Stimulatory and costimulatory effects of IL-18 directed to different small intestinal CD43 T cell subsets

Journal of Leukocyte Biology

Volumn 82, Issue 5, 2007, Pages 1166-1173

  Montufar Solis, Dina ^a   Wang, Heuy Ching ^a   Klein, John R ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Costimulation; Cytokine; Mucosa; T cells

Indexed keywords

CD3 ANTIGEN; CYTOKINE; FENTICLOR; GAMMA INTERFERON; INTERLEUKIN 18 RECEPTOR; LEUKOSIALIN;

ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL POPULATION; CELL PROLIFERATION; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SMALL INTESTINE MUCOSA; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; ANTIGENS, CD3; ANTIGENS, CD43; CD8-POSITIVE T-LYMPHOCYTES; CELL DEATH; CELL PROLIFERATION; FLOW CYTOMETRY; INTERFERON TYPE II; INTERLEUKIN-18; INTESTINAL MUCOSA; INTESTINE, SMALL; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, INTERLEUKIN-18; T-LYMPHOCYTE SUBSETS;

MURINAE;

EID: 36248957097     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0207108     Document Type: Article

References (54)

1. Kunisawa, J., Kiyono, H. (2005) A marvel of mucosal T cells and secretory antibodies for the creation of first lines of defense. Cell. Mol. Life Sci. 62, 1308-1321.
2. Beagley, K. W., Elson, C. O. (1992) Cells and cytokines in mucosal immunity and inflammation. Gastroenterol. Clin. North Am. 21, 347-366.
3. Strober, W., Fuss, I. J., Blumberg, R. S. (2002) The immunology of mucosal models of inflammation. Annu. Rev. Immunol. 20, 495-549.
4. + cytotoxic T cells induce relapsing colitis in normal mice. Gastroenterology 131, 485-496.
5. Saito, H., Kanamori, Y., Takemori, T., Nariuchi, H., Kubota, E., Takahashi-Iwanaga, H., Iwanaga, T., Ishikawa, H. (1998) Generation of intestinal T cells from progenitors residing in gut cryptopatches. Science 280, 275-278.
6. Nonaka, S., Naito, T., Chen, H., Yamamoto, M., Moro, K., Kiyono, H., Hamada, H., Ishikawa, H. (2005) Intestinal gamma delta T cells develop in mice lacking thymus, all lymph nodes, Peyer's patches, and isolated lymphoid follicles. J. Immunol. 174, 1906-1912.
7. Hitotsumatsu, O., Hamada, H., Naganuma, M., Inoue, N., Ishii, H., Hibi, T., Ishikawa, H. (2005) Identification and characterization of novel gut-associated lymphoid tissues in rat small intestine. J. Gastroenterol. 40, 956-963.
8. Maloy, K. J., Mowat, A. M., Zamoyska, R., Crispe, I. N. (1991) Phenotypic heterogeneity of intraepithelial T lymphocytes from mouse small intestine. Immunology 72, 555-562.
9. Lefrancois, L. (1991) Phenotypic complexity of intraepithelial lymphocytes of the small intestine. J. Immunol. 147, 1746-1751.
10. O'Keeffe, J., Doherty, D. G., Kenna, T., Sheahan, K., O'Donoghue, D. P., Hyland, J. M., O'Farrelly, C. (2004) Diverse populations of T cells with NK cell receptors accumulate in the human intestine in health and in colorectal cancer. Eur. J. Immunol. 34, 2110-2119.
11. + T cells. J. Immunol. 173, 6294-6302.
12. + T cells in murine intestinal epithelium. Eur. J. Immunol. 20, 1623-1626.
13. Ernst, P. B., Clark, D. A., Rosenthal, K. L., Befus, A. D., Bienenstock, J. (1986) Detection and characterization of cytotoxic T lymphocyte precursors in the murine intestinal intraepithelial leukocyte population. J. Immunol. 136, 2121-2126.
14. + intraepithelial lymphocytes. Nature 333, 855-858.
15. + intestinal intraepithelial lymphocytes are partially but not fully activated T cells. J. Immunol. 169, 4717-4722.
16. Yamamoto, M., Fujihashi, K., Beagley, K. W., McGhee, J. R., Kiyono, H. (1993) Cytokine synthesis by intestinal intraepithelial lymphocytes. Both γ/δ- T cell receptor-positive and α/β T cell receptor-positive T cells in the G1 phase of cell cycle produce IFN-γ and IL-5. J. Immunol. 150, 106-114.
17. + murine small intestinal intraepithelial lymphocytes during acute reovirus infection. Biochem. Biophys. Res. Commun. 342, 782-790.
