Synthesis and hydrolytic behavior of two novel tripartate codrugs of naltrexone and 6β-naltrexol with hydroxybupropion as potential alcohol abuse and smoking cessation agents

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 20, 2006, Pages 7051-7061

  Hamad, Mohamed O ^a   Kiptoo, Paul K ^a   Stinchcomb, Audra L ^a   Crooks, Peter A ^a  

^a University of Kentucky   (United States)

Author keywords

Naltrexol; Alcohol Abuse; Codrugs; Hydroxybupropion; Naltrexone; Transdermal delivery

Indexed keywords

ALCOHOL; AMFEBUTAMONE; BUFFER; CARBONIC ACID DERIVATIVE; HYDROXYBUPROPION; NALTREXOL; NALTREXONE; UNCLASSIFIED DRUG;

ALCOHOL ABUSE; ARTICLE; CALCULATION; DRUG DESIGN; DRUG SYNTHESIS; LIPID SOLUBILITY; MELTING POINT; SMOKING CESSATION; TOBACCO DEPENDENCE;

ALCOHOL DETERRENTS; BUPROPION; DRUG STABILITY; HYDROLYSIS; MOLECULAR STRUCTURE; NALTREXONE; SMOKING CESSATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

NICOTIANA TABACUM;

EID: 33748108652     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.06.018     Document Type: Article

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