Over-expression of S100A2 in pancreatic cancer correlates with progression and poor prognosis

Journal of Pathology

Volumn 213, Issue 3, 2007, Pages 275-282

  Ohuchida, K ^a   Mizumoto, K ^a   Miyasaka, Y ^a   Yu, J ^a   Cui, L ^a   Yamaguchi, H ^a   Toma, H ^a   Takahata, S ^a   Sato, N ^a   Nagai, E ^a   Yamaguchi, K ^a   Tsuneyoshi, M ^a   Tanaka, M ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

IPMN; Microdissection; Pancreatic cancer; PanIN; S100A2

Indexed keywords

BIOLOGICAL MARKER; FORMALDEHYDE; PROTEIN DERIVATIVE; S100 A2 PROTEIN; UNCLASSIFIED DRUG;

ADENOCARCINOMA; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER GROWTH; CANCER SURGERY; CANCER SURVIVAL; CARCINOGENESIS; CELL DIFFERENTIATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE COURSE; DISEASE MARKER; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRADUCTAL PAPILLARY MUCINOUS TUMOR; INVASIVE DUCTAL CARCINOMA; METASTASIS; MICRODISSECTION; PANCREAS CANCER; PANCREAS TUMOR; PANCREATIC INTRAEPITHELIAL NEOPLASIA; PANCREATITIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR GROWTH;

CARCINOMA, PANCREATIC DUCTAL; CELL DIFFERENTIATION; CELL LINE, TUMOR; CHEMOTACTIC FACTORS; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASM INVASIVENESS; PANCREAS; PANCREATIC NEOPLASMS; PARAFFIN EMBEDDING; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; S100 PROTEINS; TUMOR MARKERS, BIOLOGICAL;

EID: 35948987670     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2250     Document Type: Article

References (44)

