Primary DNA damage and genetic polymorphisms for CYP1A1, EPHX and GSTM1 in workers at a graphite electrode manufacturing plant

BMC Public Health

Volumn 7, Issue , 2007, Pages

  Moretti, Massimo ^a   Dell'Omo, Marco ^a   Villarini, Milena ^a   Pastorelli, Roberta ^b   Muzi, Giacomo ^a   Airoldi, Luisa ^b   Pasquini, Rossana ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 HYDROXYPYRENE; CYTOCHROME P450 1A1; DNA; EPOXIDE HYDROLASE; GLUTATHIONE TRANSFERASE M1; GRAPHITE; PHOSPHODIESTERASE I; POLYCYCLIC AROMATIC HYDROCARBON; 1-HYDROXYPYRENE; BIOLOGICAL MARKER; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); GLUTATHIONE S-TRANSFERASE M1; GLUTATHIONE TRANSFERASE; PYRENE DERIVATIVE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; ELECTRODE; EXON; GENE MUTATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTOXICITY; GENOTYPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; LEUKOCYTE; MALE; METAL INDUSTRY; OCCUPATIONAL EXPOSURE; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR; URINALYSIS; COMPARATIVE STUDY; CROSS-SECTIONAL STUDY; GENETICS; ITALY; MATERIALS; MEN'S HEALTH; METABOLISM; PLANT; WORKPLACE;

ADULT; BIOLOGICAL MARKERS; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; COMET ASSAY; CROSS-SECTIONAL STUDIES; CYTOCHROME P-450 CYP1A1; DNA DAMAGE; ELECTRODES; EPOXIDE HYDROLASES; GENOTYPE; GLUTATHIONE TRANSFERASE; GRAPHITE; HUMANS; ITALY; LEUKOCYTES; MALE; MANUFACTURED MATERIALS; MEN'S HEALTH; OCCUPATIONAL EXPOSURE; PLANTS; POLYMORPHISM, GENETIC; PYRENES; WORKPLACE;

EID: 36348987180     PISSN: None     EISSN: 14712458     Source Type: Journal    
DOI: 10.1186/1471-2458-7-270     Document Type: Article

References (66)

1. Cancer risk from occupational and environmental exposure to polycyclic aromatic hydrocarbons. P Boffetta N Jourenkova P Gustavsson, Cancer Causes Control 1997 8 3 444 472 10.1023/A:1018465507029 9498904
2. Risk of lung, larynx, pharynx and buccal cavity cancers among carbon electrode manufacturing workers. JJ Moulin P Wild JM Mur M Lafontaine M Lefer M Mercier-Gallay P Villemot V Whebi JP Coulon, Scand J Work Environ Health 1989 15 1 30 37 2922586
3. Preventive measures reduce exposure to polycyclic aromatic hydrocarbons at a graphite electrode plant. M Dell'Omo G Muzi G Marchionna L Latini P Carrieri P Paolemili G Abbritti, Occup Environ Med 1998 55 6 401 406 9764100
4. Application of the Salmonella mutagenicity assay and determination of polycyclic aromatic hydrocarbons in workplaces exposed to petroleum pitch and petroleum coke. S Monarca R Pasquini GS Sforzolini V Viola F Fagioli, Int Arch Occup Environ Health 1982 49 3-4 223 239 10.1007/BF00377932 7040253
5. Mutagens in urine of carbon electrode workers. R Pasquini S Monarca GS Sforzolini R Conti F Fagioli, Int Arch Occup Environ Health 1982 50 4 387 395 10.1007/BF00377835 6757140
6. Airborne exposure to polycyclic aromatic hydrocarbons (PAHs) and urinary excretion of 1-hydroxypyrene of carbon anode plant workers. T Petry P Schmid C Schlatter, Ann Occup Hyg 1996 40 3 345 357 8694494
7. Population based mortality surveillance in carbon products manufacturing plants. MJ Teta MG Ott AR Schnatter, Br JInd Med 1987 44 5 344 350
8. Cancer mortality among man-made graphite electrode manufacturing workers: results of a 38 year follow up. I Mori, Occup Environ Med 2002 59 7 473 480 10.1136/oem.59.7.473 12107297
