Rapid induction of IAP family proteins and Smac/DIABLO expression after proapoptotic stimulation with doxorubicin in RPMI 8226 multiple myeloma cells

Experimental and Molecular Pathology

Volumn 83, Issue 3, 2007, Pages 405-412

  Abe, Shinya ^a   Hasegawa, Maki ^a   Yamamoto, Kouhei ^a   Kurata, Morito ^a   Nakagawa, Yasunori ^a,b   Suzuki, Kenshi ^b   Takizawa, Touichiro ^a   Kitagawa, Masanobu ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b JAPANESE RED CROSS MEDICAL CENTER   (Japan)

Author keywords

Apoptosis; Drug resistance; IAP; Multiple myeloma; Smac DIABLO

Indexed keywords

DOXORUBICIN; INHIBITOR OF APOPTOSIS PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN 1; INHIBITOR OF APOPTOSIS PROTEIN 2; MESSENGER RNA; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SURVIVIN; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL SURVIVAL; CONTROLLED STUDY; GENE OVEREXPRESSION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MYELOMA CELL; PROTEIN EXPRESSION; TUMOR RESISTANCE; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; CELL LINE, TUMOR; DOXORUBICIN; GENE EXPRESSION REGULATION; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MITOCHONDRIAL PROTEINS; MULTIPLE MYELOMA; RNA, MESSENGER;

INTRACISTERNAL A-PARTICLES;

EID: 36049046693     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2007.04.001     Document Type: Article

References (36)

