메뉴 건너뛰기




Volumn 195, Issue 4, 2008, Pages 479-486

Comparison of naltrexone, 6α-naltrexol, and 6β-naltrexol in morphine-dependent and in nondependent rhesus monkeys

Author keywords

Antagonism; Dependence; Drug discrimination; Monkey; Naltrexol; Naltrexone; Opioid; Schild analysis

Indexed keywords

DRUG METABOLITE; MORPHINE; NALTREXOL; NALTREXONE; OPIATE ANTAGONIST; OPIATE RECEPTOR; 6 BETA HYDROXYNALTREXONE; 6 BETA-HYDROXYNALTREXONE; DRUG DERIVATIVE; MU OPIATE RECEPTOR; NARCOTIC ANTAGONIST; UNCLASSIFIED DRUG;

EID: 36349010310     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-007-0914-9     Document Type: Article
Times cited : (16)

References (29)
  • 1
    • 0034813626 scopus 로고    scopus 로고
    • Pharmacologic approaches to the management of alcoholism
    • Suppl 20
    • Anton RF (2001) Pharmacologic approaches to the management of alcoholism. J Clin Psychiatry 62(Suppl 20):11-17
    • (2001) J Clin Psychiatry , vol.62 , pp. 11-17
    • Anton, R.F.1
  • 3
    • 0031032769 scopus 로고    scopus 로고
    • Human herpes virus KSHV encodes a constitutively active G-protein coupled receptor linked to cell proliferation
    • Arvanitakis L, Geras-Raaka E, Varma A, Gershengorn MC, Cesarman E (1997) Human herpes virus KSHV encodes a constitutively active G-protein coupled receptor linked to cell proliferation. Nature (Lond) 385:347-350
    • (1997) Nature (Lond) , vol.385 , pp. 347-350
    • Arvanitakis, L.1    Geras-Raaka, E.2    Varma, A.3    Gershengorn, M.C.4    Cesarman, E.5
  • 4
    • 27744438430 scopus 로고    scopus 로고
    • Physiological relevance of constitutive activity of 5-HT2A and 5-HT2C receptors
    • Berg KA, Harvey JA, Spampinato U, Clarke WP (2005) Physiological relevance of constitutive activity of 5-HT2A and 5-HT2C receptors. Trends Pharmacol Sci 26:625-630
    • (2005) Trends Pharmacol Sci , vol.26 , pp. 625-630
    • Berg, K.A.1    Harvey, J.A.2    Spampinato, U.3    Clarke, W.P.4
  • 6
    • 0026608113 scopus 로고
    • Drug efficacy at guaninenucleotide-binding regulatory protein linked receptors: Thermodynamic interpretations of negative antagonism and of receptor activity in the absence of ligand
    • Costa T, Ogino Y, Munson PJ, Onaran O, Rodbard D (1992) Drug efficacy at guaninenucleotide-binding regulatory protein linked receptors: thermodynamic interpretations of negative antagonism and of receptor activity in the absence of ligand. Mol Pharmacol 41:549-560
    • (1992) Mol Pharmacol , vol.41 , pp. 549-560
    • Costa, T.1    Ogino, Y.2    Munson, P.J.3    Onaran, O.4    Rodbard, D.5
  • 7
    • 1842610940 scopus 로고    scopus 로고
    • Constitutive activity of the serotonin2C receptor inhibits in vivo dopamine release in the rat striatum and nucleus accumbens
    • De Deurwaerdère P, Navailles S, Berg KA, Clarke WP, Spampinato U (2004) Constitutive activity of the serotonin2C receptor inhibits in vivo dopamine release in the rat striatum and nucleus accumbens. J Neurosci 24:3235-3241
    • (2004) J Neurosci , vol.24 , pp. 3235-3241
    • De Deurwaerdère, P.1    Navailles, S.2    Berg, K.A.3    Clarke, W.P.4    Spampinato, U.5
  • 8
    • 0024421299 scopus 로고
    • Discriminative stimulus effects of naltrexone in morphine-treated rhesus monkeys
    • France CP, Woods JH (1989) Discriminative stimulus effects of naltrexone in morphine-treated rhesus monkeys. J Pharmacol Exp Ther 250:937-943
    • (1989) J Pharmacol Exp Ther , vol.250 , pp. 937-943
    • France, C.P.1    Woods, J.H.2
  • 9
    • 0025355471 scopus 로고
    • Apparent affinity of opioid antagonists in morphine-treated rhesus monkeys discriminating between saline and naltrexone
    • France CP, de Costa BR, Jacobson AE, Rice KC, Woods JH (1990) Apparent affinity of opioid antagonists in morphine-treated rhesus monkeys discriminating between saline and naltrexone. J Pharmacol Exp Ther 252:600-604
    • (1990) J Pharmacol Exp Ther , vol.252 , pp. 600-604
