메뉴 건너뛰기




Volumn 35, Issue 4, 2007, Pages 411-420

Prediction of acute toxicity in HPCT-1E3 hepatocytoma cells with liver-like transport activities

Author keywords

Acute toxicity; Cytotoxicity; HepG2; HPCT 1E3; MTT assay; Transport

Indexed keywords

2,4 DICHLOROPHENOXYACETIC ACID; ACETYLSALICYLIC ACID; AMIODARONE; AMITRIPTYLINE; ARSENIC TRIOXIDE; CHLORAMPHENICOL; CHLOROFORM; CHLOROQUINE; CHLORPROMAZINE; CYCLOSPORIN A; DIAZEPAM; DIGOXIN; DOXORUBICIN; ETHYLENE GLYCOL; FLUORIDE SODIUM; INDOMETACIN; ISONIAZID; KETOCONAZOLE; METHOTREXATE; PARA XYLENE; PARACETAMOL; PHENOBARBITAL; PHENOL; POTASSIUM CYANIDE; PRASTERONE SULFATE; PRAVASTATIN; PROBENECID; QUINIDINE; VERAPAMIL; WARFARIN; TETRAZOLIUM; THIAZOLE DERIVATIVE; THIAZOLYL BLUE; UNCLASSIFIED DRUG;

EID: 36049024371     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: 10.1177/026119290703500410     Document Type: Article
Times cited : (8)