9. Surveillance of mortality and cancer incidence among Swedish graphite electrode workers. P Gustavsson T Bellander L Johansson S Salmonsson, Environ Res 1995 70 1 7 10 10.1006/enrs.1995.1039 8603661
10. Mortality from cancer and chronic respiratory diseases among workers who manufacture carbon electrodes. F Donato S Monarca G Marchionna A Rossi C Cicioni R Chiesa D Colin P Boffetta, Occup Environ Med 2000 57 7 484 487 10.1136/oem.57.7.484 10854502
11. Polynuclear aromatic compounds, Part 1, Chemical, environmental and experimental data. IARC, IARC Monograph on the Evaluation of the Carcinogenic Risk of Chemicals to Humans Lyon (France): International Agency for Research on Cancer 1983 32
12. Functional significance of different human CYP1A1 genotypes. F Crofts E Taioli J Trachman GN Cosma D Currie P Toniolo SJ Garte, Carcinogenesis 1994 15 12 2961 2963 10.1093/carcin/15.12.2961 8001264
13. The role of glutathione and glutathione transferases in chemical carcinogenesis. B Coles B Ketterer, Crit Rev BiochemMol Biol 1990 25 1 47 70
14. Genetic variability in susceptibility and response to toxicants. M Ingelman-Sundberg, Toxicol Lett 2001 120 1-3 259 268 10.1016/S0378-4274(01) 00278-8 11323184
15. Biological indicators of genotoxic risk and metabolic polymorphisms. S Pavanello E Clonfero, Mutat Res 2000 463 3 285 308 10.1016/S1383-5742(00)00051-X 11018745
16. Impact of metabolic genotypes on levels of biomarkers of genotoxic exposure. B Schoket G Papp K Levay G Mrackova FF Kadlubar I Vincze, Mutat Res 2001 482 1-2 57 69 11535249
17. Genetic polymorphism of CYP genes, alone or in combination, as a risk modifier of tobacco-related cancers. H Bartsch U Nair A Risch M Rojas H Wikman K Alexandrov, Cancer Epidemiol Biomarkers Prev 2000 9 1 3 28 10667460
18. Impact of inherited polymorphisms in glutathione S-transferase M1, microsomal epoxide hydrolase, cytochrome P450 enzymes on DNA, and blood protein adducts of benzo(a)pyrene-diolepoxide. R Pastorelli M Guanci A Cerri E Negri C La Vecchia F Fumagalli M Mezzetti R Cappelli T Panigalli R Fanelli, Cancer Epidemiol Biomarkers Prev 1998 7 8 703 709 9718223
19. High benzo[a]pyrene diol-epoxide DNA adduct levels in lung and blood cells from individuals with combined CYP1A1 MspI/Msp-GSTM1*0/*0 genotypes. M Rojas K Alexandrov I Cascorbi J Brockmoller A Likhachev K Pozharisski G Bouvier G Auburtin L Mayer A Kopp-Schneider, Pharmacogenetics 1998 8 2 109 118 10.1097/00008571-199804000-00003 10022748
20. Aromatic DNA adduct levels in coke oven workers: correlation with polymorphisms in genes GSTP1, GSTM1, GSTT1 and CYP1A1. JP Teixeira J Gaspar G Martinho S Silva S Rodrigues O Mayan E Martin PB Farmer J Rueff, Mutat Res 2002 517 1-2 147 155 12034316
21. Usefulness of genetic susceptibility and biomarkers for evaluation of environmental health risk. WW Au HY Oh J Grady SA Salama MY Heo, Environ Mol Mutagen 2001 37 3 215 225 10.1002/em.1030 11317339
22. Genetic polymorphisms in human xenobiotica metabolizing enzymes as susceptibility factors in toxic response. H Autrup, Mutat Res 2000 464 1 65 76 10633178
23. Human microsomal epoxide hydrolase: 5'-flanking region genetic polymorphisms. S Raaka C Hassett CJ Omiencinski, Carcinogenesis 1998 19 3 387 393 10.1093/carcin/19.3.387 9525271
24. Genetic heterogeneity of the human glutathione transferases: a complex of gene families. P Board M Coggan P Johnston V Ross T Suzuki G Webb, Pharmacol Ther 1990 48 3 357 369 10.1016/0163-7258(90)90054-6 2084706