    • France, C.P.1    De Costa, B.R.2    Jacobson, A.E.3    Rice, K.C.4    Woods, J.H.5
  • 10
    • 34447298640 scopus 로고    scopus 로고
    • Time-dependent decreases in apparent pA2 values for naltrexone studied in combination with morphine in rhesus monkeys
    • Gerak LR, France CP (2007) Time-dependent decreases in apparent pA2 values for naltrexone studied in combination with morphine in rhesus monkeys. Psychopharmacology 193:315-321
    • (2007) Psychopharmacology , vol.193 , pp. 315-321
    • Gerak, L.R.1    France, C.P.2
  • 11
    • 1842854603 scopus 로고    scopus 로고
    • Combating opiate dependence: A comparison among the available pharmacological options
    • Gonzalez G, Oliverto A, Kosten TR (2004) Combating opiate dependence: a comparison among the available pharmacological options. Expert Opin Pharmacother 5:713-725
    • (2004) Expert Opin Pharmacother , vol.5 , pp. 713-725
    • Gonzalez, G.1    Oliverto, A.2    Kosten, T.R.3
  • 12
    • 33748108652 scopus 로고    scopus 로고
    • Synthesis and hydrolytic behavior of two novel tripartite codrugs of naltrexone and 6β-naltrexol with hydroxybupropion as potential alcohol abuse and smoking cessation agents
    • Hamad MO, Kiptoo PK, Stinchbomb AL, Crooks PA (2006) Synthesis and hydrolytic behavior of two novel tripartite codrugs of naltrexone and 6β-naltrexol with hydroxybupropion as potential alcohol abuse and smoking cessation agents. Bioorg Med Chem 14:7051-7061
    • (2006) Bioorg Med Chem , vol.14 , pp. 7051-7061
    • Hamad, M.O.1    Kiptoo, P.K.2    Stinchbomb, A.L.3    Crooks, P.A.4
  • 13
    • 0032587531 scopus 로고    scopus 로고
    • 2 receptor antagonists on a cranial nerve reflex in the rabbit: Evidence for inverse agonism
    • 2 receptor antagonists on a cranial nerve reflex in the rabbit: evidence for inverse agonism. Psychopharmacology 141:162-168
    • (1999) Psychopharmacology , vol.141 , pp. 162-168
    • Harvey, J.A.1    Welsh, S.E.2    Hood, H.3    Romano, A.G.4
  • 14
    • 33745278513 scopus 로고    scopus 로고
    • Enhancement of transdermal delivery of 6β-naltrexol via a codrug linked to hydroxybupropion
    • Kiptoo PK, Hamad MO, Crooks PA, Stinchcomb AL (2006) Enhancement of transdermal delivery of 6β-naltrexol via a codrug linked to hydroxybupropion. J Control Release 113:137-145
    • (2006) J Control Release , vol.113 , pp. 137-145
    • Kiptoo, P.K.1    Hamad, M.O.2    Crooks, P.A.3    Stinchcomb, A.L.4
  • 15
    • 31144477783 scopus 로고    scopus 로고
    • Differential in vivo potencies of naltrexone and 6beta-naltrexol in the monkey
    • Ko MC, Divin MF, Lee H, Woods JH, Traynor JR (2006) Differential in vivo potencies of naltrexone and 6beta-naltrexol in the monkey. J Pharmacol Exp Ther 316:772-779
    • (2006) J Pharmacol Exp Ther , vol.316 , pp. 772-779
    • Ko, M.C.1    Divin, M.F.2    Lee, H.3    Woods, J.H.4    Traynor, J.R.5
  • 16
    • 0016753944 scopus 로고
    • Metabolic reduction of naltrexone. I. Synthesis, separation and characterization of naloxone and naltrexone reduction products and qualitative assay of urine and bile following administration of naltrexone, alpha-naltrexol, or beta-naltrexol
    • Malspeis L, Bathala MS, Ludden TM, Bhat HB, Frank SG, Sokoloski TD, Morrison BE, Reuning RH (1975) Metabolic reduction of naltrexone. I. Synthesis, separation and characterization of naloxone and naltrexone reduction products and qualitative assay of urine and bile following administration of naltrexone, alpha-naltrexol, or beta-naltrexol. Res Commun Chem Pathol Pharmacol 12:43-65
    • (1975) Res Commun Chem Pathol Pharmacol , vol.12 , pp. 43-65
    • Malspeis, L.1    Bathala, M.S.2    Ludden, T.M.3    Bhat, H.B.4    Frank, S.G.5    Sokoloski, T.D.6    Morrison, B.E.7    Reuning, R.H.8
  • 17
    • 0021219060 scopus 로고
    • Bioequivalence, dose-proportionality, and pharmacokinetics of naltrexone after oral administration