18. Sydora, B. C., Mixter, P. F., Holcombe, H. R., Eghtesady, P., Williams, K., Amaral, M. C., Nel, A., Kronenberg, M. (1993) Intestinal intraepithelial lymphocytes are activated and cytolytic but do not proliferate as well as other T cells in response to mitogenic signals. J. Immunol. 150, 2179-2191.
19. + intraepithelial lymphocytes by apoptosis. Eur. J. Immunol. 20, 2809-2812.
20. Mosley, R. L., Whetsell, M., Klein, J. R. (1991) Proliferative properties of murine intestinal intraepithelial lymphocytes (IEL): IEL expressing TCRαβ or TCRγδ- are largely unresponsive to proliferative signals mediated via conventional stimulation of the CD3-TCR complex. Int. Immunol. 3, 563-569.
21. Fahrer, A. M., Konigshofer, Y., Kerr, E. M., Ghandour, G., Mack, D. H., Davis, M. M., Chien, Y. H. (2001) Attributes of γδ -intraepithelial lymphocytes as suggested by their transcriptional profile. Proc. Natl. Acad. Sci. USA 98, 10261-10266.
22. + intraepithelial lymphocytes provided by serial analysis of gene expression (SAGE). Immunity 15, 419-434.
23. Bagriacik, E. U., Armstrong, M. D., Okabe, M., Klein, J. R. (1999) Differential expression of CD43 isoforms on murine T cells and their relationship to acute intestinal graft versus host disease: studies using enhanced-green fluorescent protein transgenic mice. Int. Immunol. 11, 1651-1662.
24. Cheroutre, H. (2005) IELs: enforcing law and order in the court of the intestinal epithelium. Immunol. Rev. 206, 114-131.
25. Nakanishi, K., Yoshimoto, T., Tsutsui, H., Okamura, H. (2001) Interleukin-18 regulates both Th1 and Th2 responses. Annu. Rev. Immunol. 19, 423-474.
26. Xu, D., Chan, W. L., Leung, B. P., Hunter, D., Schulz, K., Carter, R. W., McInnes, I. B., Robinson, J. H., Liew, F. Y. (1998) Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells. J. Exp. Med. 188, 1485-1492.
27. Okamura, H., Tsutsi, H., Komatsu, T., Yutsudo, M., Hakura, A., Tanimoto, T., Torigoe, K., Okura, T., Nukada, Y., Hattori, K., et al. (1995) Cloning of a new cytokine that induces IFN-γ production by T cells. Nature 378, 88-91.
28. Kinoshita, M., Kuranaga, N., Matsumoto, A., Ono, S., Shinomiya, N., Hiraide, H., Seki, S. (2006) Multiple interleukin-18 injections promote both mouse Th1 and Th2 responses after sublethal Escherichia coli infection. Clin. Exp. Immunol. 143, 41-49.
29. Maxwell, J. R., Yadav, R., Rossi, R. J., Ruby, C. E., Weinberg, A. D., Aguila, H. L., Vella, A. T. (2006) IL-18 bridges innate and adaptive immunity through IFN-γ and the CD134 Pathway. J. Immunol. 177, 234-245.
30. Okazawa, A., Kanai, T., Nakamaru, K., Sato, T., Inoue, N., Ogata, H., Iwao, Y., Ikeda, M., Kawamura, T., Makita, S., et al. (2004) Human intestinal epithelial cell-derived interleukin (IL)-18, along with IL-2, IL-7 and IL-15, is a potent synergistic factor for the proliferation of intraepithelial lymphocytes. Clin. Exp. Immunol. 136, 269-276.
31. Lochner, M., Forster, I. (2002) Anti-interleukin-18 therapy in murine models of inflammatory bowel disease. Pathobiology 70, 164-169.
32. Siegmund, B., Zeitz, M. (2004) Therapeutic approaches in inflammatory bowel disease based on the immunopathogenesis. Rocz. Akad. Med. Bialymst. 49, 22-30.
33. Dotan, I., Mayer, L. (2002) Immunopathogenesis of inflammatory bowel disease. Curr. Opin. Gastroenterol. 18, 421-427.
34. Wiercinska-Drapalo, A., Flisiak, R., Jaroszewicz, J., Prokopowicz, D. (2005) Plasma interleukin-18 reflects severity of ulcerative colitis. World J. Gastroenterol. 11, 605-608.
35. Gordon, J. N., Di Sabatino, A., Macdonald, T. T. (2005) The pathophysiologic rationale for biological therapies in inflammatory bowel disease. Curr. Opin. Gastroenterol. 21, 431-437.
36. Reuter, B. K., Pizarro, T. T. (2004) Commentary: the role of the IL-18 system and other members of the IL-1R/TLR superfamily in innate mucosal immunity and the pathogenesis of inflammatory bowel disease: friend or foe? Eur. J. Immunol. 34, 2347-2355.