25. Coke oven workers study: the effect of exposure and GSTM1 and NAT2 genotypes on DNA adduct levels in white blood cells and lymphocytes as determined by 32P-postlabelling. B Binkova J Topinka G Mrackova D Gajdosova P Vidova Z Stavkova V Peterka T Pilcik V Rimar L Dobias, Mutat Res 1998 416 1-2 67 84 9725993
26. CYP1A1 and GSTM1 polymorphisms affect urinary 1-hydroxypyrene levels after PAH exposure. AK Alexandrie M Warholm U Carstensen A Axmon L Hagmar JO Levin C Ostman A Rannug, Carcinogenesis 2000 21 4 669 676 10.1093/carcin/21.4. 669 10753202
27. Molecular epidemiology studies on occupational and environmental exposure to mutagens and carcinogens, 1997-1999. RJ Sram B Binkova, Environ Health Perspect 2000 108 Suppl 1 57 70 10698723 10.2307/3454632
28. Determination of hydroxylated metabolites of polycyclic aromatic hydrocarbons in urine. FJ Jongeneelen RB Anzion PT Henderson, J Chromatogr 1987 413 227 232 10.1016/0378-4347(87)80230-X 3558672
29. Estimation of individual dermal and respiratory uptake of polycyclic aromatic hydrocarbons in 12 coke oven workers. JG VanRooij MM Bodelier-Bade FJ Jongeneelen, Br J Ind Med 1993 50 7 623 632 8343423
30. Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. RR Tice E Agurell D Anderson B Burlinson A Hartmann H Kobayashi Y Miyamae E Rojas JC Ryu YF Sasaki, Environ Mol Mutagen 2000 35 3 206 221 10.1002/(SICI)1098-2280(2000)35:3<206::AID-EM8>3.0.CO;2-J 10737956
31. Benzo (a) pyrene diolepoxide adducts to albumin in workers exposed to polycyclic aromatic hydrocarbons: association with specific CYP1A1, GSTM1, GSTP1 and EHPX genotypes. R Pastorelli A Cerri M Rozio M Dell'Omo G Muzi G Abbritti R Fanelli L Airoldi, Biomarkers 2001 6 5 357 374 10.1080/13547500110044267
32. Genetic polymorphisms in the 5'-flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene. S Hayashi J Watanabe K Kawajiri, J Biochem (Tokyo) 1991 110 4 559 565 1778977
33. A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility. I Cascorbi J Brockmoller I Roots, Cancer Res 1996 56 21 4965 4969 8895751
34. Genetic risk and carcinogen exposure: a common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancer. DA Bell JA Taylor DF Paulson CN Robertson JL Mohler GW Lucier, J Natl Cancer Inst 1993 85 14 1159 1164 10.1093/jnci/85.14. 1159 8320745
35. Cells of different tissues for in vitro and in vivo studies in toxicology: Compilation of isolation methods. SY Brendler-Schwaab P Schmezer U Liegibel S Weber K Michalek A Tompa BL Pool-Zobel, Toxicology In Vitro 1994 8 6 1285 1302 10.1016/0887-2333(94)90122-8
36. An improved method to determine cell viability by simultaneous staining with fluorescein diacetate-propidium iodide. KH Jones JA Senft, J Histochem Cytochem 1985 33 1 77 79 2578146
37. A simple technique for quantitation of low levels of DNA damage in individual cells. NP Singh MT McCoy RR Tice EL Schneider, Exp Cell Res 1988 175 1 184 191 10.1016/0014-4827(88)90265-0 3345800
38. In vitro genotoxic effects of the insecticide deltamethrin in human peripheral blood leukocytes: DNA damage ('comet' assay) in relation to the induction of sister-chromatid exchanges and micronuclei. M Villarini M Moretti R Pasquini G Scassellati-Sforzolini C Fatigoni M Marcarelli S Monarca AV Rodriguez, Toxicology 1998 130 2-3 129 139 10.1016/S0300-483X(98)00097-3 9865480
