Upregulation of proteinase-activated receptors and hypercontractile responses precede development of arterial lesions after balloon injury

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 291, Issue 5, 2006, Pages

  Fukunaga, Ryota ^a   Hirano, Katsuya ^a   Hirano, Mayumi ^a   Niiro, Naohisa ^a   Nishimura, Junji ^a   Maehara, Yoshihiko ^a,b   Kanaide, Hideo ^a,b  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Protease; Thrombin; Vascular injury; Vascular tone

Indexed keywords

CALCIUM ION; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); POTASSIUM ION; PROTEINASE ACTIVATED RECEPTOR; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; THROMBIN; TRYPSIN;

ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; ARTERY LESION; ARTERY LIGATION; ARTICLE; BALLOON CATHETER; BALLOON EMBOLIZATION; BLOOD FLOW VELOCITY; BLOOD VESSEL TONE; CONTROLLED STUDY; DEPOLARIZATION; FEMORAL ARTERY; HEART MUSCLE CONTRACTILITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; RECEPTOR UPREGULATION;

ANIMALS; BALLOON DILATATION; CELL DIVISION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMORAL ARTERY; IMMUNOHISTOCHEMISTRY; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; OLIGOPEPTIDES; RABBITS; RECEPTOR, PAR-1; RECEPTOR, PAR-2; THROMBIN; TIME FACTORS; TRYPSIN; TUNICA INTIMA; UP-REGULATION;

EID: 33751181465     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01313.2005     Document Type: Article

References (47)