37. Kanai, T., Uraushihara, K., Totsuka, T., Okazawa, A., Hibi, T., Oshima, S., Miyata, T., Nakamura, T., Watanabe, M. (2003) Macrophage-derived IL-18 targeting for the treatment of Crohn's disease. Curr. Drug Targets Inflamm. Allergy 2, 131-136.
38. Ludwiczek, O., Kaser, A., Novick, D., Dinarello, C. A., Rubinstein, M., Tilg, H. (2005) Elevated systemic levels of free interleukin-18 (IL-18) in patients with Crohn's disease. Eur. Cytokine Netw. 16, 27-33.
39. Monteleone, G., Fina, D., Caruso, R., Pallone, F. (2006) New mediators of immunity and inflammation in inflammatory bowel disease. Curr. Opin. Gastroenterol. 22, 361-364.
40. + T-cell subsets after experimental allogeneic bone marrow transplantation. Blood 104, 3393-3399.
41. Esfandiari, E., McInnes, I. B., Lindop, G., Huang, F. P., Field, M., Komai-Koma, M., Wei, X., Liew, F. Y. (2001) A proinflammatory role of IL-18 in the development of spontaneous autoimmune disease. J. Immunol. 167, 5338-5347.
42. Liu, B., Mori, I., Hossain, M. J., Dong, L., Takeda, K., Kimura, Y. (2004) Interleukin-18 improves the early defence system against influenza virus infection by augmenting natural killer cell-mediated cytotoxicity. J. Gen. Virol. 85, 423-428.
43. Culshaw, S., Leung, B. P., Gracie, J. A., Campbell, C. C., Thomson, D., Gemmell, C., Liew, F. Y., McInnes, I. B. (2005) Prior elevation of IL-18 promotes rapid early IFN-γ production during staphylococcal infection. Eur. J. Immunol. 35, 1438-1444.
44. Montufar-Solis, D., Klein, J. R. (2006) An improved method for isolating intraepithelial lymphocytes (IELs) from the murine small intestine with consistently high purity. J. Immunol. Methods 308, 251-254.
45. Livak, K. J., Schmittgen, T. D. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25, 402-408.
46. Born, T. L., Thomassen, E., Bird, T. A., Sims, J. E. (1998) Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling. J. Biol. Chem. 273, 29445-29450.
47. Kanai, T., Watanabe, M., Okazawa, A., Nakamaru, K., Okamoto, M., Naganuma, M., Ishii, H., Ikeda, M., Kurimoto, M., Hibi, T. (2000) Interleukin 18 is a potent proliferative factor for intestinal mucosal lymphocytes in Crohn's disease. Gastroenterology 119, 1514-1523.
48. Maerten, P., Shen, C., Colpaert, S., Liu, Z., Bullens, D. A., van Assche, G., Penninckx, F., Geboes, K., Vanham, G., Rutgeerts, P., et al. (2004) Involvement of interleukin 18 in Crohn's disease: evidence from in vitro analysis of human gut inflammatory cells and from experimental colitis models. Clin. Exp. Immunol. 135, 310-317.
49. Ahn, H. J., Maruo, S., Tomura, M., Mu, J., Hamaoka, T., Nakanishi, K., Clark, S., Kurimoto, M., Okamura, H., Fujiwara, H. (1997) A mechanism underlying synergy between IL-12 and IFN-γ-inducing factor in enhanced production of IFN-γ. J. Immunol. 159, 2125-2131.
50. Robinson, D., Shibuya, K., Mui, A., Zonin, F., Murphy, E., Sana, T., Hartley, S. B., Menon, S., Kastelein, R., Bazan, F., et al. (1997) IGIF does not drive Th1 development but synergizes with IL-12 for interferon-γ production and activates IRAK and NF-κB. Immunity 7, 571-581.
51. Ten Hove, T., Corbaz, A., Amitai, H., Aloni, S., Belzer, I., Graber, P., Drillenburg, P., van Deventer, S. J., Chvatchko, Y., Te Velde, A. A. (2001) Blockade of endogenous IL-18 ameliorates TNBS-induced colitis by decreasing local TNF-α production in mice. Gastroenterology 121, 1372-1379.
52. Siegmund, B., Fantuzzi, G., Rieder, F., Gamboni-Robertson, F., Lehr, H. A., Hartmann, G., Dinarello, C. A., Endres, S., Eigler, A. (2001) Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-γ and TNF-α production. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281, R1264-R1273.
53. Sivakumar, P. V., Westrich, G. M., Kanaly, S., Garka, K., Born, T. L., Derry, J. M., Viney, J. L. (2002) Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage. Gut 50, 812-820.
54. Wirtz, S., Becker, C., Blumberg, R., Galle, P. R., Neurath, M. F. (2002) Treatment of T cell-dependent experimental colitis in SCID mice by local administration of an adenovirus expressing IL-18 antisense mRNA. J. Immunol. 168, 411-420.