39. In vitro genotoxicity of terbutryn evaluated by the alkaline single-cell microgel-electrophoresis "comet" assay. M Villarini G Scassellati-Sforzolini M Moretti R Pasquini, Cell Biol Toxicol 2000 16 5 285 292 10.1023/A:1026794213308 11201052
40. Application of the single-cell gel-electrophoresis ('comet') assay to the detection of primary DNA damage in workers of the rubber industry: comparison of manual and computerized analysis. M Moretti M Villarini G Scassellati-Sforzolini S Monarca A Salucci A Vicent Rodriguez, Toxicological and Environmental Chemistry 1999 13 24
41. Analysis of correlated data in human biomonitoring studies. The case of high sister chromatid exchange frequency cells. S Bonassi V Fontana M Ceppi R Barale A Biggeri, Mutat Res 1999 438 1 13 21 9858669
42. The comet assay for DNA damage and repair: principles, applications, and limitations. AR Collins, Mol Biotechnol 2004 26 3 249 261 10.1385/MB:26:3:249 15004294
43. Effects of occupation, lifestyle and genetic polymorphisms of CYP1A1, CYP2E1, GSTM1 and GSTT1 on urinary 1-hydroxypyrene and 2-naphthol concentrations. HM Nan H Kim HS Lim JK Choi T Kawamoto JW Kang CH Lee YD Kim EH Kwon, Carcinogenesis 2001 22 5 787 793 10.1093/carcin/22.5.787 11323399
44. Biological monitoring of exposure to polycyclic aromatic hydrocarbon in an electrode paste plant. S Ovrebo A Haugen PE Fjeldstad K Hemminki K Szyfter, J Occup Med 1994 36 3 303 310 10.1097/00043764-199403000-00007 8195900
45. Association between urinary 1-hydroxypyrene and genotoxic effects in coke oven workers. E Siwinska D Mielzynska L Kapka, Occup Environ Med 2004 61 3 e10 10.1136/oem.2002.006643 14985527
46. Statistics of the Comet assay: a key to discriminate between genotoxic effects. P Duez G Dehon A Kumps J Dubois, Mutagenesis 2003 18 2 159 166 10.1093/mutage/18.2.159 12621072
47. Genetic polymorphism of drug-metabolizing enzymes and styrene-induced DNA damage. A Buschini G De Palma P Poli A Martino C Rossi P Mozzoni E Scotti L Buzio E Bergamaschi A Mutti, Environ Mol Mutagen 2003 41 4 243 252 10.1002/em.10150 12717779
48. Health practices and leukocyte DNA damage in Japanese hard-metal workers. Y Lu K Morimoto K Nakayama, Prev Med 2006 43 2 140 144 10.1016/j.ypmed.2006.03. 008 16643999
49. DNA damage among thyroid cancer and multiple cancer cases, controls, and long-lived individuals. AJ Sigurdson M Hauptmann BH Alexander MM Doody CB Thomas JP Struewing IM Jones, Mutat Res 2005 586 2 173 188 16099702
50. Influence of genetic polymorphisms of biotransformation enzymes on gene mutations, strand breaks of deoxyribonucleic acid, and micronuclei in mononuclear blood cells and urinary 8-hydroxydeoxyguanosine in potroom workers exposed to polyaromatic hydrocarbons. U Carstensen SM Hou AK Alexandrie B Hogstedt C Tagesson M Warholm A Rannug B Lambert A Axmon L Hagmar, Scand J Work Environ Health 1999 25 4 351 360 10505661
51. Biomonitoring of primary aluminium industry workers: detection of micronuclei and repairable DNA lesions by alkaline SCGE. R Crebelli P Carta C Andreoli G Aru G Dobrowolny S Rossi A Zijno, Mutat Res 2002 516 1-2 63 70 11943612
52. Analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine and DNA strand breaks in white blood cells of occupationally exposed workers: comparison with ambient monitoring, urinary metabolites and enzyme polymorphisms. B Marczynski HP Rihs B Rossbach J Holzer J Angerer M Scherenberg G Hoffmann T Bruning M Wilhelm, Carcinogenesis 2002 23 2 273 281 10.1093/carcin/23.2.273 11872632
