, I. D.; Nicholson, J. K.; Spraul, M.; Hofmann, M.; Lindon, J. C. J. Chromatogr. 1993, 617, 324-328.
16. Spraul, M.; Hofmann, M.; Dvortsak, P.; Nicholson, J. K.; Wilson, I. D. Anal. Chem. 1993, 65, 327-330.
17. Nicholson, J. K.; Foxall, P. J. D.; Spraul, M.; Farrant, R. D.; Lindon, J. C. Anal. Chem. 1995, 67, 793-811.
18. Sidelmann, U. G.; Gavaghan, C.; Carless, H. A. J.; Spraul, M.; Hofmann, M.; Lindon, J. C.; Wilson, I. D.; Nicholson, J. K. Anal. Chem. 1995, 67, 4441-4445.
19. Casey, A. F. PMR Spectroscopy in Medicinal and Biological Chemistry: Academic Press: London, 1971; p 30.