The role of helix 1 aspartates and salt bridges in the stability and conversion of prion protein

Journal of Biological Chemistry

Volumn 278, Issue 14, 2003, Pages 12522-12529

  Speare, Jonathan O ^a,b   Rush III, Thomas S ^b,c   Bloom, Marshall E ^a   Caughey, Byron ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b UNIVERSITY OF MONTANA   (United States)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENETIC ENGINEERING; IONIZATION; PROTEINS; SALTS; SPECTROSCOPIC ANALYSIS;

PATHOGENESIS;

BIOCHEMISTRY;

ALANINE; ARGININE; ASPARTIC ACID; ASPARTIC ACID DERIVATIVE; BRIDGED PEPTIDE; DETERGENT; HELIX 1 ASPARTATE; MUTANT PROTEIN; PRION PROTEIN; SODIUM CHLORIDE; UNCLASSIFIED DRUG; DISULFIDE; GUANIDINE; INORGANIC SALT;

AMINO ACID SUBSTITUTION; ARTICLE; BRAIN SPONGIOSIS; CELL FREE SYSTEM; CHEMICAL MODIFICATION; CIRCULAR DICHROISM; DENATURATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN MODIFICATION; PROTEIN STABILITY; PROTEIN STRUCTURE; ANIMAL; CHEMISTRY; GENETICS; HAMSTER; HEAT; MUTAGENESIS; PRION; PROTEIN DENATURATION; PROTEIN SECONDARY STRUCTURE; SYRIAN HAMSTER;

CRICETINAE;

ANIMALS; ASPARTIC ACID; CELL-FREE SYSTEM; CIRCULAR DICHROISM; CRICETINAE; DISULFIDES; GUANIDINE; HEAT; MESOCRICETUS; MUTAGENESIS; PRIONS; PROTEIN DENATURATION; PROTEIN STRUCTURE, SECONDARY; SALTS;

EID: 0038576230     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M211599200     Document Type: Article

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