References (26)
  • 1
    • 0024955695 scopus 로고
    • MEIC - a new international multicenter project to evaluate the relevance to human toxicity of in vitro cytotoxicity tests
    • Bondesson, I., Ekwall, B., Hellberg, S., Romert, L., Stenberg, K. & Walum, E. (1989). MEIC - a new international multicenter project to evaluate the relevance to human toxicity of in vitro cytotoxicity tests. Cell Biology and Toxicology 5, 331-347.
    • (1989) Cell Biology and Toxicology , vol.5 , pp. 331-347
    • Bondesson, I.1    Ekwall, B.2    Hellberg, S.3    Romert, L.4    Stenberg, K.5    Walum, E.6
  • 2
    • 0032839104 scopus 로고    scopus 로고
    • Overview of the Final MEIC Results: II. The in vitro-in vivo evaluation, including the selection of a practical battery of cell tests for prediction of acute lethal blood concentrations in humans
    • Ekwall, B. (1999). Overview of the Final MEIC Results: II. The in vitro-in vivo evaluation, including the selection of a practical battery of cell tests for prediction of acute lethal blood concentrations in humans. Toxicology in Vitro 13, 665-673.
    • (1999) Toxicology in Vitro , vol.13 , pp. 665-673
    • Ekwall, B.1
  • 3
    • 0034618656 scopus 로고    scopus 로고
    • Cytotoxicity of the MEIC reference chemicals in rat hepatoma-derived Fa32 cells
    • Dierickx, P.J. (2000). Cytotoxicity of the MEIC reference chemicals in rat hepatoma-derived Fa32 cells. Toxicology 150, 159-169.
    • (2000) Toxicology , vol.150 , pp. 159-169
    • Dierickx, P.J.1
  • 4
    • 0032865119 scopus 로고    scopus 로고
    • Overview of the Final MEIC Results: I. The in vitro-in vitro evaluation
    • Clemedson, C. & Ekwall, B. (1999). Overview of the Final MEIC Results: I. The in vitro-in vitro evaluation. Toxicology in Vitro 13, 657-663.
    • (1999) Toxicology in Vitro , vol.13 , pp. 657-663
    • Clemedson, C.1    Ekwall, B.2
  • 5
    • 0038245040 scopus 로고    scopus 로고
    • The Registry of Cytotoxicity: Toxicity testing in cell cultures to predict acute toxicity (LD50) and to reduce testing in animals
    • Halle, W. (2003). The Registry of Cytotoxicity: toxicity testing in cell cultures to predict acute toxicity (LD50) and to reduce testing in animals. ATLA 31, 189-198.
    • (2003) ATLA , vol.31 , pp. 189-198
    • Halle, W.1
  • 7
    • 21444460758 scopus 로고    scopus 로고
    • Endogenous expression of liver-specific drug transporters for organic anions in the rat hepatocytoma fusion cell line HPCT-1E3
    • Halwachs, S., Kneuer, C. & Honscha, W. (2005). Endogenous expression of liver-specific drug transporters for organic anions in the rat hepatocytoma fusion cell line HPCT-1E3. European Journal of Cell Biology 84, 677-686.
    • (2005) European Journal of Cell Biology , vol.84 , pp. 677-686
    • Halwachs, S.1    Kneuer, C.2    Honscha, W.3
  • 8
    • 0027078741 scopus 로고
    • Xenobiotic-metabolizing enzyme activities in hybrid cell lines established by fusion of primary rat liver parenchymal cells with hepatoma cells
    • Utesch, D., Arand, M., Thomas, H., Petzinger, E. & Oesch, F. (1992). Xenobiotic-metabolizing enzyme activities in hybrid cell lines established by fusion of primary rat liver parenchymal cells with hepatoma cells. Xenobiotica 22, 1451-1457.
    • (1992) Xenobiotica , vol.22 , pp. 1451-1457
    • Utesch, D.1    Arand, M.2    Thomas, H.3    Petzinger, E.4    Oesch, F.5
  • 9
    • 22744440362 scopus 로고    scopus 로고
    • Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases
    • Löscher, W. & Potschka, H. (2005). Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases. Progress in Neurobiology 76, 22-76.
    • (2005) Progress in Neurobiology , vol.76 , pp. 22-76
    • Löscher, W.1    Potschka, H.2
  • 11
    • 37249056749 scopus 로고    scopus 로고
    • The Multicenter Evaluation of In vitro
    • 66pp. Research Triangle Park, NC, USA: National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods NICEATM, Anon
    • Anon. (2000). The Multicenter Evaluation of In vitro Cytotoxicity (MEIC) Summary, 66pp. Research Triangle Park, NC, USA: National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM).
    • (2000) Cytotoxicity (MEIC) Summary
  • 12
    • 84892886114 scopus 로고    scopus 로고
    • Website http:// Accessed 04.12.06
    • The MEIC in vitro Database. Website http://www. cctoxconsulting.a.se/sidan1.htm (Accessed 04.12.06).
    • The MEIC in vitro Database
  • 13
    • 0036657141 scopus 로고    scopus 로고
    • In vitro phototoxicity testing: Development and validation of a new concentration response analysis software and biostatistical analyses related to the use of various prediction models
    • Peters, B. & Holzhütter, H.G. (2002). In vitro phototoxicity testing: development and validation of a new concentration response analysis software and biostatistical analyses related to the use of various prediction models. ATLA 30, 415-432.