1. Antonaccio MJ, Normandin D, Serafino R, and Moreland S. Effects of thrombin and thrombin receptor activating peptides on rat aortic vascular smooth muscle. J Pharmacol Exp Ther 266: 125-132, 1993.
2. Badimon L, Badimon JJ, Lassila R, Heras M, Chesebro JH, and Fuster V. Thrombin regulation of platelet interaction with damaged vessel wall and isolated collagen type I at arterial flow conditions in a porcine model: effects of hirudins, heparin, and calcium chelation. Blood 78: 423-434, 1991.
3. Chesebro JH, Webster MW, Zoldhelyi P, Roche PC, Badimon L, and Badimon JJ. Antithrombotic therapy and progression of coronary artery disease. Antiplatelet versus antithrombins. Circulation 86: III100-III110, 1992.
4. Cocks TM, Fong B, Chow JM, Anderson GP, Frauman AG, Goldie RG, Henry PJ, Carr MJ, Hamilton JR, and Moffatt JD. A protective role for protease-activated receptors in the airways. Nature 398: 156-160, 1999.
5. Coughlin SR. Thrombin signalling and protease-activated receptors. Nature 407: 258-264, 2000.
6. Coughlin SR, Vu TK, Hung DT, and Wheaton VI. Characterization of a functional thrombin receptor. Issues and opportunities. J Clin Invest 89: 351-355, 1992.
7. Dabbagh K, Laurent GJ, McAnulty RJ, and Chambers RC. Thrombin stimulates smooth muscle cell procollagen synthesis and mRNA levels via a PAR-1 mediated mechanism. Thromb Haemost 79: 405-409, 1998.
8. Damiano BP, D'Andrea MR, de Garavilla L, Cheung WM, and Andrade-Gordon P. Increased expression of protease activated receptor-2 (PAR-2) in balloon-injured rat carotid artery. Thromb Haemost 81: 808-814, 1999.
9. Dery O, Corvera CU, Steinhoff M, and Bunnett NW. Proteinaseactivated receptors: novel mechanisms of signaling by serine proteases. Am J Physiol Cell Physiol 274: C1429-C1452, 1998.
10. De Smet BJ, de Kleijn D, Hanemaaijer R, Verheijen JH, Robertus L, van Der Helm YJ, Borst C, and Post MJ. Metalloproteinase inhibition reduces constrictive arterial remodeling after balloon angioplasty: a study in the atherosclerotic Yucatan micropig. Circulation 101: 2962-2967, 2000.
11. Eidt JF, Allison P, Noble S, Ashton J, Golino P, McNatt J, Buja LM, and Willerson JT. Thrombin is an important mediator of platelet aggregation in stenosed canine coronary arteries with endothelial injury. J Clin Invest 84: 18-27, 1989.
12. i-linked Ras/mitogen-activated protein kinase pathway. J Biol Chem 274: 13718-13727, 1999.
13. Emori T, Hirata Y, Imai T, Ohta K, Kanno K, Eguchi S, and Marumo F. Cellular mechanism of thrombin on endothelin-1 biosynthesis and release in bovine endothelial cell. Biochem Pharmacol 44: 2409-2411, 1992.
14. Fager G. Thrombin and proliferation of vascular smooth muscle cells. Circ Res 77: 645-650, 1995.
15. Fuster V, Falk E, Fallon JT, Badimon L, Chesebro JH, and Badimon JJ. The three processes leading to post PTCA restenosis: dependence on the lesion substrate. Thromb Haemost 74: 552-559, 1995.
16. Garcia JG. Molecular mechanisms of thrombin-induced human and bovine endothelial cell activation. J Lab Clin Med 120: 513-519, 1992.
17. 2+ mobilization, barrier dysfunction, prostaglandin synthesis, and platelet-derived growth factor mRNA expression in cultured endothelium. J Cell Physiol 156: 541-549, 1993.
18. Godin D, Rioux F, Marceau F, and Drapeau G. Mode of action of thrombin in the rabbit aorta. Br J Pharmacol 115: 903-908, 1995.
19. Hatton MW, Moar SL, and Richardson M. Deendothelialization in vivo initiates a thrombogenic reaction at the rabbit aorta surface. Correlation of uptake of fibrinogen and antithrombin III with thrombin generation by the exposed subendothelium. Am J Pathol 135: 499-508, 1989.
20. Heras M, Chesebro JH, Penny WJ, Bailey KR, Badimon L, and Fuster V. Effects of thrombin inhibition on the development of acute platelet-thrombus deposition during angioplasty in pigs. Heparin versus recombinant hirudin, a specific thrombin inhibitor. Circulation 79: 657-665, 1989.
21. Hirano K and Kanaide H. Role of protease-activated receptors in the vascular system. J Atheroscler Thromb 10: 211-225, 2003.
22. Hirano K, Yufu T, Hirano M, Nishimura J, and Kanaide H. Physiology and pathophysiology of proteinase-activated receptors (PARs): regulation of the expression of PARs. J Sci 97: 31-37, 2005.
23. Hollenberg MD and Compton SJ. International Union of Pharmacology. XXVIII. Proteinase-activated receptors. Pharmacol Rev 54: 203-217, 2002.
