Decursin suppresses human androgen-independent PC3 prostate cancer cell proliferation by promoting the degradation of β-catenin

Molecular Pharmacology

Volumn 72, Issue 6, 2007, Pages 1599-1606

  Song, Gyu Yong ^a   Lee, Jee Hyun ^a   Cho, Munju ^b   Park, Byeoung Soo ^c   Kim, Dong Eun ^d   Oh, Sangtaek ^b  

^a Chungnam National University   (South Korea)

^b Inje University   (South Korea)

^c Hankyong National University   (South Korea)

^d Konkuk University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANGELICA GIGAS EXTRACT; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BETA CATENIN; CYCLIN D1; DECURSIN; DECURSINOL; LITHIUM CHLORIDE; MYC PROTEIN; PYRANOCOUMARIN DERIVATIVE; UNCLASSIFIED DRUG; WNT PROTEIN; WNT3 PROTEIN;

ANGELICA; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; DRUG STRUCTURE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DEGRADATION; PROTEIN EXPRESSION;

ANDROGEN ANTAGONISTS; ANDROGENS; ANGELICA; BENZOPYRANS; BETA CATENIN; BUTYRIC ACIDS; CELL LINE; CELL PROLIFERATION; HUMANS; MALE; PLANT EXTRACTS; PLANT ROOTS; PROSTATIC NEOPLASMS;

EID: 36349034670     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.107.040253     Document Type: Article

References (40)