1. Jemal A, Murray T, Samuels A, Ghafoor A, Ward E, Thun MJ. Cancer statistics, 2003. CA Cancer J Clin 2003;53:5-26.
2. Yeo CJ, Cameron JL, Lillemoe KD, Sitzmann JV, Hruban RH, Goodman SN, et al. Pancreaticoduodenectomy for cancer of the head of the pancreas. 201 patients. Ann Surg 1995;221:721-731; discussion, 31-33.
3. Burris HA III, Moore MJ, Andersen J, Green MR, Rothenberg ML, Modiano MR, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 1997;15:2403-2413.
4. Moore MJ. Brief communication: a new combination in the treatment of advanced pancreatic cancer. Semin Oncol 2005;32:5-6.
5. Liu D, Rudland PS, Sibson DR, Platt-Higgins A, Barraclough R. Expression of calcium-binding protein S100A2 in breast lesions. Br J Cancer 2000;83:1473-149.
6. 2+-binding proteins of the S100 family in malignant human breast-cancer cell lines and biopsy samples. Int J Cancer 1994;57:684-690.
7. Feng G, Xu X, Youssef EM, Lotan R. Diminished expression of S100A2, a putative tumor suppressor, at early stage of human lung carcinogenesis. Cancer Res 2001;61:7999-8004.
8. 2+-binding S100 proteins. Histol Histopathol 2001;16:707-712.
9. Nagy N, Brenner C, Markadieu N, Chaboteaux C, Camby I, Schafer BW, et al. S100A2, a putative tumor suppressor gene, regulates in vitro squamous cell carcinoma migration. Lab Invest 2001;81:599-612.
10. 2+-binding S100 proteins in epithelial tumours of the skin. Virchows Arch 1998;432:53-59.
11. Hough CD, Cho KR, Zonderman AB, Schwartz DR, Morin PJ. Coordinately up-regulated genes in ovarian cancer. Cancer Res 2001;61:3869- 3876.
12. Hsieh HL, Schafer BW, Sasaki N, Heizmann CW. Expression analysis of S100 proteins and RAGE in human tumors using tissue microarrays. Biochem Biophys Res Commun 2003;307:375-381.
13. El-Rifai W, Moskaluk CA, Abdrabbo MK, Harper J, Yoshida C, Riggins GJ, et al. Gastric cancers over-express S100A calcium-binding proteins. Cancer Res 2002;62:6823-6826.
14. Tan M, Heizmann CW, Guan K, Schafer BW, Sun Y. Transcriptional activation of the human S100A2 promoter by wild-type p53. FEBS Lett 1999;445:265-268.
15. Ohuchida K, Mizumoto K, Ishikawa N, Fujii K, Konomi H, Nagai E, et al. The role of S100A6 in pancreatic cancer development and its clinical implication as a diagnostic marker and therapeutic target. Clin Cancer Res 2005;11:7785-7793.
16. Antonov J, Goldstein DR, Oberli A, Baltzer A, Pirotta M, Fleischmann A, et al. Reliable gene expression measurements from degraded RNA by quantitative real-time PCR depend on short amplicons and a proper normalization. Lab Invest 2005;85:1040-1050.
17. Lekanne Deprez RH, Fijnvandraat AC, Ruijter JM, Moorman AF. Sensitivity and accuracy of quantitative real-time polymerase chain reaction using SYBR green I depends on cDNA synthesis conditions. Anal Biochem 2002;307:63-69.
18. Lewis F, Maughan NJ, Smith V, Hillan K, Quirke P. Unlocking the archive - gene expression in paraffin-embedded tissue. J Pathol 2001;195:66-71.
19. Hruban RH, Adsay NV, Albores-Saavedra J, Compton C, Garrett ES, Goodman SN, et al. Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions. Am J Surg Pathol 2001;25:579-586.
20. House MG, Guo M, Iacobuzio-Donahue C, Herman JG. Molecular progression of promoter methylation in intraductal papillary mucinous neoplasms (IPMN) of the pancreas. Carcinogenesis 2003;24:193-198.
21. Nakata B, Yashiro M, Nishioka N, Aya M, Yamada S, Takenaka C, et al. Genetic alterations in adenoma-carcinoma sequencing of intraductal papillary-mucinous neoplasm of the pancreas. Int J Oncol 2002;21:1067-1072.
22. Lowenfels AB, Maisonneuve P, Cavallini G, Ammann RW, Lankisch PG, Andersen JR, et al. Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group. N Engl J Med 1993;328: 1433-1437.
23. Karlson BM, Ekbom A, Josefsson S, McLaughlin JK, Fraumeni JF Jr, Nyren O. The risk of pancreatic cancer following pancreatitis: an association due to confounding? Gastroenterology 1997;113:587-592.
24. Ohuchida K, Mizumoto K, Murakami M, Qian LW, Sato N, Nagai E, et al. Radiation to stromal fibroblasts increases invasiveness of pancreatic cancer cells through tumor-stromal interactions. Cancer Res 2004;64:3215-3222.
25. Tachikawa T, Irie T. A new molecular biology approach in morphology: basic method and application of laser microdissection. Med Electron Microsc 2004;37:82-88.