53. Biological monitoring of genotoxic hazard in workers of the rubber industry. M Moretti M Villarini G Scassellati-Sforzolini S Monarca M Libraro C Fatigoni F Donato C Leonardis L Perego, Environ Health Perspect 1996 104 Suppl 3 543 545 8781380 10.2307/3432820
54. DNA damage in T- and B-lymphocytes and granulocytes in emission inspection and incineration workers exposed to polycyclic aromatic hydrocarbons. D Sul E Oh H Im M Yang CW Kim E Lee, Mutat Res 2003 538 1-2 109 119 12834760
55. Biological monitoring the exposure to polycyclic aromatic hydrocarbons of coke oven workers in relation to smoking and genetic polymorphisms for GSTM1 and GSTT1. JH van Delft MS Steenwinkel JG van Asten N de Vogel TC Bruijntjes-Rozier T Schouten P Cramers L Maas MH van Herwijnen F van Schooten, Ann Occup Hyg 2001 45 5 395 408 11418090
56. The effect of smoking on DNA effects in the comet assay: a meta-analysis. H Hoffmann J Hogel G Speit, Mutagenesis 2005 20 6 455 466 10.1093/mutage/gei064 16280345
57. Racial differences in restriction fragment length polymorphisms and messenger RNA inducibility of the human CYP1A1 gene. G Cosma F Crofts D Currie I Wirgin P Toniolo SJ Garte, Cancer Epidemiol Biomarkers Prev 1993 2 1 53 57 8093594
58. Microsomal epoxide hydrolase polymorphisms and lung cancer risk in non-Hispanic whites. H Zhao MR Spitz KM Gwyn X Wu, Mol Carcinog 2002 33 2 99 104 10.1002/mc.10023 11813302
59. The GSTM1 null genotype as a potential risk modifier for squamous cell carcinoma of the lung. A Hirvonen K Husgafvel-Pursiainen S Anttila H Vainio, Carcinogenesis 1993 14 7 1479 1481 10.1093/carcin/14.7.1479 8330369
60. Biomonitoring of occupational exposure to styrene in a plastics lamination plant. M Somorovska E Jahnova J Tulinska M Zamecnikova J Sarmanova A Terenova L Vodickova A Liskova B Vallova P Soucek, Mutat Res 1999 428 1-2 255 269 10517998
61. The effect of relevant genotypes on PAH exposure-related biomarkers. T Kuljukka-Rabb L Nylund R Vaaranrinta K Savela P Mutanen T Veidebaum M Sorsa A Rannug K Peltonen, J Expo Anal Environ Epidemiol 2002 12 1 81 91 10.1038/sj.jea.7500204 11859435
62. Influence of genetic polymorphisms of CYP1A1 and GSTM1 on the urinary levels of 1-hydroxypyrene. P Apostoli G Neri D Lucas M Manno F Berthou, Toxicol Lett 2003 144 1 27 34 10.1016/S0378-4274(03)00227-3 12919721
63. Reduced nucleotide excision repair and GSTM1-null genotypes influence anti-B[a]PDE-DNA adduct levels in mononuclear white blood cells of highly PAH-exposed coke oven workers. S Pavanello A Pulliero E Siwinska D Mielzynska E Clonfero, Carcinogenesis 2005 26 1 169 175 10.1093/carcin/bgh303 15471894
64. Modulation of benzo[a]pyrene diolepoxide-DNA adduct levels in human white blood cells by CYP1A1, GSTM1 and GSTT1 polymorphism. M Rojas I Cascorbi K Alexandrov E Kriek G Auburtin L Mayer A Kopp-Schneider I Roots H Bartsch, Carcinogenesis 2000 21 1 35 41 10.1093/carcin/21.1.35 10607731
65. Comet assay in genetic ecotoxicology: a review. S Cotelle JF Ferard, Environ Mol Mutagen 1999 34 4 246 255 10.1002/(SICI)1098-2280(1999)34:4<246:: AID-EM4>3.0.CO;2-V 10618172
66. A mortality cohort study among workers in a graphite electrode production plant in Italy. DF Merlo S Garattini U Gelatti C Simonati L Covolo M Ceppi F Donato, Occup Environ Med 2004 61 2 e9 10.1136/oem.2003.009357 14739393