1. Abe S., Yamamoto K., Hasegawa M., Inoue M., Kurata M., Hirokawa K., and Kitagawa M. Bone marrow cells of myelodysplastic syndromes exhibit significant expression of apollon, livin and ILP-2 with reduction after transformation to overt leukemia. Leuk. Res. 29 (2005) 1095-1096
2. Adida C., Crotty P.L., McGrath J., Berrebi D., Diebold J., and Altieri D.C. Developmentally regulated expression of the novel cancer anti-apoptotic gene survivin in human and mouse differentiation. Am. J. Pathol. 152 (1998) 43-49
3. Altieri D.C., and Marchisio C. Survivin apoptosis: An interloper between cell death and cell proliferation in cancer. Lab. Invest. 79 (1999) 1327-1333
4. Ambrosini G., Adida C., and Altieri D.C. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat. Med. 3 (1997) 917-921
5. Crnkovic-Mertens I., Hoppe-Seyler F., and Butz K. Induction of apoptosis in tumor cells by siRNA-mediated silencing of the livin/ML-IAP/KIAP gene. Oncogene 22 (2003) 8330-8336
6. Dalton W.S., Durie B.G., Alberts D.S., Gerlach J.H., and Cress A.E. Characterization of a new drug-resistant human myeloma cell line that express P-glycoprotein. Cancer Res. 46 (1986) 5125-5130
7. Deveraux Q.L., and Reed J.C. IAP family proteins, suppressors of apoptosis. Genes Dev. 13 (1999) 239-252
8. Du C., Fang M., Li Y., Li L., and Wang X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 102 (2000) 33-42
9. Duckett C.S. IAP proteins: sticking it to Smac. Biochem. J. 385 (2005) e1-e2
10. Galluzzi L., Larochette N., Zamzami N., and Kroemer G. Mitochondria as therapeutic targets for cancer chemotherapy. Oncogene 25 (2006) 4812-4830
11. Kashkar H., Seeger J.-M., Hombach A., Deggerich A., Yazdanpanah B., Utermöhlen O., Heimlich G., Abken H., and Krönke M. XIAP targeting sensitizes Hodgkin lymphoma cells for cytolytic T-cell attack. Blood 108 (2006) 3434-3440
12. r mouse strain. Exp. Hematol. 24 (1996) 1423-1431
13. Kitagawa M., Saito I., Kuwata T., Yoshida S., Yamaguchi S., Takahashi M., Tanizawa T., Kamiyama R., and Hirokawa K. Overexpression of tumor necrosis factor (TNF)-α and interferon (IFN)-γ by bone marrow cells from patients with myelodysplastic syndromes. Leukemia 11 (1997) 2049-2054
14. Kitagawa M., Yamaguchi S., Takahashi M., Tanizawa T., Hirokaw K., and Kamiyama R. Localization of Fas and Fas ligand in bone marrow cells demonstrating myelodysplasia. Leukemia 12 (1998) 486-492
15. Kitagawa M., Yamaguchi S., Hasegawa M., Tanaka K., Sado T., Hirokawa K., and Aizawa S. Friend leukemia virus-infection enhances DNA-damage-induced apoptosis of hematopoietic cells in C3H hosts. J. Virol. 76 (2002) 7790-7798
16. Li J., Feng Q., Kim J.-M., Schneiderman D., Liston P., Li M., Vanderhyden B., Faught W., Fung M., Fung K., Senterman M., Korneluk R.G., and Tsang B.K. Human ovarian cancer and cisplatin resistance: possible role of inhibitor of apoptosis proteins. Endocrinology 142 (2001) 370-380
17. Liston P., Fong W.G., and Korneluk R.G. The inhibitors of apoptosis: there is more to life than Bcl2. Oncogene 22 (2003) 8568-8580
18. Liu T., Brouha B., and Grossman D. Rapid induction of mitochondrial events and caspase-independent apoptosis in Survivin-targeted melanoma cells. Oncogene 23 (2004) 39-48
19. Miller L.K. An expression of IAPs: salvation and surprises from BIR motifs. Trends Cell Biol. 9 (1999) 323-328
20. Mitsiades C.S., Mitsiades N., Poulaki V., Schlossman R., Akiyama M., Chauhan D., Hideshima T., Treon S.P., Munshi N.C., Richardson P.G., and Anderson K.C. Actication of NF-kB and pregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications. Oncogene 21 (2002) 5673-5683
21. Mitsiades N., Mitsiades C.S., Poulaki V., Chauhan D., Richardson P.G., Hideshima T., Munshi N., Treon S.P., and Anderso K.C. Biologic sequelae of nuclear factor-κB blockade in multiple myeloma: therapeutic applications. Blood 99 (2002) 4079-4086
22. Mizukawa K., Kawamura A., Sasayama T., Tanaka K., Kamei M., Sasaki M., and Kohmura E. Synthetic Smac peptide enhances the effect of etoposide-induced apoptosis in human glioblastoma cell lines. J. Neuro-Oncol. 77 (2006) 247-255
23. Nakagawa Y., Abe Y., Kurata M., Hasegawa M., Yamamoto K., Inoue M., Takemura T., Suzuki K., and Kitagawa M. IAP family protein expression correlates with poor outcome of multiple myeloma patients in association with chemotherapy-induced overexpression of multidrug resistance genes. Am. J. Hematol. 81 (2006) 824-831
24. Notarbartolo M., Cervello M., Dusonchet L., Cusimano A., and D'Alessandro N. Resistance to diverse apoptotic triggers in multidrug resistant HL60 cells and its possible relationship to the expression of P-glycoprotein, Fas and of the novel anti-apoptosis factors IAP (inhibitory of apoptosis proteins). Cancer Lett. 180 (2002) 91-101
25. Notarbartolo M., Poma P., Perri D., Dusonchet L., Cervello M., and D'Alessandro N. Antitumor effects of curcumin, alone or in combination with cisplatin or doxorubicin, on human hepatic cancer cells. Analysis of their possible relationship to changes in NF-kB activation levels and in IAP gene expression. Cancer Lett. 224 (2005) 53-65
26. Schimmer A.D., and Dalili S. Targeting the IAP family of caspase inhibitors as an emerging therapeutic strategy. Hematology (Am Soc Hematol Education Program) (2005) 215-219
27. Shin S., Sung B.J., Cho Y.-S., Kim H.-J., Ha N.-C., Hwang J.-I., Chung C.W., Jung Y.K., and Oh B.H. An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7. Biochemistry 40 (2001) 1117-1123
28. Tamm I., Wang Y., Sausville E., Scudiero D.A., Vigna N., Oltersdorf T., and Reed J.C. IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res. 58 (1998) 5315-5320
29. Tyagi A.K., Agarwal C., Singh R.P., Shroyer K.R., Glode L.M., and Agarwal R. Silibinin down-regulates survivin protein and mRNA expression and causes caspases activation and apoptosis in human bladder transitional-cell papilloma RT4 cells. Biochem. Biophys. Res. Commun. 312 (2003) 1178-1184
30. Vaux D.L., and Slike J. IAPs, RINGs and ubiquitylation. Nat. Rev., Mol. Cell Biol. 6 (2005) 287-297
31. Velculescu V.E., Madden S., Zhang L., Lash A.E., Yu J., Rago C., Lal A., Wang C.J., Beaudry G.A., Ciriello K.M., Cook B.P., Dufault M.R., Ferguson A.T., Gao Y., He T.C., Hermeking H., Hiraldo S.K., Hwang P.M., Lopez M.A., Laderer H.F., Mathews B., Petroziello J.M., Polyak K., Zawel L., Kinzler K.W., et al. Analysis of human transcriptomes. Nat. Genet. 23 (1999) 387-388
32. Verhagen A.M., Ekert P.G., Pakusch M., Silke J., Connolly L.M., Reid G.E., Moritz R.L., Simpson R.J., and Vaux D.L. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 102 (2000) 43-53
33. Wittmann S., Bal P., Donapaty S., Nimmanapalli R., Guo F., Yamaguchi H., Huang M., Jove R., Wang H.G., and Bhalla K. Flavopiridol down-regulates antiapoptotic proteins and sensitizes human breast cancer cells to epothiline B-induced apoptosis. Cancer Res. 63 (2003) 93-99
34. Wright C.W., and Duckett C.S. Reawakening the cellular death program in neoplasia through the therapeutic blockade of IAP function. J. Clin. Invest. 115 (2005) 2673-2678
35. Yamamoto K., Abe S., Nakagawa Y., Suzuki K., Hasegawa M., Inoue M., Kurata M., Hirokawa K., and Kitagawa M. Expression of IAP family proteins in myelodysplastic syndromes transforming to overt leukemia. Leuk. Res. 28 (2004) 1203-1211
36. Yonesaka K., Tamura K., Kurata T., Satoh T., Ikeda M., Fukuoka M., and Nakagawa K. Small interfering RNA targeting survivin sensitizes lung cancer cell with mutant p53 to adriamycin. Int. J. Cancer 118 (2006) 812-820