750 MHz HPLC-NMR spectroscopic studies on the separation and characterization of the positional isomers of the glucuronides of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid

Analytical Chemistry

Volumn 68, Issue 1, 1996, Pages 106-110

  Sidelmann, Ulla G ^a,f   Lenz, Eva M ^a   Spraul, Manfred ^b   Hofmann, Martin ^b   Troke, Jeff ^c   Sanderson, Paul N ^d   Lindon, John C ^d   Wilson, Ian D ^e   Nicholson, Jeremy K ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b Bruker Analytik GmbH   (Germany)

^c Walton Manor   (United Kingdom)

^d WELLCOME RESEARCH LABORATORIES   (United Kingdom)

^e ASTRAZENECA   (United Kingdom)

^f UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

6,11 DIHYDRO 11 OXODIBENZO[B,E]OXEPIN 2 ACETIC ACID; GLUCURONIDE; NONSTEROID ANTIINFLAMMATORY AGENT; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; DRUG STRUCTURE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; ISOMERISM; NUCLEAR MAGNETIC RESONANCE; ORAL DRUG ADMINISTRATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; URINALYSIS;

ACETIC ACIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; ISOMERISM; MAGNETIC RESONANCE SPECTROSCOPY; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0029893798     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac950752p     Document Type: Article

References (25)

1. Illing, H. A.; Wilson, I. D. Biochem. Pharmacol. 1981, 30, 3381-3384.
2. Hucker, H. B.; Quaint, K. C.; Dugan, D. E. Prog. Drug Met 1978, 5, 199-204.
3. Spahn-Langguth, H.; Benet, L. Z. Drug Metab. Rev. 1992, 24, 5-48.
4. Clive, D. M.; Stoff, J F. N. Engl. J. Med. 1984, 310, 563-572.
5. Pohl, L. R.; Satoh, H.; Christ, D. D.; Kenna, J. G. Annu. Rev. Pharmacol. 1988, 28, 367-387.
6. Williams, A. M.; Worall, S.; Jersey, J.; Dickinson, R. G. Biomed. Pharmacol. 1992, 43, 745-755.
7. Smith, P. C.; McDonagh, A. F.; Benet, L. Z. J. Clin. Invest. 1986, 77, 934-939.
8. Smith, P. C.; Song, W. Q.; Rodriguez, R. J. Drug Metab. Dispos. 1992, 20, 962-965.
9. Bradow, G ; Kan, L. S.; Fenselau, C. Chem. Res. Toxicol. 1989, 2, 316-324.
10. King, A. R.; Dickinson, R. G. Biochem. Pharmacol. 1991, 42, 2289-2299.
11. Smith, P. C.; McDonagh, A. F.; Benet, L. Z. Drug Metab. Dispos. 1990, 18, 634-644
12. Feneselau, C. In Conjugation - Deconjugation Reactions in Drug Metabolism and Toxicity, Kauffman, F. C., Ed.; Springer-Verlag: Berlin, 1994; pp 367-389.
13. Weiss, J. S.; Guatam, A; Lauff, J. J.; Sundberg, M. W.; Jatlow, P., Boyer, J.L.; Sahgson, D. N. Engl. J. Med. 1983, 309, 147-150.
14. Ruelius, H. W.; Young, E. M.; Kirkman, S. K.; Schillings, R. T.; Sisenwine, S. F.; Janssen, F W. Biochem. Pharmacol. 1985, 34, 451-452.
15. Fischer, E. Chem. Ber. 1920, 53, 1621-1633.
16. Sidelmann, U.; Gavaghan, C.; Carless, H. A. J.; Farrant, R. D.; Lindon, J. C.; Hansen, S. H.; Wilson, I. D.; Nicholson, J. K. J. Am. Chem. Soc., submitted.
17. Spannh-Langguth, H.; Benet, L. Z. Drug Metab Rev. 1992, 24, 5-48.
18. Farrant, R. D.; Spraul, M.; Wilson, I. D.; Nicholls, A. W.; Nicholson, J. K.; Lindon, J. C. J. Pharm. Biomed. Anal 1995, 13, 971-977.
19. Sidelmann, U. G.; Gavaghan, C.; Carless, H. A. J.; Lindon, J. C., Wilson, I. D.; Nicholson, J. K. Anal Chem 1995, 67, 3401-3404.
20. Wilson, I.; Nicholson, J. K.; Spraul, M.; Hofmann, M.; Nicholson, J. K.; Lindon, J. C. J. Chromatogr. 1993, 617, 324-328.
21. Nicholson, J. K.; Foxall, P. J. D.; Spraul, M.; Farrant, R. D.; Lindon, J. C. Anal. Chem. 1995, 34, 793-811.
22. Kaspersen, F. M.; Van Boeckel, C. A. A. Xenobiotica 1987, 17, 1451-1471.
23. Farrant, R. D.; Spraul, M.; Wilson, I. D.; Nicholls, A. W.; Nicholson, J. K.; Lindon, J. C. J. Pharm Biomed. Anal 1995, 13, 971-977.
24. Sidelmann, U. G.; Nicholls, A. W.; Meadows, P.; Gilbert, J., Lindon, J. C.; Wilson, I. D.; Nicholson, J. K. J. Chromatogr., in press.
25. Sidelmann, U. G.; Gavaghan, C.; Carless, H. A. J.; Spraul, M.; Huffman, M.; Lindon, J. C., Wilson, I. D.; Nicholson, J. K. Anal. Chem., in press.