1. Aberle H, Bauer A, Stappert J, Kispert A, and Kemler R (1997) β-catenin is a target for the ubiquitin-proteasome pathway. EMBO J 16:3797-3804.
2. Barker N and Clevers H (2000) Catenins, Wnt signaling and cancer. Bioassays 22:961-965.
3. Chesire DR, Ewing CM, Gage WR, and Issac WB (2000) Detection and analysis of β-catenin mutation in prostate cancer. Prostate 45:323-334.
4. Chesire DR and Issac WB (2002) Ligand-dependent inhibition of β-catenin/TCF signaling by androgen receptor. Oncogene 21:8453-8469.
5. Chi HJ and Kim HS (1970) Studies on the components of Umbelliferae plants in Korea: pharmacological study of decursin, decursinol and nodakenin. Korean J Pharmacol 1:25-32.
6. Cho M, Gwak J, Park S, Won J, Kim DE, Yea SS, Cha IJ, Kim TK, Shin JG, and Oh S (2005) Diclofenac attenuates Wnt/β-catenin signaling in colon cancer cells by activation of NF-κB. FEBS Lett 579:4213- 4218.
7. de la Taille A, Rubin MA, Chen MW, Vacherot F, Burchardt M, Buttyan R, and Chopin D (2003) β-catenin-related anomalies in apoptosis-resistant and hormone-refractory prostate cancer cells. Clin Cancer Res 9:1801-1807.
8. Dignam JD, Lebovitz RM, and Roeder RG (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11:1475-1489.
9. Gerstein AV, Almeida TA, Zhao G, Chess E, Buhler K, Pienta K, Rubin MA, Vessella R, and Papadopoulos N (2002) APC/CTNNB1 (β-catenin) pathway alterations in human prostate cancers. Genes Chromosomes Cancer 34:9-16.
10. Giles RH, van Es JH, and Clevers H (2003) Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta 1653:1-24.
11. Guo J, Jiang C, Wang Z, Lee HJ, Hu H, Malewicz B, Lee HJ, Lee JH, Baek NI, Jeong JH, et al. (2007) A novel class of pyranocoumarin anti-androgen receptor signaling compounds. Mol Cancer Ther 6:907-917.
12. Gwak J, Cho M, Gong SJ, Won J, Kim DE, Kim EY, Lee SS, Kim M, Kim TK, Shin JG, et al. (2006) Protein-kinase-C-mediated beta-catenin phosphorylation negatively regulates the Wnt/β-catenin pathway. J Cell Sci 119:4702-4709.
13. Hart M, Concordet JP, Lassot I, Albert I, del los Santos R, Durand H, Perret C, Rubinfeld B, Margottin F, Benarous R, et al. (1999) The F-box protein β-TrCP associates with phosphorylated β-catenin and regulates its activity in the cell. Curr Biol 9:207-210.
14. Hart MJ, del los Santos R, Albert IN, Rubinfeld B, and Polakis P (1998) Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β. Curr Biol 8:573-581.
15. He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B, and Kinzler KW (1998) Identification of c-MYC as a target of the APC pathway. Science 281:1509-1512.
16. Horvath LG, Lelliott JE, Kench JG, Lee DS, Williams ED, Saunders DN, Grygiel JJ, Sutherland RL, and Henshall SM (2007) Secreted Frizzled-related protein 4 inhibits proliferation and metastatic potential in prostate cancer. Prostate 67:1081-1090.
17. Jemal A, Murray T, Ward E, Samuels A, Tiwari RC, Ghafoor A, Feuer EJ, and Thun MJ (2005) Cancer statistics, 2005. CA Cancer J Clin 55:10-30.
18. Jiang C, Lee HJ, Li GX, Guo J, Malewicz B, Zhao Y, Lee EO, Lee HJ, Lee JH, Kim MS, et al. (2006) Potent antiandrogen and androgen receptor activities of an Angelica gigas-containing herbal formulation: identification of decursin as a novel and active compound with implications fro prevention and treatment of prostate cancer. Cancer Res 66:453-463.
19. Kim HH, Ahn KS, Han H, Choung SY, Choi SY, and Kim IH (2005) Decursin and PDBu: two PKC activators distinctively acting in the megakaryocytic differentiation of K562 human erythroleukemia cells. Leuk Res 29:1407-1413.
20. Klein PS and Melton DA (1996) A molecular mechanism for the effect of lithium on development. Proc Natl Acad Sci U S A 93:8455-8459.
21. 2+ pathway: a new vertebrate Wnt signaling pathway takes shape. Trends Genet 16:279-283.
22. Latres E, Chiaur DS, and Pagano M (1999) The human F box protein β-Trcp associates with the Cul1/Skp1 complex and regulates the stability of β-catenin. Oncogene 18:849-854.
23. Lee E, Salic A, Kruger R, Heinrich R, and Kirschner MW (2003a) The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway [published erratum appears in PLoS Biol 2:E89, 2004]. PLoS Biol 1:E10.
24. Lee JH, Choi YS, Kim JH, Jeong HG, Kim DH, Yun MY, Kim EK, and Song GY (2006) A mass preparation method of (+)-decursinol from the roots of Angelica gigas. Yakhak Hoechi 50:338-344.
25. Lee S, Lee YS, Jung SH, Shin KH, Kim BK, and Kang SS (2003b) Antitumor activity of decursinol angulated and decursin from Angelica gigas. Arch Pharmacol Res 26:727-730.
26. Lim JD, Kim IH, Kim HH, Ahn KS, and Han HG (2001) Enantioselective synthesis of decursinol angelate and decursin. Tetrahedron Lett 43:4001.
27. Liu C, Li Y, Semenov M, Han C, Baeg GH, Tan Y, Zhang Z, Lin X, and He X (2002) Control of β-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108:837-847.
28. Liu J, Stevens J, Rote CA, Yost HJ, Hu Y, Neufeld KL, White RL, and Matsunami N (2001) Siah-1 mediates a novel β-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. Mol Cell 7:927-936.
29. Mulholland DJ, Read JT, Rennie PS, Cox ME, and Nelson CC (2003) Functional localization and competition between the androgen receptor and T-cell factor for nuclear b-catenin: a means for inhibition of the Tcf signaling axis. Oncogene 22:5602-5613.
30. Park S, Gwak J, Cho M, Song T, Won J, Kim DE, Shin JG, and Oh S (2006) Hexachlorophene inhibits Wnt/β-catenin pathway by promoting Siah-mediated β-catenin degradation. Mol Pharmacol 70:960-966, 2006.
31. Polakis P (2000) Wnt signaling and cancer. Genes Dev 14:1837-1851.
32. Sherr CJ (1996) Cancer cell cycle. Science 274:1672-1677.
33. Takahashi M, Tsunoda T, Seiki M, Nakamura Y, and Furukawa Y (2002) Identification of membrane-type matrix metalloproteinase-1 as a target of the β-catenin/Tcf4 complex in human colorectal cancers. Oncogene 21:5861-5867.
34. Tetsu O and McCormick F (1999) β-Catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398:422-426.
35. Utsunomiya T, Doki Y, Takemoto H, Shiozaki H, Yano M, Sekimoto M, Tamura S, Yasuda T, Fujiwara Y, and Monden M (2001) Correlation of β-catenin and cyclin D1 expression in colon cancers. Oncology 61:226-233.
36. Winklbauer R, Medina A, Swain RK, and Steinbeisser H (2001) Frizzled-7 signalling controls tissue separation during Xenopus gastrulation. Nature 413:856-860.
37. β-TRCP-ubiquitin ligase complex associates specifically with phosphory-lated destruction motifs in IκBα and β-catenin and stimulates IκBα ubiquitination in vitro. Genes Dev 13:270-283.
38. Wodarz A and Nusse R (1998) Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol 14:59-88.
39. 1 arrest and apoptosis in human prostate carcinoma cells. Cancer Res 65:1035-1044.
40. Zi X, Guo Y, Simoneau AR, Hope C, Xie J, Holcombe RF, and Hoang BH (2005) Expression of Frzb/secreted Frizzled-related protein 3, a secreted Wnt antagonist, in human androgen-independent prostate cancer PC-3 cells suppresses tumor growth and cellular invasiveness. Cancer Res 65:9762-9770.