    • Meyer MC, Straughn AB, Lo MW, Schary WL, Whitney CC (1984) Bioequivalence, dose-proportionality, and pharmacokinetics of naltrexone after oral administration. J Clin Psychiatry 45:15-19
    • (1984) J Clin Psychiatry , vol.45 , pp. 15-19
    • Meyer, M.C.1    Straughn, A.B.2    Lo, M.W.3    Schary, W.L.4    Whitney, C.C.5
  • 18
    • 0028861330 scopus 로고
    • Inverse agonism, pharmacological curiosity or potential therapeutic strategy
    • Milligan G, Bond RA, Lee M (1995) Inverse agonism, pharmacological curiosity or potential therapeutic strategy. Trends Pharmacol Sci 16:10-13
    • (1995) Trends Pharmacol Sci , vol.16 , pp. 10-13
    • Milligan, G.1    Bond, R.A.2    Lee, M.3
  • 20
    • 0036255855 scopus 로고    scopus 로고
    • In vivo and in vitro studies of 6β-naltrexol, the major human metabolite of naltrexone
    • Porter SJ, Somogyi AA, White JM (2002) In vivo and in vitro studies of 6β-naltrexol, the major human metabolite of naltrexone. Addict Biol 7:218-225
    • (2002) Addict Biol , vol.7 , pp. 218-225
    • Porter, S.J.1    Somogyi, A.A.2    White, J.M.3
  • 21
    • 19444361830 scopus 로고    scopus 로고
    • In vivo characterization of 6beta-naltrexol, an opioid ligand with less inverse agonist activity compared with naltrexone and naloxone in opioid-dependent mice
    • Raehal KM, Lowery JJ, Bhamidipati CM, Paolino RM, Blair JR, Wang D, Sadee W, Bilsky EJ (2005) In vivo characterization of 6beta-naltrexol, an opioid ligand with less inverse agonist activity compared with naltrexone and naloxone in opioid-dependent mice. J Pharmacol Exp Ther 313:1150-1162
    • (2005) J Pharmacol Exp Ther , vol.313 , pp. 1150-1162
    • Raehal, K.M.1    Lowery, J.J.2    Bhamidipati, C.M.3    Paolino, R.M.4    Blair, J.R.5    Wang, D.6    Sadee, W.7    Bilsky, E.J.8
  • 24
    • 0018655874 scopus 로고
    • PA2 and receptor differentiation: A statistical analysis of competitive antagonism
    • Tallarida RJ, Cowan A, Adler MW (1979) pA2 and receptor differentiation: a statistical analysis of competitive antagonism. Life Sci 25:637-654
    • (1979) Life Sci , vol.25 , pp. 637-654
    • Tallarida, R.J.1    Cowan, A.2    Adler, M.W.3
  • 25
    • 23744466581 scopus 로고    scopus 로고
    • Opioid antagonists differ according to negative intrinsic efficacy in a mouse model of acute dependence
    • Walker EA, Sterious SN (2005) Opioid antagonists differ according to negative intrinsic efficacy in a mouse model of acute dependence. Br J Pharmacol 145:975-983
    • (2005) Br J Pharmacol , vol.145 , pp. 975-983
    • Walker, E.A.1    Sterious, S.N.2
  • 26
    • 0034972443 scopus 로고    scopus 로고
    • Inverse agonists and neutral antagonists at μ opioid receptor (MOR): Possible role of basal receptor signaling in narcotic dependence
    • Wang D, Raehal KM, Bilsky EJ, Sadee W (2001) Inverse agonists and neutral antagonists at. μ. opioid receptor (MOR): possible role of basal receptor signaling in narcotic dependence. J Neurochem 77:1590-1600
    • (2001) J Neurochem , vol.77 , pp. 1590-1600
    • Wang, D.1    Raehal, K.M.2    Bilsky, E.J.3    Sadee, W.4
  • 28
    • 34247234605 scopus 로고    scopus 로고
    • Different effects of opioid antagonists on μ-, δ-, and κ-opioid receptors with and without agonist pretreatment
    • Wang D, Sun X, Sadee W (2007) Different effects of opioid antagonists on μ-, δ-, and κ-opioid receptors with and without agonist pretreatment. J Pharmacol Exp Ther 321:544-552
    • (2007) J Pharmacol Exp Ther , vol.321 , pp. 544-552
    • Wang, D.1    Sun, X.2    Sadee, W.3
  • 29
    • 0028299699 scopus 로고
    • Constitutive m-opioid receptor activation as a regulatory mechanism underlying narcotic tolerance and dependence
    • Wang Z, Edward JB, Porreca F, Sadee W (1994) Constitutive μ-opioid receptor activation as a regulatory mechanism underlying narcotic tolerance and dependence. Life Sci 54:PL339-PL350
    • (1994) Life Sci , vol.54
    • Wang, Z.1    Edward, J.B.2    Porreca, F.3    Sadee, W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.