24. 2+ channel in the proliferating smooth muscle cells of rat aorta. J Cell Biochem 87: 242-251, 2002.
25. Komuro T, Miwa S, Minowa T, Okamoto Y, Enoki T, Ninomiya H, Zhang XF, Uemura Y, Kikuchi H, and Masaki T. The involvement of a novel mechanism distinct from the thrombin receptor in the vasocontraction induced by trypsin. Br J Pharmacol 120: 851-856, 1997.
26. Ku DD and Dai J. Expression of thrombin receptors in human atherosclerotic coronary arteries leads to an exaggerated vasoconstrictory response in vitro. J Cardiovasc Pharmacol 30: 649-657, 1997.
27. Ku DD and Zaleski JK. Receptor mechanism of thrombin-induced endothelium-dependent and endothelium-independent coronary vascular effects in dogs. J Cardiovasc Pharmacol 22: 609-616, 1993.
28. 2+ currents in rat aortic smooth muscle cells in primary culture. Circ Res 79: 14-19, 1996.
29. 2+ channels in rat aorta smooth muscle cells in primary culture. Circ Res 67: 469-480, 1990.
30. Ma L, Perini R, McKnight W, Dicay M, Klein A, Hollenberg MD, and Wallace JL. Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets. Proc Natl Acad Sci USA 102: 216-220, 2005.
31. Macfarlane SR, Seatter MJ, Kanke T, Hunter GD, and Plevin R. Proteinase-activated receptors. Pharmacol Rev 53: 245-282, 2001.
32. Major TC, Overhiser RW, and Panek RL. Evidence for NO involvement in regulating vascular reactivity in balloon-injured rat carotid artery. Am J Physiol Heart Circ Physiol 269: H988-H996, 1995.
33. Malik AB and Fenton JW II. Thrombin-mediated increase in vascular endothelial permeability. Semin Thromb Hemost 18: 193-199, 1992.
34. McNamara CA, Sarembock IJ, Gimple LW, Fenton JW II, Coughlin SR, and Owens GK. Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor. J Clin Invest 91: 94-98, 1993.
35. Muramatsu I, Laniyonu A, Moore GJ, and Hollenberg MD. Vascular actions of thrombin receptor peptide. Can J Physiol Pharmacol 70: 996-1003, 1992.
36. Napoli C, Cicala C, Wallace JL, de Nigris F, Santagada V, Caliendo G, Franconi F, Ignarro LJ, and Cirino G. Protease-activated receptor-2 modulates myocardial ischemia-reperfusion injury in the rat heart. Proc Natl Acad Sci USA 97: 3678-3683, 2000.
37. Nelken NA, Soifer SJ, O'Keefe J, Vu TK, Charo IF, and Coughlin SR. Thrombin receptor expression in normal and atherosclerotic human arteries. J Clin Invest 90: 1614-1621, 1992.
38. 2+ sensitivity in α-toxin permeabilized arterial smooth muscle. Biochem Biophys Res Commun 157: 677-683, 1988.
39. Nitsch C, Scotti AL, Monard D, Heim C, and Sontag KH. The glia-derived protease nexin 1 persists for over 1 year in rat brain areas selectively lesioned by transient global ischaemia. Eur J Neurosci 5: 292-297, 1993.
40. 2+ channel and dystrophin expression after balloon injury in rat aortic cells. Cardiovasc Res 49: 177-188, 2001.
41. Richard B, Pichon S, Arocas V, Venisse L, Berrou E, Bryckaert M, Jandrot-Perrus M, and Bouton MC. The serpin protease nexin-1 regulates vascular smooth muscle cell adhesion, spreading, migration and response to thrombin. JAMA 4: 322-328, 2006.
42. 2+-induced tension development in chemically skinned smooth muscle fibers. J Gen Physiol 72: 1-14, 1978.
43. Shankar R, de la Motte CA, Poptic EJ, and DiCorleto PE. Thrombin receptor-activating peptides differentially stimulate platelet-derived growth factor production, monocytic cell adhesion, and E-selectin expression in human umbilical vein endothelial cells. J Biol Chem 269: 13936-13941, 1994.
44. Shoji T, Yonemitsu Y, Komori K, Tanii M, Itoh H, Sata S, Shimokawa H, Hasegawa M, Sueishi K, and Maehara Y. Intramuscular gene transfer of FGF-2 attenuates endothelial dysfunction and inhibits intimal hyperplasia of vein grafts in poor-runoff limbs of rabbit. Am J Physiol Heart Circ Physiol 285: H173-H182, 2003.
45. Steinberg SF. The cardiovascular actions of protease-activated receptors. Mol Pharmacol 67: 2-11, 2005.
46. Weksler BB. Antiplatelet agents in stroke prevention. Combination therapy: present and future. Cerebrovasc Dis 10: 41-48, 2000.
47. Wilcox JN, Rodriguez J, Subramanian R, Ollerenshaw J, Zhong C, Hayzer DJ, Horaist C, Hanson SR, Lumsden A, and Salam TA. Characterization of thrombin receptor expression during vascular lesion formation. Circ Res 75: 1029-1038, 1994.