Up-regulation of proteinase-activated receptor 1 and increased contractile responses to thrombin after subarachnoid haemorrhage

British Journal of Pharmacology

Volumn 152, Issue 7, 2007, Pages 1131-1139

  Maeda, Y ^a   Hirano, K ^a   Kai, Y ^a   Hirano, M ^a   Suzuki, S O ^a   Sasaki, T ^a   Kanaide, H ^a,b  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Basilar artery; Post haemorrhagic cerebral vasospasm; Rabbit; Smooth muscle; Thrombin

Indexed keywords

CALCIUM; ENDOTHELIN 1; HEPARIN; POTASSIUM; PROTEINASE ACTIVATED RECEPTOR 1; THROMBIN; THROMBIN RECEPTOR ACTIVATING PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASILAR ARTERY; BRAIN VASOSPASM; CISTERNA MAGNA; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM; HEPARINIZATION; IMMUNOBLOTTING; MALE; MYOFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RABBIT; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE RELAXATION; SUBARACHNOID HEMORRHAGE; UPREGULATION;

ANIMALS; BASILAR ARTERY; CALCIUM; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPARIN; MALE; MUSCLE, SMOOTH, VASCULAR; ORGAN CULTURE TECHNIQUES; POTASSIUM; RABBITS; RECEPTOR, PAR-1; SUBARACHNOID HEMORRHAGE; THROMBIN; UP-REGULATION; VASOCONSTRICTION; VASOSPASM, INTRACRANIAL;

EID: 36448936767     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0707435     Document Type: Article

References (34)