    • (2002) ATLA , vol.30 , pp. 415-432
    • Peters, B.1    Holzhütter, H.G.2
  • 14
    • 33749527916 scopus 로고    scopus 로고
    • Assessment of the drug susceptibility of Plasmodium falciparum clinical isolates from Africa by using a Plasmodium lactate dehydrogenase immunodetection assay and an inhibitory maximum effect model for precise measurement of the 50-percent inhibitory concentration
    • Kaddouri, H., Nakache, S., Houze, S., Mentre, F. & Le Bras, J. (2006). Assessment of the drug susceptibility of Plasmodium falciparum clinical isolates from Africa by using a Plasmodium lactate dehydrogenase immunodetection assay and an inhibitory maximum effect model for precise measurement of the 50-percent inhibitory concentration. Antimicrobial Agents and Chemotherapy 50, 3343-3349.
    • (2006) Antimicrobial Agents and Chemotherapy , vol.50 , pp. 3343-3349
    • Kaddouri, H.1    Nakache, S.2    Houze, S.3    Mentre, F.4    Le Bras, J.5
  • 15
    • 27644474180 scopus 로고    scopus 로고
    • Comparison of the cytotoxicity of the MEIC reference chemicals measured in protein free and in complete culture medium
    • Dierickx, P.J. (2005). Comparison of the cytotoxicity of the MEIC reference chemicals measured in protein free and in complete culture medium. Toxicology in Vitro 19, 859-864.
    • (2005) Toxicology in Vitro , vol.19 , pp. 859-864
    • Dierickx, P.J.1
  • 17
    • 18144442630 scopus 로고    scopus 로고
    • Toxicological implications of hepatobiliary transporters
    • Kato, Y., Suzuki, H. & Sugiyama, Y. (2002). Toxicological implications of hepatobiliary transporters. Toxicology 181-182, 287-290.
    • (2002) Toxicology , vol.181-182 , pp. 287-290
    • Kato, Y.1    Suzuki, H.2    Sugiyama, Y.3
  • 19
    • 17444420647 scopus 로고    scopus 로고
    • Organic anion transporter (Slc22a) family members as mediators of toxicity
    • Sweet, D.H. (2005). Organic anion transporter (Slc22a) family members as mediators of toxicity. Toxicology and Applied Pharmacology 204, 198-215.
    • (2005) Toxicology and Applied Pharmacology , vol.204 , pp. 198-215
    • Sweet, D.H.1
  • 20
    • 0029793039 scopus 로고    scopus 로고
    • Ranking of P-glycoprotein substrates and inhibitors by a calcein-AM fluorometry screening assay
    • Tiberghien, F. & Loor, F. (1996). Ranking of P-glycoprotein substrates and inhibitors by a calcein-AM fluorometry screening assay. Anticancer Drugs 7, 568-578.
    • (1996) Anticancer Drugs , vol.7 , pp. 568-578
    • Tiberghien, F.1    Loor, F.2
  • 21
    • 0027339633 scopus 로고
    • Terfenadine (Seldane): A new drug for restoring sensitivity to multidrug resistant cancer cells
    • Hait, W.N., Gesmonde, J.F., Murren, J.R., Yang, J.M., Chen, H.X. & Reiss, M. (1993). Terfenadine (Seldane): a new drug for restoring sensitivity to multidrug resistant cancer cells. Biochemical Pharmacology 45, 401-406.
    • (1993) Biochemical Pharmacology , vol.45 , pp. 401-406
    • Hait, W.N.1    Gesmonde, J.F.2    Murren, J.R.3    Yang, J.M.4    Chen, H.X.5    Reiss, M.6
  • 22
    • 0037260573 scopus 로고    scopus 로고
    • Impact of Mrp2 on the biliary excretion and intestinal absorption of furosemide, probenecid, and methotrexate using Eisai hyperbilirubinemic rats
    • Chen, C., Scott, D., Hanson, E., Franco, J., Berryman, E., Volberg, M. & Liu, X. (2003). Impact of Mrp2 on the biliary excretion and intestinal absorption of furosemide, probenecid, and methotrexate using Eisai hyperbilirubinemic rats. Pharmaceutical Research 20, 31-37.
    • (2003) Pharmaceutical Research , vol.20 , pp. 31-37
    • Chen, C.1    Scott, D.2    Hanson, E.3    Franco, J.4    Berryman, E.5    Volberg, M.6    Liu, X.7
  • 23
    • 0036175452 scopus 로고    scopus 로고
    • Comparative inhibitory effects of different compounds on rat Oatp1 (Slc21a1)- and Oatp2 (Slc21a5)-mediated transport
    • Shitara, Y., Sugiyama, D., Kusuhara, H., Kato, Y., Abe, T., Meier, P.J., Itoh, T. & Sugiyama, Y. (2002). Comparative inhibitory effects of different compounds on rat Oatp1 (Slc21a1)- and Oatp2 (Slc21a5)-mediated transport. Pharmaceutical Research 19, 147-153.
    • (2002) Pharmaceutical Research , vol.19 , pp. 147-153
    • Shitara, Y.1    Sugiyama, D.2    Kusuhara, H.3    Kato, Y.4    Abe, T.5    Meier, P.J.6    Itoh, T.7    Sugiyama, Y.8
  • 26
    • 1242272736 scopus 로고    scopus 로고
    • Organic anion transporting polypeptides of the OATP/SLC21 family: Phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties
    • Hagenbuch, B. & Meier, P. (2004). Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties. Pflügers Archiv - European Journal of Physiology 447, 653-665.
    • (2004) Pflügers Archiv - European Journal of Physiology , vol.447 , pp. 653-665
    • Hagenbuch, B.1    Meier, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.