26. Ohuchida K, Mizumoto K, Ohhashi S, Yamaguchi H, Konomi H, Nagai E, et al. Twist, a novel oncogene, is upregulated in pancreatic cancer: clinical implication of Twist expression in pancreatic juice. Int J Cancer 2007;120:1634-1640.
27. Matsubara D, Niki T, Ishikawa S, Goto A, Ohara E, Yokomizo T, et al. Differential expression of S100A2 and S100A4 in lung adenocarcinomas: clinicopathological significance, relationship to p53 and identification of their target genes. Cancer Sci 2005;96:844-857.
28. Ohuchida K, Mizumoto K, Ohhashi S, Yamaguchi H, Konomi H, Nagai E, et al. S100A11, a putative tumor suppressor gene, is over-expressed in pancreatic carcinogenesis. Clin Cancer Res 2006;12:5417-5422.
29. Biankin AV, Biankin SA, Kench JG, Morey AL, Lee CS, Head DR, et al. Aberrant p16(INK4A) and DPC4/Smad4 expression in intraductal papillary mucinous tumours of the pancreas is associated with invasive ductal adenocarcinoma. Gut 2002;50:861-868.
30. Soldini D, Gugger M, Burckhardt E, Rappeler A, Laissue JA, Mazzucchelli L. Progressive genomic alterations in intraductal papillary mucinous tumours of the pancreas and morphologically similar lesions of the pancreatic ducts. J Pathol 2003;199:453-461.
31. Hermanova M, Nenutil R, Kren L, Feit J, Pavlovsky Z, Dite P. Proliferative activity in pancreatic intraepithelial neoplasias of chronic pancreatitis resection specimens: detection of a high-risk lesion. Neoplasma 2004;51:400-404.
32. Rosty C, Geradts J, Sato N, Wilentz RE, Roberts H, Sohn T, et al. p16 inactivation in pancreatic intraepithelial neoplasias (PanINs) arising in patients with chronic pancreatitis. Am J Surg Pathol 2003;27:1495- 1501.
33. Ohuchida K, Mizumoto K, Yamada D, Fujii K, Ishikawa N, Konomi H, et al. Quantitative analysis of MUC1 and MUC5AC mRNA in pancreatic juice for preoperative diagnosis of pancreatic cancer. Int J Cancer 2006;118:405-411.
34. Ohuchida K, Mizumoto K, Fujita H, Yamaguchi H, Konomi H, Nagai E, et al. Sonic hedgehog is an early developmental marker of intraductal papillary mucinous neoplasms: clinical implications of mRNA levels in pancreatic juice. J Pathol 2006;210:42-48.
35. Wang H, Zhang Z, Li R, Ang KK, Zhang H, Caraway NP, et al. Over-expression of S100A2 protein as a prognostic marker for patients with stage I non small cell lung cancer. Int J Cancer 2005;116:285-290.
36. Diederichs S, Bulk E, Steffen B, Ji P, Tickenbrock L, Lang K, et al. S100 family members and trypsinogens are predictors of distant metastasis and survival in early-stage non-small cell lung cancer. Cancer Res 2004;64:5564-5569.
37. Villaret DB, Wang T, Dillon D, Xu J, Sivam D, Cheever MA, et al. Identification of genes over-expressed in head and neck squamous cell carcinoma using a combination of complementary DNA subtraction and microarray analysis. Laryngoscope 2000;110:374-381.
38. Abe K, Suda K, Arakawa A, Yamasaki S, Sonoue H, Mitani K, et al. Different patterns of p16INK4A and p53 protein expressions in intraductal papillary-mucinous neoplasms and pancreatic intraepithelial neoplasia. Pancreas 2007;34:85-91.
39. Moore PS, Sipos B, Orlandini S, Sorio C, Real FX, Lemoine NR, et al. Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4. Virchows Arch 2001;439:798-802.
40. Sipos B, Moser S, Kalthoff H, Torek V, Lohr M, Kloppel G. A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform. Virchows Arch 2003;442:444-452.
41. Slebos RJ, Resnick MA, Taylor JA. Inactivation of the p53 tumor suppressor gene via a novel Alu rearrangement. Cancer Res 1998;58:5333-5336.
42. Vimalachandran D, Greenhalf W, Thompson C, Luttges J, Prime W, Campbell F, et al. High nuclear S100A6 (Calcyclin) is significantly associated with poor survival in pancreatic cancer patients. Cancer Res 2005;65:3218-3225.
43. Rosty C, Ueki T, Argani P, Jansen M, Yeo CJ, Cameron JL, et al. Over-expression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation. Am J Pathol 2002;160:45-50.
44. Ohuchida K, Mizumoto K, Yu J, Yamaguchi H, Konomi H, Nagai E, et al. S100A6 is increased in a stepwise manner during pancreatic carcinogenesis: clinical value of expression analysis in 98 pancreatic juice samples. Cancer Epidemiol Biomarkers Prev 2007;16:649-654.