1. Brass LF (1992). Homologous desensitization of HEL cell thrombin receptors. Distinguishable roles for proteolysis and phosphorylation. J Biol Chem 267: 6044-6050.
2. Brass LF, Pizarro S, Ahuja M, Belmonte E, Blanchard N, Stadel JM et al. (1994). Changes in the structure and function of the human thrombin receptor during receptor activation, internalization, and recycling. J Biol Chem 269: 2943-2952.
3. Cook DA (1995). Mechanisms of cerebral vasospasm in subarachnoid haemorrhage. Pharmacol Ther 66: 259-284.
4. Coughlin SR (2000). Thrombin signalling and protease-activated receptors. Nature 407: 258-264.
5. Dery O, Corvera CU, Steinhoff M, Bunnett NW (1998). Proteinase-activated receptors: novel mechanisms of signaling by serine proteases. Am J Physiol 274: C1429-C1452.
6. i-linked Ras/mitogen-activated protein kinase pathway. J Biol Chem 274: 13718-13727.
7. Fisher CM, Kistler JP, Davis JM (1980). Relation of cerebral vasospasm to subarachnoid hemorrhage visualized by computerized tomographic scanning. Neurosurg 6: 1-9.
8. Fukunaga R, Hirano K, Hirano M, Niiro N, Nishimura J, Maehara Y et al. (2006). The up-regulation of proteinase-activated receptors and the hyper-contractile responses precede the development of arterial lesions after balloon injury. Am J Physiol Heart Circ Physiol 291: H2388-H2395.
9. Harder DR, Dernbach P, Waters A (1987). Possible cellular mechanism for cerebral vasospasm after experimental subarachnoid hemorrhage in the dog. J Clin Invest 80: 875-880.
10. Hirano K (2007). The roles of proteinase-activated receptors in the vascular physiology and pathophysiology. Arterioscler Thromb Vasc Biol 27: 27-36.
11. Hirano K, Kanaide H (2003). Role of protease-activated receptors in the vascular system. J Atheroscler Thromb 10: 211-225.
12. Hollenberg MD, Compton SJ (2002). International union of pharmacology. XXVIII. Proteinase-activated receptors. Pharmacol Rev 54: 203-217.
13. Inglese J, Freedman NJ, Koch WJ, Lefkowitz RJ (1993). Structure and mechanism of the G protein-coupled receptor kinases. J Biol Chem 268: 23735-23738.
14. i in smooth muscle strips using front-surface fluorometry. In: Lambert DG (ed). Methods Mol Biol. Humana Press: Totowa, NJ, pp 251-259.
15. Kassell NF, Sasaki T, Colohan AR, Nazar G (1985). Cerebral vasospasm following aneurysmal subarachnoid hemorrhage. Stroke 16: 562-572.
16. Kasuya H, Shimizu T, Okada T, Takahashi K, Summerville T, Kitamura K (1988). Activation of the coagulation system in the subarachnoid space after subarachnoid haemorrhage: serial measurement of fibrinopeptide A and bradykinin of cerebrospinal fluid and plasma in patients with subarachnoid haemorrhage. Acta Neurochir 91: 120-125.
17. Kasuya H, Shimizu T, Takakura K (1998). Thrombin activity in CSF after SAH is correlated with the degree of SAH the persistence of subarachnoid clot and the development of vasospasm. Acta Neurochir 140: 579-584.
18. Ku DD, Dai J (1997). Expression of thrombin receptors in human atherosclerotic coronary arteries leads to an exaggerated vasoconstrictory response in vitro. J Cardiovasc Pharmacol 30: 649-657.
19. Leger AJ, Jacques SL, Badar J, Kaneider NC, Derian CK, Andrade-Gordon P et al. (2006). Blocking the protease-activated receptor 1-4 heterodimer in platelet-mediated thrombosis. Circulation 113: 1244-1254.
20. Macdonald RL, Weir BK (1991). A review of hemoglobin and the pathogenesis of cerebral vasospasm. Stroke 22: 971-982.
21. Macfarlane SR, Seatter MJ, Kanke T, Hunter GD, Plevin R (2001). Proteinase-activated receptors. Pharmacol Rev 53: 245-282.
22. 2+ sensitivity in the bovine middle cerebral artery. Br J Pharmacol 140: 871-880.
23. Nakamura K, Nishimura J, Hirano K, Ibayashi S, Fujishima M, Kanaide H (2001). Hydroxyfasudil, an active metabolite of fasudil hydrochloride, relaxes the rabbit basilar artery by disinhibition of myosin light chain phosphatase. J Cereb Blood Flow Metab 21: 876-885.
24. Nelken NA, Soifer SJ, O'Keefe J, Vu TK, Charo IF, Coughlin SR (1992). Thrombin receptor expression in normal and atherosclerotic human arteries. J Clin Invest 90: 1614-1621.
25. 2+ sensitivity in α-toxin permeabilized arterial smooth muscle. Biochem Biophys Res Commun 157: 677-683.
26. Sato M, Tani E, Fujikawa H, Kaibuchi K (2000). Involvement of Rho-kinase-mediated phosphorylation of myosin light chain in enhancement of cerebral vasospasm. Circ Res 87: 195-200.
27. Smigel M, Katada T, Northup JK, Bokoch GM, Ui M, Gilman AG (1984). Mechanisms of guanine nucleotide-mediated regulation of adenylate cyclase activity. Adv Cyclic Nucleotide Protein Phosphorylation Res 17: 1-18.
28. Suzuki M, Kudo A, Otawara Y, Hirashima Y, Takaku A, Ogawa A (1999). Extrinsic pathway of blood coagulation and thrombin in the cerebrospinal fluid after subarachnoid hemorrhage. Neurosurg 44: 487-493.
29. Todo H, Ohta S, Wang J, Ichikawa H, Ohue S, Kumon Y et al. (1998). Impairment in biochemical level of arterial dilative capability of a cyclic nucleotides-dependent pathway by induced vasospasm in the canine basilar artery. J Cereb Blood Flow Metab 18: 808-817.
30. Tosaka M, Okajima F, Hashiba Y, Saito N, Nagano T, Watanabe T et al. (2001). Sphingosine 1-phosphate contracts canine basilar arteries in vitro and in vivo - possible role in pathogenesis of cerebral vasospasm. Stroke 32: 2913-2919.
31. Vermeulen M, van Vliet HH, Lindsay KW, Hijdra A, van Gijn J (1985). Source of fibrin/fibrinogen degradation products in the CSF after subarachnoid hemorrhage. J Neurosurg 63: 573-577.
32. Wilcox J, Rodriguez J, Subramanian R, Ollerenshaw J, Zhong C, Hayzer D et al. (1994). Characterization of thrombin receptor expression during vascular lesion formation. Circ Res 75: 1029-1038.
33. Yanamoto H, Kikuchi H, Sato M, Shimizu Y, Yoneda S, Okamoto S (1992). Therapeutic trial of cerebral vasospasm with the serine protease inhibitor, FUT-175, administered in the acute stage after subarachnoid hemorrhage. Neurosurg 30: 358-363.
34. Zhang Z, Nagata I, Kikuchi H, Xue JH, Sakai N, Sakai H et al. (2001). Broad-spectrum and selective serine protease inhibitors prevent expression of platelet-derived growth factor-BB and cerebral vasospasm after subarachnoid hemorrhage - vasospasm caused by cisternal injection of recombinant platelet-derived growth factor-BB. Stroke 32: 1665-1672.