Genomic modulation of mitochondrial respiratory genes in the hypertrophied heart reflects adaptive changes in mitochondrial and contractile function

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 293, Issue 5, 2007, Pages

  Zungu, Makhosazane ^a   Alcolea, Maria Pilar ^b,c   García Palmer, Francisco José ^c   Young, Martin E ^d   Essop, M Faadiel ^e  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b UNIVERSITAT DE LES ILLES BALEARS   (Spain)

^c Instituto de Salud Carlos III   (Spain)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

^e STELLENBOSCH UNIVERSITY   (South Africa)

Author keywords

Gene expression; Hypertrophy; Hypobaric hypoxia; Mitochondria

Indexed keywords

CITRATE SYNTHASE; CYTOCHROME C OXIDASE; MITOCHONDRIAL DNA; NUCLEAR RESPIRATORY FACTOR 1; OXYGEN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; ENZYME ACTIVITY; GENE CONTROL; GENE EXPRESSION REGULATION; HEART FUNCTION; HEART LEFT VENTRICLE; HEART MITOCHONDRION; HEART MUSCLE CONTRACTILITY; HEART RIGHT VENTRICLE; HEART RIGHT VENTRICLE HYPERTROPHY; HEART WORK; HYPOXIA; LONG TERM EXPOSURE; MALE; MITOCHONDRIAL GENETICS; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTON TRANSPORT; RAT; TRANSCRIPTION REGULATION; WISTAR RAT;

ADAPTATION, PHYSIOLOGICAL; CARDIOMEGALY; CELL RESPIRATION; CELLS, CULTURED; CHROMOSOME MAPPING; GENE EXPRESSION REGULATION; MITOCHONDRIA, HEART; MITOCHONDRIAL PROTEINS; MYOCARDIAL CONTRACTION; OXYGEN; PROTEOME; VENTRICULAR DYSFUNCTION, LEFT;

EID: 36148984184     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00806.2006     Document Type: Article

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